CN114555094A - 两性霉素b的混合酰胺衍生物 - Google Patents

两性霉素b的混合酰胺衍生物 Download PDF

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Publication number
CN114555094A
CN114555094A CN202080070120.2A CN202080070120A CN114555094A CN 114555094 A CN114555094 A CN 114555094A CN 202080070120 A CN202080070120 A CN 202080070120A CN 114555094 A CN114555094 A CN 114555094A
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China
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unsubstituted
substituted
compound
alkyl
hydrogen
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Pending
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CN202080070120.2A
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English (en)
Chinese (zh)
Inventor
张家报
S·严
M·D·伯克
A·马吉
Y·年
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University of Illinois System
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University of Illinois System
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Publication of CN114555094A publication Critical patent/CN114555094A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202080070120.2A 2019-08-08 2020-08-10 两性霉素b的混合酰胺衍生物 Pending CN114555094A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962884464P 2019-08-08 2019-08-08
US62/884464 2019-08-08
US201962951753P 2019-12-20 2019-12-20
US62/951753 2019-12-20
PCT/US2020/045566 WO2021026520A1 (en) 2019-08-08 2020-08-10 Hybrid amide derivatives of amphotericin b

Publications (1)

Publication Number Publication Date
CN114555094A true CN114555094A (zh) 2022-05-27

Family

ID=74503735

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080070120.2A Pending CN114555094A (zh) 2019-08-08 2020-08-10 两性霉素b的混合酰胺衍生物

Country Status (12)

Country Link
US (1) US20230016424A1 (https=)
EP (1) EP4009985A4 (https=)
JP (1) JP7636004B2 (https=)
KR (1) KR20220071185A (https=)
CN (1) CN114555094A (https=)
AU (1) AU2020325163B2 (https=)
BR (1) BR112022001866A2 (https=)
CA (1) CA3149916A1 (https=)
CL (1) CL2022000319A1 (https=)
IL (1) IL290289B2 (https=)
MX (1) MX2022001678A (https=)
WO (1) WO2021026520A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12022551513A1 (en) 2019-12-20 2023-04-24 Mirati Therapeutics Inc Sos1 inhibitors
US20230357303A1 (en) * 2020-08-10 2023-11-09 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin b
CN115536716B (zh) * 2021-06-29 2025-08-08 中国科学院上海药物研究所 两性霉素b半合成衍生物及其制备方法和用途
TW202519239A (zh) * 2023-07-19 2025-05-16 美國伊利諾大學理事會 利用遺失蛋白質（ｍｉｓｓｉｎｇ ｐｒｏｔｅｉｎｓ）之小分子模擬物恢復生理機能
GB202406857D0 (en) * 2024-05-15 2024-06-26 Univ Manchester Polyenes

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783527A (en) * 1979-04-09 1988-11-08 Politechnika Gdanska Amides of amphoteric polyene macrolide antibiotics
WO2001091758A1 (en) * 2000-05-31 2001-12-06 Intrabiotics Pharmaceuticals, Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
CN104520309A (zh) * 2012-06-15 2015-04-15 布里特股份公司 抗真菌抗生素两性霉素b的n-取代第二代衍生物及其制备方法和应用
WO2016168568A1 (en) * 2015-04-15 2016-10-20 Revolution Medicines, Inc. Derivatives of amphotericin b
US20170042923A1 (en) * 2015-08-10 2017-02-16 Lehigh University Reduced toxicity molecular conjugates of anti-fungal agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2776927B1 (fr) * 1998-04-07 2002-07-05 Univ Paris Curie Compositions pour la vectorisation de molecules
MX365184B (es) * 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
WO2015164289A1 (en) 2014-04-21 2015-10-29 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections
JP6543272B2 (ja) * 2014-05-16 2019-07-10 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ 低減された毒性を有するアンホテリシンｂ誘導体
TWI702223B (zh) 2014-06-12 2020-08-21 日商塩野義製藥股份有限公司 多烯巨環內酯衍生物
AU2016205187B2 (en) 2015-01-08 2020-02-27 The Board Of Trustees Of The University Of Illinois Concise synthesis of urea derivatives of amphotericin B
RU2688658C1 (ru) * 2018-04-10 2019-05-22 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Противогрибковый полусинтетический полиеновый антибиотик, его водорастворимые соли и фармацевтические композиции на их основе

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783527A (en) * 1979-04-09 1988-11-08 Politechnika Gdanska Amides of amphoteric polyene macrolide antibiotics
WO2001091758A1 (en) * 2000-05-31 2001-12-06 Intrabiotics Pharmaceuticals, Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
CN104520309A (zh) * 2012-06-15 2015-04-15 布里特股份公司 抗真菌抗生素两性霉素b的n-取代第二代衍生物及其制备方法和应用
WO2016168568A1 (en) * 2015-04-15 2016-10-20 Revolution Medicines, Inc. Derivatives of amphotericin b
US20170042923A1 (en) * 2015-08-10 2017-02-16 Lehigh University Reduced toxicity molecular conjugates of anti-fungal agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
魏红 等: "《化学实验 （I、II）》", vol. 1, 人民卫生出版社, pages: 451 - 453 *

Also Published As

Publication number Publication date
JP2022543420A (ja) 2022-10-12
AU2020325163B2 (en) 2026-04-23
EP4009985A4 (en) 2023-09-06
IL290289A (en) 2022-04-01
CL2022000319A1 (es) 2022-10-21
CA3149916A1 (en) 2021-02-11
IL290289B1 (en) 2025-11-01
US20230016424A1 (en) 2023-01-19
WO2021026520A1 (en) 2021-02-11
IL290289B2 (en) 2026-03-01
MX2022001678A (es) 2022-05-18
AU2020325163A1 (en) 2022-03-03
KR20220071185A (ko) 2022-05-31
EP4009985A1 (en) 2022-06-15
BR112022001866A2 (pt) 2022-03-29
JP7636004B2 (ja) 2025-02-26

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