BR112015005416A2 - produção de ácidos orgânicos por meio de fermentação em baixo ph - Google Patents
produção de ácidos orgânicos por meio de fermentação em baixo phInfo
- Publication number
- BR112015005416A2 BR112015005416A2 BR112015005416A BR112015005416A BR112015005416A2 BR 112015005416 A2 BR112015005416 A2 BR 112015005416A2 BR 112015005416 A BR112015005416 A BR 112015005416A BR 112015005416 A BR112015005416 A BR 112015005416A BR 112015005416 A2 BR112015005416 A2 BR 112015005416A2
- Authority
- BR
- Brazil
- Prior art keywords
- low
- fermentation
- organic acid
- acid production
- organic acids
- Prior art date
Links
- 150000007524 organic acids Chemical class 0.000 title abstract 5
- 230000004151 fermentation Effects 0.000 title abstract 3
- 238000000855 fermentation Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 235000005985 organic acids Nutrition 0.000 abstract 4
- 244000005700 microbiome Species 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/56—Lactic acid
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261701293P | 2012-09-14 | 2012-09-14 | |
| PCT/US2013/059828 WO2014043591A1 (en) | 2012-09-14 | 2013-09-13 | Production of organic acids by fermentation at low ph |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015005416A2 true BR112015005416A2 (pt) | 2017-08-08 |
Family
ID=50278737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015005416A BR112015005416A2 (pt) | 2012-09-14 | 2013-09-13 | produção de ácidos orgânicos por meio de fermentação em baixo ph |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11072807B2 (enExample) |
| EP (1) | EP2895593B1 (enExample) |
| JP (3) | JP2015528312A (enExample) |
| KR (1) | KR102253532B1 (enExample) |
| CN (1) | CN104812889B (enExample) |
| BR (1) | BR112015005416A2 (enExample) |
| CA (1) | CA2884266C (enExample) |
| MY (1) | MY182946A (enExample) |
| WO (1) | WO2014043591A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101978063B (zh) | 2007-11-20 | 2018-10-16 | 帝斯曼知识产权资产管理有限公司 | 在真核细胞中生产琥珀酸 |
| KR102311681B1 (ko) * | 2015-07-28 | 2021-10-12 | 삼성전자주식회사 | 내산성을 갖는 효모 세포, 그를 이용하여 유기산을 생산하는 방법 및 상기 내산성 효모 세포를 생산하는 방법 |
| KR20240005196A (ko) * | 2016-03-02 | 2024-01-11 | 피티티 글로벌 케미컬 퍼블릭 컴퍼니 리미티드 | 유전자 조작된 미생물로부터 개선된 뮤콘산 생산 |
| EP3267345A1 (en) * | 2016-07-06 | 2018-01-10 | European Molecular Biology Laboratory | Methods for adaptive laboratory evolution |
| JP2020530271A (ja) | 2017-06-30 | 2020-10-22 | ピーティーティー グローバル ケミカル パブリック カンパニー リミテッド | 安定化されたコピー数の機能性ｄｎａ配列を有する微生物及び関連方法 |
| WO2019005340A1 (en) | 2017-06-30 | 2019-01-03 | Myriant Corporation | GENETICALLY MODIFIED YEAST HAVING INCREASED PRODUCTION OF SUCCINIC ACID |
| KR102691949B1 (ko) * | 2018-02-16 | 2024-08-06 | 피티티 글로벌 케미칼 피씨엘 | 락트산 생성을 위한 미생물 및 방법 |
| CN108676736B (zh) * | 2018-04-20 | 2020-05-19 | 华中农业大学 | 一株可降解柠檬酸的毕赤酵母菌及其应用 |
| US12209236B2 (en) * | 2018-05-25 | 2025-01-28 | Danisco Us Inc. | Overexpression of fumarate reductase results in an increased fermentation rate in yeast |
| US12018245B2 (en) * | 2019-08-19 | 2024-06-25 | Ptt Global Chemical Public Company Limited | Yeast having improvement of lactic acid tolerance and use thereof |
| CN117467551A (zh) * | 2022-07-29 | 2024-01-30 | 中国科学院天津工业生物技术研究所 | 一种高产l-苹果酸的耐酸酵母菌株及其构建方法和应用 |
| CN119875861A (zh) * | 2023-10-24 | 2025-04-25 | 中国石油化工股份有限公司 | 一株耐酸马克斯克鲁维酵母菌株及其在生产丁二酸中的应用 |
| CN119162073A (zh) * | 2024-11-01 | 2024-12-20 | 湖南省微生物研究院 | 一株柠檬酸杆菌基因工程菌株及其构建方法和应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1294728B1 (it) * | 1997-09-12 | 1999-04-12 | Biopolo S C A R L | Ceppi di lievito per la riproduzione di acido lattico |
| US20070031950A1 (en) | 1998-09-11 | 2007-02-08 | Winkler Aaron A | Production of D-lactic acid with yeast |
| HUP0201204A3 (en) | 1999-05-21 | 2004-07-28 | Cargill Dow Llc Minnetonka | Methods and materials for synthesis of organic products |
| US7141410B2 (en) | 2000-11-22 | 2006-11-28 | Natureworks Llc | Methods and materials for the production of organic products in cells of Candida species |
| RU2182689C1 (ru) | 2001-06-14 | 2002-05-20 | Юрий Эдуардович Зевацкий | Способ и устройство для охлаждения рабочего тела и способ генерации микроволнового излучения |
| UA80976C2 (en) * | 2002-05-30 | 2007-11-26 | Cargill Dow Llc | Processes and materials for production of d-lactic acid in yeast |
| JP2008545429A (ja) | 2005-06-02 | 2008-12-18 | カーギル インコーポレイテッド | 遺伝子操作されたＩｓｓａｔｃｈｅｎｋｉａｏｒｉｅｎｔａｌｉｓ種又はその近隣種の酵母及びこの酵母を用いた発酵方法 |
| JP2009507493A (ja) * | 2005-09-09 | 2009-02-26 | ジェノマティカ・インコーポレイテッド | 増殖連動型のコハク酸塩生成のための方法と生物 |
| CA2623751A1 (en) | 2005-09-22 | 2007-04-05 | Tate & Lyle Ingredients Americas, Inc. | Improved strains for the production of organic acids |
| CN101287833A (zh) | 2005-10-14 | 2008-10-15 | 东丽株式会社 | 酵母和l-乳酸的制造方法 |
| US20080090273A1 (en) | 2005-11-21 | 2008-04-17 | Aaron Adriaan Winkler | Malic Acid Production in Recombinant Yeast |
| JP5121070B2 (ja) | 2005-11-23 | 2013-01-16 | ネイチャーワークス・エル・エル・シー | Ｌ−又はｄ−ラクタート：フェリチトクロームｃ酸化還元酵素遺伝子が機能しない乳酸産生酵母 |
| DE102007019184A1 (de) | 2007-04-20 | 2008-10-23 | Organo Balance Gmbh | Mikroorganismus zur Herstellung von Bernsteinsäure |
| WO2009011974A1 (en) | 2007-05-18 | 2009-01-22 | Microbia Precision Engineering, Inc. | Organic acid production by fungal cells |
| PL2173881T3 (pl) | 2007-07-23 | 2017-05-31 | Dsm Ip Assets B.V. | Acetylo-coa wytwarzający enzymy w drożdżach |
| EP2222854A1 (en) | 2007-11-20 | 2010-09-01 | DSM IP Assets B.V. | Dicarboxylic acid production in a filamentous fungus |
| ES2389989T3 (es) * | 2007-11-20 | 2012-11-05 | Dsm Ip Assets B.V. | Producción de ácido dicarboxílico en levadura recombinante |
| CN101978063B (zh) | 2007-11-20 | 2018-10-16 | 帝斯曼知识产权资产管理有限公司 | 在真核细胞中生产琥珀酸 |
| CN102016053A (zh) | 2008-02-15 | 2011-04-13 | 帝斯曼知识产权资产管理有限公司 | 生产二羧酸的方法 |
| EP3176265A1 (en) | 2008-07-08 | 2017-06-07 | DSM IP Assets B.V. | Dicarboxylic acid production by fermentation at low ph |
| DE102008051727A1 (de) | 2008-10-17 | 2010-04-22 | Organo Balance Gmbh | Mikroorganismus zur Herstellung von Bernsteinsäure |
| US20100104771A1 (en) | 2008-10-24 | 2010-04-29 | Applied Materials, Inc. | Electrode and power coupling scheme for uniform process in a large-area pecvd chamber |
| RU2422526C2 (ru) | 2009-01-30 | 2011-06-27 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов (ФГУП ГосНИИгенетика) | СПОСОБ ПОЛУЧЕНИЯ ЯНТАРНОЙ КИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ ДРОЖЖЕЙ, ПРИНАДЛЕЖАЩИХ К РОДУ Yarrowia |
| BRPI1009992A2 (pt) * | 2009-04-02 | 2020-08-18 | University Of Florida Research Foundation, Inc. | células bacterianas |
| WO2010118932A1 (en) | 2009-04-15 | 2010-10-21 | Dsm Ip Assets B.V. | Dicarboxylic acid production process |
| BR112012002153A2 (pt) * | 2009-07-30 | 2015-09-15 | Metabolic Explorer Sa | metilglioxal sintase mutante (mgs) para a produção de material bioquímico por fermentação |
| WO2011023700A2 (en) | 2009-08-27 | 2011-03-03 | Dsm Ip Assets B.V. | Dicarboxylic acid fermentation process |
| WO2011063157A2 (en) | 2009-11-18 | 2011-05-26 | Myriant Technologies Llc | Organic acid production in microorganisms by combined reductive and oxidative tricarboxylic acid cycle pathways |
| US8945140B2 (en) * | 2010-06-18 | 2015-02-03 | Vantage Surgical Systems, Inc. | Surgical procedures using instrument to boundary spacing information extracted from real-time diagnostic scan data |
| BR112013006883A2 (pt) | 2010-09-24 | 2016-06-07 | Dsm Ip Assets Bv | processo de produção de ácido dicarboxílico |
| EP2495304A1 (en) * | 2010-12-03 | 2012-09-05 | DSM IP Assets B.V. | Dicarboxylic acid production in a yeast cell |
| WO2012103263A2 (en) | 2011-01-25 | 2012-08-02 | Finley Kenneth R | Compositions and methods for malate and fumarate production |
| EP2668281A4 (en) | 2011-01-25 | 2015-08-26 | Cargill Inc | COMPOSITIONS AND METHODS OF SUCCINATE MANUFACTURE |
-
2013
- 2013-09-13 KR KR1020157009348A patent/KR102253532B1/ko active Active
- 2013-09-13 CA CA2884266A patent/CA2884266C/en active Active
- 2013-09-13 JP JP2015532113A patent/JP2015528312A/ja active Pending
- 2013-09-13 WO PCT/US2013/059828 patent/WO2014043591A1/en not_active Ceased
- 2013-09-13 US US14/428,202 patent/US11072807B2/en active Active
- 2013-09-13 BR BR112015005416A patent/BR112015005416A2/pt not_active Application Discontinuation
- 2013-09-13 CN CN201380058737.2A patent/CN104812889B/zh active Active
- 2013-09-13 EP EP13836449.2A patent/EP2895593B1/en active Active
- 2013-09-13 MY MYPI2015000632A patent/MY182946A/en unknown
-
2018
- 2018-05-08 JP JP2018089765A patent/JP6879976B2/ja active Active
-
2020
- 2020-04-30 JP JP2020080054A patent/JP2020127417A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2895593B1 (en) | 2019-12-11 |
| JP2020127417A (ja) | 2020-08-27 |
| US11072807B2 (en) | 2021-07-27 |
| EP2895593A4 (en) | 2016-06-22 |
| US20150240270A1 (en) | 2015-08-27 |
| KR102253532B1 (ko) | 2021-05-18 |
| CN104812889B (zh) | 2018-08-28 |
| CA2884266C (en) | 2022-05-24 |
| JP2018134108A (ja) | 2018-08-30 |
| JP6879976B2 (ja) | 2021-06-02 |
| MY182946A (en) | 2021-02-05 |
| CA2884266A1 (en) | 2014-03-20 |
| CN104812889A (zh) | 2015-07-29 |
| JP2015528312A (ja) | 2015-09-28 |
| WO2014043591A1 (en) | 2014-03-20 |
| KR20150055006A (ko) | 2015-05-20 |
| EP2895593A1 (en) | 2015-07-22 |
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