BR112017013149B1 - Composto, composição farmacêutica e uso dos mesmos - Google Patents
Composto, composição farmacêutica e uso dos mesmos Download PDFInfo
- Publication number
- BR112017013149B1 BR112017013149B1 BR112017013149-8A BR112017013149A BR112017013149B1 BR 112017013149 B1 BR112017013149 B1 BR 112017013149B1 BR 112017013149 A BR112017013149 A BR 112017013149A BR 112017013149 B1 BR112017013149 B1 BR 112017013149B1
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- certain embodiments
- cancer
- shows
- chemical entity
- Prior art date
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462093564P | 2014-12-18 | 2014-12-18 | |
| US62/093,564 | 2014-12-18 | ||
| US201562115223P | 2015-02-12 | 2015-02-12 | |
| US62/115,223 | 2015-02-12 | ||
| US201562180222P | 2015-06-16 | 2015-06-16 | |
| US62/180,222 | 2015-06-16 | ||
| PCT/IB2015/002489 WO2016097862A2 (en) | 2014-12-18 | 2015-12-17 | Solid state forms of fused heteroaromatic pyrrolidinones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112017013149A2 BR112017013149A2 (pt) | 2018-04-10 |
| BR112017013149B1 true BR112017013149B1 (pt) | 2022-10-11 |
Family
ID=55299676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017013149-8A BR112017013149B1 (pt) | 2014-12-18 | 2015-12-17 | Composto, composição farmacêutica e uso dos mesmos |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10676473B2 (enExample) |
| EP (2) | EP3677582B1 (enExample) |
| JP (3) | JP6778195B2 (enExample) |
| KR (1) | KR102037502B1 (enExample) |
| CN (1) | CN107108609B (enExample) |
| AU (1) | AU2015365580B2 (enExample) |
| BR (1) | BR112017013149B1 (enExample) |
| CA (1) | CA2970864C (enExample) |
| CL (1) | CL2017001561A1 (enExample) |
| CO (1) | CO2017005910A2 (enExample) |
| CR (1) | CR20170249A (enExample) |
| DK (1) | DK3233857T3 (enExample) |
| DO (1) | DOP2017000130A (enExample) |
| EA (1) | EA032291B1 (enExample) |
| EC (1) | ECSP17038100A (enExample) |
| ES (1) | ES2788454T3 (enExample) |
| GE (1) | GEP20197050B (enExample) |
| IL (1) | IL252941B (enExample) |
| MX (1) | MX373586B (enExample) |
| MY (1) | MY199935A (enExample) |
| NZ (1) | NZ732371A (enExample) |
| PE (1) | PE20171179A1 (enExample) |
| PH (1) | PH12017501123A1 (enExample) |
| PL (1) | PL3233857T3 (enExample) |
| SG (1) | SG11201701911QA (enExample) |
| TN (1) | TN2017000080A1 (enExample) |
| UA (1) | UA120632C2 (enExample) |
| WO (1) | WO2016097862A2 (enExample) |
| ZA (1) | ZA201701800B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3233857T3 (pl) * | 2014-12-18 | 2020-07-27 | Takeda Pharmaceutical Company Limited | Stałe postacie skondensowanych heteroaromatycznych pirolidynonów |
| JP2019520419A (ja) * | 2016-07-13 | 2019-07-18 | 武田薬品工業株式会社 | 脾臓チロシンキナーゼ阻害剤と他の治療薬の併用 |
| SG11202002475TA (en) | 2017-10-19 | 2020-04-29 | Bayer Animal Health Gmbh | Use of fused heteroaromatic pyrrolidones for treatment and prevention of diseases in animals |
