KR880701708A - 금속 킬레이트-단백질 공액체를 형성하기 위한 골격이 다중치환된 킬레이트 - Google Patents

금속 킬레이트-단백질 공액체를 형성하기 위한 골격이 다중치환된 킬레이트

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KR880701708A
KR880701708A KR1019880700490A KR880700490A KR880701708A KR 880701708 A KR880701708 A KR 880701708A KR 1019880700490 A KR1019880700490 A KR 1019880700490A KR 880700490 A KR880700490 A KR 880700490A KR 880701708 A KR880701708 A KR 880701708A
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dtpa
polysubstituted
diethylenetriamine
amino acid
acid
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오토 에이. 간소우
마틴 더블유. 브레츠빌
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오토 에이. 간소우
마틴 더블유. 브레츠빌
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C331/16—Isothiocyanates
    • C07C331/18—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms
    • C07C331/22—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C331/24—Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
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    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A61K51/048—DTPA (diethylenetriamine tetraacetic acid)
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    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
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    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
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    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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Abstract

내용 없음

Description

금속 킬레이트-단백질 공액체를 형성하기 위한 골격이 디중치환된 킬레이트
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 R1이 파라-니트로벤질이고, R3,4가 본 명세서에 기재된 것과 아릴/일킬기인 다중치환된 딩텔렌트리아민 제조를 위한 반응식을 나타낸 것이다. R3,4가 메틸기인 경우, 반응식중의 디에틸렌트리아민 생성물은 표1의 화합물(d)이다.
제2도는 PG가 보호기(하기 참조)를 나타내고, R 및 R'가 파라-니트로벤질 또는 각각 본 명세서에 기재된 것과 같은 아릴/알킬기인 다중치환된 디에틸렌트리아민 제조를 위한 반응식을 나타낸 것이다. R이 파라-니트로벤질이고, R'가 메틸인 경우, 생성물 디에틸렌트리아민은 표1의 화합물(a)이다. R이 메틸이고, R'가 파라-니트로벤질인 경우, 생성물 디에틸렌트리아민 표1의 화합물(C)이다.

Claims (14)

  1. (a)아미노 보호 알파 아미노산을 아미노산 아미드와 반응시키는 단계, (b)보호된 아미노산을 탈보호시키는 단계, (c)단계(b)에서 얻은 생성물을 환원시켜 다중치환된 디에틸렌트리아민을 제조하는 단계및 (d)상기 디에틸렌트리아민을 할로아세트산 또는 할로아세테이트 에스테르로 알킬화함으로써 목적하는 다중치환된 디에틸렌트리아민펜타아세트산 또는 그의 에스테르로 전환시키는 일련의 단계로 되는 다중치환된 디에틸렌트리아민펜타아세트산 킬레이트의 제조방법
  2. (a)아미노 보호 알파 아미노산을 알파 아미노케톤과 반응시키는 단계, (b)생성된 케톤을 메톡실아민과 반응시킴으로써 옥심 에테르로 전환시키는 단계 및 (c)생성된 옥심 에테르를 탈보호하고, 이어서 탈보호된 옥심 에테르를 환원시켜서 할로아세트산 또는 에스테르로 알킬화한 후 목적하는 다중치환된 디에틸렌트리아민펜타아세트산 또는 그의 에스테르를 얻는 디에틸렌트리아민을 제조하는 단계로 되는 다중치환된 디에틸렌트리아민펜타아세트산 킬레이트의 제조방법
  3. 디에틸렌트리아민펜타아세트산(DTPA)의 탄소 골격에 결합되는 1개의 측쇄를 갖고, 약 1-7 pH범위를 갖는 수용액 중에서 안정하고 단백질의 아미노산 잔기와 직접 반응하여 pH 약 6-11의 공액 pH에서 안정한 공유 결합을 형성하는 기능기를 함유하고, DTPA의 탄소 골격에 결합된 1-8의 탄소 원자수를 갖는 1개 이상의 부가적인 측쇄를 갖는 하기 일반식(2) 또는 (3)으로 표시되는 다중치환된 DTPA
  4. 제3항에 있어서, 기능기가 할로아세트아미드인 다중치환된 DTPA
  5. 제3항에 있어서, 기능기가 이소티오시아네이트인 다중치환된 DTPA
  6. 제3항에 있어서, 기능기가 N-히드록시숙신아미드 에스테르인 다중치환된 DTPA
  7. 제3항에 있어서, R1-R4, R1'-R4'기들이 다음가 같은 다중치환된 DTPA
    여기서, SCNBz는 파라-이소티오시아네이트벤질기이다.
  8. 단백질과 공액된 제3항에 의한 DTPA
  9. 제8항에 있어서, 상기 단백질의 모노-또는 폴리-클로날 항체 또는 이들의 단편인 DTPA
  10. 방사성 원소로 표지화된 제9항에 의한 DTPA
  11. 제10항에 있어서, 방사성 표지가 In-111, Y-90, Bi-212, Ga-68 및 Sc-47로 되는 군중에서 선택되는 DTPA
  12. 숙주중의 표적 부위에서 방사선 치료 효과 또는 라디오이미징(radioimaging)효과를 얻는데 유효한양의 제11항의 화합물을 숙주에 투여하는 것으로 되는 숙주중의 표적 부위에 방사성 원소 표지화 화합물을 도출시키는 방법
  13. 트리아민의 탄소 골격에 결합된 적어도 2개의 측쇄를 갖고, 니트로기를 함유하는 하기 일반식의 다중치환된 디에틸렌트리아민
  14. 제13항에 있어서, R1-R4, R1'-R4'가 다음과 같은 다중치환된 디에틸렌트리아민
    여기서, SCNBz는 파라-이소티오시아네이트벤질기이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880700490A 1986-09-05 1987-09-04 금속 킬레이트-단백질 결합체를 형성하기 위한 다중치환된 골격을 갖는 킬레이트 KR920003590B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/903,723 US4831175A (en) 1986-09-05 1986-09-05 Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
US903723 1986-09-05
PCT/US1987/002207 WO1988001618A1 (en) 1986-09-05 1987-09-04 Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
CA000594072A CA1338721C (en) 1986-09-05 1989-03-17 Backbone polysubstituted chelates for forming a metal chelate-protein conjugate

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KR880701708A true KR880701708A (ko) 1988-11-04
KR920003590B1 KR920003590B1 (ko) 1992-05-04

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KR1019880700490A KR920003590B1 (ko) 1986-09-05 1987-09-04 금속 킬레이트-단백질 결합체를 형성하기 위한 다중치환된 골격을 갖는 킬레이트

