BR9607933A - Reagente para preparar um radiofarmacêutico agente de formação de imagem cintigráfica e radioterapêutico complexo composição kit para preparar uma preparação radiofarmacêutica processo para rotular um reagente para formar uma imagem de um sítio e para fazer um reagente composição de matéria e uso do reagente - Google Patents

Reagente para preparar um radiofarmacêutico agente de formação de imagem cintigráfica e radioterapêutico complexo composição kit para preparar uma preparação radiofarmacêutica processo para rotular um reagente para formar uma imagem de um sítio e para fazer um reagente composição de matéria e uso do reagente

Info

Publication number
BR9607933A
BR9607933A BR9607933A BR9607933A BR9607933A BR 9607933 A BR9607933 A BR 9607933A BR 9607933 A BR9607933 A BR 9607933A BR 9607933 A BR9607933 A BR 9607933A BR 9607933 A BR9607933 A BR 9607933A
Authority
BR
Brazil
Prior art keywords
reagent
prepare
radiopharmaceutical
composition
label
Prior art date
Application number
BR9607933A
Other languages
English (en)
Inventor
Richard T Dean
Daniel A Pearson
Edgar R Civitello
John Lister-James
Original Assignee
Diatide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatide Inc filed Critical Diatide Inc
Publication of BR9607933A publication Critical patent/BR9607933A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
BR9607933A 1995-03-31 1996-03-29 Reagente para preparar um radiofarmacêutico agente de formação de imagem cintigráfica e radioterapêutico complexo composição kit para preparar uma preparação radiofarmacêutica processo para rotular um reagente para formar uma imagem de um sítio e para fazer um reagente composição de matéria e uso do reagente BR9607933A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/414,424 US5849261A (en) 1991-02-08 1995-03-31 Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
PCT/US1996/004308 WO1996030055A2 (en) 1995-03-31 1996-03-29 Radiolabeled peptides for diagnosis and therapy

Publications (1)

Publication Number Publication Date
BR9607933A true BR9607933A (pt) 1998-06-02

Family

ID=23641398

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9607933A BR9607933A (pt) 1995-03-31 1996-03-29 Reagente para preparar um radiofarmacêutico agente de formação de imagem cintigráfica e radioterapêutico complexo composição kit para preparar uma preparação radiofarmacêutica processo para rotular um reagente para formar uma imagem de um sítio e para fazer um reagente composição de matéria e uso do reagente

Country Status (19)

Country Link
US (2) US5849261A (pt)
EP (1) EP0820313A2 (pt)
JP (1) JPH11503420A (pt)
KR (1) KR19980703459A (pt)
CN (1) CN1087631C (pt)
AR (1) AR002980A1 (pt)
AU (1) AU710923B2 (pt)
BR (1) BR9607933A (pt)
CA (1) CA2216851C (pt)
HU (1) HUP9801390A3 (pt)
IL (1) IL117725A (pt)
MX (1) MX9707426A (pt)
NO (1) NO974494L (pt)
NZ (1) NZ306677A (pt)
PL (1) PL192734B1 (pt)
RU (1) RU2171117C2 (pt)
TW (1) TW449482B (pt)
WO (1) WO1996030055A2 (pt)
ZA (1) ZA962527B (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109071606A (zh) * 2016-06-13 2018-12-21 国立大学法人鹿儿岛大学 利用IgG结合肽的位点特异性放射性同位素标记抗体

