BR112020025696A2 - Derivados de tetra-hidrotienopiridina n-substituída e usos dos mesmos - Google Patents

Derivados de tetra-hidrotienopiridina n-substituída e usos dos mesmos Download PDF

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Publication number
BR112020025696A2
BR112020025696A2 BR112020025696-0A BR112020025696A BR112020025696A2 BR 112020025696 A2 BR112020025696 A2 BR 112020025696A2 BR 112020025696 A BR112020025696 A BR 112020025696A BR 112020025696 A2 BR112020025696 A2 BR 112020025696A2
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BR
Brazil
Prior art keywords
mmol
cyano
core
tetrahydrothieno
methyl
Prior art date
Application number
BR112020025696-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Cyrille Kounde
Wei Lin Sandra Sim
Oliver Simon
Wang Gang
Hui Quan Yeo
Bryan KS Yeung
Fumiaki Yokokawa
Bin Zou
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=67841114&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112020025696(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112020025696A2 publication Critical patent/BR112020025696A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112020025696-0A 2018-06-19 2019-06-18 Derivados de tetra-hidrotienopiridina n-substituída e usos dos mesmos BR112020025696A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862687068P 2018-06-19 2018-06-19
US62/687,068 2018-06-19
PCT/IB2019/055121 WO2019244047A1 (en) 2018-06-19 2019-06-18 N-substituted tetrahydrothienopyridine derivatives and uses thereof

Publications (1)

Publication Number Publication Date
BR112020025696A2 true BR112020025696A2 (pt) 2021-03-16

Family

ID=67841114

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020025696-0A BR112020025696A2 (pt) 2018-06-19 2019-06-18 Derivados de tetra-hidrotienopiridina n-substituída e usos dos mesmos

Country Status (24)

Country Link
US (3) US12012417B2 (https=)
EP (2) EP4169925B1 (https=)
JP (1) JP7328260B2 (https=)
KR (1) KR102835904B1 (https=)
CN (1) CN112313237A (https=)
AU (1) AU2019291488B2 (https=)
BR (1) BR112020025696A2 (https=)
CA (1) CA3100957A1 (https=)
CL (1) CL2020003248A1 (https=)
CR (1) CR20200618A (https=)
CU (1) CU20200100A7 (https=)
EA (1) EA202190046A1 (https=)
EC (1) ECSP20080995A (https=)
ES (2) ES3062606T3 (https=)
IL (1) IL279441B2 (https=)
JO (1) JOP20200326A1 (https=)
MA (1) MA52976A (https=)
MX (1) MX2020013852A (https=)
MY (1) MY201990A (https=)
PE (1) PE20210097A1 (https=)
PH (1) PH12020552185A1 (https=)
SA (1) SA520420809B1 (https=)
SG (1) SG11202012625PA (https=)
WO (1) WO2019244047A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3663299B1 (en) * 2017-08-01 2023-03-08 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Bicyclic compound acting as ror gamma inhibitor
BR112020025696A2 (pt) 2018-06-19 2021-03-16 Novartis Ag Derivados de tetra-hidrotienopiridina n-substituída e usos dos mesmos
USD1006154S1 (en) * 2023-06-27 2023-11-28 Qiongfang Mao Cable crossover attachment
WO2025238553A1 (en) 2024-05-14 2025-11-20 Novartis Ag Dosing regimens for n-(3-cyano-5-(cyclohexylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-2-(4-sulfamoylphenyl)acetamide for use in treating or preventing a dengue virus disease or disorder
WO2025253267A1 (en) 2024-06-06 2025-12-11 Janssen Pharmaceuticals, Inc. Combination of mosnodenvir and close analogs with nitd-688 for use in the treatment and prevention of dengue disease

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Also Published As

Publication number Publication date
CL2020003248A1 (es) 2021-07-09
KR102835904B1 (ko) 2025-07-22
MA52976A (fr) 2021-04-28
US20220073535A1 (en) 2022-03-10
EP4169925A3 (en) 2023-06-14
US20260070920A1 (en) 2026-03-12
CN112313237A (zh) 2021-02-02
CR20200618A (es) 2021-01-21
ES3062606T3 (en) 2026-04-13
JP7328260B2 (ja) 2023-08-16
SG11202012625PA (en) 2021-01-28
US12331060B2 (en) 2025-06-17
AU2019291488B2 (en) 2022-02-24
EP3810613A1 (en) 2021-04-28
JOP20200326A1 (ar) 2020-12-14
IL279441A (en) 2021-01-31
SA520420809B1 (ar) 2022-08-17
ES2941946T3 (es) 2023-05-26
JP2021529159A (ja) 2021-10-28
PE20210097A1 (es) 2021-01-12
MX2020013852A (es) 2021-05-27
AU2019291488A1 (en) 2021-02-04
EA202190046A1 (ru) 2021-03-24
KR20210022645A (ko) 2021-03-03
CU20200100A7 (es) 2021-08-06
MY201990A (en) 2024-03-27
EP4169925B1 (en) 2025-11-19
EP3810613B1 (en) 2023-01-11
ECSP20080995A (es) 2021-02-26
WO2019244047A1 (en) 2019-12-26
IL279441B2 (en) 2023-06-01
PH12020552185A1 (en) 2021-06-07
CA3100957A1 (en) 2019-12-26
US20240352030A1 (en) 2024-10-24
EP4169925A2 (en) 2023-04-26
US12012417B2 (en) 2024-06-18

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Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B154 Notification of filing of divisional application [chapter 15.50 patent gazette]

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