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US (1) US4831175A (ko)
EP (1) EP0328529B1 (ko)
JP (2) JP2555391B2 (ko)
KR (1) KR920003590B1 (ko)
AT (2) ATE144496T1 (ko)
AU (1) AU611105B2 (ko)
CA (1) CA1338721C (ko)
DE (3) DE3788961T2 (ko)
WO (1) WO1988001618A1 (ko)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246692A (en) * 1986-09-05 1993-09-21 The United States Of America As Represented By The Secretary Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
US5227474A (en) * 1987-02-13 1993-07-13 Abbott Laboratories Bifunctional chelating agents
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
US5696239A (en) * 1988-10-31 1997-12-09 The Dow Chemical Company Conjugates possessing ortho ligating functionality and complexes thereof
IE980697A1 (en) * 1988-10-31 2000-12-13 Dow Chemical Co Chelants possessing ortho ligating functionality and complexes thereof
US5342604A (en) * 1988-10-31 1994-08-30 The Dow Chemical Company Complexes possessing ortho ligating functionality
US5686410A (en) * 1989-07-20 1997-11-11 Novartis Ag Polypeptide derivatives
US5124471A (en) * 1990-03-26 1992-06-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Bifunctional dtpa-type ligand
US5403862A (en) * 1992-01-17 1995-04-04 University Of Utah Research Foundation Method for oral decorporation of metals
US5494935A (en) * 1992-01-17 1996-02-27 University Of Utah Research Foundation Methods for oral decorporation of metals
DE69303494T2 (de) * 1992-11-13 1997-01-16 Idec Pharma Corp Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma
US7744877B2 (en) * 1992-11-13 2010-06-29 Biogen Idec Inc. Expression and use of anti-CD20 Antibodies
CN1320044A (zh) * 1998-08-11 2001-10-31 Idec药物公司 包括施用抗－cd20抗体的b－细胞淋巴瘤联合疗法
DE69941903D1 (de) * 1998-11-09 2010-02-25 Biogen Idec Inc Behandlung von patienten die eine knochenmarktransplantation oder eine transplantation peripherer blutstammzellen erhalten mit anti-cd20 antikörpern
PT2055313E (pt) 1998-11-09 2015-08-25 Biogen Idec Inc Tratamento de malignidades hematológicas associadas a células tumorais em circulação utilizando anticorpo quimérico anti-cd20
US20020102208A1 (en) 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
MY133346A (en) 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
US6207858B1 (en) * 1999-03-03 2001-03-27 Idec Pharmaceuticals Corporation Regioselective synthesis of DTPA derivatives
EP1918305A1 (en) 1999-08-11 2008-05-07 Biogen Idec Inc. New clinical parameters for determining hematologic toxicity prior to radioimmunotherapy
US8557244B1 (en) 1999-08-11 2013-10-15 Biogen Idec Inc. Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody
EP2264070A1 (en) 1999-08-11 2010-12-22 Biogen-Idec Inc. Treatment of intermediate-and high-grade non-hodgkins lymphoma with anti-CD20 antibody
US6682902B2 (en) 1999-12-16 2004-01-27 Schering Aktiengesellschaft DNA encoding a novel RG1 polypeptide
AU2001259142C1 (en) * 2000-04-25 2006-11-23 Biogen Idec Inc. Intrathecal administration of rituximab for treatment of central nervous system lymphomas
ATE541860T1 (de) 2000-10-02 2012-02-15 Novartis Vaccines & Diagnostic Humane antikörper gegen cd40 zur therapie von b- zell tumoren
JP2005503999A (ja) 2001-01-31 2005-02-10 アイデック ファーマスーティカルズ コーポレイション 腫瘍性疾患の治療のためのｃｄ２３拮抗剤の使用
EP1372724A2 (en) 2001-01-31 2004-01-02 Idec Pharmaceuticals Corporation Use of immunoregulatory antibodies in the treatment of neoplastic disorders
US20020159996A1 (en) 2001-01-31 2002-10-31 Kandasamy Hariharan Use of CD23 antagonists for the treatment of neoplastic disorders
CA2442801A1 (en) * 2001-04-02 2002-10-10 Idec Pharmaceutical Corporation Recombinant antibodies coexpressed with gntiii
