BR112022001866A2 - Derivados de amida híbridos de anfotericina b - Google Patents

Derivados de amida híbridos de anfotericina b

Info

Publication number
BR112022001866A2
BR112022001866A2 BR112022001866A BR112022001866A BR112022001866A2 BR 112022001866 A2 BR112022001866 A2 BR 112022001866A2 BR 112022001866 A BR112022001866 A BR 112022001866A BR 112022001866 A BR112022001866 A BR 112022001866A BR 112022001866 A2 BR112022001866 A2 BR 112022001866A2
Authority
BR
Brazil
Prior art keywords
amide derivatives
amphotericin
hybrid
amb
epi
Prior art date
Application number
BR112022001866A
Other languages
English (en)
Portuguese (pt)
Inventor
Arun Maji
Jiabao Zhang
D Burke Martin
Su Yan
Yong Nian
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Publication of BR112022001866A2 publication Critical patent/BR112022001866A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BR112022001866A 2019-08-08 2020-08-10 Derivados de amida híbridos de anfotericina b BR112022001866A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962884464P 2019-08-08 2019-08-08
US201962951753P 2019-12-20 2019-12-20
PCT/US2020/045566 WO2021026520A1 (en) 2019-08-08 2020-08-10 Hybrid amide derivatives of amphotericin b

Publications (1)

Publication Number Publication Date
BR112022001866A2 true BR112022001866A2 (pt) 2022-03-29

Family

ID=74503735

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022001866A BR112022001866A2 (pt) 2019-08-08 2020-08-10 Derivados de amida híbridos de anfotericina b

Country Status (12)

Country Link
US (1) US20230016424A1 (https=)
EP (1) EP4009985A4 (https=)
JP (1) JP7636004B2 (https=)
KR (1) KR20220071185A (https=)
CN (1) CN114555094A (https=)
AU (1) AU2020325163B2 (https=)
BR (1) BR112022001866A2 (https=)
CA (1) CA3149916A1 (https=)
CL (1) CL2022000319A1 (https=)
IL (1) IL290289B2 (https=)
MX (1) MX2022001678A (https=)
WO (1) WO2021026520A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12022551513A1 (en) 2019-12-20 2023-04-24 Mirati Therapeutics Inc Sos1 inhibitors
AU2021325676A1 (en) * 2020-08-10 2023-03-30 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin B
CN115536716B (zh) * 2021-06-29 2025-08-08 中国科学院上海药物研究所 两性霉素b半合成衍生物及其制备方法和用途
TW202519239A (zh) * 2023-07-19 2025-05-16 美國伊利諾大學理事會 利用遺失蛋白質（ｍｉｓｓｉｎｇ ｐｒｏｔｅｉｎｓ）之小分子模擬物恢復生理機能
GB202406857D0 (en) * 2024-05-15 2024-06-26 Univ Manchester Polyenes

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122086B1 (en) * 1979-04-09 1982-06-30 Politechnika Gdanska Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh
FR2776927B1 (fr) * 1998-04-07 2002-07-05 Univ Paris Curie Compositions pour la vectorisation de molecules
US6664241B2 (en) * 2000-05-31 2003-12-16 Micrologix Biotech Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
MX365184B (es) * 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
KR20150027217A (ko) * 2012-06-15 2015-03-11 블러트 에스.에이. 항진균성 항생 암포테리신 b의 n-치환된 제2 세대 유도체, 및 이의 제조 및 응용 방법
WO2015164289A1 (en) * 2014-04-21 2015-10-29 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections
ES2749927T3 (es) * 2014-05-16 2020-03-24 Univ Illinois Derivado de anfotericina b con toxicidad reducida
MA39568A1 (fr) * 2014-06-12 2017-09-29 Shionogi & Co Dérivé de macrolide de polyène
WO2016112260A1 (en) * 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Concise synthesis of urea derivatives of amphotericin b
JP7240811B2 (ja) * 2015-04-15 2023-03-16 スファンガ セラピューティクス インコーポレイテッド アムホテリシンｂの誘導体
US10322187B2 (en) * 2015-08-10 2019-06-18 Lehigh University Reduced toxicity molecular conjugates of anti-fungal agents
RU2688658C1 (ru) * 2018-04-10 2019-05-22 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Противогрибковый полусинтетический полиеновый антибиотик, его водорастворимые соли и фармацевтические композиции на их основе
TW202415384A (zh) * 2022-06-24 2024-04-16 美國伊利諾大學理事會 雙性黴素b之複合醯胺衍生物於dsgpeg2k微胞中之調配物

