BR112018007525A2 - composições imunogênicas de circovírus suíno tipo 3 e métodos de produzir e usar as mesmas - Google Patents

composições imunogênicas de circovírus suíno tipo 3 e métodos de produzir e usar as mesmas

Info

Publication number
BR112018007525A2
BR112018007525A2 BR112018007525A BR112018007525A BR112018007525A2 BR 112018007525 A2 BR112018007525 A2 BR 112018007525A2 BR 112018007525 A BR112018007525 A BR 112018007525A BR 112018007525 A BR112018007525 A BR 112018007525A BR 112018007525 A2 BR112018007525 A2 BR 112018007525A2
Authority
BR
Brazil
Prior art keywords
methods
producing
porcine circovirus
immunogenic compositions
porcine
Prior art date
Application number
BR112018007525A
Other languages
English (en)
Inventor
Hause Ben
Original Assignee
Kansas State University Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58518470&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112018007525(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kansas State University Research Foundation filed Critical Kansas State University Research Foundation
Publication of BR112018007525A2 publication Critical patent/BR112018007525A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/10011—Circoviridae
    • C12N2750/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

a invenção trata de uma nova espécie de circovírus, circo-vírus porcino do tipo 3 (pcv3), foi identificado a partir de porcas com sintomas clínicos normalmente associados com a infecção por circovírus porcino tipo 2 (pcv2) e em fetos abortados. análises moleculares e sorológicas sugerem que pcv3 comumente circula em suínos dos eua. a presente divulgação proporciona composições imunológicas e métodos relacionados com a produção e administração de tais composições.
BR112018007525A 2015-10-16 2016-10-17 composições imunogênicas de circovírus suíno tipo 3 e métodos de produzir e usar as mesmas BR112018007525A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562242866P 2015-10-16 2015-10-16
PCT/US2016/057369 WO2017066772A1 (en) 2015-10-16 2016-10-17 Porcine circovirus type 3 immunogenic compositions and methods of making and using the same

Publications (1)

Publication Number Publication Date
BR112018007525A2 true BR112018007525A2 (pt) 2018-10-30

Family

ID=58518470

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018007525A BR112018007525A2 (pt) 2015-10-16 2016-10-17 composições imunogênicas de circovírus suíno tipo 3 e métodos de produzir e usar as mesmas

Country Status (7)

