JP6215970B2 - 注射可能なモルヒネ製剤 - Google Patents

注射可能なモルヒネ製剤 Download PDF

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Publication number
JP6215970B2
JP6215970B2 JP2015562121A JP2015562121A JP6215970B2 JP 6215970 B2 JP6215970 B2 JP 6215970B2 JP 2015562121 A JP2015562121 A JP 2015562121A JP 2015562121 A JP2015562121 A JP 2015562121A JP 6215970 B2 JP6215970 B2 JP 6215970B2
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JP
Japan
Prior art keywords
morphine
formulation
months
formulations
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015562121A
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English (en)
Japanese (ja)
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JP2016512210A (ja
JP2016512210A5 (enExample
Inventor
キュイン，アラン
オアロ，ディディエ
ロマン，ポーリン
Original Assignee
フレゼニウス カービ ドイチュラント ゲーエムベーハー
フレゼニウス カービ ドイチュラント ゲーエムベーハー
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Publication of JP2016512210A publication Critical patent/JP2016512210A/ja
Publication of JP2016512210A5 publication Critical patent/JP2016512210A5/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
JP2015562121A 2013-03-14 2014-03-12 注射可能なモルヒネ製剤 Active JP6215970B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361785218P 2013-03-14 2013-03-14
US61/785,218 2013-03-14
PCT/EP2014/054831 WO2014140095A1 (en) 2013-03-14 2014-03-12 Injectable morphine formulations

Publications (3)

Publication Number Publication Date
JP2016512210A JP2016512210A (ja) 2016-04-25
JP2016512210A5 JP2016512210A5 (enExample) 2017-06-01
JP6215970B2 true JP6215970B2 (ja) 2017-10-18

Family

ID=50288050

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015562121A Active JP6215970B2 (ja) 2013-03-14 2014-03-12 注射可能なモルヒネ製剤

Country Status (8)

Country Link
US (7) US9072781B2 (enExample)
EP (2) EP2968132B1 (enExample)
JP (1) JP6215970B2 (enExample)
CN (2) CN109125254A (enExample)
AU (1) AU2014230834B9 (enExample)
BR (1) BR112015021586B1 (enExample)
CA (1) CA2902343C (enExample)
WO (1) WO2014140095A1 (enExample)

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* Cited by examiner, † Cited by third party
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JP6930922B2 (ja) * 2015-05-25 2021-09-01 アイジーエル ファーマ，インコーポレイティド 放射性同位体用ｄｏｔｍｐキット製剤
US20180064703A1 (en) 2016-09-02 2018-03-08 Sun Pharmaceutical Industries Ltd. Stable infusion dosage form of morphine
ES3027562T3 (en) * 2016-09-23 2025-06-16 Gruenenthal Gmbh Stable formulation for parenteral administration of tapentadol
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EP4265253A4 (en) * 2020-12-18 2024-11-27 FUJIFILM Toyama Chemical Co., Ltd. PHARMACEUTICAL COMPOSITION

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Also Published As

Publication number Publication date
CA2902343A1 (en) 2014-09-18
JP2016512210A (ja) 2016-04-25
AU2014230834B9 (en) 2017-08-31
US10213424B2 (en) 2019-02-26
EP2968132B1 (en) 2017-09-13
US20250228846A1 (en) 2025-07-17
AU2014230834A1 (en) 2015-09-10
AU2014230834B2 (en) 2017-08-03
EP3143988A1 (en) 2017-03-22
US20200345720A1 (en) 2020-11-05
EP2968132A1 (en) 2016-01-20
CN109125254A (zh) 2019-01-04
WO2014140095A1 (en) 2014-09-18
BR112015021586A2 (pt) 2017-07-18
CA2902343C (en) 2022-08-02
US9192608B2 (en) 2015-11-24
US20160175297A1 (en) 2016-06-23
US20140275144A1 (en) 2014-09-18
CN104042565A (zh) 2014-09-17
US20230414604A1 (en) 2023-12-28
US9072781B2 (en) 2015-07-07
BR112015021586B1 (pt) 2023-01-31
US20190167665A1 (en) 2019-06-06
US20150246036A1 (en) 2015-09-03

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