BR112016005228A8 - Uso de uma ou mais glicosidases e processo para produzir um oligossacarídeo - Google Patents

Uso de uma ou mais glicosidases e processo para produzir um oligossacarídeo

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Publication number
BR112016005228A8
BR112016005228A8 BR112016005228A BR112016005228A BR112016005228A8 BR 112016005228 A8 BR112016005228 A8 BR 112016005228A8 BR 112016005228 A BR112016005228 A BR 112016005228A BR 112016005228 A BR112016005228 A BR 112016005228A BR 112016005228 A8 BR112016005228 A8 BR 112016005228A8
Authority
BR
Brazil
Prior art keywords
oligosaccharide
glycosidases
producing
purifying
nucleic acids
Prior art date
Application number
BR112016005228A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112016005228A2 (https=
Inventor
Jennewein Stefan
Original Assignee
Jennewein Biotechnologie Gmbh
Chr Hansen Hmo Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49117764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112016005228(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Jennewein Biotechnologie Gmbh, Chr Hansen Hmo Gmbh filed Critical Jennewein Biotechnologie Gmbh
Publication of BR112016005228A2 publication Critical patent/BR112016005228A2/pt
Publication of BR112016005228A8 publication Critical patent/BR112016005228A8/pt

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • C07H1/06Separation; Purification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • C12N15/72Expression systems using regulatory sequences derived from the lac-operon
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/12Disaccharides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/14Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/20Preparation of compounds containing saccharide radicals produced by the action of an exo-1,4 alpha-glucosidase, e.g. dextrose
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01023Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/10Plasmid DNA
    • C12N2800/101Plasmid DNA for bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185Escherichia
    • C12R2001/19Escherichia coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BR112016005228A 2013-09-10 2014-07-04 Uso de uma ou mais glicosidases e processo para produzir um oligossacarídeo BR112016005228A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13183670.2A EP2845905B8 (en) 2013-09-10 2013-09-10 Production of oligosaccharides
PCT/EP2014/064280 WO2015036138A1 (en) 2013-09-10 2014-07-04 Production of oligosaccharides

Publications (2)

Publication Number Publication Date
BR112016005228A2 BR112016005228A2 (https=) 2017-09-05
BR112016005228A8 true BR112016005228A8 (pt) 2022-11-08

Family

ID=49117764

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016005228A BR112016005228A8 (pt) 2013-09-10 2014-07-04 Uso de uma ou mais glicosidases e processo para produzir um oligossacarídeo

Country Status (11)

