LV14606A - Novel factor xii inhibitor - Google Patents

Novel factor xii inhibitor

Info

Publication number
LV14606A
LV14606A LVP-11-69A LV110069A LV14606A LV 14606 A LV14606 A LV 14606A LV 110069 A LV110069 A LV 110069A LV 14606 A LV14606 A LV 14606A
Authority
LV
Latvia
Prior art keywords
factor xii
novel factor
xii inhibitor
inhibitor
provides
Prior art date
Application number
LVP-11-69A
Other languages
Latvian (lv)
Other versions
LV14606B (en
Inventor
Ivars KALVIŅŠ
Anatolijs Birmans
Māris VĒVERIS
Original Assignee
Tetra, Sia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tetra, Sia filed Critical Tetra, Sia
Priority to LVP-11-69A priority Critical patent/LV14606B/en
Priority to PCT/LV2012/000008 priority patent/WO2012158003A1/en
Publication of LV14606A publication Critical patent/LV14606A/en
Publication of LV14606B publication Critical patent/LV14606B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

The present invention provides meldonium acetylsalicylate as novel factor XII inhibitor and use thereof as anticoagulant agent. Further the present invention provides for synergistic therapeutic combination comprising meldonium acetylsalicylate and warfarin sodium for use as anticoagulant agent.
LVP-11-69A 2011-05-17 2011-05-17 Novel factor xii inhibitor LV14606B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
LVP-11-69A LV14606B (en) 2011-05-17 2011-05-17 Novel factor xii inhibitor
PCT/LV2012/000008 WO2012158003A1 (en) 2011-05-17 2012-05-16 Novel factor xii inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LVP-11-69A LV14606B (en) 2011-05-17 2011-05-17 Novel factor xii inhibitor

Publications (2)

Publication Number Publication Date
LV14606A true LV14606A (en) 2012-11-20
LV14606B LV14606B (en) 2013-01-20

Family

ID=47177156

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-11-69A LV14606B (en) 2011-05-17 2011-05-17 Novel factor xii inhibitor

Country Status (2)

Country Link
LV (1) LV14606B (en)
WO (1) WO2012158003A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113929735A (en) * 2020-06-29 2022-01-14 首都医科大学 Gly-Pro-Arg-Pro-NHCH2CH2NH-warfarin, its synthesis, activity and application

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LV14963B (en) 2013-06-28 2015-10-20 Tetra, Sia Corrector of endothelial dysfunction
EP3440107A4 (en) * 2016-04-06 2020-02-19 CSL Limited Method of treating atherosclerosis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041430A (en) 1989-09-18 1991-08-20 Du Pont Mereck Pharmaceutical Company Oral anticoagulant/platelet inhibitor low dose formulation
AU7793291A (en) 1990-05-10 1991-11-27 Cetus Corporation Inhibitors of factor xii activation and applications thereof
WO1994020535A1 (en) 1992-12-11 1994-09-15 Corvas International, Inc. ECOTIN AS A FACTOR Xa, XIa, AND XIIa INHIBITOR
DE60225434T2 (en) 2001-04-24 2009-03-12 Aryx Therapeutics, Fremont CUMARINE DERIVATIVES AND ITS USE AS ANTICOAGULANTS
RU2259371C2 (en) 2003-05-05 2005-08-27 Общество с ограниченной ответственностью Научно-технологическое предприятие "Лиганд" Substituted 5r1,6r2 -1,3,4-thiadiazine-2-amines and pharmaceutical compositions comprising thereof as pharmacologically active agents eliciting anticoagulant and anti-aggregating effect
US7459564B2 (en) 2005-01-13 2008-12-02 Bristol-Myers Squibb Company Substituted biaryl compounds as factor XIa inhibitors
US7259185B2 (en) * 2005-06-15 2007-08-21 Morton Grove Pharmaceuticals, Inc. Stable warfarin sodium liquid formulation and method of making same
UA13376U (en) * 2005-12-07 2006-03-15 M I Pyrogov Vinnytsia State Me Method for treating ischemic heart disease
WO2007070816A2 (en) 2005-12-14 2007-06-21 Bristol-Myers Squibb Company Thiophene derivatives as factor xia inhibitors
WO2007070826A1 (en) 2005-12-14 2007-06-21 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
UA16210U (en) * 2006-03-28 2006-07-17 Univ Oo Bohomolets Nat Medical Method for treating ischemic stroke
WO2008076805A2 (en) 2006-12-15 2008-06-26 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
US8324199B2 (en) 2008-03-13 2012-12-04 Bristol-Myers Squibb Company Pyridazine derivatives as factor xia inhibitors
WO2010151095A1 (en) 2009-06-25 2010-12-29 Tetra, Sia Novel acetylsalicylic acid salts
WO2010151096A1 (en) * 2009-06-25 2010-12-29 Tetra, Sia Therapeutic combinations of nicotinic acid and meldonium

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113929735A (en) * 2020-06-29 2022-01-14 首都医科大学 Gly-Pro-Arg-Pro-NHCH2CH2NH-warfarin, its synthesis, activity and application
CN113929735B (en) * 2020-06-29 2023-08-01 首都医科大学 Gly-Pro-Arg-Pro-NHCH 2 CH 2 NH-warfarin, its synthesis, activity and use

Also Published As

Publication number Publication date
LV14606B (en) 2013-01-20
WO2012158003A1 (en) 2012-11-22

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