Country Link
US (5) US10450351B2 (pt)
EP (1) EP3362467A4 (pt)
JP (3) JP7088835B2 (pt)
CN (1) CN108431024A (pt)
BR (1) BR112018007525A2 (pt)
RU (2) RU2744193C2 (pt)
WO (1) WO2017066772A1 (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3362467A4 (en) 2015-10-16 2019-06-12 Kansas State University Research Foundation IMMUNOGENIC COMPOSITIONS AGAINST PORCINIC CIRCOVIRUS TYPE 3 AND METHODS OF MAKING AND USING SAME
CN108660115B (zh) 2017-03-29 2021-12-03 普莱柯生物工程股份有限公司 一种猪圆环病毒3型毒株、及其疫苗组合物、制备方法和应用
CN106929607A (zh) * 2017-04-25 2017-07-07 华南农业大学 一种检测猪圆环病毒3型病毒的引物对、方法及试剂盒
CN108785667B (zh) * 2017-04-28 2021-04-27 普莱柯生物工程股份有限公司 一种猪圆环病毒3型免疫原性组合物、制备方法和应用
CN107083450A (zh) * 2017-05-27 2017-08-22 河北农业大学 猪圆环病毒3型pcr检测试剂盒及检测方法
CN109010817B (zh) * 2017-06-09 2021-12-03 普莱柯生物工程股份有限公司 一种预防和/或治疗猪圆环病毒3型感染的疫苗组合物及其制备方法和应用
CN109010818B (zh) * 2017-06-09 2021-11-09 普莱柯生物工程股份有限公司 一种预防和/或治疗猪圆环病毒感染的二联疫苗组合物及其制备方法和应用
CN109125719B (zh) * 2017-06-19 2022-06-14 普莱柯生物工程股份有限公司 一种含猪圆环病毒3型、猪圆环病毒2型抗原的免疫原性组合物及其应用
CN107287350A (zh) * 2017-06-27 2017-10-24 广东温氏食品集团股份有限公司 一种检测猪圆环病毒3型的引物、试剂盒及方法
CN107385112A (zh) * 2017-08-22 2017-11-24 河北省检验检疫科学技术研究院 检测猪圆环病毒3型的核酸、实时荧光rpa试剂盒及方法
CN107312875B (zh) * 2017-08-29 2020-07-10 福建省农业科学院畜牧兽医研究所 检测猪圆环病毒3型的环介导等温扩增方法的引物组
CN107338332A (zh) * 2017-08-30 2017-11-10 江西农业大学 猪圆环病毒3型SYBR Green I实时荧光定量PCR检测引物对及试剂盒
CN107854688B (zh) * 2017-11-06 2018-10-12 陕西诺威利华生物科技有限公司 猪圆环病毒2型与猪圆环病毒3型二价灭活疫苗及其制备方法
CN107875378B (zh) * 2017-11-08 2019-10-25 武汉中拓康明生物科技有限公司 一种猪圆环病毒3型灭活苗及其制备方法
WO2019110820A1 (en) * 2017-12-08 2019-06-13 Ceva Sante Animale Recombinant swinepox virus encoding a pcv3 antigen
CN107955839A (zh) * 2017-12-13 2018-04-24 华南农业大学 用于检测猪圆环病毒2型和圆环病毒3型的双重pcr引物、检测方法及试剂盒
CN108159409A (zh) * 2017-12-25 2018-06-15 南京大爻网络科技有限公司 一种猪圆环病毒3型Cap蛋白疫苗及其制备方法和应用
CN107916303A (zh) * 2017-12-28 2018-04-17 广州维佰生物科技有限公司 快速鉴别猪圆环病毒1型、2型和3型的hrm检测引物、试剂盒及方法
CN107937619B (zh) * 2017-12-29 2020-08-04 江苏省农业科学院 一种用于检测猪圆环病毒3型的引物组合物及其应用
CN108276480A (zh) * 2018-01-24 2018-07-13 华南农业大学 Pcv3抗原表位的多肽序列筛选方法
KR102153365B1 (ko) * 2018-03-19 2020-09-08 주식회사 옵티팜 신규한 바이러스 유사입자, 이를 포함하는 돼지 써코바이러스 3에 의한 질환에 대한 백신 조성물, 및 이의 제조 방법
CN108531656A (zh) * 2018-05-03 2018-09-14 广西壮族自治区兽医研究所 一种快速区分猪圆环病毒2型和3型的二重pcr检测引物及试剂盒
CN108611359B (zh) * 2018-05-04 2021-11-19 武汉科前生物股份有限公司 猪圆环病毒3型病毒样颗粒的制备方法及其应用
CN108796124A (zh) * 2018-05-22 2018-11-13 广西壮族自治区兽医研究所 一种快速区分pcv1、pcv2和pcv3的多重pcr检测引物组及试剂盒
CN109053896B (zh) * 2018-07-03 2021-08-17 青岛明勤生物科技有限公司 一种猪圆环病毒二价基因工程疫苗
CN109251967A (zh) * 2018-08-03 2019-01-22 暨南大学 基于数字pcr技术检测猪圆环病毒3型菌的引物和探针及其试剂盒与方法
CN109207441B (zh) * 2018-08-12 2022-05-27 扬州大学 重组杆状病毒表达猪圆环病毒3型Cap蛋白及其构建方法与引物
CN109207522B (zh) * 2018-08-12 2022-05-27 扬州大学 表达猪圆环病毒3型截短Cap蛋白重组杆状病毒及其构建方法与引物
CN108761098A (zh) * 2018-08-22 2018-11-06 河南中泽生物工程有限公司 致病性猪圆环病毒双联抗原快速检测试纸及其制备方法
CN108977583A (zh) * 2018-08-22 2018-12-11 中国检验检疫科学研究院 猪圆环病毒3型微滴数字pcr检测引物和探针及其应用
KR20210092762A (ko) * 2018-11-15 2021-07-26 캔사스 스테이트 유니버시티 리서치 파운데이션 아프리카 돼지 열병 바이러스에 대한 면역원성 조성물
CN109678935A (zh) * 2018-12-13 2019-04-26 广西壮族自治区兽医研究所 PCV3Cap蛋白抗原多肽、抗PCV3 Cap蛋白的多克隆抗体及其应用
CN109694857B (zh) * 2018-12-20 2023-08-18 哈药集团生物疫苗有限公司 表达猪圆环病毒3型Cap蛋白的重组杆状病毒及其应用
CN109762052B (zh) * 2019-01-18 2022-03-08 南京农业大学 猪圆环病毒3型Cap重组蛋白及其编码基因和应用
CN109852622B (zh) * 2019-01-18 2022-05-27 南京农业大学 一种可溶性PCV3Cap蛋白及其编码基因和应用
US11701419B2 (en) * 2019-04-04 2023-07-18 Boehringer Ingelheim Animal Health USA Inc. Porcine Circovirus Type 3 (PCV3) vaccines, and production and uses thereof
CN110195071B (zh) * 2019-04-26 2022-09-30 华南农业大学 一种猪圆环病毒3型感染性克隆的构建及鉴定方法
CN110257428B (zh) * 2019-07-01 2020-09-15 武汉科前生物股份有限公司 一种表达猪圆环病毒3型orf2基因的重组腺病毒及制备方法与应用
CN113046472B (zh) * 2019-12-27 2023-03-28 北京市农林科学院 用于检测猪圆环病毒的三重pcr引物及试剂盒
