BR112022001866A2 - Derivados de amida híbridos de anfotericina b - Google Patents

Derivados de amida híbridos de anfotericina b

Info

Publication number
BR112022001866A2
BR112022001866A2 BR112022001866A BR112022001866A BR112022001866A2 BR 112022001866 A2 BR112022001866 A2 BR 112022001866A2 BR 112022001866 A BR112022001866 A BR 112022001866A BR 112022001866 A BR112022001866 A BR 112022001866A BR 112022001866 A2 BR112022001866 A2 BR 112022001866A2
Authority
BR
Brazil
Prior art keywords
amide derivatives
amphotericin
hybrid
amb
epi
Prior art date
Application number
BR112022001866A
Other languages
English (en)
Inventor
Arun Maji
Jiabao Zhang
D Burke Martin
Su Yan
Yong Nian
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Publication of BR112022001866A2 publication Critical patent/BR112022001866A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

derivados de amida híbridos de anfotericina b”.referência cruzada a pedidos relacionados. a presente invenção refere-se a derivados de c16 amida de c2'-epi-anfotericina b (c2'epiamb) e anfotericina b (amb), caracterizados por eficácia clínica melhorada com toxicidade reduzida em comparação com amb. também são descritas composições farmacêuticas compreendendo qualquer tipo dos derivados de c16 amida, e métodos terapêuticos de utilização de qualquer tipo de derivados de c16 amida; e métodos para preparar os derivados de c16 amida de c2'-epi-anfotericina b.
BR112022001866A 2019-08-08 2020-08-10 Derivados de amida híbridos de anfotericina b BR112022001866A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962884464P 2019-08-08 2019-08-08
US201962951753P 2019-12-20 2019-12-20
PCT/US2020/045566 WO2021026520A1 (en) 2019-08-08 2020-08-10 Hybrid amide derivatives of amphotericin b

Publications (1)

Publication Number Publication Date
BR112022001866A2 true BR112022001866A2 (pt) 2022-03-29

Family

ID=74503735

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022001866A BR112022001866A2 (pt) 2019-08-08 2020-08-10 Derivados de amida híbridos de anfotericina b

Country Status (12)

Country Link
US (1) US20230016424A1 (pt)
EP (1) EP4009985A4 (pt)
JP (1) JP2022543420A (pt)
KR (1) KR20220071185A (pt)
CN (1) CN114555094A (pt)
AU (1) AU2020325163A1 (pt)
BR (1) BR112022001866A2 (pt)
CA (1) CA3149916A1 (pt)
CL (1) CL2022000319A1 (pt)
IL (1) IL290289A (pt)
MX (1) MX2022001678A (pt)
WO (1) WO2021026520A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022035752A1 (en) * 2020-08-10 2022-02-17 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin b
CN115536716A (zh) * 2021-06-29 2022-12-30 中国科学院上海药物研究所 两性霉素b半合成衍生物及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122086B1 (en) * 1979-04-09 1982-06-30 Politechnika Gdanska Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh
FR2776927B1 (fr) * 1998-04-07 2002-07-05 Univ Paris Curie Compositions pour la vectorisation de molecules
US6664241B2 (en) * 2000-05-31 2003-12-16 Micrologix Biotech Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
MX365184B (es) * 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
RU2014152459A (ru) * 2012-06-15 2016-08-10 Блирт С.А. N-замещенные производные второго поколения противогрибкового антибиотика амфотерицина в и способы их получения и применения
CA3213127A1 (en) * 2015-04-15 2016-10-20 Sfunga Therapeutics, Inc. Derivatives of amphotericin b
US10322187B2 (en) * 2015-08-10 2019-06-18 Lehigh University Reduced toxicity molecular conjugates of anti-fungal agents

Also Published As

Publication number Publication date
EP4009985A4 (en) 2023-09-06
CA3149916A1 (en) 2021-02-11
IL290289A (en) 2022-04-01
MX2022001678A (es) 2022-05-18
JP2022543420A (ja) 2022-10-12
WO2021026520A1 (en) 2021-02-11
EP4009985A1 (en) 2022-06-15
US20230016424A1 (en) 2023-01-19
KR20220071185A (ko) 2022-05-31
AU2020325163A1 (en) 2022-03-03
CN114555094A (zh) 2022-05-27
CL2022000319A1 (es) 2022-10-21

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