| WO2019088039A1 (en) | 2017-10-30 | 2019-05-09 | Takeda Pharmaceutical Company Limited | Treatment of acute myeloid leukemia |
| EP3896063B1 (en) * | 2018-12-14 | 2024-01-24 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Crystalline forms of the syk inhibitor 5-fluoro-1-methyl-3-[[5-[4-(3-oxetanyl)-1-piperazinyl]-2-pyridinyl]amino]-6-(1h-pyrazol-3-yl)-2(1h)-quinolinone hydrochloride salt (1:1) |
| US20220081422A1 (en) | 2019-02-07 | 2022-03-17 | Janssen Biotech, Inc. | Dihydroorotate dehydrogenase inhibitors |
| TW202104207A (zh) | 2019-04-17 | 2021-02-01 | 美商健生生物科技公司 | 二氫乳清酸脫氫酶抑制劑 |
| AU2020363021A1 (en) | 2019-10-10 | 2022-04-07 | Janssen Biotech, Inc. | Bi-aryl dihydroorotate dehydrogenase inhibitors |
| IL293965A (en) | 2019-12-19 | 2022-08-01 | Janssen Pharmaceutica Nv | History of Spiro straight chain transformed |
| WO2022074534A1 (en) | 2020-10-05 | 2022-04-14 | Janssen Biotech, Inc. | Combinations of dihydroorotate dehydrogenase inhibitors and hypomethylating agents |
| CN115698005B (zh) * | 2020-12-18 | 2024-02-06 | 山东轩竹医药科技有限公司 | 稠环类AhR抑制剂 |
| WO2022237720A1 (en) | 2021-05-11 | 2022-11-17 | Janssen Pharmaceutica Nv | Combination therapies |
| EP4337215A1 (en) | 2021-05-11 | 2024-03-20 | JANSSEN Pharmaceutica NV | Combination therapies |
| CN120282784A (zh) | 2022-11-30 | 2025-07-08 | 詹森药业有限公司 | 包含多发性内分泌癌蛋白-mll抑制剂和bcl-2抑制剂的组合 |
| EP4626426A1 (en) | 2022-11-30 | 2025-10-08 | JANSSEN Pharmaceutica NV | Combinations comprising a menin-mll inhibitor and at least one other therapeutic agent |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007070872A1 (en) * | 2005-12-15 | 2007-06-21 | Rigel Pharmaceuticals, Inc. | Kinase inhibitors and their uses |
| SG181857A1 (en) * | 2009-12-23 | 2012-07-30 | Takeda Pharmaceutical | Fused heteroaromatic pyrrolidinones as syk inhibitors |
| US9056873B2 (en) | 2011-06-22 | 2015-06-16 | Takeda Pharmaceutical Company Limited | Substituted 6-aza-isoindolin-1-one derivatives |
| WO2016048982A2 (en) * | 2014-09-24 | 2016-03-31 | Millennium Pharmaceuticals, Inc. | COMBINATION TREATMENT WITH PI3Kα INHIBITORS AND TAXANES |
| PL3233857T3 (pl) * | 2014-12-18 | 2020-07-27 | Takeda Pharmaceutical Company Limited | Stałe postacie skondensowanych heteroaromatycznych pirolidynonów |
-
2015
- 2015-12-17 PL PL15831150T patent/PL3233857T3/pl unknown
- 2015-12-17 NZ NZ732371A patent/NZ732371A/en not_active IP Right Cessation
- 2015-12-17 AU AU2015365580A patent/AU2015365580B2/en active Active
- 2015-12-17 US US14/973,180 patent/US10676473B2/en active Active
- 2015-12-17 MX MX2017007162A patent/MX373586B/es active IP Right Grant
- 2015-12-17 CR CR20170249A patent/CR20170249A/es unknown
- 2015-12-17 EP EP20156863.1A patent/EP3677582B1/en active Active
- 2015-12-17 SG SG11201701911QA patent/SG11201701911QA/en unknown
- 2015-12-17 JP JP2017532678A patent/JP6778195B2/ja active Active
- 2015-12-17 ES ES15831150T patent/ES2788454T3/es active Active
- 2015-12-17 GE GEAP201514545A patent/GEP20197050B/en unknown
- 2015-12-17 TN TN2017000080A patent/TN2017000080A1/en unknown
