LV14606A - Jauns XII faktora inhibitors - Google Patents

Jauns XII faktora inhibitors

Info

Publication number
LV14606A
LV14606A LVP-11-69A LV110069A LV14606A LV 14606 A LV14606 A LV 14606A LV 110069 A LV110069 A LV 110069A LV 14606 A LV14606 A LV 14606A
Authority
LV
Latvia
Prior art keywords
factor xii
novel factor
xii inhibitor
inhibitor
provides
Prior art date
Application number
LVP-11-69A
Other languages
English (en)
Other versions
LV14606B (lv
Inventor
Ivars KALVIŅŠ
Anatolijs Birmans
Māris VĒVERIS
Original Assignee
Tetra, Sia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tetra, Sia filed Critical Tetra, Sia
Priority to LVP-11-69A priority Critical patent/LV14606B/lv
Priority to PCT/LV2012/000008 priority patent/WO2012158003A1/en
Publication of LV14606A publication Critical patent/LV14606A/lv
Publication of LV14606B publication Critical patent/LV14606B/lv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Izgudrojumā aprakstīts meldonija acetilsalicilāts kā jauns XII faktora inhibitors un tā lietošana par antikoagulantu. Izgudrojumā papildus ir aprakstīta sinerģiska ārstnieciskā kombinācija, kas ietver meldonija acetilsalicilātu un varfarīna nātrija sāli pielietojumam par antikoagulantu.
LVP-11-69A 2011-05-17 2011-05-17 Jauns XII faktora inhibitors LV14606B (lv)

Priority Applications (2)

Application Number Priority Date Filing Date Title
LVP-11-69A LV14606B (lv) 2011-05-17 2011-05-17 Jauns XII faktora inhibitors
PCT/LV2012/000008 WO2012158003A1 (en) 2011-05-17 2012-05-16 Novel factor xii inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LVP-11-69A LV14606B (lv) 2011-05-17 2011-05-17 Jauns XII faktora inhibitors

Publications (2)

Publication Number Publication Date
LV14606A true LV14606A (lv) 2012-11-20
LV14606B LV14606B (lv) 2013-01-20

Family

ID=47177156

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-11-69A LV14606B (lv) 2011-05-17 2011-05-17 Jauns XII faktora inhibitors

Country Status (2)

Country Link
LV (1) LV14606B (lv)
WO (1) WO2012158003A1 (lv)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113929735A (zh) * 2020-06-29 2022-01-14 首都医科大学 Gly-Pro-Arg-Pro-NHCH2CH2NH-华法林,其合成,活性和应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LV14963B (lv) 2013-06-28 2015-10-20 Tetra, Sia Endoteliālās disfunkcijas korektors
AU2017247004B2 (en) * 2016-04-06 2022-07-07 Csl Limited Method of treating atherosclerosis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041430A (en) 1989-09-18 1991-08-20 Du Pont Mereck Pharmaceutical Company Oral anticoagulant/platelet inhibitor low dose formulation
CA2082643A1 (en) 1990-05-10 1991-11-11 Jan H. Nuijens Inhibitors of factor xii activation and applications thereof
WO1994020535A1 (en) 1992-12-11 1994-09-15 Corvas International, Inc. ECOTIN AS A FACTOR Xa, XIa, AND XIIa INHIBITOR
AU2002256361B2 (en) 2001-04-24 2008-01-24 Arxy Therapeutics Coumarin derivatives to be used as anticoagulants
RU2259371C2 (ru) 2003-05-05 2005-08-27 Общество с ограниченной ответственностью Научно-технологическое предприятие "Лиганд" Замещенные 5r1,6r2 1,3,4-тиадиазин-2 амины и содержащие их фармацевтические композиции в качестве фармакологически активных средств, обладающих антикоагулянтным и антиагрегантным действием
JP5236293B2 (ja) 2005-01-13 2013-07-17 ブリストル−マイヤーズ スクイブ カンパニー Ｘｉａ因子阻害剤としての置換ビアリール化合物
WO2006138534A2 (en) * 2005-06-15 2006-12-28 Morton Grove Pharmaceuticals, Inc. Stable warfarin sodium liquid formulation and method of making same
UA13376U (en) * 2005-12-07 2006-03-15 M I Pyrogov Vinnytsia State Me Method for treating ischemic heart disease
ATE511502T1 (de) 2005-12-14 2011-06-15 Bristol Myers Squibb Co Arylpropionamid-, arylacrylamid-, arylpropinamid- oder arylmethylharnstoffanaloge als faktor-xia- inhibitoren
US8466295B2 (en) 2005-12-14 2013-06-18 Bristol-Myers Squibb Company Thiophene derivatives as factor XIa inhibitors
UA16210U (en) * 2006-03-28 2006-07-17 Univ Oo Bohomolets Nat Medical Method for treating ischemic stroke
CN101605779B (zh) 2006-12-15 2013-11-20 百时美施贵宝公司 作为凝血因子xia抑制剂的芳基丙酰胺、芳基丙烯酰胺、芳基丙炔酰胺或芳基甲基脲类似物
ATE543811T1 (de) 2008-03-13 2012-02-15 Bristol Myers Squibb Co Pyridazinderivate als faktor-xia-inhibitoren
EA021344B1 (ru) * 2009-06-25 2015-05-29 Тетра Сиа Терапевтические комбинации никотиновой кислоты и мелдония
JP5706409B2 (ja) 2009-06-25 2015-04-22 テトラ，エスイーアー 新規なサリチル酸塩