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
WO1998002192A1 (en) * 1996-07-12 1998-01-22 Immunomedics, Inc. Radiometal-binding peptide analogues
US6083480A (en) * 1997-05-01 2000-07-04 Diatide, Inc. Calcitonin receptor binding reagents
US6395255B1 (en) * 1998-06-15 2002-05-28 Thomas Jefferson University Radiolabeled vasoactive intestinal peptide analogs for imaging and therapy
US6409987B1 (en) 1999-04-07 2002-06-25 Intimax Corporation Targeted agents useful for diagnostic and therapeutic applications
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
US7175953B2 (en) * 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
US6323313B1 (en) 1999-06-01 2001-11-27 The University Of Washington Annexin derivative with endogenous chelation sites
TWI290146B (en) * 1999-07-29 2007-11-21 Dyax Corp Binding moieties for fibrin
AU6909700A (en) * 1999-08-16 2001-03-13 Uab Research Foundation Gene transfer imaging and uses thereof
US6358491B1 (en) * 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
EP1257576B1 (en) * 2000-02-18 2004-09-15 Dabur Research Foundation Vasoactive intestinal peptide analogs
WO2001060863A1 (en) * 2000-02-18 2001-08-23 Dabur Research Foundation Radiolabeled vasoactive intestinal peptide analogs for diagnosis and radiotherapy
KR100430061B1 (ko) * 2000-03-21 2004-05-03 재단법인 아산사회복지재단 글루코스 유도체에 방사성 동위원소가 표지된 착화합물 및이를 생산하기 위한 조성물이 포함된 키트
US6828304B1 (en) 2000-07-31 2004-12-07 Dabur Research Foundation Peptides for treatment of cancer
KR20020023636A (ko) * 2000-09-23 2002-03-29 송영욱 신규한 방사성 레늄 주석 화합물
US6902718B2 (en) * 2000-10-24 2005-06-07 Diatide, Inc. Stabilization of radiopharmaceutical compositions using hydrophilic thioethers
US6984373B2 (en) * 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
GB0105224D0 (en) 2001-03-02 2001-04-18 Nycomed Amersham Plc Improved peptide-chelate conjugates
WO2003033030A1 (en) * 2001-10-19 2003-04-24 Thomas Jefferson University Pacap compositions and methods for tumor imaging and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
ES2506142T3 (es) 2002-03-01 2014-10-13 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico
EP1587944A4 (en) 2002-03-01 2007-03-21 Dyax Corp KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
EP1506412A1 (en) * 2002-05-08 2005-02-16 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with vasoactive intestinal peptide receptor 2 (vpac2)
JP2005534697A (ja) * 2002-08-06 2005-11-17 エピックス ファーマシューティカルズ， インコーポレイテッド ペプチド凝集体
DK2284180T3 (en) 2003-03-03 2015-12-21 Dyax Corp Uses of peptides that specifically bind to the HGF receptor (cMET)
CN100341582C (zh) * 2005-01-07 2007-10-10 北京肿瘤医院 一种含sn3类配体的血管活性肠肽衍生物药物及其制备方法
EP1700608A1 (en) 2005-03-10 2006-09-13 Schering AG Chelators for radioactively labeled conjugates comprising a stabilizing sidechain
CN101089020B (zh) * 2006-06-13 2011-04-20 中国科学院上海应用物理研究所 血管活性肠肽类似物及其放射性标记物，以及它们的制备方法
US20080121535A1 (en) * 2006-09-28 2008-05-29 Cady Roger K Biometric Testing and Monitoring Method and Device
US20080160557A1 (en) * 2006-09-28 2008-07-03 Cady Roger K Diagnostic Test for Head and Facial Pain
US20100016364A1 (en) * 2006-09-28 2010-01-21 Cady Roger K Method of predictive determination of responsiveness to pharmacological intervention
US10925977B2 (en) * 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
US20080187894A1 (en) * 2006-12-14 2008-08-07 Cady Roger K Method and System for Interactive Cognitive Testing
JP5159636B2 (ja) * 2006-12-21 2013-03-06 日本メジフィジックス株式会社 放射性画像診断剤
EP2147684A1 (en) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
AR075900A1 (es) 2009-03-19 2011-05-04 Wyeth Llc Metodos para la preparacion de acidos (2-(8,9-dioxo-2,6-diazabiciclico (5.2.0) non-1(7)-en-2-il)etil) fosfonico y sus precursores.
WO2010121133A2 (en) 2009-04-17 2010-10-21 The General Hospital Corporation Multimodal imaging of fibrin
CA2797033C (en) * 2010-04-22 2021-10-19 Longevity Biotech, Inc. Highly active polypeptides and methods of making and using the same
EP2968469A4 (en) 2013-03-15 2016-08-31 Longevity Biotech Inc PEPTIDES COMPRISING NON-ENDOGENIC AMINO ACIDS AND METHODS OF MAKING AND USING SAME
