BR112022001866A2 - Derivados de amida híbridos de anfotericina b - Google Patents
Derivados de amida híbridos de anfotericina bInfo
- Publication number
- BR112022001866A2 BR112022001866A2 BR112022001866A BR112022001866A BR112022001866A2 BR 112022001866 A2 BR112022001866 A2 BR 112022001866A2 BR 112022001866 A BR112022001866 A BR 112022001866A BR 112022001866 A BR112022001866 A BR 112022001866A BR 112022001866 A2 BR112022001866 A2 BR 112022001866A2
- Authority
- BR
- Brazil
- Prior art keywords
- amide derivatives
- amphotericin
- hybrid
- amb
- epi
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962884464P | 2019-08-08 | 2019-08-08 | |
| US201962951753P | 2019-12-20 | 2019-12-20 | |
| PCT/US2020/045566 WO2021026520A1 (en) | 2019-08-08 | 2020-08-10 | Hybrid amide derivatives of amphotericin b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022001866A2 true BR112022001866A2 (pt) | 2022-03-29 |
Family
ID=74503735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022001866A BR112022001866A2 (pt) | 2019-08-08 | 2020-08-10 | Derivados de amida híbridos de anfotericina b |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230016424A1 (https=) |
| EP (1) | EP4009985A4 (https=) |
| JP (1) | JP7636004B2 (https=) |
| KR (1) | KR20220071185A (https=) |
| CN (1) | CN114555094A (https=) |
| AU (1) | AU2020325163B2 (https=) |
| BR (1) | BR112022001866A2 (https=) |
| CA (1) | CA3149916A1 (https=) |
| CL (1) | CL2022000319A1 (https=) |
| IL (1) | IL290289B2 (https=) |
| MX (1) | MX2022001678A (https=) |
| WO (1) | WO2021026520A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12022551513A1 (en) | 2019-12-20 | 2023-04-24 | Mirati Therapeutics Inc | Sos1 inhibitors |
| US20230357303A1 (en) * | 2020-08-10 | 2023-11-09 | The Board Of Trustees Of The University Of Illinois | Hybrid amide derivatives of amphotericin b |
| CN115536716B (zh) * | 2021-06-29 | 2025-08-08 | 中国科学院上海药物研究所 | 两性霉素b半合成衍生物及其制备方法和用途 |
| TW202519239A (zh) * | 2023-07-19 | 2025-05-16 | 美國伊利諾大學理事會 | 利用遺失蛋白質（ｍｉｓｓｉｎｇ ｐｒｏｔｅｉｎｓ）之小分子模擬物恢復生理機能 |
| GB202406857D0 (en) * | 2024-05-15 | 2024-06-26 | Univ Manchester | Polyenes |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL122086B1 (en) * | 1979-04-09 | 1982-06-30 | Politechnika Gdanska | Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh |
| FR2776927B1 (fr) * | 1998-04-07 | 2002-07-05 | Univ Paris Curie | Compositions pour la vectorisation de molecules |
| US6664241B2 (en) * | 2000-05-31 | 2003-12-16 | Micrologix Biotech Inc. | Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof |
| MX365184B (es) * | 2010-12-21 | 2019-05-21 | Centro De Investig Y De Estudios Avanzados Del I P N | Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen. |
| KR20150027217A (ko) * | 2012-06-15 | 2015-03-11 | 블러트 에스.에이. | 항진균성 항생 암포테리신 b의 n-치환된 제2 세대 유도체, 및 이의 제조 및 응용 방법 |
| WO2015164289A1 (en) | 2014-04-21 | 2015-10-29 | Cidara Therapeutics, Inc. | Compositions and methods for the treatment of fungal infections |
| JP6543272B2 (ja) * | 2014-05-16 | 2019-07-10 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ | 低減された毒性を有するアンホテリシンｂ誘導体 |
| TWI702223B (zh) | 2014-06-12 | 2020-08-21 | 日商塩野義製藥股份有限公司 | 多烯巨環內酯衍生物 |
| AU2016205187B2 (en) | 2015-01-08 | 2020-02-27 | The Board Of Trustees Of The University Of Illinois | Concise synthesis of urea derivatives of amphotericin B |
| CA3021061C (en) * | 2015-04-15 | 2023-10-24 | Martin D. Burke | Derivatives of amphotericin b |
| US10322187B2 (en) * | 2015-08-10 | 2019-06-18 | Lehigh University | Reduced toxicity molecular conjugates of anti-fungal agents |
| RU2688658C1 (ru) * | 2018-04-10 | 2019-05-22 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" | Противогрибковый полусинтетический полиеновый антибиотик, его водорастворимые соли и фармацевтические композиции на их основе |
-
2020
- 2020-08-10 EP EP20850514.9A patent/EP4009985A4/en active Pending
- 2020-08-10 WO PCT/US2020/045566 patent/WO2021026520A1/en not_active Ceased
- 2020-08-10 KR KR1020227007294A patent/KR20220071185A/ko active Pending
- 2020-08-10 MX MX2022001678A patent/MX2022001678A/es unknown
- 2020-08-10 CN CN202080070120.2A patent/CN114555094A/zh active Pending
- 2020-08-10 IL IL290289A patent/IL290289B2/en unknown
- 2020-08-10 JP JP2022506948A patent/JP7636004B2/ja active Active
- 2020-08-10 BR BR112022001866A patent/BR112022001866A2/pt unknown
- 2020-08-10 US US17/633,254 patent/US20230016424A1/en active Pending
- 2020-08-10 AU AU2020325163A patent/AU2020325163B2/en active Active
- 2020-08-10 CA CA3149916A patent/CA3149916A1/en active Pending
-
2022
- 2022-02-07 CL CL2022000319A patent/CL2022000319A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022543420A (ja) | 2022-10-12 |
| AU2020325163B2 (en) | 2026-04-23 |
| EP4009985A4 (en) | 2023-09-06 |
| IL290289A (en) | 2022-04-01 |
| CL2022000319A1 (es) | 2022-10-21 |
| CA3149916A1 (en) | 2021-02-11 |
| IL290289B1 (en) | 2025-11-01 |
| US20230016424A1 (en) | 2023-01-19 |
| WO2021026520A1 (en) | 2021-02-11 |
| IL290289B2 (en) | 2026-03-01 |
| MX2022001678A (es) | 2022-05-18 |
| AU2020325163A1 (en) | 2022-03-03 |
| KR20220071185A (ko) | 2022-05-31 |
| EP4009985A1 (en) | 2022-06-15 |
| CN114555094A (zh) | 2022-05-27 |
| JP7636004B2 (ja) | 2025-02-26 |
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