BR112022014423A2 - Produção de hmo - Google Patents
Produção de hmoInfo
- Publication number
- BR112022014423A2 BR112022014423A2 BR112022014423A BR112022014423A BR112022014423A2 BR 112022014423 A2 BR112022014423 A2 BR 112022014423A2 BR 112022014423 A BR112022014423 A BR 112022014423A BR 112022014423 A BR112022014423 A BR 112022014423A BR 112022014423 A2 BR112022014423 A2 BR 112022014423A2
- Authority
- BR
- Brazil
- Prior art keywords
- hmo
- production
- oligosaccharide
- hmo production
- nucleic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S5/00—Position-fixing by co-ordinating two or more direction or position line determinations; Position-fixing by co-ordinating two or more distance determinations
- G01S5/02—Position-fixing by co-ordinating two or more direction or position line determinations; Position-fixing by co-ordinating two or more distance determinations using radio waves
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Remote Sensing (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pediatric Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Radar, Positioning & Navigation (AREA)
- General Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Selective Calling Equipment (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA202000087 | 2020-01-23 | ||
| PCT/EP2021/051468 WO2021148611A1 (en) | 2020-01-23 | 2021-01-22 | Hmo production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022014423A2 true BR112022014423A2 (pt) | 2022-09-27 |
Family
ID=74494875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022014423A BR112022014423A2 (pt) | 2020-01-23 | 2021-01-22 | Produção de hmo |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20230072639A1 (https=) |
| EP (2) | EP4093877A1 (https=) |
| JP (1) | JP2023511523A (https=) |
| CN (2) | CN115003814A (https=) |
| AU (2) | AU2021209395A1 (https=) |
| BR (1) | BR112022014423A2 (https=) |
| WO (3) | WO2021148618A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK180952B1 (en) * | 2020-12-22 | 2022-08-10 | Glycom As | A dfl-producing strain |
| BR112023014557A2 (pt) | 2021-01-22 | 2023-10-17 | Glycom As | Nova proteína (fred) da superfamília de facilitadores principais (mfs) na produção de hmos sialiado |
| DK181242B1 (en) * | 2021-05-17 | 2023-05-30 | Dsm Ip Assets Bv | GENETICALLY ENGINEERED CELLS COMPRISING A RECOMBINANT NUCLEIC ACID SEQUNCE ENCODING AN α-1,2-FUCOSYLTRANSFERASE CAPABLE OF PRODUCING LNFP-I, NUCLEIC ACID SEQUENCES ENCODING SAME AND METHODS FOR USE OF SAME |
| DK181497B1 (en) | 2021-05-17 | 2024-03-12 | Dsm Ip Assets Bv | ENHANCING FORMATION OF THE HMOS LNT AND/OR LNnT BY MODIFYING LACTOSE IMPORT IN THE CELL |
| DK181991B1 (en) | 2021-11-11 | 2025-05-15 | Dsm Ip Assets Bv | Combined fermentation process for producing one or more human milk oligosaccharide(s) (hmo(s)) in escherichia coli |
| US20260028634A1 (en) | 2022-03-02 | 2026-01-29 | Dsm Ip Assets B.V. | New sialyltransferases for in vivo synthesis of 3'sl and 6'sl |
| DK181319B1 (en) | 2022-03-02 | 2023-08-10 | Dsm Ip Assets Bv | Genetically engineered cells and methods comprising use of a sialyltransferase for in vivo synthesis of 3’sl |
| DK181683B1 (en) | 2022-03-02 | 2024-09-20 | Dsm Ip Assets Bv | Cells exprssing new sialyltransferases for in vivo synthesis of lst-a, methods using same and constructs encoding said sialyltransferases |
| US20250290078A1 (en) | 2022-04-29 | 2025-09-18 | Dsm Ip Assets B.V. | Hmo producing microorganism with increased robustness towards glucose gradients |
| WO2023235555A1 (en) * | 2022-06-02 | 2023-12-07 | Bee-Io Honey Technologies Ltd. | Cultured buffalo milk production methods, systems, compositions and uses thereof |
| DK181765B1 (en) | 2022-07-15 | 2024-12-04 | Dsm Ip Assets Bv | Cells expressing new fucosyltransferases for in vivo synthesis of lnfp-iii, and methods and uses of same |
| EP4577061A1 (en) | 2022-08-25 | 2025-07-02 | DSM IP Assets B.V. | Hybrid method for producing complex hmos |