CN111253477B (zh) * 2020-03-10 2022-05-31 天康制药(苏州)有限公司 猪圆环病毒3型Cap蛋白、核酸、病毒样颗粒、疫苗及制备方法和应用
CN112961941A (zh) * 2021-03-16 2021-06-15 安徽农业大学 一种基于mira荧光法快速检测pcv3病毒的引物和探针
CN113265426B (zh) * 2021-05-24 2023-10-31 龙岩学院 一种稳定表达猪圆环病毒2型orf3蛋白细胞株的构建及应用
CN114369685A (zh) * 2021-12-08 2022-04-19 吉林农业大学 基于Taqman探针的水貂圆环病毒实时荧光定量PCR试剂盒
CN115418369A (zh) * 2022-04-07 2022-12-02 佛山科学技术学院 重组链球菌及其构建方法与应用
CN115028688B (zh) * 2022-04-28 2024-04-16 山东信得科技股份有限公司 PCV3 Cap蛋白抗原肽、抗体及PCV3检测用免疫组化试剂盒
CN114736310B (zh) * 2022-06-10 2022-10-28 北京华夏兴洋生物科技有限公司 产生圆环病毒2型病毒样颗粒的蛋白质及生物材料与应用
CN115044613A (zh) * 2022-06-20 2022-09-13 岭南现代农业科学与技术广东省实验室肇庆分中心 一种表达猪圆环病毒cap蛋白的基因工程细胞系及其构建方法和应用
CN115819567B (zh) * 2022-11-19 2023-09-01 深圳盛源生物技术有限公司 一种单克隆抗体及其在检测试剂盒中的应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9301272A (nl) 1993-07-20 1995-02-16 Aesculaap Bv Chicken Anemia Virus mutanten en vaccins en toepassingen gebaseerd op de virale eiwitten VP1, VP2 en VP3 of daarvoor coderende sequenties van dat virus.
FR2769322B1 (fr) * 1997-10-03 2002-03-08 Merial Sas Nouveaux circovirus porcins, vaccins et reactifs de diagnostic
US6497883B1 (en) * 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
DE60144201D1 (de) * 2000-12-20 2011-04-21 Intervet Int Bv Lawsonia intracellularis Impfstoff
CA2484604C (en) * 2002-05-03 2011-08-02 Massachusetts Institute Of Technology .delta. 4,5 glycuronidase and uses thereof
CN1579553A (zh) * 2004-05-18 2005-02-16 浙江大学 Ii型猪圆环病毒核酸疫苗的制备方法及其应用
US7833707B2 (en) * 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
WO2006132598A1 (en) * 2005-06-07 2006-12-14 Temasek Life Sciences Laboratory Limited Porcine circovirus type 2 vaccines
DK3127551T3 (da) * 2005-12-29 2020-10-12 Boehringer Ingelheim Animal Health Usa Inc Pcv2-immunogen-sammensætning til at mindske kliniske symptomer i grise
EP1968630B1 (en) * 2005-12-29 2018-01-24 Boehringer Ingelheim Vetmedica, Inc. Multivalent pcv2 immunogenic compositions
US20090017064A1 (en) * 2007-07-10 2009-01-15 Wyeth Methods and Compositions for Immunizing Pigs Against Porcine Circovirus
JP5543921B2 (ja) * 2007-10-15 2014-07-09 コリドン ピーティーワイ リミテッド 免疫応答をモジュレートするための発現系
NZ586238A (en) * 2007-12-21 2012-10-26 Wyeth Llc Methods and compositions for immunizing pigs against porcine circovirus
EP2276507A4 (en) * 2008-04-16 2011-11-16 Virginia Tech Intell Prop PCV2GEN-1REP CHIMERIC PORCINIC CIRCOVIRUS AND USES THEREOF
AU2009288289B2 (en) * 2008-08-25 2012-11-08 Amplimmune, Inc. PD-1 antagonists and methods of use thereof
NZ592338A (en) * 2008-09-26 2012-11-30 Oncomed Pharm Inc Frizzled-binding agents and uses thereof
RU2553223C2 (ru) * 2009-08-21 2015-06-10 Виргиния Тек Интеллекчуал Пропертиз, Инк. ВАКЦИНЫ НА ОСНОВЕ СВИНОГО ВИРУСА Torque teNO И СПОСОБЫ ДИАГНОСТИКИ ИНФЕКЦИЙ, ВЫЗВАННЫХ ЭТИМ ВИРУСОМ
EP2528931A4 (en) * 2010-01-25 2013-12-04 Blood Systems Inc CYCLOVIRUS AND USE METHOD THEREFOR
HUE047972T2 (hu) * 2010-03-16 2020-05-28 Virginia Tech Intellectual Properties Inc Gyengített, élõ kiméra sertés cirkovírus vakcina
EP2388683A1 (en) * 2010-05-19 2011-11-23 ABB Technology AG Simplified navigation among process control views in a process control system
UA113192C2 (xx) * 2011-12-06 2016-12-26 Імуногенна композиція проти цирковірусу свиней типу 2 (pcv2)
CN104353084A (zh) * 2014-05-29 2015-02-18 贵州大学 基于猪圆环病毒核酸疫苗的制备方法
EP3362467A4 (en) 2015-10-16 2019-06-12 Kansas State University Research Foundation IMMUNOGENIC COMPOSITIONS AGAINST PORCINIC CIRCOVIRUS TYPE 3 AND METHODS OF MAKING AND USING SAME
US11701419B2 (en) 2019-04-04 2023-07-18 Boehringer Ingelheim Animal Health USA Inc. Porcine Circovirus Type 3 (PCV3) vaccines, and production and uses thereof

