BR112017008266A2 - partículas semelhantes a vírus modificadas de cmv - Google Patents

partículas semelhantes a vírus modificadas de cmv

Info

Publication number
BR112017008266A2
BR112017008266A2 BR112017008266-7A BR112017008266A BR112017008266A2 BR 112017008266 A2 BR112017008266 A2 BR 112017008266A2 BR 112017008266 A BR112017008266 A BR 112017008266A BR 112017008266 A2 BR112017008266 A2 BR 112017008266A2
Authority
BR
Brazil
Prior art keywords
cell epitopes
modified
cmv
vlps
virus
Prior art date
Application number
BR112017008266-7A
Other languages
English (en)
Inventor
Bachmann Martin
Zeltins Andris
Pumpens Paul
Original Assignee
Saiba Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54337283&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112017008266(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Saiba Gmbh filed Critical Saiba Gmbh
Publication of BR112017008266A2 publication Critical patent/BR112017008266A2/pt

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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Abstract

a presente invenção refere-se a partículas semelhantes a vírus de vírus de planta do vírus do mosaico do pepino (cmv) e em particular a vlps modificadas de cmv que compreendem epitopos de células th, em particular epitopos de célula th universal. além disso, estas vlps modificadas servem como, preferencialmente, plataforma de vacina, para gerar respostas imunes, em particular respostas de anticorpos, contra antígenos ligados às referidas vlps modificadas. a presença dos epitopos de célula th, em particular epitopos de célula th universal, levou a um aumento adicional na resposta imune gerada.
BR112017008266-7A 2014-10-22 2015-10-20 partículas semelhantes a vírus modificadas de cmv BR112017008266A2 (pt)

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PCT/EP2015/074269 WO2016062720A1 (en) 2014-10-22 2015-10-20 Modified virus-like particles of cmv

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