| WO2024110667A1 (en) | 2022-11-25 | 2024-05-30 | Dsm Ip Assets B.V. | Two-strain system for producing oligosaccharides |
| CN120677242A (zh) | 2023-02-24 | 2025-09-19 | 帝斯曼知识产权资产管理有限公司 | 用于体内合成人乳寡糖的产物特异性转运蛋白 |
| DK181822B1 (en) | 2023-06-07 | 2025-01-30 | Dsm Ip Assets Bv | Genetically engineered strains with reduced byproduct formation and methods and uses of same |
| DK182227B1 (en) | 2023-10-17 | 2025-12-18 | Dsm Ip Assets Bv | Genetically engineered cells comprising new fucosyltransferases for in vivo synthesis of complex fucosylated human milk oligosaccharides mixtures comprising lnfp-vi, methods using the same, and uses of new fucosyltransferases thereof. |
| DK202430472A1 (en) | 2024-08-19 | 2026-02-24 | Dsm Ip Assets Bv | Alpha-1,2 fucosyltransferase mutants with increased alpha 1,3-fucosyltransferase activity |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7363028B2 (en) | 2003-11-04 | 2008-04-22 | Universal Electronics, Inc. | System and method for controlling device location determination |
| DK2440661T3 (en) | 2009-06-08 | 2018-03-12 | Jennewein Biotechnologie Gmbh | HMO synthesis |
| EP2675899A4 (en) | 2011-02-16 | 2014-09-10 | Glycosyn LLC | BIOSYNTHESIS OF HUMAN MILK OLIGOSACCHARIDES IN MANIPULATED BACTERIA |
| EP2760875A4 (en) * | 2011-09-30 | 2015-08-26 | Glycom As | SYNTHESIS OF HMO NUCLEAR STRUCTURES |
| EP3461890B1 (en) * | 2014-03-31 | 2025-09-24 | Chr. Hansen HMO GmbH | Total fermentation of oligosaccharides |
| DE202015009782U1 (de) | 2014-06-11 | 2020-02-10 | Glycom A/S | Trennung von 2'-O-Fucosyllactose aus Fermentationsbrühe |
| EP3191499A4 (en) | 2014-09-09 | 2018-06-06 | Glycosyn LLC | Alpha (1,3) fucosyltransferases for use in the production of fucosylated oligosaccharides |
| US10676770B2 (en) | 2014-12-16 | 2020-06-09 | Glycom A/S | Separation of 2′-FL from a fermentation broth |
| EP3141610A1 (en) | 2015-09-12 | 2017-03-15 | Jennewein Biotechnologie GmbH | Production of human milk oligosaccharides in microbial hosts with engineered import / export |
| DE202017007249U1 (de) | 2016-03-07 | 2020-04-23 | Glycom A/S | Abtrennung von Oligosacchariden aus der Fermentationsbrühe |
| EP4674526A3 (en) | 2016-04-19 | 2026-04-01 | Glycom A/S | Separation of oligosaccharides from fermentation broth |
| ES2856749T3 (es) | 2016-10-29 | 2021-09-28 | Chr Hansen Hmo Gmbh | Proceso para la producción de oligosacáridos fucosilados |
| EP3635429A1 (en) | 2017-05-04 | 2020-04-15 | Eaton Intelligent Power Limited | Multi-dimensional location of an object using multiple electrical devices |
| US11608504B2 (en) | 2017-12-21 | 2023-03-21 | Glycom A/S | Nucleic acid construct for in vitro and in vivo gene expression |
| US20190323052A1 (en) | 2018-04-23 | 2019-10-24 | Dupont Nutrition Biosciences Aps | Increasing export of 2? fucosyllactose from microbial cells through the expression of a heterologous nucleic acid |
| WO2019209241A1 (en) * | 2018-04-23 | 2019-10-31 | Dupont Nutrition Biosciences Aps | Increasing export of 2' fucosyllactose from microbial cells through the expression of a heterologous nucleic acid |
| US20190323053A1 (en) | 2018-04-23 | 2019-10-24 | Dupont Nutrition Biosciences Aps | Increasing activity of 2? fucosyllactose transporters endogenous to microbial cells |
| EP3569713A1 (en) * | 2018-05-16 | 2019-11-20 | Jennewein Biotechnologie GmbH | Use of glycosidases in the production of oligosaccharides |
| CN109609422A (zh) * | 2018-11-20 | 2019-04-12 | 安徽天凯生物科技有限公司 | 一种可以产2’-岩藻基乳糖菌株的构建方法 |
| US10519475B1 (en) | 2018-11-21 | 2019-12-31 | Amyris, Inc. | Biosynthesis of compounds in yeast |
-
2021
- 2021-01-22 US US17/759,267 patent/US20230072639A1/en active Pending
- 2021-01-22 US US17/759,261 patent/US12351806B2/en active Active
- 2021-01-22 EP EP21702885.1A patent/EP4093877A1/en active Pending
- 2021-01-22 JP JP2022540697A patent/JP2023511523A/ja active Pending
