BR112015030343A2 - composições e métodos para redução ou prevenção de metástase - Google Patents

composições e métodos para redução ou prevenção de metástase

Info

Publication number
BR112015030343A2
BR112015030343A2 BR112015030343A BR112015030343A BR112015030343A2 BR 112015030343 A2 BR112015030343 A2 BR 112015030343A2 BR 112015030343 A BR112015030343 A BR 112015030343A BR 112015030343 A BR112015030343 A BR 112015030343A BR 112015030343 A2 BR112015030343 A2 BR 112015030343A2
Authority
BR
Brazil
Prior art keywords
compositions
reducing
methods
gla
treatment
Prior art date
Application number
BR112015030343A
Other languages
English (en)
Other versions
BR112015030343A8 (pt
Inventor
Matzner Pini
Ben-Eliyahu Shamgar
G Reed Steven
Original Assignee
Infectious Disease Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infectious Disease Res Inst filed Critical Infectious Disease Res Inst
Publication of BR112015030343A2 publication Critical patent/BR112015030343A2/pt
Publication of BR112015030343A8 publication Critical patent/BR112015030343A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

abstract compositions comprising glucopyranosyl lipid adjuvant (gla) and methods for reducing or preventing the formation of cancer metastasis utilizing same are provided. the compositions may be formulated for local-regional delivery. the compositions may be substantially devoid of a cancer antigen. the treatment with gla may be combined with treatment with a cox2 inhibitor and a beta-adrenergic blocker. ---------------- tradução do resumo resumo patente de invenção: "composições e métodos para redução ou prevenção de metástase". a presente invenção refere-se a composições compreen-dendo adjuvante de lipídeo de glicopiranosila (gla) e métodos para redução ou prevenção da formação de metástase de câncer utilizando as mesmas são providos. as composições podem ser formuladas para aplicação local-regional. as composições podem ser substancialmente destituídas de um antígeno para câncer. o tratamento com gla pode ser combinado com tratamento com um inibidor de cox2 e um blo-queador beta-adrenérgico.
BR112015030343A 2013-06-04 2014-06-04 uso de um adjuvante de lipídeo de glicopiranosila (gla) e composição farmacêutica compreendendo o referido adjuvante BR112015030343A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361830675P 2013-06-04 2013-06-04
US14/256,881 US9463198B2 (en) 2013-06-04 2014-04-18 Compositions and methods for reducing or preventing metastasis
PCT/US2014/040954 WO2014197629A1 (en) 2013-06-04 2014-06-04 Compositions and methods for reducing or preventing metastasis

Publications (2)

Publication Number Publication Date
BR112015030343A2 true BR112015030343A2 (pt) 2017-07-25
BR112015030343A8 BR112015030343A8 (pt) 2019-12-24

Family

ID=52008572

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015030343A BR112015030343A8 (pt) 2013-06-04 2014-06-04 uso de um adjuvante de lipídeo de glicopiranosila (gla) e composição farmacêutica compreendendo o referido adjuvante

Country Status (8)

Country Link
US (1) US9463198B2 (pt)
EP (2) EP3650028A1 (pt)
JP (2) JP6509827B2 (pt)
CN (2) CN105473159A (pt)
BR (1) BR112015030343A8 (pt)
CA (1) CA2914501C (pt)
HK (1) HK1218518A1 (pt)
WO (1) WO2014197629A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3124491B1 (en) 2009-06-05 2019-10-30 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants and vaccine compositions as well as pharmaceutical compositions containing them
CN107540730B (zh) 2012-05-16 2021-07-16 免疫设计公司 用于hsv-2的疫苗
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
TWI782047B (zh) * 2017-06-30 2022-11-01 日商小野藥品工業股份有限公司 癌症復發及/或轉移抑制劑
AU2021329884A1 (en) * 2020-08-17 2023-02-16 SURGE Therapeutics, Inc. Immune modulation of myeloid derived suppressive cell function for cancer treatment
WO2022136952A1 (en) 2020-12-23 2022-06-30 Infectious Disease Research Institute Solanesol vaccine adjuvants and methods of preparing same

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