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113929735A (zh) * 2020-06-29 2022-01-14 首都医科大学 Gly-Pro-Arg-Pro-NHCH2CH2NH-华法林,其合成,活性和应用
CN113929735B (zh) * 2020-06-29 2023-08-01 首都医科大学 Gly-Pro-Arg-Pro-NHCH2CH2NH-华法林,其合成,活性和应用

Also Published As

Publication number Publication date
WO2012158003A1 (en) 2012-11-22
LV14606B (lv) 2013-01-20

Similar Documents

Publication Publication Date Title
CY1124499T1 (el) Λιπιδια για συστασεις διανομης θεραπευτικου παραγοντα
HK1254470A1 (zh) 3'平伏氟取代的神經氨酸酶抑制劑化合物、組合物及其用作抗病毒劑的方法
CR20140024A (es) Compuestos inhibidores de metaloenzimas
UY33937A (es) Composiciones farmacéuticas que contienen inhibidores de dpp-4 y/o sglt-2 y metformina
PH12014501273A1 (en) Intranasal dexmedetomidine compositions and methods of use thereof
UY33930A (es) Inhibidores novedosos de quinasas
IN2014DN10670A (lv)
MY157341A (en) Methods and compositions for treating lung cancer
MX2015008813A (es) Composiciones y metodos para contrarrestar la inhibicion del factor xa.
EA201490761A1 (ru) R(+)-n-формилпропаргиламиноиндан
UA117032C2 (uk) Селективний інгібітор фосфатидилінозитол-3-кінази-гамма
BR112013022052A2 (pt) ligantes antagonísticos de dr3
MX369290B (es) Inhibidores de fbx03.
TN2013000283A1 (en) Monoterpene derivatives of chalcone or dihydrochalcone and their use as depigmenting agents
MX2015017035A (es) Inhibidor de la señalizacion de cd40 y un compuesto adicional, en donde el compuesto adicional es un acido labil, un derivado de acido labil, un agonista del receptor tgr5, un agonista del fxr o una combinacion de los mismos, para el tratamiento de inflamacion cronica, y la prevencion de cancer gastrointestinal o fibrosis.
EP2576536A4 (en) INHIBITORS OF HEMATOPOIETIC PROSTAGLANDIN D2 SYNTHASE
JO3337B1 (ar) تركيبات صيدلية تشمل أليسبوريفير
LV14606A (lv) Jauns XII faktora inhibitors
UA117567C2 (uk) Композиція, яка стимулює лактацію, на основі фосфатидилсерину
MX337612B (es) Composicion de oligosacaridos para prevenir o reducir el riesgo de sindrome metabolico.
IN2012DE02272A (lv)
IL231566A0 (en) Choline kinase inhibitor compounds, preparations containing them and their uses
MX354501B (es) Ingrediente perfumante de la familia galbano.
MX2013008559A (es) Derivados de leptina.
UA94339C2 (ru) применение корвитина в качестве средства фригопротекторного действия