BR112022014367A2 - Produção de hmo - Google Patents
Produção de hmoInfo
- Publication number
- BR112022014367A2 BR112022014367A2 BR112022014367A BR112022014367A BR112022014367A2 BR 112022014367 A2 BR112022014367 A2 BR 112022014367A2 BR 112022014367 A BR112022014367 A BR 112022014367A BR 112022014367 A BR112022014367 A BR 112022014367A BR 112022014367 A2 BR112022014367 A2 BR 112022014367A2
- Authority
- BR
- Brazil
- Prior art keywords
- hmo
- production
- relates
- recombinant production
- hmo production
- Prior art date
Links
- 239000003623 enhancer Substances 0.000 abstract 1
- 210000004251 human milk Anatomy 0.000 abstract 1
- 235000020256 human milk Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920001542 oligosaccharide Polymers 0.000 abstract 1
- 150000002482 oligosaccharides Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PRODUÇÃO DE HMO. A presente invenção refere-se ao campo da produção recombinante de moléculas biológicas em células hospedeiras. Mais particularmente, refere-se a um método para a produção recombinante de oligossacarídeos do leite humano (HMO) usando uma célula geneticamente modificada que expressa uma proteína da superfamília de facilitadores principais (MFS).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA202000086 | 2020-01-23 | ||
PCT/EP2021/051472 WO2021148614A1 (en) | 2020-01-23 | 2021-01-22 | Hmo production |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022014367A2 true BR112022014367A2 (pt) | 2022-09-13 |
Family
ID=74556857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022014367A BR112022014367A2 (pt) | 2020-01-23 | 2021-01-22 | Produção de hmo |
Country Status (7)
Country | Link |
---|---|
US (1) | US20230227876A1 (pt) |
EP (1) | EP4093747A1 (pt) |
JP (1) | JP2023511522A (pt) |
CN (1) | CN115003687A (pt) |
AU (1) | AU2021210607A1 (pt) |
BR (1) | BR112022014367A2 (pt) |
WO (1) | WO2021148614A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK180952B1 (en) * | 2020-12-22 | 2022-08-10 | Glycom As | A dfl-producing strain |
TW202246496A (zh) * | 2021-01-20 | 2022-12-01 | 比利時商因比奥斯公司 | 在宿主細胞中產生包含ln3作為核心結構的寡醣 |
WO2022157280A1 (en) | 2021-01-22 | 2022-07-28 | Glycom A/S | New major facilitator superfamily (mfs) protein (fred) in production of sialylated hmos |
DK202170552A1 (en) | 2021-11-11 | 2023-09-01 | Dsm Ip Assets Bv | Combined fermentation process for producing one or more human milk oligosaccharide(s) (hmo(s)) |
WO2023209098A1 (en) | 2022-04-29 | 2023-11-02 | Dsm Ip Assets B.V. | Hmo producing microorganism with increased robustness towards glucose gradients |
DK202200561A1 (en) * | 2022-06-13 | 2024-02-14 | Dsm Ip Assets Bv | Sigma factor modifications for biosynthetic production |
DK202200689A1 (en) | 2022-07-15 | 2024-02-27 | Dsm Ip Assets Bv | New fucosyltransferases for in vivo synthesis of lnfp-iii |
WO2024042235A1 (en) | 2022-08-25 | 2024-02-29 | Dsm Ip Assets B.V. | Hybrid method for producing complex hmos |
WO2024110667A1 (en) | 2022-11-25 | 2024-05-30 | Dsm Ip Assets B.V. | Two-strain system for producing oligosaccharides |
CN117867054A (zh) * | 2023-01-09 | 2024-04-12 | 山东恒鲁生物科技有限公司 | 合成hmo的方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ597129A (en) | 2009-06-08 | 2012-12-21 | Jennewein Biotechnologie Gmbh | Hmo synthesis |
WO2012112777A2 (en) | 2011-02-16 | 2012-08-23 | Glycosyn LLC | Biosynthesis of human milk oligosaccharides in engineered bacteria |
EP2927316B1 (en) * | 2014-03-31 | 2018-11-07 | Jennewein Biotechnologie GmbH | Total fermentation of oligosaccharides |
WO2015188834A1 (en) | 2014-06-11 | 2015-12-17 | Glycom A/S | Separation of 2'-o-fucosyllactose from fermentation broth |
WO2016040531A1 (en) | 2014-09-09 | 2016-03-17 | Glycosyn LLC | Alpha (1,3) fucosyltransferases for use in the production of fucosylated oligosaccharides |
DE202015009775U1 (de) | 2014-12-16 | 2020-02-05 | Glycom A/S | Abscheidung von 2'-FL aus einer Fermentationsbrühe |
EP3141610A1 (en) * | 2015-09-12 | 2017-03-15 | Jennewein Biotechnologie GmbH | Production of human milk oligosaccharides in microbial hosts with engineered import / export |
EP3426670A4 (en) | 2016-03-07 | 2019-11-13 | Glycom A/S | SEPARATION OF OLIGOSACCHARIDES FROM A FERMENTATION BROTH |
EP3445770A4 (en) | 2016-04-19 | 2020-03-18 | Glycom A/S | SEPARATION OF OLIGOSACCHARIDES FROM A FERMENTATION BROTH |
ES2856749T3 (es) * | 2016-10-29 | 2021-09-28 | Chr Hansen Hmo Gmbh | Proceso para la producción de oligosacáridos fucosilados |
CN111727253A (zh) * | 2017-12-21 | 2020-09-29 | 格礼卡姆股份公司 | 用于体外和体内基因表达的核酸构建体 |
US20190323052A1 (en) | 2018-04-23 | 2019-10-24 | Dupont Nutrition Biosciences Aps | Increasing export of 2? fucosyllactose from microbial cells through the expression of a heterologous nucleic acid |
US20190323053A1 (en) | 2018-04-23 | 2019-10-24 | Dupont Nutrition Biosciences Aps | Increasing activity of 2? fucosyllactose transporters endogenous to microbial cells |
EP3569713A1 (en) * | 2018-05-16 | 2019-11-20 | Jennewein Biotechnologie GmbH | Use of glycosidases in the production of oligosaccharides |
-
2021
- 2021-01-22 CN CN202180009967.4A patent/CN115003687A/zh active Pending
- 2021-01-22 EP EP21703602.9A patent/EP4093747A1/en active Pending
- 2021-01-22 JP JP2022540677A patent/JP2023511522A/ja active Pending
- 2021-01-22 WO PCT/EP2021/051472 patent/WO2021148614A1/en unknown
- 2021-01-22 US US17/759,273 patent/US20230227876A1/en active Pending
- 2021-01-22 BR BR112022014367A patent/BR112022014367A2/pt not_active Application Discontinuation
- 2021-01-22 AU AU2021210607A patent/AU2021210607A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2021148614A1 (en) | 2021-07-29 |
EP4093747A1 (en) | 2022-11-30 |
JP2023511522A (ja) | 2023-03-20 |
AU2021210607A1 (en) | 2022-07-14 |
CN115003687A (zh) | 2022-09-02 |
US20230227876A1 (en) | 2023-07-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |