MX2017006594A - Proteinas y congujados proteinicos con efecto hidrofobo aumentado. - Google Patents

Proteinas y congujados proteinicos con efecto hidrofobo aumentado.

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Publication number
MX2017006594A
MX2017006594A MX2017006594A MX2017006594A MX2017006594A MX 2017006594 A MX2017006594 A MX 2017006594A MX 2017006594 A MX2017006594 A MX 2017006594A MX 2017006594 A MX2017006594 A MX 2017006594A MX 2017006594 A MX2017006594 A MX 2017006594A
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MX
Mexico
Prior art keywords
protein
peg conjugate
proteins
increased hydrophobicity
protein conjugates
Prior art date
Application number
MX2017006594A
Other languages
English (en)
Inventor
S Rosendahl Mary
B Mantripragada Sankaram
B Gomez Eliana
Original Assignee
Antriabio Inc
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Filing date
Publication date
Application filed by Antriabio Inc filed Critical Antriabio Inc
Publication of MX2017006594A publication Critical patent/MX2017006594A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
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    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Algunos ejemplos pueden incluir un método para hacer una sal de conjugado de proteínas pegiladas con efecto hidrófobo aumentado. El método puede incluir proporcionar una disolución proteínica acuosa. Esta solución proteínica acuosa puede incluir una proteína y un amortiguador de pH. El método puede también incluir la reacción de un polietilenglicol con la proteína para formar un conjugado de proteínas pegiladas. El método puede incluir además la protonación de un grupo amino en el conjugado de proteínas pegiladas con un ácido orgánico hidrofábico en una fase orgánica. La protonación puede formar la sal de conjugado de proteínas pegiladas que tiene un anión hidrófobo que aumenta el efecto hidrófobo de la sal de conjugado de proteínas pegiladas.
MX2017006594A 2014-12-02 2015-12-01 Proteinas y congujados proteinicos con efecto hidrofobo aumentado. MX2017006594A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462086294P 2014-12-02 2014-12-02
US14/954,591 US10046058B2 (en) 2014-12-02 2015-11-30 Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
US14/954,701 US20160151511A1 (en) 2014-12-02 2015-11-30 Proteins and protein conjugates with increased hydrophobicity
PCT/US2015/063102 WO2016089818A1 (en) 2014-12-02 2015-12-01 Proteins and protein conjugates with increased hydrophobicity

Publications (1)

Publication Number Publication Date
MX2017006594A true MX2017006594A (es) 2017-09-01

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ID=56078492

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Application Number Title Priority Date Filing Date
MX2017006594A MX2017006594A (es) 2014-12-02 2015-12-01 Proteinas y congujados proteinicos con efecto hidrofobo aumentado.

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Country Link
US (3) US10046058B2 (es)
EP (2) EP3226844A4 (es)
JP (1) JP2017536387A (es)
KR (1) KR20170086049A (es)
CN (1) CN106999443A (es)
AU (1) AU2015355180A1 (es)
BR (1) BR112017011531A2 (es)
CA (1) CA2966207A1 (es)
MX (1) MX2017006594A (es)
RU (1) RU2712644C2 (es)
WO (1) WO2016089818A1 (es)

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US20160151510A1 (en) 2016-06-02
CN106999443A (zh) 2017-08-01
EP3695831A1 (en) 2020-08-19
CA2966207A1 (en) 2016-06-09
AU2015355180A1 (en) 2017-05-25
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RU2017122609A (ru) 2019-01-09
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KR20170086049A (ko) 2017-07-25
EP3226844A4 (en) 2018-06-20
US20160151511A1 (en) 2016-06-02
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US20180318429A1 (en) 2018-11-08

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