LV14606A - Jauns XII faktora inhibitors - Google Patents

Jauns XII faktora inhibitors

Info

Publication number
LV14606A
LV14606A LVP-11-69A LV110069A LV14606A LV 14606 A LV14606 A LV 14606A LV 110069 A LV110069 A LV 110069A LV 14606 A LV14606 A LV 14606A
Authority
LV
Latvia
Prior art keywords
factor xii
novel factor
xii inhibitor
inhibitor
provides
Prior art date
Application number
LVP-11-69A
Other languages
English (en)
Other versions
LV14606B (lv
Inventor
Ivars KALVIŅŠ
Anatolijs Birmans
Māris VĒVERIS
Original Assignee
Tetra, Sia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tetra, Sia filed Critical Tetra, Sia
Priority to LVP-11-69A priority Critical patent/LV14606B/lv
Priority to PCT/LV2012/000008 priority patent/WO2012158003A1/en
Publication of LV14606A publication Critical patent/LV14606A/lv
Publication of LV14606B publication Critical patent/LV14606B/lv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Izgudrojumā aprakstīts meldonija acetilsalicilāts kā jauns XII faktora inhibitors un tā lietošana par antikoagulantu. Izgudrojumā papildus ir aprakstīta sinerģiska ārstnieciskā kombinācija, kas ietver meldonija acetilsalicilātu un varfarīna nātrija sāli pielietojumam par antikoagulantu.
LVP-11-69A 2011-05-17 2011-05-17 Jauns XII faktora inhibitors LV14606B (lv)

Priority Applications (2)

Application Number Priority Date Filing Date Title
LVP-11-69A LV14606B (lv) 2011-05-17 2011-05-17 Jauns XII faktora inhibitors
PCT/LV2012/000008 WO2012158003A1 (en) 2011-05-17 2012-05-16 Novel factor xii inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LVP-11-69A LV14606B (lv) 2011-05-17 2011-05-17 Jauns XII faktora inhibitors

Publications (2)

Publication Number Publication Date
LV14606A true LV14606A (lv) 2012-11-20
LV14606B LV14606B (lv) 2013-01-20

Family

ID=47177156

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-11-69A LV14606B (lv) 2011-05-17 2011-05-17 Jauns XII faktora inhibitors

Country Status (2)

Country Link
LV (1) LV14606B (lv)
WO (1) WO2012158003A1 (lv)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113929735A (zh) * 2020-06-29 2022-01-14 首都医科大学 Gly-Pro-Arg-Pro-NHCH2CH2NH-华法林,其合成,活性和应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LV14963B (lv) 2013-06-28 2015-10-20 Tetra, Sia Endoteliālās disfunkcijas korektors
CN109071629A (zh) * 2016-04-06 2018-12-21 杰特有限公司 治疗动脉粥样硬化的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041430A (en) 1989-09-18 1991-08-20 Du Pont Mereck Pharmaceutical Company Oral anticoagulant/platelet inhibitor low dose formulation
WO1991017258A1 (en) 1990-05-10 1991-11-14 Cetus Corporation Inhibitors of factor xii activation and applications thereof
WO1994020535A1 (en) 1992-12-11 1994-09-15 Corvas International, Inc. ECOTIN AS A FACTOR Xa, XIa, AND XIIa INHIBITOR
ATE388143T1 (de) 2001-04-24 2008-03-15 Aryx Therapeutics Cumarin derivate und ihre verwendung als anticoagulantien
RU2259371C2 (ru) 2003-05-05 2005-08-27 Общество с ограниченной ответственностью Научно-технологическое предприятие "Лиганд" Замещенные 5r1,6r2 1,3,4-тиадиазин-2 амины и содержащие их фармацевтические композиции в качестве фармакологически активных средств, обладающих антикоагулянтным и антиагрегантным действием
WO2006076575A2 (en) 2005-01-13 2006-07-20 Bristol-Myers Squibb Company Substituted biaryl compounds as factor xia inhibitors
US7259185B2 (en) * 2005-06-15 2007-08-21 Morton Grove Pharmaceuticals, Inc. Stable warfarin sodium liquid formulation and method of making same
UA13376U (en) * 2005-12-07 2006-03-15 M I Pyrogov Vinnytsia State Me Method for treating ischemic heart disease
US8466295B2 (en) 2005-12-14 2013-06-18 Bristol-Myers Squibb Company Thiophene derivatives as factor XIa inhibitors
CA2633252A1 (en) 2005-12-14 2007-06-21 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
UA16210U (en) * 2006-03-28 2006-07-17 Univ Oo Bohomolets Nat Medical Method for treating ischemic stroke
CN101605779B (zh) 2006-12-15 2013-11-20 百时美施贵宝公司 作为凝血因子xia抑制剂的芳基丙酰胺、芳基丙烯酰胺、芳基丙炔酰胺或芳基甲基脲类似物
CN102026996B (zh) 2008-03-13 2015-01-07 百时美施贵宝公司 作为凝血因子xia抑制剂的哒嗪衍生物
EA021588B1 (ru) 2009-06-25 2015-07-30 Тетра Сиа Бетаиновые соли ацетилсалициловой кислоты
CN102802618B (zh) * 2009-06-25 2014-06-18 泰特拉有限公司 烟酸和米曲肼的治疗组合

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113929735A (zh) * 2020-06-29 2022-01-14 首都医科大学 Gly-Pro-Arg-Pro-NHCH2CH2NH-华法林,其合成,活性和应用
CN113929735B (zh) * 2020-06-29 2023-08-01 首都医科大学 Gly-Pro-Arg-Pro-NHCH2CH2NH-华法林,其合成,活性和应用

Also Published As

Publication number Publication date
LV14606B (lv) 2013-01-20
WO2012158003A1 (en) 2012-11-22

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