Also Published As

Publication number Publication date
CN114555094A (zh) 2022-05-27
CA3149916A1 (en) 2021-02-11
IL290289A (en) 2022-04-01
CL2022000319A1 (es) 2022-10-21
WO2021026520A1 (en) 2021-02-11
IL290289B1 (en) 2025-11-01
EP4009985A1 (en) 2022-06-15
EP4009985A4 (en) 2023-09-06
MX2022001678A (es) 2022-05-18
JP7636004B2 (ja) 2025-02-26
AU2020325163B2 (en) 2026-04-23
IL290289B2 (en) 2026-03-01
JP2022543420A (ja) 2022-10-12
KR20220071185A (ko) 2022-05-31
US20230016424A1 (en) 2023-01-19
AU2020325163A1 (en) 2022-03-03

Similar Documents

Publication Publication Date Title
BR112022001866A2 (pt) Derivados de amida híbridos de anfotericina b
BR112022007481A2 (pt) Lipídios ionizáveis e composições de nanopartículas dos mesmos
PH12021551256A1 (en) Pantetheine derivatives and uses thereof
BR112022026321A2 (pt) Análogos de 1'-ciano nucleosídeo e usos dos mesmos
MX2020007014A (es) Compuestos de benzamida.
BR112022004424A2 (pt) Pró-fármacos antivirais e formulações dos mesmos
BR112014018990A8 (pt) Derivados de ácido benzotiazol-6-il acético e seu uso para tratamento de uma infecção
EA201800064A1 (ru) 1,1,1-трифтор-3-гидроксипропан-2-ил карбаматные производные и 1,1,1-трифтор-4-гидроксибутан-2-ил карбаматные производные в качестве ингибиторов magl
CR20220126A (es) Moduladores de sting (estimulador de genes de interferón)
BR112018002499A2 (pt) método de preparação de um composto da fórmula (a) ou um seu sal, solvato ou conjugado de aminoácido farmaceuticamente aceitável, composto produzido pelo método e composição farmacêutica
CY1114521T1 (el) Ενωσεις βενζαμιδιου χρησιμες ως αναστολεις αποακετυλασων ιστονων
BR112021011325A2 (pt) Derivados de rapamicina
MX2021006969A (es) Ligante peptidico.
CY1120530T1 (el) Απο του στοματος χορηγησιμη φαρμακευτικη συνθεση
EA201890532A1 (ru) Новые аннелированные бензамиды
BR112019018615A2 (pt) compostos antimicrobianos, composições e usos dos mesmos
BR112022008457A2 (pt) Agente terapêutico e agente profilático para distúrbios gastrointestinais funcionais e xerostomia
BR112022000782A2 (pt) Composto, composição farmacêutica, processo para preparar um composto, composto intermediário, e, uso de um composto, ou de um sal farmaceuticamente aceitável ou solvato do mesmo, ou de uma composição farmacêutica
EA201991023A1 (ru) Фармацевтическая композиция для парентерального введения, содержащая карглумовую кислоту
PH12020552186A1 (en) Cyanotriazole compounds and uses thereof
AU2020353055A8 (en) Antiviral pyrazolopyridinone compounds
BR112022003751A2 (pt) Análogos de hemoglobina reticulada com tiosuccinila e métodos de uso e preparação dos mesmos
MX2023001649A (es) Derivados de amida hibrida de anfotericina b.
CL2025002072A1 (es) Inhibidores de prmt5–mta.
CO2022017895A2 (es) Inhibidores de cisteína proteasas y sus métodos de uso