AU2020325163B2 - Hybrid amide derivatives of amphotericin B - Google Patents

Hybrid amide derivatives of amphotericin B

Info

Publication number
AU2020325163B2
AU2020325163B2 AU2020325163A AU2020325163A AU2020325163B2 AU 2020325163 B2 AU2020325163 B2 AU 2020325163B2 AU 2020325163 A AU2020325163 A AU 2020325163A AU 2020325163 A AU2020325163 A AU 2020325163A AU 2020325163 B2 AU2020325163 B2 AU 2020325163B2
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AU
Australia
Prior art keywords
substituted
unsubstituted
compound
alkyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020325163A
Other languages
English (en)
Other versions
AU2020325163A1 (en
Inventor
Martin D. Burke
Arun Maji
Yong NIAN
Su YAN
Jiabao Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois System
Original Assignee
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Illinois System filed Critical University of Illinois System
Publication of AU2020325163A1 publication Critical patent/AU2020325163A1/en
Application granted granted Critical
Publication of AU2020325163B2 publication Critical patent/AU2020325163B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2020325163A 2019-08-08 2020-08-10 Hybrid amide derivatives of amphotericin B Active AU2020325163B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962884464P 2019-08-08 2019-08-08
US62/884,464 2019-08-08
US201962951753P 2019-12-20 2019-12-20
US62/951,753 2019-12-20
PCT/US2020/045566 WO2021026520A1 (en) 2019-08-08 2020-08-10 Hybrid amide derivatives of amphotericin b

Publications (2)

Publication Number Publication Date
AU2020325163A1 AU2020325163A1 (en) 2022-03-03
AU2020325163B2 true AU2020325163B2 (en) 2026-04-23

Family

ID=74503735

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2020325163A Active AU2020325163B2 (en) 2019-08-08 2020-08-10 Hybrid amide derivatives of amphotericin B

Country Status (12)

Country Link
US (1) US20230016424A1 (https=)
EP (1) EP4009985A4 (https=)
JP (1) JP7636004B2 (https=)
KR (1) KR20220071185A (https=)
CN (1) CN114555094A (https=)
AU (1) AU2020325163B2 (https=)
BR (1) BR112022001866A2 (https=)
CA (1) CA3149916A1 (https=)
CL (1) CL2022000319A1 (https=)
IL (1) IL290289B2 (https=)
MX (1) MX2022001678A (https=)
WO (1) WO2021026520A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12022551513A1 (en) 2019-12-20 2023-04-24 Mirati Therapeutics Inc Sos1 inhibitors
US20230357303A1 (en) * 2020-08-10 2023-11-09 The Board Of Trustees Of The University Of Illinois Hybrid amide derivatives of amphotericin b
CN115536716B (zh) * 2021-06-29 2025-08-08 中国科学院上海药物研究所 两性霉素b半合成衍生物及其制备方法和用途
TW202519239A (zh) * 2023-07-19 2025-05-16 美國伊利諾大學理事會 利用遺失蛋白質（ｍｉｓｓｉｎｇ ｐｒｏｔｅｉｎｓ）之小分子模擬物恢復生理機能
GB202406857D0 (en) * 2024-05-15 2024-06-26 Univ Manchester Polyenes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783527A (en) * 1979-04-09 1988-11-08 Politechnika Gdanska Amides of amphoteric polyene macrolide antibiotics
WO2012085784A2 (en) * 2010-12-21 2012-06-28 Centro De Investigación Y De Estudios Avanzados Del Instituto Politécnico Nacional New amphotericin analogous compounds and pharmaceutical compositions containing them
US9738677B2 (en) * 2014-05-16 2017-08-22 The Board Of Trustees Of The University Of Illinois Amphotericin B derivative with reduced toxicity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2776927B1 (fr) * 1998-04-07 2002-07-05 Univ Paris Curie Compositions pour la vectorisation de molecules
US6664241B2 (en) * 2000-05-31 2003-12-16 Micrologix Biotech Inc. Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
KR20150027217A (ko) * 2012-06-15 2015-03-11 블러트 에스.에이. 항진균성 항생 암포테리신 b의 n-치환된 제2 세대 유도체, 및 이의 제조 및 응용 방법
WO2015164289A1 (en) 2014-04-21 2015-10-29 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections
TWI702223B (zh) 2014-06-12 2020-08-21 日商塩野義製藥股份有限公司 多烯巨環內酯衍生物
AU2016205187B2 (en) 2015-01-08 2020-02-27 The Board Of Trustees Of The University Of Illinois Concise synthesis of urea derivatives of amphotericin B
CA3021061C (en) * 2015-04-15 2023-10-24 Martin D. Burke Derivatives of amphotericin b
US10322187B2 (en) * 2015-08-10 2019-06-18 Lehigh University Reduced toxicity molecular conjugates of anti-fungal agents
RU2688658C1 (ru) * 2018-04-10 2019-05-22 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Противогрибковый полусинтетический полиеновый антибиотик, его водорастворимые соли и фармацевтические композиции на их основе

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783527A (en) * 1979-04-09 1988-11-08 Politechnika Gdanska Amides of amphoteric polyene macrolide antibiotics
WO2012085784A2 (en) * 2010-12-21 2012-06-28 Centro De Investigación Y De Estudios Avanzados Del Instituto Politécnico Nacional New amphotericin analogous compounds and pharmaceutical compositions containing them
US9738677B2 (en) * 2014-05-16 2017-08-22 The Board Of Trustees Of The University Of Illinois Amphotericin B derivative with reduced toxicity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FALKOWSKI LEONARD, ANDRZEJ JARZEBSKI, BARBARA STEFANSKA, ELZBIETA BYLEC, EDWARD BOROWSKI: "THE SYNTHESIS OF AMIDES OF POLYENE MACROLIDE ANTIBIOTICS ", THE JOURNAL OF ANTIBIOTICS, vol. 33, no. 1, 1 January 1980 (1980-01-01), pages 103 - 104, XP093069106, DOI: doi.org/10.7164/antibiotics.33.103 *
JARZEBSKI A ET AL: "SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF AMIDES OF AMPHOTERICIN B", THE JOURNAL OF ANTIBIOTICS, NATURE PUBLISHING GROUP UK, LONDON, vol. 35, no. 2, 1 February 1982 (1982-02-01), pages 220 - 229 *
VALÉRIE PAQUET ET AL: "Synthesis and In Vitro Biological Properties of Novel Cationic Derivatives of Amphotericin B", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, vol. 14, no. 8, 14 January 2008 (2008-01-14), pages 2465 - 2481 *

Also Published As

Publication number Publication date
JP2022543420A (ja) 2022-10-12
EP4009985A4 (en) 2023-09-06
IL290289A (en) 2022-04-01
CL2022000319A1 (es) 2022-10-21
CA3149916A1 (en) 2021-02-11
IL290289B1 (en) 2025-11-01
US20230016424A1 (en) 2023-01-19
WO2021026520A1 (en) 2021-02-11
IL290289B2 (en) 2026-03-01
MX2022001678A (es) 2022-05-18
AU2020325163A1 (en) 2022-03-03
KR20220071185A (ko) 2022-05-31
EP4009985A1 (en) 2022-06-15
BR112022001866A2 (pt) 2022-03-29
CN114555094A (zh) 2022-05-27
JP7636004B2 (ja) 2025-02-26

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