DE68923274T2 - Verfahren zur herstellung eines mit metall-radionuklid-markierten proteins. - Google Patents

Verfahren zur herstellung eines mit metall-radionuklid-markierten proteins.

Info

Publication number
DE68923274T2
DE68923274T2 DE68923274T DE68923274T DE68923274T2 DE 68923274 T2 DE68923274 T2 DE 68923274T2 DE 68923274 T DE68923274 T DE 68923274T DE 68923274 T DE68923274 T DE 68923274T DE 68923274 T2 DE68923274 T2 DE 68923274T2
Authority
DE
Germany
Prior art keywords
protein
proteinaceous material
radionuclide
reacting
coupling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68923274T
Other languages
English (en)
Other versions
DE68923274D1 (de
Inventor
Wilhelmus Goedemans
Karel Panek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of DE68923274D1 publication Critical patent/DE68923274D1/de
Application granted granted Critical
Publication of DE68923274T2 publication Critical patent/DE68923274T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE68923274T 1988-02-09 1989-02-08 Verfahren zur herstellung eines mit metall-radionuklid-markierten proteins. Expired - Fee Related DE68923274T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NL8800302 1988-02-09
NL8801728 1988-07-08
NL8802408 1988-09-30
PCT/US1989/000500 WO1989007456A1 (en) 1988-02-09 1989-02-08 Method of preparing a metal-radionuclide-labelled protein

Publications (2)

Publication Number Publication Date
DE68923274D1 DE68923274D1 (de) 1995-08-03
DE68923274T2 true DE68923274T2 (de) 1995-11-09

Family

ID=27352196

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68923274T Expired - Fee Related DE68923274T2 (de) 1988-02-09 1989-02-08 Verfahren zur herstellung eines mit metall-radionuklid-markierten proteins.

Country Status (7)

Country Link
EP (1) EP0401302B1 (de)
AT (1) ATE124269T1 (de)
AU (2) AU635204B2 (de)
DE (1) DE68923274T2 (de)
FI (1) FI903917A0 (de)
IL (1) IL89222A (de)
WO (1) WO1989007456A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0454726A4 (en) * 1988-12-22 1991-11-27 Xoma Corporation Hindered linking agents and methods
FR2650749B1 (fr) * 1989-08-08 1994-09-02 Univ Rouen Methode de diagnostic et/ou de traitement, notamment du cancer
WO1991002547A1 (en) * 1989-08-24 1991-03-07 Australian Nuclear Science & Technology Organisation Radio-labelled antibodies for imaging
JPH05504763A (ja) * 1989-11-30 1993-07-22 マリンクロッド・メディカル・インコーポレイテッド 金属放射性核種でラベル付けされたタンパク質の調製方法
EP0485664A1 (de) * 1990-11-13 1992-05-20 Mallinckrodt Diagnostica (Holland) B.V. Verfahren zur Herstellung von einem diagnostischen Mittel zur Feststellung von Entzündungen
DE59207867D1 (de) * 1991-02-05 1997-02-27 Cis Bio International Saclay Verfahren zur Herstellung einer mit Technetium-99m markierten organspezifischen Substanz
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
WO1992018536A2 (en) * 1991-04-22 1992-10-29 Mallinckrodt Medical, Inc. Method for detecting an localizing tissues having neurokinine 1 receptors
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5403573A (en) * 1992-04-23 1995-04-04 The Curators Of The University Of Missouri Radiolabeled protein composition and method for radiation synovectomy
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
AU6670894A (en) * 1993-05-03 1994-11-21 Mallinckrodt Medical, Inc. Method for preparing a metal-radionuclide-labelled protein
CA2167167A1 (en) * 1993-07-19 1995-02-02 Alfred Pollak Hydrazino-type radionuclide chelators having an n3s configuration
US5858327A (en) * 1993-09-03 1999-01-12 Resolutions Pharmaceuticals, Inc. Hydrazino-type N2 S2 radionuclide chelating compounds
US5574140A (en) * 1993-09-03 1996-11-12 Resolution Pharmaceutical Inc. Hydrazino-type N2 S2 chelators
DE19505960A1 (de) * 1995-02-21 1996-08-22 Deutsches Krebsforsch Konjugat zur individuellen Dosierung von Arzneimitteln
US6043256A (en) * 1996-09-16 2000-03-28 Grassetti; Davide R. Antimutagenic agents
KR100367125B1 (ko) * 1996-12-02 2003-08-27 그라코 인크. 패턴제어식분배장치
EP2380596A1 (de) 2010-04-20 2011-10-26 Technische Universität München Cyclopentapeptid-Derivate und deren Verwendungen
EP2380597A1 (de) 2010-04-20 2011-10-26 Technische Universität München Cyclopeptid-Derivate und deren Verwendungen
CN106573959B (zh) 2014-06-06 2022-03-25 慕尼黑工业大学 修饰的环五肽及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3223585A (en) * 1965-02-23 1965-12-14 American Cyanamid Co Pesticidal monosulfur heterocyclic compositions
JPS5835520B2 (ja) * 1976-06-01 1983-08-03 株式会社第一ラジオアイソト−プ研究所 ６−カルボキシメチルチオコルチゾ−ルおよびその誘導体
US4479930A (en) * 1982-07-26 1984-10-30 Trustees Of The University Of Massachusetts Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
CA1336076C (en) * 1985-01-14 1995-06-27 Alan R. Fritzberg Metal radionuclide labeled proteins for diagnosis and therapy
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling

