BR112017012889A2 - composição de meio e método para preparar toxina botulínica - Google Patents
composição de meio e método para preparar toxina botulínicaInfo
- Publication number
- BR112017012889A2 BR112017012889A2 BR112017012889A BR112017012889A BR112017012889A2 BR 112017012889 A2 BR112017012889 A2 BR 112017012889A2 BR 112017012889 A BR112017012889 A BR 112017012889A BR 112017012889 A BR112017012889 A BR 112017012889A BR 112017012889 A2 BR112017012889 A2 BR 112017012889A2
- Authority
- BR
- Brazil
- Prior art keywords
- medium
- botulinum toxin
- hydrolyzate
- composition
- present
- Prior art date
Links
- 108030001720 Bontoxilysin Proteins 0.000 title abstract 4
- 229940053031 botulinum toxin Drugs 0.000 title abstract 4
- 239000001888 Peptone Substances 0.000 abstract 3
- 108010080698 Peptones Proteins 0.000 abstract 3
- 239000013028 medium composition Substances 0.000 abstract 3
- 235000019319 peptone Nutrition 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 2
- 239000005018 casein Substances 0.000 abstract 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 2
- 235000021240 caseins Nutrition 0.000 abstract 2
- AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical class CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 abstract 2
- 229940066779 peptones Drugs 0.000 abstract 2
- 235000013311 vegetables Nutrition 0.000 abstract 2
- 241000193155 Clostridium botulinum Species 0.000 abstract 1
- 241000193464 Clostridium sp. Species 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- 108010068370 Glutens Proteins 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 1
- 235000005822 corn Nutrition 0.000 abstract 1
- 235000012343 cottonseed oil Nutrition 0.000 abstract 1
- 235000021312 gluten Nutrition 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
composição de meio e método para preparar toxina botulínica refere-se, mais particularmente, a uma composição de meio para cultura de clostridium sp. capaz de produzir toxina botulínica. a composição de meio da presente invenção compreende pelo menos um hidrolisado de caseína e pelo menos uma peptona derivada de vegetal selecionada a partir do grupo que consiste em um hidrolisado de ervilha, um hidrolisado de semente de algodão e um hidrolisado de glúten de milho. quando o meio de acordo com a presente invenção, que contém peptonas derivadas de vegetal, hidrolisados de caseína e minerais, é utilizado para cultura de clostridium botulinum, a taxa de crescimento da bactéria no meio é maior do que aquela do meio que está em uso atualmente e o meio compreendendo peptonas derivadas de planta isoladas. além disso, quando o meio da presente invenção é utilizado, uma alta concentração de toxina botulínica pode ser produzida cultivando a bactéria em um modo seguro.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150059655A KR101729251B1 (ko) | 2015-04-28 | 2015-04-28 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| PCT/KR2016/004431 WO2016175566A1 (en) | 2015-04-28 | 2016-04-28 | Medium composition for preparing botulinum toxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017012889A2 true BR112017012889A2 (pt) | 2018-01-30 |
Family
ID=57199640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017012889A BR112017012889A2 (pt) | 2015-04-28 | 2016-04-28 | composição de meio e método para preparar toxina botulínica |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10117927B2 (pt) |
| EP (1) | EP3289070B1 (pt) |
| JP (2) | JP2018506262A (pt) |
| KR (1) | KR101729251B1 (pt) |
| CN (1) | CN107109353A (pt) |
| AR (1) | AR104676A1 (pt) |
| AU (1) | AU2016253789B2 (pt) |
| BR (1) | BR112017012889A2 (pt) |
| CA (1) | CA2968044C (pt) |
| DK (1) | DK3289070T3 (pt) |
| ES (1) | ES2805726T3 (pt) |
| HR (1) | HRP20201067T1 (pt) |
| HU (1) | HUE050244T2 (pt) |
| MX (1) | MX2017008199A (pt) |
| PL (1) | PL3289070T3 (pt) |
| PT (1) | PT3289070T (pt) |
| RU (1) | RU2689705C2 (pt) |
| SA (1) | SA517381722B1 (pt) |
| TW (1) | TWI592485B (pt) |
| WO (1) | WO2016175566A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101723168B1 (ko) * | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| KR101723167B1 (ko) * | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| KR102209159B1 (ko) * | 2019-03-29 | 2021-01-29 | (주)제테마 | 독소의 제조방법 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB790521A (en) | 1955-11-15 | 1958-02-12 | Bristol Lab Inc | Improvements in or relating to antibiotics |
| WO2000001840A1 (en) | 1998-07-03 | 2000-01-13 | Dsm N.V. | Fermentation process to produce clavulanic acid at a low concentration of free amino acids |
| US6558926B1 (en) | 1999-07-16 | 2003-05-06 | Massachusetts Institute Of Technology | Method for production of tetanus toxin using media substantially free of animal products |
| RU2230325C2 (ru) * | 2002-08-15 | 2004-06-10 | Научно-исследовательский институт микробиологии Министерства обороны Российской Федерации | Способ приготовления очищенного препарата ботулинического токсина типа а |
| US7160699B2 (en) | 2003-09-25 | 2007-01-09 | Allergan, Inc. | Media for clostridium bacterium and processes for obtaining a clostridial toxin |
| US7148041B2 (en) | 2003-09-25 | 2006-12-12 | Allergan, Inc. | Animal product free media and processes for obtaining a botulinum toxin |
| ES2317066T3 (es) | 2003-10-17 | 2009-04-16 | Ranbaxy Laboratories Limited | Produccion de tacrolimus (fk-506)utilizando nuevas especies de streptomyces. |
| WO2006042542A2 (en) * | 2004-10-19 | 2006-04-27 | Statens Serum Institut | Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin |
| CA2556537A1 (en) * | 2005-03-03 | 2006-09-03 | Allergan, Inc. | Media for clostridium bacterium and processes for obtaining a clostridial toxin |
| FR2918671B1 (fr) * | 2007-07-10 | 2010-10-15 | Sanofi Pasteur | Milieu de culture d'haemophilus influenzae type b. |
| CN101698826A (zh) * | 2007-12-19 | 2010-04-28 | 杨宇 | 胰酪胨肉毒梭菌增菌肉汤 |
| KR20090120222A (ko) * | 2008-05-19 | 2009-11-24 | (주)메디톡스 | 식물 유래 성분 함유 배지 및 가요성 폐쇄 용기를 이용하여클로스트리디움 보툴리눔 독소를 생산하는 방법 |
| US8236356B2 (en) | 2008-06-11 | 2012-08-07 | Roche Diagnostics Operations, Inc. | Growth medium for Clostridium histolyticum |
| US8129139B2 (en) | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
| WO2012125948A1 (en) | 2011-03-16 | 2012-09-20 | Biospecifics Technologies Corp. | Compositions and methods for producing clostridial collagenases |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| CN103215310B (zh) * | 2013-03-27 | 2015-01-21 | 中棉紫光生物科技（上海）有限公司 | 用于发酵的棉籽蛋白及其制备方法和应用 |
| KR101339349B1 (ko) | 2013-08-02 | 2013-12-09 | 주식회사 대웅 | 보툴리눔 독소의 제조방법 |
-
2015
- 2015-04-28 KR KR1020150059655A patent/KR101729251B1/ko active IP Right Grant
-
2016
- 2016-04-27 AR ARP160101184A patent/AR104676A1/es unknown
- 2016-04-27 TW TW105113081A patent/TWI592485B/zh active
- 2016-04-28 MX MX2017008199A patent/MX2017008199A/es unknown
- 2016-04-28 PL PL16786752T patent/PL3289070T3/pl unknown
- 2016-04-28 ES ES16786752T patent/ES2805726T3/es active Active
- 2016-04-28 EP EP16786752.2A patent/EP3289070B1/en active Active
- 2016-04-28 AU AU2016253789A patent/AU2016253789B2/en active Active
- 2016-04-28 PT PT167867522T patent/PT3289070T/pt unknown
- 2016-04-28 US US15/521,833 patent/US10117927B2/en active Active
- 2016-04-28 WO PCT/KR2016/004431 patent/WO2016175566A1/en active Application Filing
- 2016-04-28 BR BR112017012889A patent/BR112017012889A2/pt active Search and Examination
- 2016-04-28 DK DK16786752.2T patent/DK3289070T3/da active
- 2016-04-28 HU HUE16786752A patent/HUE050244T2/hu unknown
- 2016-04-28 CA CA2968044A patent/CA2968044C/en active Active
- 2016-04-28 JP JP2017524477A patent/JP2018506262A/ja active Pending
- 2016-04-28 RU RU2017120813A patent/RU2689705C2/ru active
- 2016-04-28 CN CN201680004193.5A patent/CN107109353A/zh active Pending
-
2017
- 2017-06-14 SA SA517381722A patent/SA517381722B1/ar unknown
-
2019
- 2019-06-26 JP JP2019118235A patent/JP6887467B2/ja active Active
-
2020
- 2020-07-07 HR HRP20201067TT patent/HRP20201067T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUE050244T2 (hu) | 2020-11-30 |
| RU2689705C2 (ru) | 2019-05-28 |
| DK3289070T3 (da) | 2020-07-27 |
| HRP20201067T1 (hr) | 2021-02-05 |
| JP2018506262A (ja) | 2018-03-08 |
| RU2017120813A (ru) | 2018-12-14 |
| ES2805726T3 (es) | 2021-02-15 |
| PT3289070T (pt) | 2020-07-16 |
| KR20160127998A (ko) | 2016-11-07 |
| EP3289070A4 (en) | 2018-09-26 |
| CN107109353A (zh) | 2017-08-29 |
| EP3289070B1 (en) | 2020-05-06 |
| TW201638329A (zh) | 2016-11-01 |
| CA2968044A1 (en) | 2016-11-03 |
| TWI592485B (zh) | 2017-07-21 |
| JP2020072649A (ja) | 2020-05-14 |
| EP3289070A1 (en) | 2018-03-07 |
| RU2017120813A3 (pt) | 2018-12-14 |
| MX2017008199A (es) | 2017-12-04 |
| PL3289070T3 (pl) | 2020-11-16 |
| WO2016175566A1 (en) | 2016-11-03 |
| KR101729251B1 (ko) | 2017-04-21 |
| US10117927B2 (en) | 2018-11-06 |
| US20170252431A1 (en) | 2017-09-07 |
| AU2016253789B2 (en) | 2018-12-06 |
| CA2968044C (en) | 2022-08-09 |
| AU2016253789A1 (en) | 2017-06-01 |
| AR104676A1 (es) | 2017-08-09 |
| JP6887467B2 (ja) | 2021-06-16 |
| SA517381722B1 (ar) | 2021-03-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112015024308A2 (pt) | microalgas do gênero euglena, método para produzir polissacarídeose, método para produzir um composto orgânico | |
| BR112015029601A2 (pt) | produção de diterpeno extracelular | |
| BR112017012885A2 (pt) | composição de meio e método para preparar toxina botulínica | |
| AR084283A1 (es) | Evento syht04r de la soja y composiciones y metodos para la deteccion del mismo | |
| BR112017007770A2 (pt) | cultura in vitro, população de hipscs, método para modificar um locus-alvo genômico, e, hipsc. | |
| BR112017025614A2 (pt) | método para produzir glicosídeo de esteviol e composição | |
| BR112018008864A2 (pt) | meios e métodos de fermentação para a produção de polissacarídeos em uma cultura de células bacterianas | |
| BR112016002526A2 (pt) | método para produção de um composto heterólogo não catabólico e um isoprenoide heterólogo, e, composição de fermentação | |
| BR112018007070A2 (pt) | método, composição e kit para a preparação de uma planta a partir de um protoplasto, planta regenerada e composição para clivagem de dna | |
| BR112016012870A8 (pt) | composições e métodos para melhorar a produção de alface | |
| BR112016027290A2 (pt) | métodos para a produção de ramnolipídeos". | |
| AR084377A1 (es) | Metodos y composiciones relacionados con enzimas de alcohol graso biosintetico | |
| AU2017285758A1 (en) | Method for improving salt tolerance of plant | |
| BR112017012889A2 (pt) | composição de meio e método para preparar toxina botulínica | |
| AR100101A1 (es) | Cepas de streptomyces microflavus y métodos de uso de las mismas para controlar enfermedades y plagas en plantas | |
| BR112016005456A2 (pt) | método para produzir um l-aminoácido por um método de fermentação, e, dna isolado | |
| BR112017012893A2 (pt) | composição de meio e método para preparar toxina botulínica | |
| MY171575A (en) | Corynebacterium genus microorganism for producing l-lysine and method for producing l-lysine by using the same | |
| WO2015177641A3 (en) | Methods of oil production in microorganisms | |
| ECSP23086870A (es) | Un fab anti-tslp con estabilidad mejorada | |
| EP4116713A3 (en) | Compositions, devices, and methods of osteoarthritis sensitivity testing | |
| BR112016018096A2 (pt) | Método para produzir biocombustíveis renováveis leves | |
| BR112016025099A2 (pt) | método para aumentar capacidade de síntese de biomassa de micro-organismos e micro-organismos modificados a partir dos mesmos | |
| BR112019001067A2 (pt) | micro-organismo que tem atividade de aciltransferase e usos do mesmo | |
| BR112015032141A2 (pt) | Método para a produção recombinante de um polipeptídeo, e. coli e uso |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] |