- 2021-01-22 AU AU2021209395A patent/AU2021209395A1/en not_active Abandoned
- 2021-01-22 CN CN202180010751.XA patent/CN115003814A/zh active Pending
- 2021-01-22 AU AU2021211904A patent/AU2021211904A1/en not_active Abandoned
- 2021-01-22 BR BR112022014423A patent/BR112022014423A2/pt not_active Application Discontinuation
- 2021-01-22 WO PCT/EP2021/051476 patent/WO2021148618A1/en not_active Ceased
- 2021-01-22 EP EP21703604.5A patent/EP4093878A1/en not_active Withdrawn
- 2021-01-22 WO PCT/EP2021/051479 patent/WO2021148620A1/en not_active Ceased
- 2021-01-22 WO PCT/EP2021/051468 patent/WO2021148611A1/en not_active Ceased
- 2021-01-22 CN CN202180010226.8A patent/CN115003812A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021148618A1 (en) | 2021-07-29 |
| AU2021211904A1 (en) | 2022-07-14 |
| CN115003812A (zh) | 2022-09-02 |
| US20230046359A1 (en) | 2023-02-16 |
| WO2021148620A1 (en) | 2021-07-29 |
| US12351806B2 (en) | 2025-07-08 |
| EP4093877A1 (en) | 2022-11-30 |
| EP4093878A1 (en) | 2022-11-30 |
| WO2021148618A9 (en) | 2021-11-18 |
| WO2021148611A1 (en) | 2021-07-29 |
| JP2023511523A (ja) | 2023-03-20 |
| CN115003814A (zh) | 2022-09-02 |
| AU2021209395A1 (en) | 2022-07-14 |
| US20230072639A1 (en) | 2023-03-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112022014423A2 (pt) | Produção de hmo | |
| BR112022014414A2 (pt) | Produção de hmo | |
| BR112022014420A2 (pt) | Produção de hmo | |
| BR112022014367A2 (pt) | Produção de hmo | |
| BR112022011904A2 (pt) | Produção de oligossacarídeo sialilado em células hospedeiras | |
| MX389743B (es) | Proceso mejorado para la producción de oligosacáridos fucosilados. | |
| BR112018004725A2 (pt) | método para a produção de oligossacarídeos de leite humano em hospedeiros microbianos com importação/exportação modificada e célula hospedeira microbiana | |
| BR112012016320A2 (pt) | "método para tratar material celulósico, polipeptídeo, molécula de ácido nucleico isolada, vetor de expressão recombinante, célula hospedeira, processos para produzir um polipeptídeo, e para obter uma preparação de enzima, preparação de enzima, e, uso do polipeptídeo ou da preparação de enzima." | |
| MX2009002388A (es) | Uso de celulas humanas originarias de leucemia mieloide para la expresion de anticuerpos. | |
| WO2022136337A3 (en) | A dfl-producing strain | |
| BRPI0924899B8 (pt) | Síntese hmo | |
| BR112013000822A2 (pt) | método e método de duas etapas para a produção de uma população de células exterminadoras naturais (nk) ativadas, população de células nk ativadas e método para suprimir a proliferação de células tumorais | |
| BR112012009886A2 (pt) | célula, e, método para produzir uma proteína recombinante em uma célula hospedeira | |
| CO2021013823A2 (es) | Bioconjugados de antígenos–polisacáridos de e. coli, métodos de producción y métodos de utilización de los mismos | |
| BR112022009836A2 (pt) | Método para fornecer células imunes com função aumentada | |
| DK2211924T3 (da) | Tværbunden hyaluronsyre og collagen og anvendelser deraf | |
| BR112012033699A2 (pt) | polipeptídeo tendo atividade beta-glicosidase e seus usos | |
| BR112013020426A2 (pt) | processo e sistema para fabricação de produtos de material compósito, assim como produtos fabricados com este processo ou sistema | |
| BR112016010340A2 (pt) | novos métodos para se produzir tert ativa | |
| MX2022001814A (es) | Produccion mejorada de oligosacaridos en levadura. | |
| MX2021000421A (es) | Métodos y composiciones que usan células dendríticas recombinantes para el tratamiento del cáncer. | |
| BR112022003604A2 (pt) | Produção de oligossacarídeos sialilados em células de bacillus | |
| MX2023000153A (es) | Exportación mejorada de los oligosacáridos a partir de las células bacterianas. | |
| BR112014029866A2 (pt) | controle de fratura de fusão em tubulação de resina bimodal | |
| BR112014018610A2 (pt) | alfa-amilase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |