BR112017011531A2 - microesfera, métodos para preparar um sal de conjugado de proteína-peg e um conjugado de proteína-peg com hidrofobicidade aumentada, para preparar microesferas de liberação controlada e para preparar uma solução ou suspensão de um polímero biodegradável e de um sal de conjugado de proteína-peg, e, composição. - Google Patents

microesfera, métodos para preparar um sal de conjugado de proteína-peg e um conjugado de proteína-peg com hidrofobicidade aumentada, para preparar microesferas de liberação controlada e para preparar uma solução ou suspensão de um polímero biodegradável e de um sal de conjugado de proteína-peg, e, composição.

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Publication number
BR112017011531A2
BR112017011531A2 BR112017011531A BR112017011531A BR112017011531A2 BR 112017011531 A2 BR112017011531 A2 BR 112017011531A2 BR 112017011531 A BR112017011531 A BR 112017011531A BR 112017011531 A BR112017011531 A BR 112017011531A BR 112017011531 A2 BR112017011531 A2 BR 112017011531A2
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BR
Brazil
Prior art keywords
protein
preparing
peg
conjugate
peg conjugate
Prior art date
Application number
BR112017011531A
Other languages
English (en)
Inventor
B Gomez Eliana
S Rosendahl Mary
B Mantripragada Sankaram
Original Assignee
Antriabio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antriabio Inc filed Critical Antriabio Inc
Publication of BR112017011531A2 publication Critical patent/BR112017011531A2/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
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    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
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    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
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Abstract

exemplos podem incluir um método para preparar um sal de conjugado de proteína-peg com hidrofobicidade aumentada. o método pode incluir proporcionar uma solução de proteína aquosa. esta solução de proteína aquosa pode incluir uma proteína e um tampão de ph. o método pode também incluir a reação de um polietileno glicol com a proteína para formar um conjugado de proteína-peg. o método pode ainda incluir protonar um grupo amino no conjugado de proteína-peg com um ácido orgânico hidrofóbico em uma fase orgânica. a protonação pode formar o sal de conjugado de proteína-peg tendo um ânion hidrofóbico que aumenta a hidrofobicidade sal de conjugado de peg.
BR112017011531A 2014-12-02 2015-12-01 microesfera, métodos para preparar um sal de conjugado de proteína-peg e um conjugado de proteína-peg com hidrofobicidade aumentada, para preparar microesferas de liberação controlada e para preparar uma solução ou suspensão de um polímero biodegradável e de um sal de conjugado de proteína-peg, e, composição. BR112017011531A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462086294P 2014-12-02 2014-12-02
US14/954,591 US10046058B2 (en) 2014-12-02 2015-11-30 Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
US14/954,701 US20160151511A1 (en) 2014-12-02 2015-11-30 Proteins and protein conjugates with increased hydrophobicity
PCT/US2015/063102 WO2016089818A1 (en) 2014-12-02 2015-12-01 Proteins and protein conjugates with increased hydrophobicity

Publications (1)

Publication Number Publication Date
BR112017011531A2 true BR112017011531A2 (pt) 2018-02-27

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Application Number Title Priority Date Filing Date
BR112017011531A BR112017011531A2 (pt) 2014-12-02 2015-12-01 microesfera, métodos para preparar um sal de conjugado de proteína-peg e um conjugado de proteína-peg com hidrofobicidade aumentada, para preparar microesferas de liberação controlada e para preparar uma solução ou suspensão de um polímero biodegradável e de um sal de conjugado de proteína-peg, e, composição.

Country Status (11)

Country Link
US (3) US10046058B2 (pt)
EP (2) EP3226844A4 (pt)
JP (1) JP2017536387A (pt)
KR (1) KR20170086049A (pt)
CN (1) CN106999443A (pt)
AU (1) AU2015355180A1 (pt)
BR (1) BR112017011531A2 (pt)
CA (1) CA2966207A1 (pt)
MX (1) MX2017006594A (pt)
RU (1) RU2712644C2 (pt)
WO (1) WO2016089818A1 (pt)

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EP3695831A1 (en) 2020-08-19
CA2966207A1 (en) 2016-06-09
AU2015355180A1 (en) 2017-05-25
WO2016089818A1 (en) 2016-06-09
KR20170086049A (ko) 2017-07-25
US20160151511A1 (en) 2016-06-02
US20180318429A1 (en) 2018-11-08
MX2017006594A (es) 2017-09-01
CN106999443A (zh) 2017-08-01
EP3226844A1 (en) 2017-10-11
US20160151510A1 (en) 2016-06-02
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