- 2015-12-17 DK DK15831150.6T patent/DK3233857T3/da active
- 2015-12-17 WO PCT/IB2015/002489 patent/WO2016097862A2/en not_active Ceased
- 2015-12-17 BR BR112017013149-8A patent/BR112017013149B1/pt not_active IP Right Cessation
- 2015-12-17 KR KR1020177019929A patent/KR102037502B1/ko active Active
- 2015-12-17 CA CA2970864A patent/CA2970864C/en active Active
- 2015-12-17 EP EP15831150.6A patent/EP3233857B1/en active Active
- 2015-12-17 EA EA201791369A patent/EA032291B1/ru unknown
- 2015-12-17 UA UAA201707489A patent/UA120632C2/uk unknown
- 2015-12-17 MY MYPI2017702209A patent/MY199935A/en unknown
- 2015-12-17 PE PE2017000944A patent/PE20171179A1/es unknown
- 2015-12-17 CN CN201580068971.2A patent/CN107108609B/zh active Active
-
2017
- 2017-03-13 ZA ZA2017/01800A patent/ZA201701800B/en unknown
- 2017-05-31 DO DO2017000130A patent/DOP2017000130A/es unknown
- 2017-06-15 CL CL2017001561A patent/CL2017001561A1/es unknown
- 2017-06-15 PH PH12017501123A patent/PH12017501123A1/en unknown
- 2017-06-15 IL IL252941A patent/IL252941B/en active IP Right Grant
- 2017-06-15 CO CONC2017/0005910A patent/CO2017005910A2/es unknown
- 2017-06-16 EC ECIEPI201738100A patent/ECSP17038100A/es unknown
-
2020
- 2020-04-30 JP JP2020080282A patent/JP6974534B2/ja active Active
- 2020-05-08 US US16/870,653 patent/US11352355B2/en active Active
-
2021
- 2021-11-04 JP JP2021180105A patent/JP2022017477A/ja active Pending
-
2022
- 2022-12-23 US US18/088,286 patent/US20230348461A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11352355B2 (en) | Solid state forms of fused heteroaromatic pyrrolidinones | |
| KR20220101664A (ko) | Pd-1/pd-l1 억제제의 염 및 결정질 형태 | |
| CA2906257A1 (en) | Macrocyclic rip2 kinase inhibitors | |
| US20240350501A1 (en) | SALT OF N-(2,6-DIETHYLPHENYL)-8-({4-[4-(DIMETHYLAMINO) PIPERIDIN-1-YL]-2-METHOXYPHENYL}AMINO)-1-METHYL-4,5-DIHYDRO-1H-PYRAZOLO[4,3-h]QUINAZOLINE-3-CARBOXAMIDE, ITS PREPARATION, AND FORMULATIONS CONTAINING IT | |
| CN112574208B (zh) | 取代的稠合三环衍生物及其组合物及用途 | |
| CN114874189B (zh) | 取代的杂芳基衍生物及其组合物及用途 | |
| HK40033008A (en) | Solid state forms of fused heteroaromatic pyrrolidinones | |
| HK40033008B (en) | Solid state forms of fused heteroaromatic pyrrolidinones | |
| JP7332091B2 (ja) | インドリン－１－カルボキサミド化合物、そのための調製方法及びその医学的使用 | |
| HK1243406B (zh) | 稠合杂芳族吡咯烷酮的固态形式 | |
| HK40042275A (en) | Indoline-1-formamide compound, preparation method therefor, and medical use thereof | |
| HK40022862B (en) | Salt of a compound inhibiting mps1 kinase, its preparation and formulations containing it | |
| HK40022862A (en) | Salt of a compound inhibiting mps1 kinase, its preparation and formulations containing it |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/12/2015, OBSERVADAS AS CONDICOES LEGAIS |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 8A ANUIDADE. |
|
| B24D | Patent annual fee: restoration after fee payment | ||
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 10A ANUIDADE. |