CR20170249A - Formas en estado sólido de pirrolidinonas heteroaromáticas fusionadas - Google Patents
Formas en estado sólido de pirrolidinonas heteroaromáticas fusionadasInfo
- Publication number
- CR20170249A CR20170249A CR20170249A CR20170249A CR20170249A CR 20170249 A CR20170249 A CR 20170249A CR 20170249 A CR20170249 A CR 20170249A CR 20170249 A CR20170249 A CR 20170249A CR 20170249 A CR20170249 A CR 20170249A
- Authority
- CR
- Costa Rica
- Prior art keywords
- solid state
- forms
- pirrolidinones
- fusioned
- heteroaromatic
- Prior art date
Links
- 239000007787 solid Substances 0.000 title abstract 2
- 150000005829 chemical entities Chemical class 0.000 abstract 3
- 102000000551 Syk Kinase Human genes 0.000 abstract 2
- 108010016672 Syk Kinase Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- MJHOMTRKVMKCNE-NWDGAFQWSA-N mivavotinib Chemical compound C1=NN(C)C=C1C1=NC(N[C@H]2[C@H](CCCC2)N)=C(F)C2=C1C(=O)NC2 MJHOMTRKVMKCNE-NWDGAFQWSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462093564P | 2014-12-18 | 2014-12-18 | |
| US201562115223P | 2015-02-12 | 2015-02-12 | |
| US201562180222P | 2015-06-16 | 2015-06-16 | |
| PCT/IB2015/002489 WO2016097862A2 (en) | 2014-12-18 | 2015-12-17 | Solid state forms of fused heteroaromatic pyrrolidinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20170249A true CR20170249A (es) | 2017-09-25 |
Family
ID=55299676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20170249A CR20170249A (es) | 2014-12-18 | 2015-12-17 | Formas en estado sólido de pirrolidinonas heteroaromáticas fusionadas |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10676473B2 (enExample) |
| EP (2) | EP3677582B1 (enExample) |
| JP (3) | JP6778195B2 (enExample) |
| KR (1) | KR102037502B1 (enExample) |
| CN (1) | CN107108609B (enExample) |
| AU (1) | AU2015365580B2 (enExample) |
| BR (1) | BR112017013149B1 (enExample) |
| CA (1) | CA2970864C (enExample) |
| CL (1) | CL2017001561A1 (enExample) |
| CO (1) | CO2017005910A2 (enExample) |
| CR (1) | CR20170249A (enExample) |
| DK (1) | DK3233857T3 (enExample) |
| DO (1) | DOP2017000130A (enExample) |
| EA (1) | EA032291B1 (enExample) |
| EC (1) | ECSP17038100A (enExample) |
| ES (1) | ES2788454T3 (enExample) |
| GE (2) | GEAP201914545A (enExample) |
| IL (1) | IL252941B (enExample) |
| MX (1) | MX373586B (enExample) |
| MY (1) | MY199935A (enExample) |
| NZ (1) | NZ732371A (enExample) |
| PE (1) | PE20171179A1 (enExample) |
| PH (1) | PH12017501123A1 (enExample) |
| PL (1) | PL3233857T3 (enExample) |
| SG (1) | SG11201701911QA (enExample) |
| TN (1) | TN2017000080A1 (enExample) |
| UA (1) | UA120632C2 (enExample) |
| WO (1) | WO2016097862A2 (enExample) |
| ZA (1) | ZA201701800B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA032291B1 (ru) * | 2014-12-18 | 2019-05-31 | Такеда Фармасьютикал Компани Лимитед | Твердые формы конденсированных гетероароматических пирролидинонов |
| EP3484466A1 (en) * | 2016-07-13 | 2019-05-22 | Takeda Pharmaceutical Company Limited | Combination of spleen tyrosine kinase inhibitors and other therapeutic agents |
| CN111194319A (zh) | 2017-10-19 | 2020-05-22 | 拜耳动物保健有限责任公司 | 稠合的杂芳族吡咯烷酮类化合物用于治疗和预防动物中的疾病的用途 |
| WO2019088039A1 (en) | 2017-10-30 | 2019-05-09 | Takeda Pharmaceutical Company Limited | Treatment of acute myeloid leukemia |
| KR102874906B1 (ko) * | 2018-12-14 | 2025-10-21 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | Syk 억제제의 염 및 이의 결정형 |
| JP2022519383A (ja) | 2019-02-07 | 2022-03-23 | ヤンセン バイオテツク，インコーポレーテツド | ジヒドロオロト酸デヒドロゲナーゼ阻害剤 |
| TW202104207A (zh) | 2019-04-17 | 2021-02-01 | 美商健生生物科技公司 | 二氫乳清酸脫氫酶抑制劑 |
| CN114630822B (zh) | 2019-10-10 | 2024-10-01 | 詹森生物科技公司 | 联芳基二氢乳清酸脱氢酶抑制剂 |
| UY38988A (es) | 2019-12-19 | 2021-06-30 | Janssen Pharmaceutica Nv | Derivados espiráncos sustituidos de cadena lineal |
| WO2022074534A1 (en) | 2020-10-05 | 2022-04-14 | Janssen Biotech, Inc. | Combinations of dihydroorotate dehydrogenase inhibitors and hypomethylating agents |
| WO2022127753A1 (zh) * | 2020-12-18 | 2022-06-23 | 山东轩竹医药科技有限公司 | 稠环类AhR抑制剂 |
| KR20240006638A (ko) | 2021-05-11 | 2024-01-15 | 얀센 파마슈티카 엔브이 | 조합 요법 |
| KR20240006631A (ko) | 2021-05-11 | 2024-01-15 | 얀센 파마슈티카 엔브이 | 조합 요법 |
| KR102539612B1 (ko) | 2021-12-24 | 2023-06-02 | 엘에스일렉트릭(주) | IP 기반 RAPIEnet을 지원하는 통신 디바이스 및 이를 포함하는 네트워크 시스템 |
| WO2024114664A1 (en) | 2022-11-30 | 2024-06-06 | Janssen Pharmaceutica Nv | Combinations comprising a menin-mll inhibitor and at least one other therapeutic agent |
| EP4626427A1 (en) | 2022-11-30 | 2025-10-08 | Janssen Pharmaceutica NV | Combinations comprising a menin-mll inhibitor and a bcl-2 inhibitor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1960372B1 (en) * | 2005-12-15 | 2015-12-09 | Rigel Pharmaceuticals, Inc. | Kinase inhibitors and their uses |
| US8440689B2 (en) * | 2009-12-23 | 2013-05-14 | Takeda Pharmaceutical Company Limited | Fused heteroaromatic pyrrolidinones |
| EP2723739B1 (en) * | 2011-06-22 | 2016-08-24 | Takeda Pharmaceutical Company Limited | Substituted 6-aza-isoindolin-1-one derivatives |
| TW201625263A (zh) * | 2014-09-24 | 2016-07-16 | 千禧製藥公司 | 利用ＰＩ３Ｋα抑制劑與紫杉烷之組合治療 |
| EA032291B1 (ru) * | 2014-12-18 | 2019-05-31 | Такеда Фармасьютикал Компани Лимитед | Твердые формы конденсированных гетероароматических пирролидинонов |
-
2015
- 2015-12-17 EA EA201791369A patent/EA032291B1/ru unknown
- 2015-12-17 GE GEAP201914545A patent/GEAP201914545A/en unknown
- 2015-12-17 PE PE2017000944A patent/PE20171179A1/es unknown
- 2015-12-17 GE GEAP201514545A patent/GEP20197050B/en unknown
- 2015-12-17 US US14/973,180 patent/US10676473B2/en active Active
- 2015-12-17 BR BR112017013149-8A patent/BR112017013149B1/pt not_active IP Right Cessation
- 2015-12-17 AU AU2015365580A patent/AU2015365580B2/en active Active
- 2015-12-17 JP JP2017532678A patent/JP6778195B2/ja active Active
- 2015-12-17 CN CN201580068971.2A patent/CN107108609B/zh active Active
- 2015-12-17 NZ NZ732371A patent/NZ732371A/en not_active IP Right Cessation
- 2015-12-17 SG SG11201701911QA patent/SG11201701911QA/en unknown
- 2015-12-17 ES ES15831150T patent/ES2788454T3/es active Active
- 2015-12-17 MY MYPI2017702209A patent/MY199935A/en unknown
- 2015-12-17 CR CR20170249A patent/CR20170249A/es unknown
- 2015-12-17 MX MX2017007162A patent/MX373586B/es active IP Right Grant
- 2015-12-17 DK DK15831150.6T patent/DK3233857T3/da active
- 2015-12-17 PL PL15831150T patent/PL3233857T3/pl unknown
- 2015-12-17 EP EP20156863.1A patent/EP3677582B1/en active Active
- 2015-12-17 EP EP15831150.6A patent/EP3233857B1/en active Active
- 2015-12-17 KR KR1020177019929A patent/KR102037502B1/ko active Active
- 2015-12-17 CA CA2970864A patent/CA2970864C/en active Active
- 2015-12-17 UA UAA201707489A patent/UA120632C2/uk unknown
- 2015-12-17 WO PCT/IB2015/002489 patent/WO2016097862A2/en not_active Ceased
- 2015-12-17 TN TN2017000080A patent/TN2017000080A1/en unknown
-
2017
- 2017-03-13 ZA ZA2017/01800A patent/ZA201701800B/en unknown
- 2017-05-31 DO DO2017000130A patent/DOP2017000130A/es unknown
- 2017-06-15 PH PH12017501123A patent/PH12017501123A1/en unknown
- 2017-06-15 CO CONC2017/0005910A patent/CO2017005910A2/es unknown
- 2017-06-15 IL IL252941A patent/IL252941B/en active IP Right Grant
- 2017-06-15 CL CL2017001561A patent/CL2017001561A1/es unknown
- 2017-06-16 EC ECIEPI201738100A patent/ECSP17038100A/es unknown
-
2020
- 2020-04-30 JP JP2020080282A patent/JP6974534B2/ja active Active
- 2020-05-08 US US16/870,653 patent/US11352355B2/en active Active
-
2021
- 2021-11-04 JP JP2021180105A patent/JP2022017477A/ja active Pending
-
2022
- 2022-12-23 US US18/088,286 patent/US20230348461A1/en active Pending
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