Also Published As

Publication number Publication date
EP3362467A4 (en) 2019-06-12
US20180305410A1 (en) 2018-10-25
JP7088835B2 (ja) 2022-06-21
JP2022120083A (ja) 2022-08-17
US11780889B2 (en) 2023-10-10
EP3362467A1 (en) 2018-08-22
US20210188919A1 (en) 2021-06-24
RU2018117649A3 (pt) 2020-03-06
RU2771533C2 (ru) 2022-05-05
CN108431024A (zh) 2018-08-21
US20220251144A1 (en) 2022-08-11
US11780887B2 (en) 2023-10-10
JP2018535251A (ja) 2018-11-29
RU2744193C2 (ru) 2021-03-03
JP7445375B2 (ja) 2024-03-07
US10954274B2 (en) 2021-03-23
JP2024059815A (ja) 2024-05-01
US10450351B2 (en) 2019-10-22
RU2018117649A (ru) 2019-11-19
WO2017066772A1 (en) 2017-04-20
US20240092838A1 (en) 2024-03-21
US20200031876A1 (en) 2020-01-30
RU2021103502A3 (pt) 2021-06-18
RU2021103502A (ru) 2021-03-23

Similar Documents

Publication Publication Date Title
BR112018007525A2 (pt) composições imunogênicas de circovírus suíno tipo 3 e métodos de produzir e usar as mesmas
CO2017011245A2 (es) Conjugados proteína-polisacárido de estreptococo grupo b, métodos para producir conjugados, composiciones inmunógenas que comprenden conjugados y sus usos
MX2016004063A (es) Variante de la proteina pcv2 orf2 y particulas similares al virus compuestas por esta.
BR112022001185A2 (pt) Método de eliciamento de uma resposta imune administrando uma população de polimerossomos tendo um antígeno associado com uma população de polimerossomos tendo um adjuvante associado, bem como composições compreendendo as duas populações de polimerossomos
EP3616716A3 (en) Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
PH12017501370A1 (en) Bivalent swine influenza virus vaccine
MX2016003419A (es) Metodos y composiciones para sindrome respiratorio coronavirus de oriente medio (mers-cov) inmunogenico.
WO2017214596A8 (en) Compositions and methods for preventing and treating zika virus infection
BRPI0920240B8 (pt) composição adjuvante
AR044696A1 (es) Composicion de vacunas
PH12019500954A1 (en) Vaccine against porcine parvovirus
EA201790558A1 (ru) Композиция с пониженной иммуногенностью
WO2017156511A8 (en) Live attenuated zika virus vaccine
EA201991041A1 (ru) Вакцина против свиного парвовируса и вируса свиного репродуктивного и респираторного синдрома и способы ее получения
EA201990010A1 (ru) Вакцина против вируса инфекционного бронхита
BR112018010679A2 (pt) métodos para tratar, prevenir e diagnosticar a infecção por vírus da diarréia epidêmica porcina
ZA202107428B (en) Porcine circovirus type 3 (pcv3) vaccines, and production and uses thereof
PH12015501721A1 (en) Porcine parvovirus 5b, methods of use and vaccine
BR112015031226A2 (pt) Composição de vacina, e, uso da composição de vacina
BR112018074910A2 (pt) composição imunológica, e, método de indução de uma resposta imunológica contra o vírus da influenza equina em um sujeito
PH12017501100B1 (en) Recombinant swinepox virus and vaccines
CL2017001595A1 (es) Composiciones de vacuna para el virus del dengue y métodos de uso de las mismas
CO2018008184A2 (es) Virus de vacuna del síndrome respiratorio y reproductivo porcino
EA202191145A1 (ru) Вакцина виб 4/91 с гетерологичным шиповидным белком
ZA202104747B (en) Novel trypanosomal vaccine

Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]