BR112015021586B1 - Formulação de morfina farmacêutica injetável e kit - Google Patents
Formulação de morfina farmacêutica injetável e kit Download PDFInfo
- Publication number
- BR112015021586B1 BR112015021586B1 BR112015021586-6A BR112015021586A BR112015021586B1 BR 112015021586 B1 BR112015021586 B1 BR 112015021586B1 BR 112015021586 A BR112015021586 A BR 112015021586A BR 112015021586 B1 BR112015021586 B1 BR 112015021586B1
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- Prior art keywords
- morphine
- formulation
- months
- fact
- agent
- Prior art date
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- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title claims abstract description 624
- 239000000203 mixture Substances 0.000 title claims abstract description 354
- 238000009472 formulation Methods 0.000 title claims abstract description 339
- 229960005181 morphine Drugs 0.000 title claims abstract description 311
- GRVOTVYEFDAHCL-RTSZDRIGSA-N morphine sulfate pentahydrate Chemical compound O.O.O.O.O.OS(O)(=O)=O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O GRVOTVYEFDAHCL-RTSZDRIGSA-N 0.000 claims abstract description 48
- 229960004715 morphine sulfate Drugs 0.000 claims abstract description 35
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 19
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 68
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 67
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Classifications
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361785218P | 2013-03-14 | 2013-03-14 | |
| US61/785,218 | 2013-03-14 | ||
| PCT/EP2014/054831 WO2014140095A1 (en) | 2013-03-14 | 2014-03-12 | Injectable morphine formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015021586A2 BR112015021586A2 (pt) | 2017-07-18 |
| BR112015021586B1 true BR112015021586B1 (pt) | 2023-01-31 |
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| BR112015021586-6A BR112015021586B1 (pt) | 2013-03-14 | 2014-03-12 | Formulação de morfina farmacêutica injetável e kit |
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| WO (1) | WO2014140095A1 (enExample) |
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| JP6726666B2 (ja) * | 2014-12-03 | 2020-07-22 | ツェー・エス・エル・ベーリング・アクチエンゲゼルシャフト | 免疫グロブリンを含む安定性が高められた医薬製品 |
| US20170189352A1 (en) | 2015-03-13 | 2017-07-06 | Par Pharmaceutical, Inc. | Epinephrine formulations |
| US9119876B1 (en) | 2015-03-13 | 2015-09-01 | Par Pharmaceutical, Inc. | Epinephrine formulations |
| JP6930922B2 (ja) * | 2015-05-25 | 2021-09-01 | アイジーエル ファーマ，インコーポレイティド | 放射性同位体用ｄｏｔｍｐキット製剤 |
| US11369700B2 (en) | 2015-05-25 | 2022-06-28 | IGL Pharma Inc. | DOTMP kit formulations for radioisotopes |
| US20180064703A1 (en) * | 2016-09-02 | 2018-03-08 | Sun Pharmaceutical Industries Ltd. | Stable infusion dosage form of morphine |
| BR112019005439A2 (pt) * | 2016-09-23 | 2019-06-18 | Gruenenthal Gmbh | formulação estável para administração parenteral de tapentadol |
| WO2019183416A1 (en) | 2018-03-23 | 2019-09-26 | Nevakar Inc. | Epinephrine compositions and containers |
| CN114207101B (zh) | 2019-07-31 | 2024-05-31 | 埃科莱布美国股份有限公司 | 免用个人防护设备的脱灰剂组合物 |
| WO2021168133A1 (en) * | 2020-02-19 | 2021-08-26 | Nevakar Inc. | Isoproterenol compositions and methods |
| JPWO2022131117A1 (enExample) * | 2020-12-18 | 2022-06-23 |
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-
2014
- 2014-03-12 EP EP16188526.4A patent/EP3143988A1/en not_active Withdrawn
- 2014-03-12 WO PCT/EP2014/054831 patent/WO2014140095A1/en not_active Ceased
- 2014-03-12 JP JP2015562121A patent/JP6215970B2/ja active Active
- 2014-03-12 EP EP14710529.0A patent/EP2968132B1/en not_active Not-in-force
- 2014-03-12 AU AU2014230834A patent/AU2014230834B9/en active Active
- 2014-03-12 US US14/207,245 patent/US9072781B2/en active Active
- 2014-03-12 CA CA2902343A patent/CA2902343C/en active Active
- 2014-03-12 BR BR112015021586-6A patent/BR112015021586B1/pt active IP Right Grant
- 2014-03-14 CN CN201410097764.7A patent/CN104042565A/zh active Pending
- 2014-03-14 CN CN201811072429.6A patent/CN109125254A/zh active Pending
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2015
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2019
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2020
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2023
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2024
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|---|---|
| US20160175297A1 (en) | 2016-06-23 |
| US9192608B2 (en) | 2015-11-24 |
| JP6215970B2 (ja) | 2017-10-18 |
| AU2014230834B9 (en) | 2017-08-31 |
| CN109125254A (zh) | 2019-01-04 |
| US9072781B2 (en) | 2015-07-07 |
| US10213424B2 (en) | 2019-02-26 |
| US20190167665A1 (en) | 2019-06-06 |
| EP3143988A1 (en) | 2017-03-22 |
| CN104042565A (zh) | 2014-09-17 |
| CA2902343A1 (en) | 2014-09-18 |
| EP2968132A1 (en) | 2016-01-20 |
| AU2014230834B2 (en) | 2017-08-03 |
| US20150246036A1 (en) | 2015-09-03 |
| CA2902343C (en) | 2022-08-02 |
| JP2016512210A (ja) | 2016-04-25 |
| EP2968132B1 (en) | 2017-09-13 |
| US20230414604A1 (en) | 2023-12-28 |
| US20250228846A1 (en) | 2025-07-17 |
| AU2014230834A1 (en) | 2015-09-10 |
| BR112015021586A2 (pt) | 2017-07-18 |
| WO2014140095A1 (en) | 2014-09-18 |
| US20140275144A1 (en) | 2014-09-18 |
| US20200345720A1 (en) | 2020-11-05 |
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