EP1397339A1 (en) * 2001-06-22 2004-03-17 Schering Aktiengesellschaft (ethylene)-(propylene)-triaminepentaacetic acid derivatives, process for their production, and their use for the production of pharmaceutical agents
US20030194371A1 (en) * 2001-07-10 2003-10-16 Schering Ag (Ethylene)-(propylene) - triaminepentaacetic acid derivatives, process for their production, and their use for the production of pharmaceutical agents
TWI240632B (en) 2001-07-30 2005-10-01 Epix Medical Inc Purified peptides for peptide-based multimeric targeted contrast agents
CA2467363A1 (en) 2001-11-16 2003-06-12 Idec Pharmaceuticals Corporation Polycistronic expression of antibodies
US20080063639A1 (en) * 2002-01-18 2008-03-13 Pierre Fabre Medicament Method for the treatment of psoriasis comprising novel anti-IGF-IR antibodies
US20030232014A1 (en) * 2002-03-01 2003-12-18 Mds Proteomics Inc. Phosphorylated proteins and uses related thereto
WO2004066933A2 (en) * 2003-01-27 2004-08-12 Biogen Idec Ma Inc. Compositions and methods for treating cancer using igsf9 and liv-1
DE10305463A1 (de) * 2003-02-04 2004-08-12 Schering Ag Enantiomerenreines (4S,8S)- und (4R,8R)-4-p-Nitrobenzyl-8-methyl-3,6,9-triza-3N,6N,9N-tricarboxymethyl-1,11-undecandisäure und deren Abkömmlinge, Verfahren zu deren Herstellung und Verwendung zur Herstellung pharmazeutischer Mittel
DE10305462A1 (de) * 2003-02-04 2004-08-12 Schering Ag Konjugate enantiomerenreiner (4S,8S)- und (4R,8R)-4-p-Benzyl-8-methyl-3,6,9-triaza-3N, 6N, 9N-tricarboxymethyl-1,11-undecandisäure mit Biomolekülen, Verfahren zu deren Herstellung und Verwendung zur Herstellung
ES2557769T3 (es) 2003-03-19 2016-01-28 Amgen Fremont Inc. Anticuerpos contra el antígeno del dominio de inmunoglobulina de células T y el dominio 1 de mucina (TIM-1) y usos de los mismos
CA2532394C (en) * 2003-07-22 2013-09-17 Schering Aktiengesellschaft Rg1 antibodies and uses thereof
ATE516819T1 (de) 2003-11-04 2011-08-15 Novartis Vaccines & Diagnostic Verfahren zur behandlung von b-zell-bedingtem krebs
EP2243492A1 (en) 2003-11-04 2010-10-27 Novartis Vaccines and Diagnostics, Inc. Use of antagonist anti-cd40 monoclonal antibodies for treatment of multiple myeloma
DE602004028037D1 (de) 2003-11-04 2010-08-19 Novartis Vaccines & Diagnostic Verfahren zur behandlung von krebs mit expression des cd40-antigens
EP1682177B8 (en) 2003-11-04 2010-09-01 Novartis Vaccines and Diagnostics, Inc. Use of antagonist anti-cd40 antibodies for treatment of chronic lymphocytic leukemia
SI1680141T1 (sl) 2003-11-04 2010-12-31 Novartis Vaccines & Diagnostic Postopki terapije za trdne tumorje, ki izražajo CD-40 celično-površinski antigen
BRPI0416243A (pt) * 2003-11-05 2007-01-09 Palingen Inc método de tratamento de um paciente humano que sofre de uma condição que inclui uma hiper-proliferação de células b; formulação farmacêutica para injeção parenteral; kit para o tratamento de um paciente que sofre de uma condição que inclui uma hiper-proliferação de células b; e método para purgar a medula óssea de um paciente que sofre de cáncer linfóide de células b malignas antes do reimplante da medula óssea no paciente após a terapia mieloablativa
JP4912153B2 (ja) * 2003-12-01 2012-04-11 イミューノメディクス、インコーポレイテッド タンパク質とキレート剤とのコンジュゲートを調製するための改良された方法
FR2873699B1 (fr) 2004-07-29 2009-08-21 Pierre Fabre Medicament Sa Nouveaux anticorps anti igf ir rt leurs utilisations
CA2586285A1 (en) 2004-11-05 2006-05-18 Palingen, Inc. Antibody induced cell membrane wounding
US20100029911A1 (en) * 2004-11-24 2010-02-04 Aplagen Gmbh Method For Solid-Phase Peptide Synthesis And Purification
WO2006071441A2 (en) 2004-11-30 2006-07-06 Curagen Corporation Antibodies directed to gpnmb and uses thereof
BRPI0606398A (pt) 2005-01-05 2008-03-11 Biogen Idec Inc moléculas de criptoligação
FR2888850B1 (fr) 2005-07-22 2013-01-11 Pf Medicament Nouveaux anticorps anti-igf-ir et leurs applications
