CN110628842A - 寡糖的生产 - Google Patents

寡糖的生产 Download PDF

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Publication number
CN110628842A
CN110628842A CN201910957609.0A CN201910957609A CN110628842A CN 110628842 A CN110628842 A CN 110628842A CN 201910957609 A CN201910957609 A CN 201910957609A CN 110628842 A CN110628842 A CN 110628842A
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oligosaccharides
lacto
host microorganism
beta
oligosaccharide
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Chinese (zh)
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斯特凡·延内魏因
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Jennifer Biotechnology Co Ltd
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Jennifer Biotechnology Co Ltd
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Application filed by Jennifer Biotechnology Co Ltd filed Critical Jennifer Biotechnology Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/12—Disaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/20—Preparation of compounds containing saccharide radicals produced by the action of an exo-1,4 alpha-glucosidase, e.g. dextrose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/101—Plasmid DNA for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201910957609.0A 2013-09-10 2014-07-04 寡糖的生产 Pending CN110628842A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13183670.2 2013-09-10
EP13183670.2A EP2845905B8 (en) 2013-09-10 2013-09-10 Production of oligosaccharides
CN201480061563.XA CN105722991A (zh) 2013-09-10 2014-07-04 寡糖的生产

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480061563.XA Division CN105722991A (zh) 2013-09-10 2014-07-04 寡糖的生产

Publications (1)

Publication Number Publication Date
CN110628842A true CN110628842A (zh) 2019-12-31

Family

ID=49117764

Family Applications (5)

Application Number Title Priority Date Filing Date
CN201910957609.0A Pending CN110628842A (zh) 2013-09-10 2014-07-04 寡糖的生产
CN202410094021.8A Pending CN118028396A (zh) 2013-09-10 2014-07-04 寡糖的生产
CN201910957839.7A Pending CN110643658A (zh) 2013-09-10 2014-07-04 寡糖的生产
CN202410094161.5A Pending CN118028397A (zh) 2013-09-10 2014-07-04 寡糖的生产
CN201480061563.XA Pending CN105722991A (zh) 2013-09-10 2014-07-04 寡糖的生产

Family Applications After (4)

Application Number Title Priority Date Filing Date
CN202410094021.8A Pending CN118028396A (zh) 2013-09-10 2014-07-04 寡糖的生产
CN201910957839.7A Pending CN110643658A (zh) 2013-09-10 2014-07-04 寡糖的生产
CN202410094161.5A Pending CN118028397A (zh) 2013-09-10 2014-07-04 寡糖的生产
CN201480061563.XA Pending CN105722991A (zh) 2013-09-10 2014-07-04 寡糖的生产

Country Status (11)

Country Link
US (3) US11427845B2 (https=)
EP (3) EP3572521A1 (https=)
JP (3) JP6894703B2 (https=)
KR (1) KR102335067B1 (https=)
CN (5) CN110628842A (https=)
AU (1) AU2014320757C1 (https=)
BR (1) BR112016005228A8 (https=)
DK (1) DK2845905T3 (https=)
ES (1) ES2875327T3 (https=)
PL (1) PL2845905T3 (https=)
WO (1) WO2015036138A1 (https=)

Cited By (1)

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WO2023169200A1 (zh) * 2022-03-11 2023-09-14 山东恒鲁生物科技有限公司 重组酵母菌及其应用

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PL2845905T3 (pl) * 2013-09-10 2021-09-27 Chr. Hansen HMO GmbH Wytwarzanie oligosacharydów
DK2896628T3 (en) 2014-01-20 2019-01-14 Jennewein Biotechnologie Gmbh Process for Effective Purification of Neutral Milk Oligosaccharides (HMOs) from Microbial Fermentation
PL3277287T3 (pl) * 2015-03-31 2024-04-22 Glycom A/S Mieszaniny oligosacharydów mleka ludzkiego zawierające 3'-O-sialilolaktozę
US10829508B2 (en) 2015-12-18 2020-11-10 Glycom A/S Fermentative production of oligosaccharides
EP4674526A3 (en) 2016-04-19 2026-04-01 Glycom A/S Separation of oligosaccharides from fermentation broth
EP3474861A4 (en) 2016-06-24 2020-04-15 Glycom A/S COMPOUNDS COMPRISING HMOS FOR THE PREVENTION AND / OR TREATMENT OF VIRAL AND / OR BACTERIAL INFECTIONS.
CN106190938B (zh) * 2016-07-18 2019-05-14 南开大学 一种构建的重组大肠杆菌及生物合成3’-唾液乳糖的方法
SG10202100843TA (en) * 2016-07-28 2021-03-30 Fonterra Cooperative Group Ltd Dairy product and process
AU2017326654C1 (en) * 2016-09-19 2022-07-21 Prolacta Bioscience, Inc. Purified human milk oligosaccharides compositions
ES2856749T3 (es) * 2016-10-29 2021-09-28 Chr Hansen Hmo Gmbh Proceso para la producción de oligosacáridos fucosilados
FI3821712T3 (fi) 2017-01-13 2023-01-13 Parannetulla menetelmällä saatu hapatettu maitotuote
JP2018140968A (ja) * 2017-02-28 2018-09-13 日本食品化工株式会社 １，６−アンヒドロ−β−Ｄ−グルコフラノース含有糖質の製造方法
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US11214588B2 (en) 2017-06-30 2022-01-04 Glycom A/S Synthesis of oligosaccharides
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PL3524067T3 (pl) 2018-02-08 2025-06-09 Chr. Hansen HMO GmbH Suszona rozpyłowo mieszanina oligosacharydów mleka ludzkiego
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CN112154150A (zh) * 2018-05-23 2020-12-29 帝斯曼知识产权资产管理有限公司 寡糖的生产
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CN109735479B (zh) * 2019-01-30 2022-04-01 光明乳业股份有限公司 一种合成2’-岩藻糖基乳糖的重组枯草芽孢杆菌及其构建方法与应用
JP7348675B2 (ja) 2019-05-21 2023-09-21 高麗大学校産学協力団 α－及びβ－１，４－グリコシド結合を全て切断する酵素の用途
PH12021551814A1 (en) * 2019-06-04 2022-03-21 Nutricia Nv NUTRITIONAL COMPOSITION COMPRISING 2’FUCOSYLLACTOSE AND 3’GALACTOSYLLACTOSE
EP4025072B1 (en) 2019-09-04 2025-08-20 Inbiose N.V. Process for removing an antifoam agent from a solution comprising a human milk oligosaccharide and related compositions
TW202126317A (zh) 2019-09-24 2021-07-16 美商普拉塔生技公司 用於治療發炎和免疫疾病之組成物和方法
JP2023519488A (ja) 2020-03-12 2023-05-11 グリコム・アクティーゼルスカブ ２’－ｆｌの結晶化
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CN114107342B (zh) * 2021-12-27 2024-01-26 黄山同兮生物科技有限公司 一种去除发酵液中乳糖的方法
KR102616020B1 (ko) 2021-12-31 2023-12-22 매일유업 주식회사 모유 올리고당 혼합물을 유효성분으로 포함하는 장관면역 개선용, 장 염증 예방 또는 개선용 조성물
CN115011535A (zh) * 2022-05-10 2022-09-06 南通励成生物工程有限公司 一种以葡萄糖为碳源合成2’-岩藻糖基乳糖的菌株及其构建方法和应用
KR20240002283A (ko) * 2022-06-28 2024-01-05 주식회사 삼양사 2’-푸코실락토오스 제조방법
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JPH05276969A (ja) * 1992-04-03 1993-10-26 Nippon Shinyaku Co Ltd 高純度マルトオリゴ糖の製法
US20040121431A1 (en) * 2000-11-16 2004-06-24 Michio Kubota Polypeptide having alpha-isomaltosyl-transferase activity
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CN102459605A (zh) * 2009-06-08 2012-05-16 詹尼温生物技术有限责任公司 Hmo合成
US20120129802A1 (en) * 2009-08-07 2012-05-24 Silvia Giacomelli Process for the production of ultrapure galacto-oligosaccharides
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JPS5995895A (ja) * 1982-11-22 1984-06-02 Meiji Seika Kaisha Ltd フラクトオリゴ糖の精製法
JPH05276969A (ja) * 1992-04-03 1993-10-26 Nippon Shinyaku Co Ltd 高純度マルトオリゴ糖の製法
US20040121431A1 (en) * 2000-11-16 2004-06-24 Michio Kubota Polypeptide having alpha-isomaltosyl-transferase activity
US20110065152A1 (en) * 2008-03-12 2011-03-17 Uday Kashinath Avalakki Process for production of galactooligosaccharides (gos)
CN102459605A (zh) * 2009-06-08 2012-05-16 詹尼温生物技术有限责任公司 Hmo合成
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