MX2022001814A - Produccion mejorada de oligosacaridos en levadura. - Google Patents
Produccion mejorada de oligosacaridos en levadura.Info
- Publication number
- MX2022001814A MX2022001814A MX2022001814A MX2022001814A MX2022001814A MX 2022001814 A MX2022001814 A MX 2022001814A MX 2022001814 A MX2022001814 A MX 2022001814A MX 2022001814 A MX2022001814 A MX 2022001814A MX 2022001814 A MX2022001814 A MX 2022001814A
- Authority
- MX
- Mexico
- Prior art keywords
- yeast cells
- yeast
- hmos
- producing
- genetically modified
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
- C12Y306/03—Hydrolases acting on acid anhydrides (3.6) acting on acid anhydrides; catalysing transmembrane movement of substances (3.6.3)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01271—GDP-L-fucose synthase (1.1.1.271)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01069—Galactoside 2-alpha-L-fucosyltransferase (2.4.1.69)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01152—4-Galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase (2.4.1.152)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
- C12Y204/99004—Beta-galactoside alpha-2,3-sialyltransferase (2.4.99.4)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/01057—N-Acylneuraminate-9-phosphate synthase (2.5.1.57)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07023—UDP-N-acetylglucosamine diphosphorylase (2.7.7.23)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07043—N-Acylneuraminate cytidylyltransferase (2.7.7.43)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01047—GDP-mannose 4,6-dehydratase (4.2.1.47), i.e. GMD
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y501/00—Racemaces and epimerases (5.1)
- C12Y501/03—Racemaces and epimerases (5.1) acting on carbohydrates and derivatives (5.1.3)
- C12Y501/03014—UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) (5.1.3.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/85—Saccharomyces
- C12R2001/865—Saccharomyces cerevisiae
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
En la presente, se proporcionan células de levadura con modificaciones genéticas capaces de producir uno o mas oligosacáridos de la leche materna humana (HMO, por sus siglas en inglés) y métodos de elaboración de esas células. Las células de levadura se diseñan para que comprendan un ácido nucleico heterólogo que codifique una proteína transportadora y uno o más ácidos nucleicos heterólogos que codifiquen enzimas de una vía biosintética de HMO. También se proporcionan composiciones de fermentación que incluyen las células de levadura con modificaciones genéticas descritas y métodos relacionados de producción y recuperación de HMO generados por las células de levadura.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962886074P | 2019-08-13 | 2019-08-13 | |
PCT/US2020/046227 WO2021030617A2 (en) | 2019-08-13 | 2020-08-13 | Improved oligosaccharide production in yeast |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022001814A true MX2022001814A (es) | 2022-06-27 |
Family
ID=74570437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022001814A MX2022001814A (es) | 2019-08-13 | 2020-08-13 | Produccion mejorada de oligosacaridos en levadura. |
Country Status (8)
Country | Link |
---|---|
US (1) | US20220298536A1 (es) |
EP (1) | EP4013884A4 (es) |
JP (1) | JP2022544267A (es) |
CN (1) | CN114450417A (es) |
BR (1) | BR112022002584A2 (es) |
CA (1) | CA3146593A1 (es) |
MX (1) | MX2022001814A (es) |
WO (1) | WO2021030617A2 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023122270A2 (en) * | 2021-12-23 | 2023-06-29 | Amyris, Inc. | Compositions and methods for improved production of human milk oligosaccharides |
WO2023192161A2 (en) * | 2022-03-28 | 2023-10-05 | Intrinsic Medicine, Inc. | Methods and compositions for attenuating immune response associated with rna therapeutics |
WO2023230411A1 (en) * | 2022-05-26 | 2023-11-30 | Amyris, Inc. | Improved oligosaccharide production in yeast |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2660698T3 (es) * | 2009-06-08 | 2018-03-23 | Jennewein Biotechnologie Gmbh | Síntesis de HMO |
EP3141610A1 (en) * | 2015-09-12 | 2017-03-15 | Jennewein Biotechnologie GmbH | Production of human milk oligosaccharides in microbial hosts with engineered import / export |
WO2019099649A1 (en) * | 2017-11-20 | 2019-05-23 | Manus Bio, Inc. | Microbial host cells for production of steviol glycosides |
-
2020
- 2020-08-13 CA CA3146593A patent/CA3146593A1/en active Pending
- 2020-08-13 CN CN202080061688.8A patent/CN114450417A/zh active Pending
- 2020-08-13 MX MX2022001814A patent/MX2022001814A/es unknown
- 2020-08-13 US US17/634,392 patent/US20220298536A1/en active Pending
- 2020-08-13 WO PCT/US2020/046227 patent/WO2021030617A2/en unknown
- 2020-08-13 EP EP20853477.6A patent/EP4013884A4/en active Pending
- 2020-08-13 BR BR112022002584A patent/BR112022002584A2/pt unknown
- 2020-08-13 JP JP2022508771A patent/JP2022544267A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4013884A2 (en) | 2022-06-22 |
CN114450417A (zh) | 2022-05-06 |
WO2021030617A3 (en) | 2021-06-03 |
CA3146593A1 (en) | 2021-02-18 |
BR112022002584A2 (pt) | 2022-08-09 |
EP4013884A4 (en) | 2023-12-20 |
WO2021030617A2 (en) | 2021-02-18 |
US20220298536A1 (en) | 2022-09-22 |
JP2022544267A (ja) | 2022-10-17 |
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