CA2629453C (en) 2005-11-10 2018-03-06 Curagen Corporation Method of treating ovarian and renal cancer using antibodies against t cell immunoglobulin domain and mucin domain 1 (tim-1) antigen
FI20055653A (fi) * 2005-12-08 2007-06-09 Wallac Oy Leimausreagenssi
DOP2006000277A (es) 2005-12-12 2007-08-31 Bayer Pharmaceuticals Corp Anticuerpos anti mn y métodos para su utilización
US7727525B2 (en) * 2006-05-11 2010-06-01 City Of Hope Engineered anti-CD20 antibody fragments for in vivo targeting and therapeutics
GB0700133D0 (en) 2007-01-04 2007-02-14 Humabs Llc Human cytomegalovirus neutralising antibodies and use thereof
WO2008115854A2 (en) * 2007-03-19 2008-09-25 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Multifunctional nanoparticles and compositions and methods of use thereof
EP2014681A1 (en) * 2007-07-12 2009-01-14 Pierre Fabre Medicament Novel antibodies inhibiting c-met dimerization, and uses thereof
WO2009012288A2 (en) * 2007-07-17 2009-01-22 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Trifunctional imaging agent for monoclonal antibody tumor-targeted imaging
ES2402334T3 (es) 2007-08-02 2013-04-30 Gilead Biologics, Inc Procedimientos y composiciones para el tratamiento y el diagnóstico de la fibrosis
US10189803B2 (en) 2008-02-22 2019-01-29 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
US9446995B2 (en) 2012-05-21 2016-09-20 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
PL3009449T3 (pl) 2008-07-16 2018-09-28 Institute For Research In Biomedicine Przeciwciała neutralizujące ludzkie cytomegalowirusy i ich zastosowanie
JP5475774B2 (ja) 2008-07-16 2014-04-16 インスティテュート フォー リサーチ イン バイオメディシン ヒトサイトメガロウイルス中和抗体およびその使用
CA2731686C (en) * 2008-07-25 2020-04-07 Institute For Research In Biomedicine Neutralizing anti-influenza a virus antibodies and uses thereof
US8871207B2 (en) 2008-07-25 2014-10-28 Humabs, LLC Neutralizing anti-influenza A virus antibodies and uses thereof
EP2172485A1 (en) 2008-10-01 2010-04-07 Pierre Fabre Medicament Novel anti CXCR4 antibodies and their use for the treatment of cancer
NZ592054A (en) 2008-10-13 2013-06-28 Inst Research In Biomedicine Dengue virus neutralizing antibodies and uses thereof
AR074439A1 (es) 2008-12-02 2011-01-19 Pf Medicament Anticuerpo anti-cmet (receptor c-met)
US8545839B2 (en) * 2008-12-02 2013-10-01 Pierre Fabre Medicament Anti-c-Met antibody
AU2009334498A1 (en) 2008-12-31 2011-07-21 Biogen Idec Ma Inc. Anti-lymphotoxin antibodies
EP2308897A1 (en) 2009-10-09 2011-04-13 Pierre Fabre Medicament Chimeric antibodies specific for CD151 and use thereof in the treatment of cancer
WO2011092593A2 (en) 2010-01-20 2011-08-04 Institute For Research In Biomedicine Hiv-1 neutralizing antibodies and uses thereof
EP2371863A1 (en) 2010-03-30 2011-10-05 Pierre Fabre Médicament Humanized anti CXCR4 antibodies for the treatment of cancer
EP2455403A1 (en) 2010-11-23 2012-05-23 Pierre Fabre Medicament Homogeneous humanized antibodies against JAM-A that inhibit proliferation
WO2013012733A1 (en) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
EP3812397A1 (en) 2011-07-18 2021-04-28 Institute for Research in Biomedicine Neutralizing anti-influenza a virus antibodies and uses thereof
BR112014019459B1 (pt) 2012-02-08 2023-04-18 Mcure Biosciences Inc Proteínas de ligação à cdim e usos das mesmas
BR112014023063A2 (pt) 2012-03-20 2017-07-18 Corti Davide anticorpos que neutralizam rsv, mpv e pvm e usos dos mesmos
WO2013180730A1 (en) * 2012-06-01 2013-12-05 Lawrence Lowell Jeffry Large-scale high yield manufacturing process for high purity pentaalkyl esters of dtpa
CN118005782A (zh) 2013-10-02 2024-05-10 免疫医疗有限责任公司 中和抗甲型流感抗体及其用途
US10441669B2 (en) 2013-10-04 2019-10-15 Illinois Institute Of Technology Multifunctional chelators, complexes, and compositions thereof, and methods of using same
CN106573154B (zh) 2014-07-15 2021-06-15 免疫医疗有限责任公司 中和抗乙型流感抗体及其用途
US20170296650A1 (en) 2014-10-08 2017-10-19 Novartis Ag Combination of human cytomegalovirus neutralizing antibodies
WO2016075546A2 (en) 2014-11-14 2016-05-19 Antonio Lanzavecchia Antibodies that neutralize ebola virus and uses thereof
ES2838679T3 (es) 2014-11-18 2021-07-02 Humabs Biomed S A Anticuerpos que neutralizan de forma potente el virus de la rabia y otros lisavirus y su utilización
WO2016100615A2 (en) 2014-12-18 2016-06-23 The University Of Chicago Methods and composition for neutralization of influenza
PT3303384T (pt) 2015-06-01 2021-10-14 Medimmune Llc Moléculas de ligação neutralizantes anti-influenza e suas utilizações
US20180179274A1 (en) 2015-06-26 2018-06-28 Institute For Research In Biomedicine Proteins comprising a mutated lair-1 fragment and uses thereof
WO2017059878A1 (en) 2015-10-07 2017-04-13 Humabs Biomed Sa Antibodies that potently neutralize hepatitis b virus and uses thereof
CA3008442C (en) 2015-12-15 2022-03-08 Gilead Sciences, Inc. Human immunodeficiency virus neutralizing antibodies
CN108697789A (zh) 2016-01-13 2018-10-23 免疫医疗有限责任公司 治疗甲型流感的方法
WO2018010789A1 (en) 2016-07-13 2018-01-18 Humabs Biomed Sa Novel antibodies specifically binding to zika virus epitopes and uses thereof
US11235076B2 (en) 2016-08-29 2022-02-01 Fred Hutchinson Cancer Research Center Chelating platform for delivery of radionuclides
KR102595238B1 (ko) 2017-04-19 2023-10-26 인스티튜트 포 리서치 인 바이오메드슨 말라리아원충 종충에 결합하는 신규한 말라리아 백신 및 항체.
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
WO2019042555A1 (en) 2017-08-31 2019-03-07 Humabs Biomed Sa MULTISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO ZIKA VIRUS EPITOPES AND USES THEREOF
EP3758749A4 (en) 2018-03-02 2022-07-06 The University of Chicago METHOD AND COMPOSITION FOR NEUTRALIZING INFLUENZA
KR20210126558A (ko) 2018-12-19 2021-10-20 후맙스 바이오메드 에스에이 B형 간염 바이러스를 중화하는 항체 및 이의 용도
KR20220063188A (ko) 2019-08-29 2022-05-17 비르 바이오테크놀로지, 인코포레이티드 B형 간염 바이러스 감염을 치료하기 위한 항체 조성물 및 방법
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
JP2023531520A (ja) 2020-06-24 2023-07-24 ヴィア・バイオテクノロジー・インコーポレイテッド 操作されたｂ型肝炎ウイルス中和抗体およびその使用
EP4237012A1 (en) 2020-10-30 2023-09-06 Avacta Life Sciences Limited Fap-activated serum extended half-life therapeutic conjugates
EP4284428A1 (en) 2021-01-26 2023-12-06 VIR Biotechnology, Inc. Compositions and methods for treating hepatitis b virus infection
KR20230154994A (ko) 2021-03-10 2023-11-09 마빌론 아게 Tdp-43에 대한 항체 및 이의 용도
WO2022234003A1 (en) 2021-05-07 2022-11-10 Avacta Life Sciences Limited Cd33 binding polypeptides with stefin a protein
WO2023057567A1 (en) 2021-10-07 2023-04-13 Avacta Life Sciences Limited Pd-l1 binding affimers
TW202332694A (zh) 2021-10-07 2023-08-16 英商阿凡克塔生命科學公司 血清半衰期延長之ｐｄ－ｌ１結合多肽
WO2023218243A1 (en) 2022-05-12 2023-11-16 Avacta Life Sciences Limited Lag-3/pd-l1 binding fusion proteins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622420A (en) * 1980-03-18 1986-11-11 The Regents Of The University Of California Chelating agents and method
GB2109407B (en) * 1981-10-27 1985-12-18 Hybritech Inc Tumour imaging with radiolabelled monoclonal antibodies
US4454106A (en) * 1982-06-07 1984-06-12 Gansow Otto A Use of metal chelate conjugated monoclonal antibodies
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
SE8301395L (sv) * 1983-03-15 1984-09-16 Wallac Oy Kelatiserande foreningar med funktionella grupper vilka tillater kovalent koppling till bio-organiska molekyler

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US4831175A (en) 1989-05-16
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ATE144496T1 (de) 1996-11-15
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