Country Link
US (3) US11427845B2 (https=)
EP (3) EP3572520A1 (https=)
JP (3) JP6894703B2 (https=)
KR (1) KR102335067B1 (https=)
CN (5) CN110628842A (https=)
AU (1) AU2014320757C1 (https=)
BR (1) BR112016005228A8 (https=)
DK (1) DK2845905T3 (https=)
ES (1) ES2875327T3 (https=)
PL (1) PL2845905T3 (https=)
WO (1) WO2015036138A1 (https=)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2845905T3 (pl) * 2013-09-10 2021-09-27 Chr. Hansen HMO GmbH Wytwarzanie oligosacharydów
EP2896628B1 (en) 2014-01-20 2018-09-19 Jennewein Biotechnologie GmbH Process for efficient purification of neutral human milk oligosaccharides (HMOs) from microbial fermentation
WO2016157108A1 (en) * 2015-03-31 2016-10-06 Glycom A/S Mixtures of human milk oligosaccharides comprising 3 '-o-sialyllactose
ES3011213T3 (en) 2015-12-18 2025-04-07 Glycom As Fermentative production of oligosaccharides
DK3445770T3 (da) 2016-04-19 2026-02-23 Glycom As Separering af oligosaccharider fra fermenteringssuppe
EP3474861A4 (en) 2016-06-24 2020-04-15 Glycom A/S COMPOUNDS COMPRISING HMOS FOR THE PREVENTION AND / OR TREATMENT OF VIRAL AND / OR BACTERIAL INFECTIONS.
CN106190938B (zh) * 2016-07-18 2019-05-14 南开大学 一种构建的重组大肠杆菌及生物合成3’-唾液乳糖的方法
SG10202100843TA (en) * 2016-07-28 2021-03-30 Fonterra Cooperative Group Ltd Dairy product and process
BR112019005329A2 (pt) * 2016-09-19 2019-06-18 Prolacta Bioscience, Inc. composições de oligossacarídeos de leite humano purificadas
ES2856749T3 (es) * 2016-10-29 2021-09-28 Chr Hansen Hmo Gmbh Proceso para la producción de oligosacáridos fucosilados
EP3821712B1 (en) 2017-01-13 2022-11-09 Chr. Hansen A/S Fermented milk product obtained by an improved process
JP2018140968A (ja) * 2017-02-28 2018-09-13 日本食品化工株式会社 1,6−アンヒドロ−β−D−グルコフラノース含有糖質の製造方法
ES2928859T3 (es) 2017-03-17 2022-11-23 Chr Hansen Hmo Gmbh Un método para inhibir la isomerización de un sacárido reductor tras el tratamiento térmico
WO2019003135A1 (en) * 2017-06-30 2019-01-03 Glycom A/S PURIFICATION OF OLIGOSACCHARIDES
EP3425052A1 (en) 2017-07-07 2019-01-09 Jennewein Biotechnologie GmbH Fucosyltransferases and their use in producing fucosylated oligosaccharides
CN110914284B (zh) 2017-07-12 2025-01-07 格礼卡姆股份公司 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物
EP3524067B1 (en) 2018-02-08 2025-04-02 Chr. Hansen HMO GmbH Spray-dried mixture of human milk oligosaccharides
EP3494805B1 (en) 2017-12-08 2025-08-13 Chr. Hansen HMO GmbH Spray-dried tetrasaccharides
EP3494806B1 (en) 2017-12-08 2025-08-06 Chr. Hansen HMO GmbH Spray-dried lacto-n-fucopentaose
EP3494804B1 (en) 2017-12-08 2025-08-13 Chr. Hansen HMO GmbH Spray-dried 3-fucosyllactose
EP3494807A1 (en) 2017-12-11 2019-06-12 Jennewein Biotechnologie GmbH Spray-dried sialyllactose
SG11202004659QA (en) 2017-12-08 2020-06-29 Jennewein Biotechnologie Gmbh Spray-dried sialyllactose
JP7492458B2 (ja) * 2018-05-07 2024-05-29 クリスチャン・ハンセン・ハーエムオー・ゲーエムベーハー 微生物発酵によって得られた炭水化物からラクト-N-ネオテトラオース(LNnT)を精製するための簡素な方法
EP3569713A1 (en) * 2018-05-16 2019-11-20 Jennewein Biotechnologie GmbH Use of glycosidases in the production of oligosaccharides
CN112154150A (zh) * 2018-05-23 2020-12-29 帝斯曼知识产权资产管理有限公司 寡糖的生产
US10519475B1 (en) * 2018-11-21 2019-12-31 Amyris, Inc. Biosynthesis of compounds in yeast
WO2020128945A1 (en) * 2018-12-19 2020-06-25 Glycom A/S Separation of oligosaccharides
CN109735479B (zh) * 2019-01-30 2022-04-01 光明乳业股份有限公司 一种合成2’-岩藻糖基乳糖的重组枯草芽孢杆菌及其构建方法与应用
US12410419B2 (en) 2019-05-21 2025-09-09 Korea University Research And Business Foundation Use of enzyme that cleaves both alpha- and beta- 1,4-glycosidic bonds
WO2020245313A1 (en) * 2019-06-04 2020-12-10 N.V. Nutricia Nutritional composition comprising 2'fucosyllactose and 3'galactosyllactose
WO2021045968A1 (en) 2019-09-04 2021-03-11 Dupont Nutrition Biosciences Aps Process for removing an antifoam agent from a solution comprising a human milk oligosaccharide and related compositions
JP2022548785A (ja) 2019-09-24 2022-11-21 プロラクタ バイオサイエンス,インコーポレイテッド 炎症性疾患及び免疫疾患の治療のための組成物及び方法
CN115279778B (zh) 2020-03-12 2025-06-24 格礼卡姆股份公司 2’-fl的结晶
KR20230088680A (ko) 2020-08-14 2023-06-20 프롤랙타 바이오사이언스, 인코포레이티드 박테리아 요법에 사용하기 위한 인간 모유 올리고당 조성물
CA3204530A1 (en) 2021-01-12 2022-07-21 Gregory Mckenzie Synbiotic treatment regimens
DK181562B1 (en) 2021-11-11 2024-05-17 Dsm Ip Assets Bv Feed control system for a fermentation system, and related method
DK181566B1 (en) 2021-12-21 2024-05-24 Dsm Ip Assets Bv Crystallization of LNnT
CN114107342B (zh) * 2021-12-27 2024-01-26 黄山同兮生物科技有限公司 一种去除发酵液中乳糖的方法
KR102616020B1 (ko) 2021-12-31 2023-12-22 매일유업 주식회사 모유 올리고당 혼합물을 유효성분으로 포함하는 장관면역 개선용, 장 염증 예방 또는 개선용 조성물
CN116042562B (zh) * 2022-03-11 2023-10-20 山东恒鲁生物科技有限公司 重组酵母菌及其应用
CN115011535A (zh) * 2022-05-10 2022-09-06 南通励成生物工程有限公司 一种以葡萄糖为碳源合成2’-岩藻糖基乳糖的菌株及其构建方法和应用
KR20240002283A (ko) * 2022-06-28 2024-01-05 주식회사 삼양사 2’-푸코실락토오스 제조방법
EP4577061A1 (en) 2022-08-25 2025-07-02 DSM IP Assets B.V. Hybrid method for producing complex hmos
CN120265786A (zh) 2022-11-25 2025-07-04 帝斯曼知识产权资产管理有限公司 用于生产寡糖的双菌株系统
WO2024130119A2 (en) 2022-12-16 2024-06-20 Prolacta Bioscience, Inc. Synbiotic compositions for short chain fatty acid production
WO2025114343A2 (en) 2023-11-29 2025-06-05 Frieslandcampina Nederland B.V. Process for the production of human milk oligosaccharides

