JP7636004B2 - アムホテリシンｂのハイブリッドアミド誘導体 - Google Patents

アムホテリシンｂのハイブリッドアミド誘導体 Download PDF

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JP7636004B2
JP7636004B2 JP2022506948A JP2022506948A JP7636004B2 JP 7636004 B2 JP7636004 B2 JP 7636004B2 JP 2022506948 A JP2022506948 A JP 2022506948A JP 2022506948 A JP2022506948 A JP 2022506948A JP 7636004 B2 JP7636004 B2 JP 7636004B2
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JP2022543420A (ja
JP2022543420A5 (https=
JPWO2021026520A5 (https=
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ディー バーク，マーティン
マジ，アルン
ヂャン，ジアバーオー
イェン，スゥ
ニエン，ヨン
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University of Illinois System
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University of Illinois System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2022506948A 2019-08-08 2020-08-10 アムホテリシンｂのハイブリッドアミド誘導体 Active JP7636004B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962884464P 2019-08-08 2019-08-08
US62/884,464 2019-08-08
US201962951753P 2019-12-20 2019-12-20
US62/951,753 2019-12-20
PCT/US2020/045566 WO2021026520A1 (en) 2019-08-08 2020-08-10 Hybrid amide derivatives of amphotericin b

Publications (4)

Publication Number Publication Date
JP2022543420A JP2022543420A (ja) 2022-10-12
JP2022543420A5 JP2022543420A5 (https=) 2023-08-14
JPWO2021026520A5 JPWO2021026520A5 (https=) 2023-08-14
JP7636004B2 true JP7636004B2 (ja) 2025-02-26

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JP2022506948A Active JP7636004B2 (ja) 2019-08-08 2020-08-10 アムホテリシンｂのハイブリッドアミド誘導体

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US (1) US20230016424A1 (https=)
EP (1) EP4009985A4 (https=)
JP (1) JP7636004B2 (https=)
KR (1) KR20220071185A (https=)
CN (1) CN114555094A (https=)
AU (1) AU2020325163B2 (https=)
BR (1) BR112022001866A2 (https=)
CA (1) CA3149916A1 (https=)
CL (1) CL2022000319A1 (https=)
IL (1) IL290289B2 (https=)
MX (1) MX2022001678A (https=)
WO (1) WO2021026520A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12022551513A1 (en) 2019-12-20 2023-04-24 Mirati Therapeutics Inc Sos1 inhibitors
US20230357303A1 (en) * 2020-08-10 2023-11-09 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin b
CN115536716B (zh) * 2021-06-29 2025-08-08 中国科学院上海药物研究所 两性霉素b半合成衍生物及其制备方法和用途
TW202519239A (zh) * 2023-07-19 2025-05-16 美國伊利諾大學理事會 利用遺失蛋白質（ｍｉｓｓｉｎｇ ｐｒｏｔｅｉｎｓ）之小分子模擬物恢復生理機能
GB202406857D0 (en) * 2024-05-15 2024-06-26 Univ Manchester Polyenes

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040002465A1 (en) 1998-04-07 2004-01-01 Universite Pierre Et Marie Curie Polyene macrolide derivatives, use for vectoring molecules
WO2012085784A2 (en) 2010-12-21 2012-06-28 Centro De Investigación Y De Estudios Avanzados Del Instituto Politécnico Nacional New amphotericin analogous compounds and pharmaceutical compositions containing them
WO2015164289A1 (en) 2014-04-21 2015-10-29 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections
WO2016112260A1 (en) 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Concise synthesis of urea derivatives of amphotericin b
US20170042923A1 (en) 2015-08-10 2017-02-16 Lehigh University Reduced toxicity molecular conjugates of anti-fungal agents
US20190135847A1 (en) 2014-06-12 2019-05-09 Shionogi & Co., Ltd. Polyene macrolide derivative

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122086B1 (en) * 1979-04-09 1982-06-30 Politechnika Gdanska Process for preparing amides of antibiotics from the group of polyene macrolides and their derivativesvykh makrolidov i ikh proizvodnykh
US6664241B2 (en) * 2000-05-31 2003-12-16 Micrologix Biotech Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
KR20150027217A (ko) * 2012-06-15 2015-03-11 블러트 에스.에이. 항진균성 항생 암포테리신 b의 n-치환된 제2 세대 유도체, 및 이의 제조 및 응용 방법
JP6543272B2 (ja) * 2014-05-16 2019-07-10 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ 低減された毒性を有するアンホテリシンｂ誘導体
CA3021061C (en) * 2015-04-15 2023-10-24 Martin D. Burke Derivatives of amphotericin b
RU2688658C1 (ru) * 2018-04-10 2019-05-22 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Противогрибковый полусинтетический полиеновый антибиотик, его водорастворимые соли и фармацевтические композиции на их основе

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040002465A1 (en) 1998-04-07 2004-01-01 Universite Pierre Et Marie Curie Polyene macrolide derivatives, use for vectoring molecules
WO2012085784A2 (en) 2010-12-21 2012-06-28 Centro De Investigación Y De Estudios Avanzados Del Instituto Politécnico Nacional New amphotericin analogous compounds and pharmaceutical compositions containing them
US20140256663A1 (en) 2010-12-21 2014-09-11 Centro De Investigacion Y De Estudios Avanzados Del Instituto Politecnico Aacion Amphotericin Analogous Compounds and Pharmaceutical Compositions Containing Them
WO2015164289A1 (en) 2014-04-21 2015-10-29 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections
US20190135847A1 (en) 2014-06-12 2019-05-09 Shionogi & Co., Ltd. Polyene macrolide derivative
WO2016112260A1 (en) 2015-01-08 2016-07-14 The Board Of Trustees Of The University Of Illinois Concise synthesis of urea derivatives of amphotericin b
US20170042923A1 (en) 2015-08-10 2017-02-16 Lehigh University Reduced toxicity molecular conjugates of anti-fungal agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FALKOWSKI, leonald et al.，THE SYNTHESIS OF AMIDES OF POLYENE MACROLIDE ANTIBIOTICS，THE JOURNAL OF ANTIBIOTICS，1980年，vol.33, no.1，p.103-104
JARZEBSKI, Andrzej et al.，SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF AMIDES OF AMPHOTERICIN B，THE JOURNAL OF ANTIBIOTICS，1982年，vol.35, no.2，p.220-229
MAZARSKY, Jan et al.，Effect of the modefication of ionizable groups of amphotericin B on its ability to form complexs with sterols in hydroalcoholic media，Biochimica et Biophysica Acta ，1995年，vol.1236(1)，p.170-176
N.TEVYASHOVA, Anna et al.，Structure-Antifungal Activity Relationships of Polyene Antibiotics of the Amphotericin B Group，Antimicrobial Agents and Chemotheraphy，vol.57(8)，2013年，p.3815-3822

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Publication number Publication date
JP2022543420A (ja) 2022-10-12
AU2020325163B2 (en) 2026-04-23
EP4009985A4 (en) 2023-09-06
IL290289A (en) 2022-04-01
CL2022000319A1 (es) 2022-10-21
CA3149916A1 (en) 2021-02-11
IL290289B1 (en) 2025-11-01
US20230016424A1 (en) 2023-01-19
WO2021026520A1 (en) 2021-02-11
IL290289B2 (en) 2026-03-01
MX2022001678A (es) 2022-05-18
AU2020325163A1 (en) 2022-03-03
KR20220071185A (ko) 2022-05-31
EP4009985A1 (en) 2022-06-15
BR112022001866A2 (pt) 2022-03-29
CN114555094A (zh) 2022-05-27

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