BR112022014420A2 - Produção de hmo - Google Patents
Produção de hmoInfo
- Publication number
- BR112022014420A2 BR112022014420A2 BR112022014420A BR112022014420A BR112022014420A2 BR 112022014420 A2 BR112022014420 A2 BR 112022014420A2 BR 112022014420 A BR112022014420 A BR 112022014420A BR 112022014420 A BR112022014420 A BR 112022014420A BR 112022014420 A2 BR112022014420 A2 BR 112022014420A2
- Authority
- BR
- Brazil
- Prior art keywords
- hmo
- oligosaccharide
- production
- hmo production
- nucleic acid
- Prior art date
Links
- 229920001542 oligosaccharide Polymers 0.000 abstract 2
- 150000002482 oligosaccharides Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
PRODUÇÃO DE HMO. O presente conceito inventivo se refere a uma célula geneticamente modificada habilitada para a produção de um oligossacarídeo, de um modo preferido, um HMO, compreendendo um ácido nucleico recombinante que codifica uma proteína da superfamília MFS; e métodos que utilizam a referida célula para a produção do oligossacarídeo, de um modo preferido, um HMO.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA202000088 | 2020-01-23 | ||
| PCT/EP2021/051466 WO2021148610A1 (en) | 2020-01-23 | 2021-01-22 | Hmo production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022014420A2 true BR112022014420A2 (pt) | 2022-09-27 |
Family
ID=74505190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022014420A BR112022014420A2 (pt) | 2020-01-23 | 2021-01-22 | Produção de hmo |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230109661A1 (pt) |
| EP (1) | EP4093748A1 (pt) |
| JP (1) | JP2023511524A (pt) |
| CN (1) | CN114981291A (pt) |
| BR (1) | BR112022014420A2 (pt) |
| WO (1) | WO2021148610A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK181497B1 (en) * | 2021-05-17 | 2024-03-12 | Dsm Ip Assets Bv | ENHANCING FORMATION OF THE HMOS LNT AND/OR LNnT BY MODIFYING LACTOSE IMPORT IN THE CELL |
| DK202170552A1 (en) | 2021-11-11 | 2023-09-01 | Dsm Ip Assets Bv | Combined fermentation process for producing one or more human milk oligosaccharide(s) (hmo(s)) |
| DK202270078A1 (en) | 2022-03-02 | 2023-12-04 | Dsm Ip Assets Bv | New sialyltransferases for in vivo synthesis of lst-a |
| WO2023166035A2 (en) | 2022-03-02 | 2023-09-07 | Dsm Ip Assets B.V. | New sialyltransferases for in vivo synthesis of 3'sl and 6'sl |
| DK181319B1 (en) | 2022-03-02 | 2023-08-10 | Dsm Ip Assets Bv | Genetically engineered cells and methods comprising use of a sialyltransferase for in vivo synthesis of 3’sl |
| WO2023209098A1 (en) | 2022-04-29 | 2023-11-02 | Dsm Ip Assets B.V. | Hmo producing microorganism with increased robustness towards glucose gradients |
| WO2024042235A1 (en) | 2022-08-25 | 2024-02-29 | Dsm Ip Assets B.V. | Hybrid method for producing complex hmos |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2517602C2 (ru) | 2009-06-08 | 2014-05-27 | Йенневайн Биотехнологи Гмбх | Синтез нмо |
| US9453230B2 (en) | 2011-02-16 | 2016-09-27 | Glycosyn LLC | Biosynthesis of human milk oligosaccharides in engineered bacteria |
| EP3461890A1 (en) * | 2014-03-31 | 2019-04-03 | Jennewein Biotechnologie GmbH | Total fermentation of oligosaccharides |
| ES2968677T3 (es) | 2014-06-11 | 2024-05-13 | Glycom As | Separación de 2-O-fucosil-lactosa de caldo de fermentación |
| US11453900B2 (en) | 2014-09-09 | 2022-09-27 | Glycosyn LLC | Alpha (1,3) fucosyltransferases for use in the production of fucosylated oligosaccharides |
| US10676770B2 (en) | 2014-12-16 | 2020-06-09 | Glycom A/S | Separation of 2′-FL from a fermentation broth |
| EP3141610A1 (en) | 2015-09-12 | 2017-03-15 | Jennewein Biotechnologie GmbH | Production of human milk oligosaccharides in microbial hosts with engineered import / export |
| EP3426670A4 (en) | 2016-03-07 | 2019-11-13 | Glycom A/S | SEPARATION OF OLIGOSACCHARIDES FROM A FERMENTATION BROTH |
| EP3445770A4 (en) | 2016-04-19 | 2020-03-18 | Glycom A/S | SEPARATION OF OLIGOSACCHARIDES FROM A FERMENTATION BROTH |
| EP3315610B1 (en) | 2016-10-29 | 2020-12-16 | Jennewein Biotechnologie GmbH | Process for the production of fucosylated oligosaccharides |
| US11608504B2 (en) * | 2017-12-21 | 2023-03-21 | Glycom A/S | Nucleic acid construct for in vitro and in vivo gene expression |
| US20190323052A1 (en) | 2018-04-23 | 2019-10-24 | Dupont Nutrition Biosciences Aps | Increasing export of 2? fucosyllactose from microbial cells through the expression of a heterologous nucleic acid |
| US20190323053A1 (en) | 2018-04-23 | 2019-10-24 | Dupont Nutrition Biosciences Aps | Increasing activity of 2? fucosyllactose transporters endogenous to microbial cells |
| EP3569713A1 (en) * | 2018-05-16 | 2019-11-20 | Jennewein Biotechnologie GmbH | Use of glycosidases in the production of oligosaccharides |
| US10519475B1 (en) | 2018-11-21 | 2019-12-31 | Amyris, Inc. | Biosynthesis of compounds in yeast |
-
2021
- 2021-01-22 CN CN202180010202.2A patent/CN114981291A/zh active Pending
- 2021-01-22 JP JP2022540698A patent/JP2023511524A/ja active Pending
- 2021-01-22 EP EP21702884.4A patent/EP4093748A1/en active Pending
- 2021-01-22 BR BR112022014420A patent/BR112022014420A2/pt not_active Application Discontinuation
- 2021-01-22 US US17/759,275 patent/US20230109661A1/en active Pending
- 2021-01-22 WO PCT/EP2021/051466 patent/WO2021148610A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20230109661A1 (en) | 2023-04-06 |
| WO2021148610A1 (en) | 2021-07-29 |
| EP4093748A1 (en) | 2022-11-30 |
| CN114981291A (zh) | 2022-08-30 |
| WO2021148610A9 (en) | 2022-04-28 |
| JP2023511524A (ja) | 2023-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |