AU2015365580B2 - Solid state forms of fused heteroaromatic pyrrolidinones - Google Patents
Solid state forms of fused heteroaromatic pyrrolidinones Download PDFInfo
- Publication number
- AU2015365580B2 AU2015365580B2 AU2015365580A AU2015365580A AU2015365580B2 AU 2015365580 B2 AU2015365580 B2 AU 2015365580B2 AU 2015365580 A AU2015365580 A AU 2015365580A AU 2015365580 A AU2015365580 A AU 2015365580A AU 2015365580 B2 AU2015365580 B2 AU 2015365580B2
- Authority
- AU
- Australia
- Prior art keywords
- cancer
- compound
- certain embodiments
- lymphoma
- shows
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 C*[C@@](CCCC1)[C@@]1N Chemical compound C*[C@@](CCCC1)[C@@]1N 0.000 description 2
- MJHOMTRKVMKCNE-NWDGAFQWSA-N C[n]1ncc(-c(c2c3CNC2=O)nc(N[C@H](CCCC2)[C@H]2N)c3F)c1 Chemical compound C[n]1ncc(-c(c2c3CNC2=O)nc(N[C@H](CCCC2)[C@H]2N)c3F)c1 MJHOMTRKVMKCNE-NWDGAFQWSA-N 0.000 description 2
- APZAYTTYRHSPCU-UHFFFAOYSA-N CC(C)OC(c(c(Cl)n1)cc(F)c1Cl)=O Chemical compound CC(C)OC(c(c(Cl)n1)cc(F)c1Cl)=O APZAYTTYRHSPCU-UHFFFAOYSA-N 0.000 description 1
- LTDGKGCHRNNCAC-UHFFFAOYSA-N OC(c(c(Cl)n1)cc(F)c1Cl)=O Chemical compound OC(c(c(Cl)n1)cc(F)c1Cl)=O LTDGKGCHRNNCAC-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462093564P | 2014-12-18 | 2014-12-18 | |
| US62/093,564 | 2014-12-18 | ||
| US201562115223P | 2015-02-12 | 2015-02-12 | |
| US62/115,223 | 2015-02-12 | ||
| US201562180222P | 2015-06-16 | 2015-06-16 | |
| US62/180,222 | 2015-06-16 | ||
| PCT/IB2015/002489 WO2016097862A2 (en) | 2014-12-18 | 2015-12-17 | Solid state forms of fused heteroaromatic pyrrolidinones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015365580A1 AU2015365580A1 (en) | 2017-07-06 |
| AU2015365580B2 true AU2015365580B2 (en) | 2020-04-02 |
Family
ID=55299676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015365580A Active AU2015365580B2 (en) | 2014-12-18 | 2015-12-17 | Solid state forms of fused heteroaromatic pyrrolidinones |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US10676473B2 (enExample) |
| EP (2) | EP3233857B1 (enExample) |
| JP (3) | JP6778195B2 (enExample) |
| KR (1) | KR102037502B1 (enExample) |
| CN (1) | CN107108609B (enExample) |
| AU (1) | AU2015365580B2 (enExample) |
| BR (1) | BR112017013149B1 (enExample) |
| CA (1) | CA2970864C (enExample) |
| CL (1) | CL2017001561A1 (enExample) |
| CO (1) | CO2017005910A2 (enExample) |
| CR (1) | CR20170249A (enExample) |
| DK (1) | DK3233857T3 (enExample) |
| DO (1) | DOP2017000130A (enExample) |
| EA (1) | EA032291B1 (enExample) |
| EC (1) | ECSP17038100A (enExample) |
| ES (1) | ES2788454T3 (enExample) |
| GE (2) | GEAP201914545A (enExample) |
| IL (1) | IL252941B (enExample) |
| MX (1) | MX373586B (enExample) |
| MY (1) | MY199935A (enExample) |
| NZ (1) | NZ732371A (enExample) |
| PE (1) | PE20171179A1 (enExample) |
| PH (1) | PH12017501123A1 (enExample) |
| PL (1) | PL3233857T3 (enExample) |
| SG (1) | SG11201701911QA (enExample) |
| TN (1) | TN2017000080A1 (enExample) |
| UA (1) | UA120632C2 (enExample) |
| WO (1) | WO2016097862A2 (enExample) |
| ZA (1) | ZA201701800B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2788454T3 (es) * | 2014-12-18 | 2020-10-21 | Takeda Pharmaceuticals Co | Formas en estado sólido de pirrolidinonas heteroaromáticas condensadas |
| US20190231757A1 (en) * | 2016-07-13 | 2019-08-01 | Takeda Pharmaceutical Company Limited | Combination of spleen tyrosine kinase inhibitors and other therapeutic agents |
| CA3079292A1 (en) | 2017-10-19 | 2019-04-25 | Bayer Animal Health Gmbh | Use of fused heteroaromatic pyrrolidones for treatment and prevention of diseases in animals |
| WO2019088039A1 (en) | 2017-10-30 | 2019-05-09 | Takeda Pharmaceutical Company Limited | Treatment of acute myeloid leukemia |
| US12187710B2 (en) | 2018-12-14 | 2025-01-07 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Salt of Syk inhibitor and crystalline form thereof |
| KR20210125519A (ko) | 2019-02-07 | 2021-10-18 | 얀센 바이오테크 인코포레이티드 | 다이하이드로오로테이트 탈수소효소 억제제 |
| TW202104207A (zh) | 2019-04-17 | 2021-02-01 | 美商健生生物科技公司 | 二氫乳清酸脫氫酶抑制劑 |
| MX2022004335A (es) | 2019-10-10 | 2022-07-19 | Janssen Biotech Inc | Biarilos como inhibidores de la dihidroorotato deshidrogenasa. |
| TWI878414B (zh) | 2019-12-19 | 2025-04-01 | 比利時商健生藥品公司 | 經取代之直鏈螺環接衍生物 |
| WO2022074534A1 (en) | 2020-10-05 | 2022-04-14 | Janssen Biotech, Inc. | Combinations of dihydroorotate dehydrogenase inhibitors and hypomethylating agents |
| WO2022127753A1 (zh) * | 2020-12-18 | 2022-06-23 | 山东轩竹医药科技有限公司 | 稠环类AhR抑制剂 |
| KR20240006631A (ko) | 2021-05-11 | 2024-01-15 | 얀센 파마슈티카 엔브이 | 조합 요법 |
| KR20240006638A (ko) | 2021-05-11 | 2024-01-15 | 얀센 파마슈티카 엔브이 | 조합 요법 |
| KR102539612B1 (ko) | 2021-12-24 | 2023-06-02 | 엘에스일렉트릭(주) | IP 기반 RAPIEnet을 지원하는 통신 디바이스 및 이를 포함하는 네트워크 시스템 |
| EP4626426A1 (en) | 2022-11-30 | 2025-10-08 | JANSSEN Pharmaceutica NV | Combinations comprising a menin-mll inhibitor and at least one other therapeutic agent |
| JP2025540762A (ja) | 2022-11-30 | 2025-12-16 | ヤンセン ファーマシューティカ エヌ．ベー． | メニン－ｍｌｌ阻害剤及びｂｃｌ－２阻害剤を含む組み合わせ |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2516434A1 (en) * | 2009-12-23 | 2012-10-31 | Takeda Pharmaceutical Company Limited | Fused heteroaromatic pyrrolidinones as syk inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5400388B2 (ja) * | 2005-12-15 | 2014-01-29 | ライジェル ファーマシューティカルズ， インコーポレイテッド | キナーゼインヒビターおよびその利用 |
| WO2012177714A1 (en) | 2011-06-22 | 2012-12-27 | Takeda Pharmaceutical Company Limited | Substituted 6-aza-isoindolin-1-one derivatives |
| TW201625263A (zh) * | 2014-09-24 | 2016-07-16 | 千禧製藥公司 | 利用ＰＩ３Ｋα抑制劑與紫杉烷之組合治療 |
| ES2788454T3 (es) * | 2014-12-18 | 2020-10-21 | Takeda Pharmaceuticals Co | Formas en estado sólido de pirrolidinonas heteroaromáticas condensadas |
-
2015
- 2015-12-17 ES ES15831150T patent/ES2788454T3/es active Active
- 2015-12-17 NZ NZ732371A patent/NZ732371A/en not_active IP Right Cessation
- 2015-12-17 UA UAA201707489A patent/UA120632C2/uk unknown
- 2015-12-17 DK DK15831150.6T patent/DK3233857T3/da active
- 2015-12-17 GE GEAP201914545A patent/GEAP201914545A/en unknown
- 2015-12-17 EP EP15831150.6A patent/EP3233857B1/en active Active
- 2015-12-17 TN TN2017000080A patent/TN2017000080A1/en unknown
- 2015-12-17 CR CR20170249A patent/CR20170249A/es unknown
- 2015-12-17 US US14/973,180 patent/US10676473B2/en active Active
- 2015-12-17 PL PL15831150T patent/PL3233857T3/pl unknown
- 2015-12-17 CA CA2970864A patent/CA2970864C/en active Active
- 2015-12-17 EP EP20156863.1A patent/EP3677582B1/en active Active
- 2015-12-17 CN CN201580068971.2A patent/CN107108609B/zh active Active
- 2015-12-17 BR BR112017013149-8A patent/BR112017013149B1/pt not_active IP Right Cessation
- 2015-12-17 KR KR1020177019929A patent/KR102037502B1/ko active Active
- 2015-12-17 MY MYPI2017702209A patent/MY199935A/en unknown
- 2015-12-17 SG SG11201701911QA patent/SG11201701911QA/en unknown
- 2015-12-17 GE GEAP201514545A patent/GEP20197050B/en unknown
- 2015-12-17 AU AU2015365580A patent/AU2015365580B2/en active Active
- 2015-12-17 PE PE2017000944A patent/PE20171179A1/es unknown
- 2015-12-17 MX MX2017007162A patent/MX373586B/es active IP Right Grant
- 2015-12-17 EA EA201791369A patent/EA032291B1/ru unknown
- 2015-12-17 WO PCT/IB2015/002489 patent/WO2016097862A2/en not_active Ceased
- 2015-12-17 JP JP2017532678A patent/JP6778195B2/ja active Active
-
2017
- 2017-03-13 ZA ZA2017/01800A patent/ZA201701800B/en unknown
- 2017-05-31 DO DO2017000130A patent/DOP2017000130A/es unknown
- 2017-06-15 CO CONC2017/0005910A patent/CO2017005910A2/es unknown
- 2017-06-15 IL IL252941A patent/IL252941B/en active IP Right Grant
- 2017-06-15 CL CL2017001561A patent/CL2017001561A1/es unknown
- 2017-06-15 PH PH12017501123A patent/PH12017501123A1/en unknown
- 2017-06-16 EC ECIEPI201738100A patent/ECSP17038100A/es unknown
-
2020
- 2020-04-30 JP JP2020080282A patent/JP6974534B2/ja active Active
- 2020-05-08 US US16/870,653 patent/US11352355B2/en active Active
-
2021
- 2021-11-04 JP JP2021180105A patent/JP2022017477A/ja active Pending
-
2022
- 2022-12-23 US US18/088,286 patent/US20230348461A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2516434A1 (en) * | 2009-12-23 | 2012-10-31 | Takeda Pharmaceutical Company Limited | Fused heteroaromatic pyrrolidinones as syk inhibitors |
Non-Patent Citations (4)
| Title |
|---|
| BALBACH S et al: "Pharmaceutical evaluation of early development candidates: ‘The 100 mg-approach’", International Journal of Pharmaceutics, 275, (2004), pages 1-12 * |
| BASTIN R.J et al: "Salt Selection and Optimisation Procedures for Pharmaceutical New Chemical Entities", Organic Process & Development, 2000, 4, pages 427-435 * |
| CAIRA M.R: "Crystalline Polymorphism of Organic Compounds", Design of Organic solids, Weber E et al "ED", Springer, 1998 * |
| SINGHAL D et al: "Drug Polymorphism and Dosage Form Design: A practical perspective", Advanced Drug Delivery Reviews, 56, 2004, pages 335-347 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |