JP2015528312A - 低pH条件下での発酵による有機酸の生産 - Google Patents
低pH条件下での発酵による有機酸の生産 Download PDFInfo
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- JP2015528312A JP2015528312A JP2015532113A JP2015532113A JP2015528312A JP 2015528312 A JP2015528312 A JP 2015528312A JP 2015532113 A JP2015532113 A JP 2015532113A JP 2015532113 A JP2015532113 A JP 2015532113A JP 2015528312 A JP2015528312 A JP 2015528312A
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- C—CHEMISTRY; METALLURGY
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/56—Lactic acid
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- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
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- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261701293P | 2012-09-14 | 2012-09-14 | |
| US61/701,293 | 2012-09-14 | ||
| PCT/US2013/059828 WO2014043591A1 (en) | 2012-09-14 | 2013-09-13 | Production of organic acids by fermentation at low ph |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018089765A Division JP6879976B2 (ja) | 2012-09-14 | 2018-05-08 | 低pH条件下での発酵による有機酸の生産 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015528312A true JP2015528312A (ja) | 2015-09-28 |
| JP2015528312A5 JP2015528312A5 (enExample) | 2016-06-02 |
Family
ID=50278737
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532113A Pending JP2015528312A (ja) | 2012-09-14 | 2013-09-13 | 低pH条件下での発酵による有機酸の生産 |
| JP2018089765A Active JP6879976B2 (ja) | 2012-09-14 | 2018-05-08 | 低pH条件下での発酵による有機酸の生産 |
| JP2020080054A Pending JP2020127417A (ja) | 2012-09-14 | 2020-04-30 | 低pH条件下での発酵による有機酸の生産 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018089765A Active JP6879976B2 (ja) | 2012-09-14 | 2018-05-08 | 低pH条件下での発酵による有機酸の生産 |
| JP2020080054A Pending JP2020127417A (ja) | 2012-09-14 | 2020-04-30 | 低pH条件下での発酵による有機酸の生産 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11072807B2 (enExample) |
| EP (1) | EP2895593B1 (enExample) |
| JP (3) | JP2015528312A (enExample) |
| KR (1) | KR102253532B1 (enExample) |
| CN (1) | CN104812889B (enExample) |
| BR (1) | BR112015005416A2 (enExample) |
| CA (1) | CA2884266C (enExample) |
| MY (1) | MY182946A (enExample) |
| WO (1) | WO2014043591A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019528498A (ja) * | 2016-07-06 | 2019-10-10 | ヨーロピアン モレキュラー バイオロジー ラボラトリーEuropean Molecular Biology Laboratory | 適応実験室進化のための方法 |
| JP2020525026A (ja) * | 2017-06-30 | 2020-08-27 | ピーティーティー グローバル ケミカル パブリック カンパニー リミテッド | コハク酸産生が増加した遺伝子組換え酵母 |
| JP2022545630A (ja) * | 2019-08-19 | 2022-10-28 | ピーティーティー グローバル ケミカル パブリック カンパニー リミテッド | 乳酸耐性の向上を有する酵母およびその使用 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104818224A (zh) | 2007-11-20 | 2015-08-05 | 帝斯曼知识产权资产管理有限公司 | 在真核细胞中生产琥珀酸 |
| KR102311681B1 (ko) | 2015-07-28 | 2021-10-12 | 삼성전자주식회사 | 내산성을 갖는 효모 세포, 그를 이용하여 유기산을 생산하는 방법 및 상기 내산성 효모 세포를 생산하는 방법 |
| US20200181658A1 (en) * | 2016-03-02 | 2020-06-11 | Ptt Global Chemical Public Company Limited | Improved muconic acid production from genetically engineered microorganisms |
| JP2020530271A (ja) | 2017-06-30 | 2020-10-22 | ピーティーティー グローバル ケミカル パブリック カンパニー リミテッド | 安定化されたコピー数の機能性dna配列を有する微生物及び関連方法 |
| US11447802B2 (en) * | 2018-02-16 | 2022-09-20 | Ptt Global Chemical Public Company Limited | Microorganisms and processes for lactic acid production |
| CN108676736B (zh) * | 2018-04-20 | 2020-05-19 | 华中农业大学 | 一株可降解柠檬酸的毕赤酵母菌及其应用 |
| US12209236B2 (en) * | 2018-05-25 | 2025-01-28 | Danisco Us Inc. | Overexpression of fumarate reductase results in an increased fermentation rate in yeast |
| CN117467551A (zh) * | 2022-07-29 | 2024-01-30 | 中国科学院天津工业生物技术研究所 | 一种高产l-苹果酸的耐酸酵母菌株及其构建方法和应用 |
| CN119875861A (zh) * | 2023-10-24 | 2025-04-25 | 中国石油化工股份有限公司 | 一株耐酸马克斯克鲁维酵母菌株及其在生产丁二酸中的应用 |
| CN119162073A (zh) * | 2024-11-01 | 2024-12-20 | 湖南省微生物研究院 | 一株柠檬酸杆菌基因工程菌株及其构建方法和应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011502524A (ja) * | 2007-11-20 | 2011-01-27 | ディーエスエム アイピー アセッツ ビー.ブイ. | 真核細胞中におけるコハク酸の生成 |
| US20110129885A1 (en) * | 2007-04-20 | 2011-06-02 | Organo-Balance Gmbh | Microorganism for the production of succinic acid |
| US20120040422A1 (en) * | 2009-04-15 | 2012-02-16 | Dsm Ip Asset B.V. | Dicarboxylic acid production process |
| US20120225461A1 (en) * | 2009-11-18 | 2012-09-06 | Myriant Corporation | Organic acid production in microorganisms by combined reductive and oxidative tricaboxylic acid cylce pathways |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
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| IT1294728B1 (it) | 1997-09-12 | 1999-04-12 | Biopolo S C A R L | Ceppi di lievito per la riproduzione di acido lattico |
| US20070031950A1 (en) | 1998-09-11 | 2007-02-08 | Winkler Aaron A | Production of D-lactic acid with yeast |
| CA2374482C (en) | 1999-05-21 | 2012-09-18 | Cargill Dow Llc | Methods and materials for the synthesis of organic products |
| US7141410B2 (en) | 2000-11-22 | 2006-11-28 | Natureworks Llc | Methods and materials for the production of organic products in cells of Candida species |
| RU2182689C1 (ru) | 2001-06-14 | 2002-05-20 | Юрий Эдуардович Зевацкий | Способ и устройство для охлаждения рабочего тела и способ генерации микроволнового излучения |
| WO2003102200A2 (en) * | 2002-05-30 | 2003-12-11 | Cargill Dow Llc | Fermentation process using specific oxygen uptake rates as a process control |
| CN101287824A (zh) | 2005-06-02 | 2008-10-15 | 卡吉尔公司 | 东方伊氏酵母种及密切相关物种的基因修饰的酵母和采用它们的发酵方法 |
| AU2006287257A1 (en) * | 2005-09-09 | 2007-03-15 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of succinate |
| WO2007038130A2 (en) | 2005-09-22 | 2007-04-05 | Tate & Lyle Ingredients Americas, Inc. | Improved strains for the production of organic acids |
| EP1975232A4 (en) | 2005-10-14 | 2009-07-29 | Toray Industries | YEAST AND METHOD FOR THE PRODUCTION OF L-MILKY ACID |
| US20080090273A1 (en) | 2005-11-21 | 2008-04-17 | Aaron Adriaan Winkler | Malic Acid Production in Recombinant Yeast |
| WO2007117282A2 (en) | 2005-11-23 | 2007-10-18 | Natureworks Llc | Lactic acid-producing yeast cells having nonfunctional l-or d-lactate: ferricytochrome c oxidoreductase gene |
| EP2158323A4 (en) | 2007-05-18 | 2011-06-22 | Microbia Prec Engineering Inc | PRODUCTION OF ORGANIC ACID BY PILZ CELLS |
| WO2009013157A1 (en) | 2007-07-23 | 2009-01-29 | Dsm Ip Assets B.V. | Butanol production in a eukaryotic cell |
| EP2220234B1 (en) * | 2007-11-20 | 2012-06-27 | DSM IP Assets B.V. | Dicarboxylic acid production in a recombinant yeast |
| WO2009065777A1 (en) | 2007-11-20 | 2009-05-28 | Dsm Ip Assets B.V. | Dicarboxylic acid production in a filamentous fungus |
| US20110104771A1 (en) | 2008-02-15 | 2011-05-05 | Rene Verwall | Process for the production of a dicarboxylic acid |
| EA018463B1 (ru) | 2008-07-08 | 2013-08-30 | ДСМ АйПи АССЕТС Б.В. | ПОЛУЧЕНИЕ ДИКАРБОНОВЫХ КИСЛОТ ПРИ НИЗКИХ pH |
| DE102008051727A1 (de) | 2008-10-17 | 2010-04-22 | Organo Balance Gmbh | Mikroorganismus zur Herstellung von Bernsteinsäure |
| US20100104771A1 (en) | 2008-10-24 | 2010-04-29 | Applied Materials, Inc. | Electrode and power coupling scheme for uniform process in a large-area pecvd chamber |
| RU2422526C2 (ru) | 2009-01-30 | 2011-06-27 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов (ФГУП ГосНИИгенетика) | СПОСОБ ПОЛУЧЕНИЯ ЯНТАРНОЙ КИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ ДРОЖЖЕЙ, ПРИНАДЛЕЖАЩИХ К РОДУ Yarrowia |
| KR20120025450A (ko) * | 2009-04-02 | 2012-03-15 | 유니버시티 오브 플로리다 리서치 파운데이션, 인크. | 석시네이트 생성을 위한 경로의 엔지니어링 |
| JP5913099B2 (ja) * | 2009-07-30 | 2016-04-27 | メタボリック エクスプローラー | 発酵による生化学物質生産のための変異型メチルグリオキサールシンターゼ(mgs) |
| EP2470667B1 (en) | 2009-08-27 | 2017-11-15 | DSM IP Assets B.V. | Dicarboxylic acid fermentation process |
| US8945140B2 (en) * | 2010-06-18 | 2015-02-03 | Vantage Surgical Systems, Inc. | Surgical procedures using instrument to boundary spacing information extracted from real-time diagnostic scan data |
| CN103228791B (zh) | 2010-09-24 | 2016-06-15 | 帝斯曼知识产权资产管理有限公司 | 二羧酸生产工艺 |
| EP2495304A1 (en) * | 2010-12-03 | 2012-09-05 | DSM IP Assets B.V. | Dicarboxylic acid production in a yeast cell |
| WO2012103263A2 (en) | 2011-01-25 | 2012-08-02 | Finley Kenneth R | Compositions and methods for malate and fumarate production |
| US9605285B2 (en) | 2011-01-25 | 2017-03-28 | Cargill, Incorporated | Compositions and methods for succinate production |
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2013
- 2013-09-13 CA CA2884266A patent/CA2884266C/en active Active
- 2013-09-13 CN CN201380058737.2A patent/CN104812889B/zh active Active
- 2013-09-13 MY MYPI2015000632A patent/MY182946A/en unknown
- 2013-09-13 BR BR112015005416A patent/BR112015005416A2/pt not_active Application Discontinuation
- 2013-09-13 US US14/428,202 patent/US11072807B2/en active Active
- 2013-09-13 EP EP13836449.2A patent/EP2895593B1/en active Active
- 2013-09-13 WO PCT/US2013/059828 patent/WO2014043591A1/en not_active Ceased
- 2013-09-13 JP JP2015532113A patent/JP2015528312A/ja active Pending
- 2013-09-13 KR KR1020157009348A patent/KR102253532B1/ko active Active
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2018
- 2018-05-08 JP JP2018089765A patent/JP6879976B2/ja active Active
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2020
- 2020-04-30 JP JP2020080054A patent/JP2020127417A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110129885A1 (en) * | 2007-04-20 | 2011-06-02 | Organo-Balance Gmbh | Microorganism for the production of succinic acid |
| JP2011502524A (ja) * | 2007-11-20 | 2011-01-27 | ディーエスエム アイピー アセッツ ビー.ブイ. | 真核細胞中におけるコハク酸の生成 |
| US20120040422A1 (en) * | 2009-04-15 | 2012-02-16 | Dsm Ip Asset B.V. | Dicarboxylic acid production process |
| US20120225461A1 (en) * | 2009-11-18 | 2012-09-06 | Myriant Corporation | Organic acid production in microorganisms by combined reductive and oxidative tricaboxylic acid cylce pathways |
Non-Patent Citations (1)
| Title |
|---|
| J BIOL CHEM, 2011, VOL.286, NO.39, P.33737-33746, JPN6017050888, ISSN: 0003714149 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019528498A (ja) * | 2016-07-06 | 2019-10-10 | ヨーロピアン モレキュラー バイオロジー ラボラトリーEuropean Molecular Biology Laboratory | 適応実験室進化のための方法 |
| JP7181797B2 (ja) | 2016-07-06 | 2022-12-01 | ヨーロピアン モレキュラー バイオロジー ラボラトリー | 適応実験室進化のための方法 |
| JP2020525026A (ja) * | 2017-06-30 | 2020-08-27 | ピーティーティー グローバル ケミカル パブリック カンパニー リミテッド | コハク酸産生が増加した遺伝子組換え酵母 |
| JP2022545630A (ja) * | 2019-08-19 | 2022-10-28 | ピーティーティー グローバル ケミカル パブリック カンパニー リミテッド | 乳酸耐性の向上を有する酵母およびその使用 |
| JP7452900B2 (ja) | 2019-08-19 | 2024-03-19 | ピーティーティー グローバル ケミカル パブリック カンパニー リミテッド | 乳酸耐性の向上を有する酵母およびその使用 |
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| Publication number | Publication date |
|---|---|
| EP2895593B1 (en) | 2019-12-11 |
| JP2020127417A (ja) | 2020-08-27 |
| BR112015005416A2 (pt) | 2017-08-08 |
| JP6879976B2 (ja) | 2021-06-02 |
| CA2884266A1 (en) | 2014-03-20 |
| US11072807B2 (en) | 2021-07-27 |
| CA2884266C (en) | 2022-05-24 |
| WO2014043591A1 (en) | 2014-03-20 |
| US20150240270A1 (en) | 2015-08-27 |
| KR102253532B1 (ko) | 2021-05-18 |
| EP2895593A1 (en) | 2015-07-22 |
| EP2895593A4 (en) | 2016-06-22 |
| KR20150055006A (ko) | 2015-05-20 |
| CN104812889A (zh) | 2015-07-29 |
| CN104812889B (zh) | 2018-08-28 |
| JP2018134108A (ja) | 2018-08-30 |
| MY182946A (en) | 2021-02-05 |
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