BR112022014367A2 - Produção de hmo - Google Patents

Produção de hmo

Info

Publication number
BR112022014367A2
BR112022014367A2 BR112022014367A BR112022014367A BR112022014367A2 BR 112022014367 A2 BR112022014367 A2 BR 112022014367A2 BR 112022014367 A BR112022014367 A BR 112022014367A BR 112022014367 A BR112022014367 A BR 112022014367A BR 112022014367 A2 BR112022014367 A2 BR 112022014367A2
Authority
BR
Brazil
Prior art keywords
hmo
production
relates
recombinant production
hmo production
Prior art date
Application number
BR112022014367A
Other languages
English (en)
Inventor
Pedersen Margit
Bych Kampmann Katrine
Original Assignee
Glycom As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycom As filed Critical Glycom As
Publication of BR112022014367A2 publication Critical patent/BR112022014367A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PRODUÇÃO DE HMO. A presente invenção refere-se ao campo da produção recombinante de moléculas biológicas em células hospedeiras. Mais particularmente, refere-se a um método para a produção recombinante de oligossacarídeos do leite humano (HMO) usando uma célula geneticamente modificada que expressa uma proteína da superfamília de facilitadores principais (MFS).
BR112022014367A 2020-01-23 2021-01-22 Produção de hmo BR112022014367A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA202000086 2020-01-23
PCT/EP2021/051472 WO2021148614A1 (en) 2020-01-23 2021-01-22 Hmo production

Publications (1)

Publication Number Publication Date
BR112022014367A2 true BR112022014367A2 (pt) 2022-09-13

Family

ID=74556857

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022014367A BR112022014367A2 (pt) 2020-01-23 2021-01-22 Produção de hmo

Country Status (7)

Country Link
US (1) US20230227876A1 (pt)
EP (1) EP4093747A1 (pt)
JP (1) JP2023511522A (pt)
CN (1) CN115003687A (pt)
AU (1) AU2021210607A1 (pt)
BR (1) BR112022014367A2 (pt)
WO (1) WO2021148614A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK180952B1 (en) * 2020-12-22 2022-08-10 Glycom As A dfl-producing strain
AU2022210808A1 (en) * 2021-01-20 2023-08-31 Inbiose N.V. Production of oligosaccharides comprising ln3 as core structure in host cells
WO2022157280A1 (en) 2021-01-22 2022-07-28 Glycom A/S New major facilitator superfamily (mfs) protein (fred) in production of sialylated hmos
DK202170552A1 (en) 2021-11-11 2023-09-01 Dsm Ip Assets Bv Combined fermentation process for producing one or more human milk oligosaccharide(s) (hmo(s))
WO2023209098A1 (en) 2022-04-29 2023-11-02 Dsm Ip Assets B.V. Hmo producing microorganism with increased robustness towards glucose gradients
DK202200561A1 (en) * 2022-06-13 2024-02-14 Dsm Ip Assets Bv Sigma factor modifications for biosynthetic production
DK202200689A1 (en) 2022-07-15 2024-02-27 Dsm Ip Assets Bv New fucosyltransferases for in vivo synthesis of lnfp-iii
WO2024042235A1 (en) 2022-08-25 2024-02-29 Dsm Ip Assets B.V. Hybrid method for producing complex hmos

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2517602C2 (ru) 2009-06-08 2014-05-27 Йенневайн Биотехнологи Гмбх Синтез нмо
US9453230B2 (en) 2011-02-16 2016-09-27 Glycosyn LLC Biosynthesis of human milk oligosaccharides in engineered bacteria
EP3461890A1 (en) * 2014-03-31 2019-04-03 Jennewein Biotechnologie GmbH Total fermentation of oligosaccharides
ES2968677T3 (es) 2014-06-11 2024-05-13 Glycom As Separación de 2’-O-fucosil-lactosa de caldo de fermentación
US11453900B2 (en) 2014-09-09 2022-09-27 Glycosyn LLC Alpha (1,3) fucosyltransferases for use in the production of fucosylated oligosaccharides
US10676770B2 (en) 2014-12-16 2020-06-09 Glycom A/S Separation of 2′-FL from a fermentation broth
EP3141610A1 (en) 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Production of human milk oligosaccharides in microbial hosts with engineered import / export
EP3426670A4 (en) 2016-03-07 2019-11-13 Glycom A/S SEPARATION OF OLIGOSACCHARIDES FROM A FERMENTATION BROTH
EP3445770A4 (en) 2016-04-19 2020-03-18 Glycom A/S SEPARATION OF OLIGOSACCHARIDES FROM A FERMENTATION BROTH
EP3315610B1 (en) 2016-10-29 2020-12-16 Jennewein Biotechnologie GmbH Process for the production of fucosylated oligosaccharides
US11608504B2 (en) 2017-12-21 2023-03-21 Glycom A/S Nucleic acid construct for in vitro and in vivo gene expression
US20190323053A1 (en) 2018-04-23 2019-10-24 Dupont Nutrition Biosciences Aps Increasing activity of 2? fucosyllactose transporters endogenous to microbial cells
US20190323052A1 (en) 2018-04-23 2019-10-24 Dupont Nutrition Biosciences Aps Increasing export of 2? fucosyllactose from microbial cells through the expression of a heterologous nucleic acid
EP3569713A1 (en) * 2018-05-16 2019-11-20 Jennewein Biotechnologie GmbH Use of glycosidases in the production of oligosaccharides

Also Published As

Publication number Publication date
AU2021210607A1 (en) 2022-07-14
EP4093747A1 (en) 2022-11-30
JP2023511522A (ja) 2023-03-20
CN115003687A (zh) 2022-09-02
US20230227876A1 (en) 2023-07-20
WO2021148614A1 (en) 2021-07-29

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]