BR112019001327A2 - anticorpos anti-idiotípicos e métodos relacionados - Google Patents
anticorpos anti-idiotípicos e métodos relacionadosInfo
- Publication number
- BR112019001327A2 BR112019001327A2 BR112019001327-0A BR112019001327A BR112019001327A2 BR 112019001327 A2 BR112019001327 A2 BR 112019001327A2 BR 112019001327 A BR112019001327 A BR 112019001327A BR 112019001327 A2 BR112019001327 A2 BR 112019001327A2
- Authority
- BR
- Brazil
- Prior art keywords
- related methods
- idiotype antibodies
- idiotypic antibodies
- cells
- specifically
- Prior art date
Links
- 230000003302 anti-idiotype Effects 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/686—Anti-idiotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
Abstract
são fornecidos aqui anticorpos anti-idiotipo que reconhecem especificamente porções de um anticorpo anti-cd19, em particular porções de um anticorpo anti-cd19 presentes em receptores recombinantes, incluindo receptores antigênicos quiméricos (cars). a invenção se refere ainda a usos de anticorpos anti-idiotipo para identificar e/ou selecionar especificamente células que expressam tais receptores recombinantes, tais como células t car anti-cd19. a invenção se refere ainda a usos de anticorpos anti-idiotipo para ativar especificamente tais células.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662369008P | 2016-07-29 | 2016-07-29 | |
US62/369,008 | 2016-07-29 | ||
PCT/US2017/044560 WO2018023100A2 (en) | 2016-07-29 | 2017-07-29 | Anti-idiotypic antibodies and related methods |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112019001327A2 true BR112019001327A2 (pt) | 2019-04-30 |
Family
ID=59656185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112019001327-0A BR112019001327A2 (pt) | 2016-07-29 | 2017-07-29 | anticorpos anti-idiotípicos e métodos relacionados |
Country Status (11)
Country | Link |
---|---|
US (1) | US20240018268A1 (pt) |
EP (1) | EP3491024A2 (pt) |
JP (2) | JP7062640B2 (pt) |
KR (2) | KR20230107408A (pt) |
CN (2) | CN110088133B (pt) |
AU (1) | AU2017301887A1 (pt) |
BR (1) | BR112019001327A2 (pt) |
CA (1) | CA3031734A1 (pt) |
MA (1) | MA45784A (pt) |
MX (1) | MX2019001184A (pt) |
WO (1) | WO2018023100A2 (pt) |
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BR112020001719A2 (pt) * | 2017-07-29 | 2020-07-21 | Juno Therapeutics Inc | reagentes para expansão de células que expressam receptores recombinantes |
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CN108508200B (zh) * | 2018-04-18 | 2023-12-22 | 上海星湾生物技术有限公司 | 检测表达cd19 car的细胞的方法及其应用 |
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GB201820444D0 (en) * | 2018-12-14 | 2019-01-30 | Adaptimmune Ltd | Marker for T cell expansion |
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BR112022008023A2 (pt) | 2019-10-30 | 2022-07-12 | Juno Therapeutics Gmbh | Dispositivos de seleção e/ou estimulação de células e métodos de uso |
US20220401483A1 (en) | 2019-11-07 | 2022-12-22 | Juno Therapeutics, Inc. | Combination of a t cell therapy and (s)-3-[4-(4-morpholin-4-ylmethyl-benzyloxy)-l-oxo-l,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione |
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CN115279795A (zh) * | 2020-02-11 | 2022-11-01 | 克里斯珀医疗股份公司 | 靶向抗cd19嵌合抗原受体的抗独特型抗体 |
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CN112143707A (zh) * | 2020-09-29 | 2020-12-29 | 广东先康达生物科技有限公司 | 一种治疗自身免疫细胞的免疫细胞及其应用 |
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KR20230159851A (ko) | 2021-03-22 | 2023-11-22 | 주노 쎄러퓨티크스 인코퍼레이티드 | 치료 세포 조성물의 효력을 결정하는 방법 |
KR20230158573A (ko) | 2021-03-22 | 2023-11-20 | 주노 쎄러퓨티크스 인코퍼레이티드 | 바이러스 벡터 입자의 효력을 평가하는 방법 |
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JP2024517863A (ja) | 2021-05-06 | 2024-04-23 | ジュノ・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 細胞を刺激し、形質導入する方法 |
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2017
- 2017-07-29 CN CN201780059515.0A patent/CN110088133B/zh active Active
- 2017-07-29 JP JP2019504855A patent/JP7062640B2/ja active Active
- 2017-07-29 US US16/320,077 patent/US20240018268A1/en active Pending
- 2017-07-29 BR BR112019001327-0A patent/BR112019001327A2/pt unknown
- 2017-07-29 KR KR1020237022677A patent/KR20230107408A/ko not_active Application Discontinuation
- 2017-07-29 AU AU2017301887A patent/AU2017301887A1/en active Pending
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CN110088133B (zh) | 2023-12-08 |
CN110088133A (zh) | 2019-08-02 |
WO2018023100A2 (en) | 2018-02-01 |
CN117903316A (zh) | 2024-04-19 |
KR102553195B1 (ko) | 2023-07-07 |
JP2019527553A (ja) | 2019-10-03 |
JP2022084583A (ja) | 2022-06-07 |
US20240018268A1 (en) | 2024-01-18 |
MX2019001184A (es) | 2019-09-26 |
MA45784A (fr) | 2019-06-05 |
EP3491024A2 (en) | 2019-06-05 |
JP7062640B2 (ja) | 2022-05-06 |
AU2017301887A1 (en) | 2019-02-07 |
RU2019105532A3 (pt) | 2020-10-22 |
WO2018023100A3 (en) | 2018-03-08 |
CA3031734A1 (en) | 2018-02-01 |
RU2019105532A (ru) | 2020-08-28 |
KR20230107408A (ko) | 2023-07-14 |
KR20190044626A (ko) | 2019-04-30 |
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