BR112017008304A2 - tripeptidil peptidases tolerantes à prolina e seus usos - Google Patents

tripeptidil peptidases tolerantes à prolina e seus usos

Info

Publication number
BR112017008304A2
BR112017008304A2 BR112017008304-3A BR112017008304A BR112017008304A2 BR 112017008304 A2 BR112017008304 A2 BR 112017008304A2 BR 112017008304 A BR112017008304 A BR 112017008304A BR 112017008304 A2 BR112017008304 A2 BR 112017008304A2
Authority
BR
Brazil
Prior art keywords
proline
tripeptidyl peptidase
tolerant tripeptidyl
hydrolyzate
proline tolerant
Prior art date
Application number
BR112017008304-3A
Other languages
English (en)
Inventor
Matthias Kragh Karsten
Meinjohanns Ernst
Miasnikov Andrei
Ma Maria
Eisele Thomas
Haaning Svend
Edvard Degn Peter
Yde Bak Steffen
Original Assignee
Dupont Nutrition Biosciences Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dupont Nutrition Biosciences Aps filed Critical Dupont Nutrition Biosciences Aps
Publication of BR112017008304A2 publication Critical patent/BR112017008304A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/14—Pretreatment of feeding-stuffs with enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485—Exopeptidases (3.4.11-3.4.19)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/14—Dipeptidyl-peptidases and tripeptidyl-peptidases (3.4.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/14—Dipeptidyl-peptidases and tripeptidyl-peptidases (3.4.14)
    • C12Y304/14009—Tripeptidyl-peptidase I (3.4.14.9)

Abstract

um método para a produção de um hidrolisado compreendendo: (a) mistura de pelo menos uma proteína ou uma sua porção com: (a) pelo menos uma endoprotease; e (b) (a') pelo menos uma tripeptidil peptidase tolerante à prolina ou fermentado compreendendo uma tripeptidil peptidase tolerante à prolina tendo predominantemente atividade de exopeptidase em que a referida tripeptidil peptidase tolerante à prolina é capaz de clivar tripeptídeos a partir do n terminal de peptídeos tendo: prolina em p1; e aminoácidos sintéticos em p1; ou (b') pelo menos uma tripeptidil peptidase tolerante à prolina tendo atividade de exopeptidase em que a referida tripeptidil peptidase tolerante à prolina é capaz de clivar tripeptídeos a partir do n terminal de peptídeos tendo: prolina em pv; e aminoácidos sintéticos em pv; e (b) recuperação do hidrolisado. a invenção refere-se também a métodos para produção de um hidrolisado compreendendo o uso de uma endoprotease, uma exo-tripeptidil peptidase da família s53 e uma aminopeptidase, com usos de uma tripeptidil peptidase tolerante à prolina, composições, composições de aditivos alimentares e/ou de rações compreendendo as mesmas, bem como hidrolisados e usos de tripeptidil peptidases tolerantes à prolina.
BR112017008304-3A 2014-10-24 2015-10-23 tripeptidil peptidases tolerantes à prolina e seus usos BR112017008304A2 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201462068243P 2014-10-24 2014-10-24
US201462068282P 2014-10-24 2014-10-24
US201462068264P 2014-10-24 2014-10-24
US62/068,264 2014-10-24
US62/068,282 2014-10-24
US62/068,243 2014-10-24
US201462093301P 2014-12-17 2014-12-17
US62/093,301 2014-12-17
PCT/EP2015/074600 WO2016062855A1 (en) 2014-10-24 2015-10-23 Proline tolerant tripeptidyl peptidases and uses thereof

Publications (1)

Publication Number Publication Date
BR112017008304A2 true BR112017008304A2 (pt) 2018-05-15

Family

ID=54540018

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112017008304-3A BR112017008304A2 (pt) 2014-10-24 2015-10-23 tripeptidil peptidases tolerantes à prolina e seus usos
BR112017008406-6A BR112017008406A2 (pt) 2014-10-24 2015-10-23 uso de tripeptidil peptidases tolerantes a prolina em composições de aditivo alimentar

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112017008406-6A BR112017008406A2 (pt) 2014-10-24 2015-10-23 uso de tripeptidil peptidases tolerantes a prolina em composições de aditivo alimentar

Country Status (13)

Country Link
US (4) US20180295858A1 (pt)
EP (2) EP3209774B1 (pt)
JP (1) JP6878275B2 (pt)
CN (2) CN107105707B (pt)
AU (2) AU2015334890B2 (pt)
BR (2) BR112017008304A2 (pt)
CA (2) CA2965423A1 (pt)
DK (2) DK3209774T3 (pt)
ES (1) ES2791891T3 (pt)
MX (2) MX2017005268A (pt)
RU (1) RU2741080C2 (pt)
WO (2) WO2016062855A1 (pt)
ZA (1) ZA201702889B (pt)

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WO2018005229A1 (en) 2016-06-30 2018-01-04 Dupont Nutrition Biosciences Aps In feed assay of microbial proteases using peptide substrates
CN110099698B (zh) 2016-12-23 2023-02-17 海德堡医药研究有限责任公司 鹅膏蕈碱抗体缀合物
US11254919B2 (en) 2017-06-09 2022-02-22 Novozymes A/S Polynucleotide encoding polypeptide having carboxypeptidase activity
CN107467370A (zh) * 2017-10-13 2017-12-15 无锡正大生物股份有限公司 一种饲料用功能性诱食剂及其制备方法
US10980253B2 (en) * 2017-12-28 2021-04-20 Global Earth Solutions, Llc Composition, system and method for pellet or flake production
WO2020077106A1 (en) * 2018-10-11 2020-04-16 Imbria Pharmaceuticals, Inc. Compositions and methods for treating and preventing leber's hereditary optic neuropathy
CN110551790B (zh) * 2019-07-29 2021-09-14 浙江大学 一种乳源活性肽的制备方法及应用
CN117491351B (zh) * 2023-12-27 2024-04-05 中国农业科学院北京畜牧兽医研究所 一种肉鸡饲料有效磷的仿生消化测定试剂盒和测定方法

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Also Published As

Publication number Publication date
US20180295858A1 (en) 2018-10-18
RU2017117858A (ru) 2018-11-26
JP6878275B2 (ja) 2021-05-26
CA2965423A1 (en) 2016-04-28
EP3209773A1 (en) 2017-08-30
DK3209773T3 (da) 2020-06-15
CN107105707B (zh) 2022-07-22
RU2741080C2 (ru) 2021-01-22
RU2017117858A3 (pt) 2019-09-18
ZA201702889B (en) 2020-07-29
EP3209774B1 (en) 2020-02-26
AU2015334892A1 (en) 2017-05-18
WO2016062855A1 (en) 2016-04-28
CN107105709A (zh) 2017-08-29
DK3209774T3 (da) 2020-05-25
EP3209774A1 (en) 2017-08-30
US20220174981A1 (en) 2022-06-09
AU2015334890A1 (en) 2017-05-04
BR112017008406A2 (pt) 2018-02-27
EP3209773B1 (en) 2020-03-18
CN107105707A (zh) 2017-08-29
MX2017005268A (es) 2017-07-26
US20200245642A1 (en) 2020-08-06
MX2017005256A (es) 2017-07-24
AU2015334890B2 (en) 2021-12-23
ES2791891T3 (es) 2020-11-06
US20170325479A1 (en) 2017-11-16
JP2017534279A (ja) 2017-11-24
WO2016062857A1 (en) 2016-04-28
CA2965438A1 (en) 2016-04-28
CN107105709B (zh) 2021-04-30

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]