WO2015171543A1 (en) 2014-05-05 2015-11-12 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
WO2017011769A2 (en) 2015-07-15 2017-01-19 California Institute Of Technology Il-17f-specific capture agents, compositions, and methods of using and making
EP3424940A4 (en) * 2016-03-01 2019-10-30 National University Corporation Chiba University RADIOMARCED MEDICINE
EP3440101B1 (en) 2016-04-04 2021-10-06 Indi Molecular, Inc. Cd8-specific capture agents, compositions, and methods of using and making
WO2018064597A1 (en) 2016-09-29 2018-04-05 Indi Molecular, Inc. Compositions for detection, inhibition and imaging of indoleamine 2,3-dioxygenase 1 (ido1) and methods of making and using same
CN110248700A (zh) * 2017-01-24 2019-09-17 深圳市奥沃医学新技术发展有限公司 一种用于放射性治疗的定位头钉和一种立体定位装置
EP3638687A1 (en) 2017-06-15 2020-04-22 Indi Molecular, Inc. Il-17f and il-17a-specific capture agents, compositions, and methods of using and making
US11638764B2 (en) 2018-11-08 2023-05-02 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
US20200291391A1 (en) 2019-03-12 2020-09-17 Indi Molecular, Inc. Cross-linked epitopes and methods of use thereof
WO2020236969A1 (en) 2019-05-20 2020-11-26 Indi Molecular, Inc. Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1)
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
WO2022098743A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
WO2022098745A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4668503A (en) * 1982-07-26 1987-05-26 Trustees Of University Of Massachusetts Process for labeling amines with 99m Tc
US4575556A (en) * 1982-11-08 1986-03-11 Medi-Physics, Inc. Bifunctional chelating agents
US4434151A (en) * 1982-11-08 1984-02-28 Medi-Physics, Inc. Bifunctional chelating agents
US4571430A (en) * 1982-11-08 1986-02-18 Medi-Physics, Inc. Homocysteine and homocysteinamide derivatives
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
US4493523A (en) * 1983-10-18 1985-01-15 Challenger Circle F, Inc. Adaptive strain relief for wiring devices
WO1985003231A1 (en) * 1984-01-23 1985-08-01 Institutt For Energiteknikk TECHNETIUM-99m COMPOSITION FOR LABELLING PROTEINACEOUS MATERIAL AND METHOD
ATE66469T1 (de) * 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
GB8525974D0 (en) * 1985-10-22 1985-11-27 Nyegaard & Co As Chemical substance
JPS62155994A (ja) * 1985-12-27 1987-07-10 Mitsubishi Monsanto Chem Co 活性汚泥のバルキング防止剤及びそのバルキング防止方法
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
DE3728599A1 (de) * 1986-12-10 1988-06-23 Hoechst Ag Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz
US4939224A (en) * 1987-02-26 1990-07-03 The Salk Institute Biotechnology/Industrial Associates, Inc. Vasoactive intestinal peptide analogs
US4965392A (en) * 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
US5091514A (en) * 1987-03-26 1992-02-25 Neorx Corporation Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy
EP0354923B1 (en) * 1987-04-02 1994-06-29 Centocor, Inc. Method for labelling antibodies with a metal ion
JPH02500803A (ja) * 1987-07-07 1990-03-22 サイトアールエックス　バイオプール　リミテッド フィブリンに結合する化合物および方法
DE68923274T2 (de) * 1988-02-09 1995-11-09 Mallinckrodt Inc Verfahren zur herstellung eines mit metall-radionuklid-markierten proteins.
US5061641A (en) * 1988-04-01 1991-10-29 Immunomedics, Inc. Method for radiolabeling proteins
JPH03505094A (ja) * 1988-05-02 1991-11-07 ニュー　イングランド　ディーコネス　ホスピタル　コーポレイション 動脈映像のための合成ペプチド
US5218128A (en) * 1988-06-15 1993-06-08 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
US5180816A (en) * 1988-08-24 1993-01-19 Centocor One vial method for labeling protein/linker conjugates with technetium-99M
US4925650A (en) * 1988-11-16 1990-05-15 Mallinckrodt, Inc. Technetium -99m complex for examining the renal function
WO1990006323A2 (en) * 1988-11-29 1990-06-14 Centocor, Inc. Chimeric proteins incorporating a metal binding protein
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
US5248764A (en) * 1989-06-16 1993-09-28 Merck Frosst Canada, Inc. Chelate derivatives of atrial natriuretic factor (ANF)
EP0403243B1 (en) * 1989-06-16 1995-11-08 Merck Frosst Canada Inc. Chelate derivatives of atrial natriuretic factor (ANF)
US5234907A (en) * 1989-06-30 1993-08-10 Hoffmann-La Roche Inc. Synthetic vasoactive intestinal peptide analogs
US5686410A (en) * 1989-07-20 1997-11-11 Novartis Ag Polypeptide derivatives
CA2032499C (en) * 1989-07-20 2002-05-14 Rainer Albert Polypeptide derivatives
FR2650672A1 (fr) * 1989-08-02 1991-02-08 Medgenix Group Sa Procede de marquage de proteines ou polypeptides au technetium-99m, conjugue obtenu, utilisation a titre d'agent d'imagerie, kit de reconstitution desdits conjugues
US5112953A (en) * 1989-12-29 1992-05-12 Neorx Corporation Radiolabeled proteins for diagnostic or therapeutic use
US5175257A (en) * 1989-12-29 1992-12-29 Neorx Corporation Radiolabeled proteins for diagnostic or therapeutic use
EP0463450B1 (en) * 1990-06-26 1994-02-16 Sanwa Kagaku Kenkyusho Co., Ltd. Vasoactive intestinal polypeptide analogues and use thereof
JP2860157B2 (ja) * 1990-10-31 1999-02-24 日本メジフィジックス株式会社 腎機能測定用の既放射能標識テクネチウムキレート注射剤の製造方法
US5552525A (en) * 1991-02-08 1996-09-03 Diatech Inc. Technetium-99m labeled peptides for imaging inflammation
DE69230525T2 (de) * 1991-02-08 2000-06-21 Diatide, Inc. Technetium-99m markierte Polypeptide zur Bildformung
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
JPH0692991A (ja) * 1991-02-28 1994-04-05 Daicel Chem Ind Ltd 新規活性ペプチド
US5273963A (en) * 1991-03-29 1993-12-28 The George Washington University Compositions and methods for treating small cell and nonsmall cell lung cancers
CA2102633A1 (en) * 1991-06-03 1992-12-04 Peter H. Cox Radiolabelled somatostatin derivatives, their preparation and use
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5186613A (en) * 1991-12-20 1993-02-16 American Standard Inc. Reverse phase and high discharge temperature protection in a scroll compressor
ES2155447T3 (es) * 1992-01-03 2001-05-16 Rhomed Inc Aplicaciones farmaceuticas de peptidos-iones metalicos.
ATE203417T1 (de) * 1992-02-05 2001-08-15 Mallinckrodt Inc Radioaktiv markierte somatostatin
ES2194846T3 (es) * 1992-03-13 2003-12-01 Diatide Inc Peptidos marcados con tecnecio-99m para obtencion de imagenes de inflamacion.
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
JP2941057B2 (ja) * 1992-05-21 1999-08-25 ダイアテク，インコーポレイテッド 血栓造影用のテクネチウム‐９９ｍ標識ペプチド
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
DE69332203T2 (de) * 1992-10-02 2003-05-28 Diatide, Inc. Multimerische mehrzweckwirkstoffe gegen thrombose
FR2701953B1 (fr) * 1993-02-22 1995-05-24 Centre Nat Rech Scient Protéine de fusion multi-VIP et procédé de préparation de VIP recombinant.
DK0693941T3 (da) * 1993-04-08 2002-10-14 Diatide Inc Radiomærkede forbindelser til trombe-billeddannelse
EP1099707A3 (en) * 1993-06-23 2002-01-09 Diatide, Inc. Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
WO1995003280A1 (en) * 1993-07-19 1995-02-02 Resolution Pharmaceuticals Inc. Hydrazino-type radionuclide chelators having an n3s configuration
US5565424A (en) * 1994-02-07 1996-10-15 Ramot - University Authority For Applied Research And Industrial Development Ltd. Superactive VIP antagonists
US5746996A (en) * 1994-06-03 1998-05-05 Immunomedics, Inc. Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109071606A (zh) * 2016-06-13 2018-12-21 国立大学法人鹿儿岛大学 利用IgG结合肽的位点特异性放射性同位素标记抗体

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WO1996030055A3 (en) 1996-12-12
NO974494D0 (no) 1997-09-29
RU2171117C2 (ru) 2001-07-27
AR002980A1 (es) 1998-05-27
AU710923B2 (en) 1999-09-30
PL322589A1 (en) 1998-02-02
PL192734B1 (pl) 2006-12-29
US6007792A (en) 1999-12-28
CA2216851C (en) 2003-02-11
NZ306677A (en) 1999-11-29
CN1087631C (zh) 2002-07-17
CA2216851A1 (en) 1996-10-03
WO1996030055A2 (en) 1996-10-03
US5849261A (en) 1998-12-15
IL117725A (en) 2001-01-28
NO974494L (no) 1997-11-21
CN1186443A (zh) 1998-07-01
JPH11503420A (ja) 1999-03-26
TW449482B (en) 2001-08-11
IL117725A0 (en) 1996-07-23
HUP9801390A3 (en) 1998-12-28
MX9707426A (es) 1998-07-31
EP0820313A2 (en) 1998-01-28
ZA962527B (en) 1997-01-21
KR19980703459A (ko) 1998-11-05
AU5529696A (en) 1996-10-16

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