HK1254470A1 - 3'平伏氟取代的神經氨酸酶抑制劑化合物、組合物及其用作抗病毒劑的方法 - Google Patents

3'平伏氟取代的神經氨酸酶抑制劑化合物、組合物及其用作抗病毒劑的方法

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Publication number
HK1254470A1
HK1254470A1 HK18113556.9A HK18113556A HK1254470A1 HK 1254470 A1 HK1254470 A1 HK 1254470A1 HK 18113556 A HK18113556 A HK 18113556A HK 1254470 A1 HK1254470 A1 HK 1254470A1
Authority
HK
Hong Kong
Prior art keywords
virals
equatorial
fluorine
substituted
compositions
Prior art date
Application number
HK18113556.9A
Other languages
English (en)
Inventor
斯蒂芬‧威瑟斯
陳宏明
里卡多‧里森德
詹尼弗‧洛伊斯‧布萊斯切科因
Original Assignee
不列顛哥倫比亞大學
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 不列顛哥倫比亞大學 filed Critical 不列顛哥倫比亞大學
Publication of HK1254470A1 publication Critical patent/HK1254470A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK18113556.9A 2012-01-19 2018-10-23 3'平伏氟取代的神經氨酸酶抑制劑化合物、組合物及其用作抗病毒劑的方法 HK1254470A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261588577P 2012-01-19 2012-01-19

Publications (1)

Publication Number Publication Date
HK1254470A1 true HK1254470A1 (zh) 2019-07-19

Family

ID=48798456

Family Applications (2)

Application Number Title Priority Date Filing Date
HK15106111.4A HK1205513A1 (zh) 2012-01-19 2015-06-26 '平伏氟取代的神經氨酸酶抑制劑化合物、組合物及其用作抗病毒劑的方法
HK18113556.9A HK1254470A1 (zh) 2012-01-19 2018-10-23 3'平伏氟取代的神經氨酸酶抑制劑化合物、組合物及其用作抗病毒劑的方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK15106111.4A HK1205513A1 (zh) 2012-01-19 2015-06-26 '平伏氟取代的神經氨酸酶抑制劑化合物、組合物及其用作抗病毒劑的方法

Country Status (5)

Country Link
US (2) US9637465B2 (zh)
KR (1) KR102128413B1 (zh)
CN (2) CN107954963A (zh)
HK (2) HK1205513A1 (zh)
WO (1) WO2013106937A1 (zh)

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US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
ES2442024T3 (es) 2008-07-15 2014-02-07 Academia Sinica Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados
EP2454268B1 (en) 2009-07-15 2014-09-10 The University Of British Columbia 2,3-fluorinated glycosides as neuraminidase inhibitors and their use as anti-virals
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
CN107954963A (zh) * 2012-01-19 2018-04-24 不列颠哥伦比亚大学 3’平伏氟取代的神经氨酸酶抑制剂化合物、组合物及其用作抗病毒剂的方法
AU2013306098A1 (en) * 2012-08-18 2015-02-12 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
JP6486368B2 (ja) 2013-09-06 2019-03-20 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 改変されたグリコシル基を含む糖脂質を用いたヒトｉＮＫＴ細胞の活性化
CA2950423A1 (en) 2014-05-27 2015-12-03 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
CN106661099A (zh) 2014-05-27 2017-05-10 中央研究院 抗her2醣抗体及其用途
KR20240096599A (ko) 2014-05-27 2024-06-26 아카데미아 시니카 항-ｃｄ20 글리코항체 및 이의 용도
WO2015184001A1 (en) 2014-05-28 2015-12-03 Academia Sinica Anti-tnf-alpha glycoantibodies and uses thereof
KR102422375B1 (ko) 2014-09-08 2022-07-18 아카데미아 시니카 당지질을 사용한 인간 iNKT 세포 활성화
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
AU2015378564A1 (en) 2015-01-24 2017-07-13 Academia Sinica Novel glycan conjugates and methods of use thereof
CA3034057A1 (en) 2016-08-22 2018-03-01 CHO Pharma Inc. Antibodies, binding fragments, and methods of use
WO2021055753A1 (en) * 2019-09-20 2021-03-25 The Regents Of The University Of California Methods and compositions for inhibition of cmp-sugar synthetases

Family Cites Families (11)

* Cited by examiner, † Cited by third party
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SK282950B6 (sk) * 1990-04-24 2003-01-09 Biota Scientific Management Pty Ltd Deriváty alfa-D-neuramínovej kyseliny, spôsob ich prípravy, ich použitie a farmaceutické prípravky na ich báze
CA2181237A1 (en) * 1994-02-25 1995-08-31 Subramaniam Sabesan 4-n-substituted sialic acids and their sialosides
JP3141693B2 (ja) * 1994-08-16 2001-03-05 ダイキン工業株式会社 シアル酸の９位をフッ素で置換したガングリオシドｇｍ３類縁体及びその中間体
US6284494B1 (en) 1995-12-12 2001-09-04 The University Of British Columbia Methods and compositions for synthesis of oligosaccharides using mutant glycosidase enzymes
US5952203A (en) 1997-04-11 1999-09-14 The University Of British Columbia Oligosaccharide synthesis using activated glycoside derivative, glycosyl transferase and catalytic amount of nucleotide phosphate
US6894033B2 (en) * 2001-06-11 2005-05-17 Transition Therapeutics Inc. Combination therapies using vitamin B12 and therapeutic agents for treatment of viral, proliferative and inflammatory diseases
DK200201741A (da) 2002-11-12 2003-09-16 Statens Seruminstitut Vaccine comprising chimeric malaria proteins derived from Plasmodium falciparum
GB0816679D0 (en) 2008-09-11 2008-10-22 Univ Bath Compounds for treating viral infections
EP2228380A1 (en) * 2009-03-13 2010-09-15 onepharm Research & Development GmbH Novel triterpene derivatives
EP2454268B1 (en) 2009-07-15 2014-09-10 The University Of British Columbia 2,3-fluorinated glycosides as neuraminidase inhibitors and their use as anti-virals
CN107954963A (zh) 2012-01-19 2018-04-24 不列颠哥伦比亚大学 3’平伏氟取代的神经氨酸酶抑制剂化合物、组合物及其用作抗病毒剂的方法

Also Published As

Publication number Publication date
US20170165223A1 (en) 2017-06-15
CN107954963A (zh) 2018-04-24
US20140350095A1 (en) 2014-11-27
WO2013106937A9 (en) 2014-05-30
CN104321316A (zh) 2015-01-28
HK1205513A1 (zh) 2015-12-18
US9637465B2 (en) 2017-05-02
WO2013106937A1 (en) 2013-07-25
US9949945B2 (en) 2018-04-24
KR102128413B1 (ko) 2020-07-01
CN104321316B (zh) 2018-01-19
KR20140131328A (ko) 2014-11-12

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