Also Published As

Publication number Publication date
EP0401302B1 (de) 1995-06-28
AU635204B2 (en) 1993-03-18
EP0401302A1 (de) 1990-12-12
AU3105693A (en) 1993-02-25
AU658959B2 (en) 1995-05-04
EP0401302A4 (de) 1994-03-30
DE68923274D1 (de) 1995-08-03
ATE124269T1 (de) 1995-07-15
WO1989007456A1 (en) 1989-08-24
AU3368689A (en) 1989-09-06
IL89222A0 (en) 1989-09-10
IL89222A (en) 1995-03-30
FI903917A0 (fi) 1990-08-08

Similar Documents

Publication Publication Date Title
DE68923274T2 (de) Verfahren zur herstellung eines mit metall-radionuklid-markierten proteins.
US4837003A (en) Radiolabeled antibody fragments
NL162386B (nl) Werkwijze voor de bereiding van een preparaat met anti- bacteriele werking en werkwijze voor de bereiding van voor opnemen in zo'n preparaat geschikte verbindingen.
JPS61191675A (ja) 巨大分子物質
KR880701708A (ko) 금속 킬레이트-단백질 공액체를 형성하기 위한 골격이 다중치환된 킬레이트
US5218128A (en) Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
ATE93521T1 (de) Verfahren zur herstellung von substituierten indolinonderivaten.
GR3034883T3 (en) Molecule labelling using 2-hydraninopyridine derivatives.
DE3767351D1 (de) Sialosylceramide und verfahren zu deren herstellung.
HUT56288A (en) Crosslinked antibodies and process for their production
ATE10838T1 (de) 4-substituierte 2-oxoazetidin-verbindungen, verfahren zu deren herstellung und ihre verwendung zur antibiotika-herstellung.
Itano et al. 4-Thialaminine, a strongly basic chemical modification of cysteine
CH614448A5 (en) Process for the preparation of novel tertiary amines and their acid addition salts, and compounds thus prepared
ES8601483A1 (es) Un metodo de inmunoensayo para determinar la lidocaina o un derivado relacionado de la misma en una muestra a ensayar
KR880001299A (ko) 면역독소, 그의 제조방법 및 그를 함유하는 약학 조성물
DE69520561D1 (de) Phenylborsaurekomplexe
KR840003631A (ko) 아졸릴펜옥시- 테트라하이드로푸란-2-일리덴- 메탄의 제조방법
DE3885115D1 (de) Verfahren zur Herstellung von Thiolen.
YU72000A (sh) Kompleks platine, njegovo dobijanje i terapeutska primena
PT83858A (de) Verfahren zur herstellung von cefodizim
EP0147181A3 (de) Thiazolylessigsäure-Derivate und ihre Herstellung
ATE115567T1 (de) Verfahren zur herstellung von halogensulfonyl- substituierten pyridinen.
YU7389A (en) Process for obtaining reagents for hydroxyalkylizing, this way obtained new reagents and their use
US5773271A (en) Compounds from biopolymers and effector substances which are linked via optically active amino acid derivatives, processes for the preparation thereof and the use thereof
ATE2669T1 (de) Verfahren zur herstellung von cyanessigsaeurealkylestern.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee