BR112017013845A2 - derivados de glucagon - Google Patents
derivados de glucagonInfo
- Publication number
- BR112017013845A2 BR112017013845A2 BR112017013845A BR112017013845A BR112017013845A2 BR 112017013845 A2 BR112017013845 A2 BR 112017013845A2 BR 112017013845 A BR112017013845 A BR 112017013845A BR 112017013845 A BR112017013845 A BR 112017013845A BR 112017013845 A2 BR112017013845 A2 BR 112017013845A2
- Authority
- BR
- Brazil
- Prior art keywords
- glucagon
- peptide
- present
- receptors
- obesity
- Prior art date
Links
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical class C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 4
- 208000008589 Obesity Diseases 0.000 abstract 2
- 235000020824 obesity Nutrition 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000051325 Glucagon Human genes 0.000 abstract 1
- 108060003199 Glucagon Proteins 0.000 abstract 1
- 108010063919 Glucagon Receptors Proteins 0.000 abstract 1
- 102100040890 Glucagon receptor Human genes 0.000 abstract 1
- 102000006419 Glucagon-Like Peptide Receptors Human genes 0.000 abstract 1
- 108010083749 Glucagon-Like Peptide Receptors Proteins 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229960004666 glucagon Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
a presente invenção se refere a um novo peptídeo de um derivado de glucagon e uma composição para prevenir ou tratar a obesidade compreendendo o peptídeo como um ingrediente ativo. o derivado do glucagon de acordo com a presente invenção mostra um efeito de ativação mais excelente tanto no que diz respeito aos receptores do peptídeo semelhante ao glucagon 1 como aos receptores de glucagon em comparação ao glucagon nativo, e assim pode ser amplamente utilizado como um agente eficaz para o tratamento da obesidade.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020140193691A KR102418477B1 (ko) | 2014-12-30 | 2014-12-30 | 글루카곤 유도체 |
PCT/KR2015/014481 WO2016108617A1 (en) | 2014-12-30 | 2015-12-30 | Glucagon derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017013845A2 true BR112017013845A2 (pt) | 2018-01-02 |
Family
ID=56284668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017013845A BR112017013845A2 (pt) | 2014-12-30 | 2015-12-30 | derivados de glucagon |
Country Status (19)
Country | Link |
---|---|
US (3) | US10513550B2 (pt) |
EP (1) | EP3240802B1 (pt) |
JP (1) | JP6758297B2 (pt) |
KR (1) | KR102418477B1 (pt) |
CN (1) | CN107250155B (pt) |
AR (1) | AR103323A1 (pt) |
AU (1) | AU2015372767B2 (pt) |
BR (1) | BR112017013845A2 (pt) |
CA (1) | CA2972001A1 (pt) |
EA (1) | EA036479B1 (pt) |
HK (1) | HK1246323A1 (pt) |
IL (1) | IL253001B (pt) |
MX (1) | MX2017008715A (pt) |
PH (1) | PH12017501205A1 (pt) |
SG (2) | SG10201906912VA (pt) |
TW (1) | TWI696631B (pt) |
UA (1) | UA122967C2 (pt) |
WO (1) | WO2016108617A1 (pt) |
ZA (1) | ZA201704328B (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2972748A1 (en) * | 2014-12-30 | 2016-07-07 | Hanmi Pharm. Co., Ltd. | Glucagon derivative having improved stability |
DK3322437T3 (da) | 2015-06-30 | 2024-03-25 | Hanmi Pharmaceutical Co Ltd | Glukagonderivat og en sammensætning omfattende et langtidsvirkende konjugat af samme |
TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
EA038544B1 (ru) | 2015-12-31 | 2021-09-13 | Ханми Фарм. Ко., Лтд. | Тройной агонист рецепторов глюкагона/glp-1/gip |
WO2024038067A1 (en) | 2022-08-18 | 2024-02-22 | Boehringer Ingelheim International Gmbh | Combination therapy comprising long acting glp-1/glucagon and npy2 receptor agonists |
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AR092873A1 (es) * | 2012-09-26 | 2015-05-06 | Cadila Healthcare Ltd | Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon |
KR101993393B1 (ko) | 2012-11-06 | 2019-10-01 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물 |
ES2748158T3 (es) | 2012-11-06 | 2020-03-13 | Hanmi Pharm Ind Co Ltd | Formulación líquida de conjugado de proteínas que comprende la oxintomodulina y un fragmento de inmunoglobulina |
JP6594856B2 (ja) * | 2013-04-18 | 2019-10-23 | ノヴォ ノルディスク アー/エス | 医療用の安定な遷延性glp−1/グルカゴン受容体コアゴニスト |
JP6137046B2 (ja) | 2014-05-09 | 2017-05-31 | 信越化学工業株式会社 | 単量体、高分子化合物、レジスト材料及びパターン形成方法 |
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TWI696631B (zh) | 2020-06-21 |
US20220025012A1 (en) | 2022-01-27 |
EP3240802A1 (en) | 2017-11-08 |
EA036479B1 (ru) | 2020-11-16 |
SG11201705130XA (en) | 2017-07-28 |
SG10201906912VA (en) | 2019-09-27 |
HK1246323A1 (zh) | 2018-09-07 |
US20200140515A1 (en) | 2020-05-07 |
US20180002395A1 (en) | 2018-01-04 |
MX2017008715A (es) | 2017-11-17 |
EA201791498A1 (ru) | 2017-10-31 |
CN107250155B (zh) | 2021-08-10 |
KR20160082026A (ko) | 2016-07-08 |
UA122967C2 (uk) | 2021-01-27 |
WO2016108617A1 (en) | 2016-07-07 |
CN107250155A (zh) | 2017-10-13 |
EP3240802B1 (en) | 2021-07-21 |
TW201632546A (zh) | 2016-09-16 |
AR103323A1 (es) | 2017-05-03 |
JP6758297B2 (ja) | 2020-09-23 |
IL253001A0 (en) | 2017-08-31 |
KR102418477B1 (ko) | 2022-07-08 |
CA2972001A1 (en) | 2016-07-07 |
AU2015372767A1 (en) | 2017-07-13 |
US11254724B2 (en) | 2022-02-22 |
AU2015372767B2 (en) | 2020-07-16 |
EP3240802A4 (en) | 2018-10-10 |
IL253001B (en) | 2022-04-01 |
JP2018505153A (ja) | 2018-02-22 |
PH12017501205A1 (en) | 2017-10-18 |
ZA201704328B (en) | 2021-01-27 |
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