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5995895A (ja) * 1982-11-22 1984-06-02 Meiji Seika Kaisha Ltd フラクトオリゴ糖の精製法
JPS6391092A (ja) 1986-10-07 1988-04-21 Yakult Honsha Co Ltd オリゴ糖の製造法
JPH0695895A (ja) 1990-11-19 1994-04-08 Internatl Business Mach Corp <Ibm> アプリケーシヨンプログラム装置及びその方法
JPH05276969A (ja) * 1992-04-03 1993-10-26 Nippon Shinyaku Co Ltd 高純度マルトオリゴ糖の製法
JPH07274990A (ja) 1994-04-15 1995-10-24 Mitsubishi Kasei Eng Co 環状イヌロオリゴ糖の精製方法
JP3095643B2 (ja) * 1994-11-17 2000-10-10 明治製菓株式会社 高濃度糖混合液からの高純度オリゴ糖類の製造法
US7098013B2 (en) * 2000-11-16 2006-08-29 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Polypeptide having α-isomaltosyl-transferase activity
US20080145899A1 (en) * 2004-09-17 2008-06-19 Neose Technologies Inc Production of Oligosaccharides By Microorganisms
ES2626080T3 (es) * 2007-04-16 2017-07-21 Momenta Pharmaceuticals, Inc. Caracterización de N-glicanos utilizando exoglicosidasas
KR100945306B1 (ko) 2007-12-31 2010-03-03 주식회사 삼양제넥스 고순도 갈락토올리고당의 제조방법
EP2252699B1 (en) * 2008-03-12 2015-05-27 Tata Chemicals Limited Production of galactooligosaccharides by Bullera singularis and Saccharomyces sp.
RU2584599C2 (ru) * 2008-12-19 2016-05-20 Дженневейн Биотехнологие Гмбх Синтез фукозилированных соединений
DK2440661T3 (en) 2009-06-08 2018-03-12 Jennewein Biotechnologie Gmbh HMO synthesis
IT1395068B1 (it) * 2009-08-07 2012-09-05 Inalco Spa Processo per la produzione di galatto-oligosaccaridi ultrapuri
CN101870992A (zh) * 2010-06-21 2010-10-27 天津科技大学 利用基因工程菌耦合发酵合成gdp-岩藻糖的方法
EP2944690B1 (en) 2010-10-11 2017-12-20 Jennewein Biotechnologie GmbH Novel fucosyltransferases and their applications
EP2479263B1 (en) * 2011-01-20 2013-11-27 Jennewein Biotechnologie GmbH Novel Fucosyltransferases and their applications
DE12746649T1 (de) * 2011-02-16 2016-09-29 Glycosyn LLC Biosynthese menschlicher milcholigosaccaride in manipulierten Bakterien
CN103562401A (zh) * 2011-05-13 2014-02-05 格力康公司 产生人乳寡糖(hmo)或其前体的方法
EP2728009B1 (en) * 2012-10-31 2017-07-26 Jennewein Biotechnologie GmbH Process for producing monosaccharides
PL2845905T3 (pl) * 2013-09-10 2021-09-27 Chr. Hansen HMO GmbH Wytwarzanie oligosacharydów

Also Published As

Publication number Publication date
EP3572521A1 (en) 2019-11-27
JP6894703B2 (ja) 2021-06-30
US12123040B2 (en) 2024-10-22
US20220403433A1 (en) 2022-12-22
BR112016005228A2 (https=) 2017-09-05
CN118028396A (zh) 2024-05-14
EP2845905B1 (en) 2021-05-19
DK2845905T3 (da) 2021-06-14
AU2014320757C1 (en) 2018-07-19
JP2016530888A (ja) 2016-10-06
US20220389468A1 (en) 2022-12-08
EP2845905A1 (en) 2015-03-11
JP2019213552A (ja) 2019-12-19
JP6992029B2 (ja) 2022-01-13
CN118028397A (zh) 2024-05-14
AU2014320757B2 (en) 2018-04-19
JP2019213553A (ja) 2019-12-19
US11981947B2 (en) 2024-05-14
ES2875327T3 (es) 2021-11-10
US20160186223A1 (en) 2016-06-30
KR20160065111A (ko) 2016-06-08
WO2015036138A1 (en) 2015-03-19
JP7389584B2 (ja) 2023-11-30
EP3572520A1 (en) 2019-11-27
EP2845905B8 (en) 2021-07-14
CN110643658A (zh) 2020-01-03
AU2014320757A1 (en) 2016-04-28
KR102335067B1 (ko) 2021-12-03
CN105722991A (zh) 2016-06-29
CN110628842A (zh) 2019-12-31
PL2845905T3 (pl) 2021-09-27
US11427845B2 (en) 2022-08-30

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