BR112014029313A2 - conjugado de meningococos do sorogrupo x - Google Patents
conjugado de meningococos do sorogrupo xInfo
- Publication number
- BR112014029313A2 BR112014029313A2 BR112014029313A BR112014029313A BR112014029313A2 BR 112014029313 A2 BR112014029313 A2 BR 112014029313A2 BR 112014029313 A BR112014029313 A BR 112014029313A BR 112014029313 A BR112014029313 A BR 112014029313A BR 112014029313 A2 BR112014029313 A2 BR 112014029313A2
- Authority
- BR
- Brazil
- Prior art keywords
- conjugate
- composition
- serogroup
- polysaccharide
- carrier molecule
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8827—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8836—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving saccharides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261650025P | 2012-05-22 | 2012-05-22 | |
US201261698677P | 2012-09-09 | 2012-09-09 | |
US201361799528P | 2013-03-15 | 2013-03-15 | |
PCT/EP2013/060447 WO2013174832A1 (en) | 2012-05-22 | 2013-05-22 | Meningococcus serogroup x conjugate |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014029313A2 true BR112014029313A2 (pt) | 2017-06-27 |
Family
ID=48470983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014029313A BR112014029313A2 (pt) | 2012-05-22 | 2013-05-22 | conjugado de meningococos do sorogrupo x |
Country Status (14)
Country | Link |
---|---|
US (2) | US10124051B2 (es) |
EP (1) | EP2852414B9 (es) |
JP (2) | JP2015518845A (es) |
KR (1) | KR20150021933A (es) |
CN (1) | CN104736180A (es) |
AU (1) | AU2013265336A1 (es) |
BR (1) | BR112014029313A2 (es) |
CA (1) | CA2874210A1 (es) |
ES (1) | ES2820898T3 (es) |
IL (1) | IL235543A0 (es) |
MX (1) | MX2014014067A (es) |
RU (1) | RU2014151567A (es) |
SG (2) | SG11201407440WA (es) |
WO (1) | WO2013174832A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8329184B2 (en) | 2005-06-27 | 2012-12-11 | Glaxosmithkline Biologicals S.A. | Process for manufacturing vaccines |
SI2809349T1 (sl) * | 2012-01-30 | 2019-03-29 | Serum Institute Of India Private Limited | Imunogeni sestavek |
ES2820898T3 (es) * | 2012-05-22 | 2021-04-22 | Glaxosmithkline Biologicals Sa | Conjugado del serogrupo X de meningococos |
AU2013349261B2 (en) * | 2012-11-21 | 2017-09-07 | Serum Institute Of India Private Limited | Production of high yields of bacterial polysaccharides |
EP3131576B1 (en) * | 2014-04-17 | 2021-06-30 | Medizinische Hochschule Hannover | Means and methods for producing neisseria meningitidis capsular polysaccharides of low dispersity |
EP2952586B1 (en) | 2014-06-02 | 2021-10-27 | Serum Institute Of India Private Limited | Bacterial capsular polysaccharide yield enhancement by addition of defoaming agents |
EP2977759B1 (en) * | 2014-07-25 | 2017-07-12 | Serum Institute of India Private Limited | Highly sensitive immunoassay for rapid quantification of meningococcal capsular polysaccharide antigens |
MX2019002489A (es) | 2016-09-02 | 2019-10-21 | Sanofi Pasteur Inc | Vacuna contra neisseria meningitidis. |
US20230137821A1 (en) * | 2016-11-25 | 2023-05-04 | Glaxosmithkline Biologicals, S.A. | Immunogenic conjugates and use thereof |
US20230137914A1 (en) * | 2016-11-25 | 2023-05-04 | Glaxosmithkline Biologicals, S.A. | nOMV-ANTIGEN CONJUGATED COMPOUNDS AND USE THEREOF |
CN110809477A (zh) * | 2017-06-27 | 2020-02-18 | 默沙东和惠康基金会合资的希勒曼实验室私人有限公司 | 新型多价多糖-蛋白轭合物疫苗组合物及其制剂 |
US20220387614A1 (en) | 2019-11-22 | 2022-12-08 | Glaxosmithkline Biologicals Sa | Dosage and administration of a bacterial saccharide glycoconjugate vaccine |
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-
2013
- 2013-05-22 ES ES13724265T patent/ES2820898T3/es active Active
- 2013-05-22 KR KR20147034885A patent/KR20150021933A/ko not_active Application Discontinuation
- 2013-05-22 EP EP13724265.7A patent/EP2852414B9/en active Active
- 2013-05-22 SG SG11201407440WA patent/SG11201407440WA/en unknown
- 2013-05-22 BR BR112014029313A patent/BR112014029313A2/pt not_active IP Right Cessation
- 2013-05-22 MX MX2014014067A patent/MX2014014067A/es unknown
- 2013-05-22 RU RU2014151567A patent/RU2014151567A/ru not_active Application Discontinuation
- 2013-05-22 JP JP2015513141A patent/JP2015518845A/ja active Pending
- 2013-05-22 AU AU2013265336A patent/AU2013265336A1/en not_active Abandoned
- 2013-05-22 CA CA 2874210 patent/CA2874210A1/en not_active Abandoned
- 2013-05-22 SG SG10201608675YA patent/SG10201608675YA/en unknown
- 2013-05-22 WO PCT/EP2013/060447 patent/WO2013174832A1/en active Application Filing
- 2013-05-22 US US14/401,024 patent/US10124051B2/en active Active
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2014
- 2014-11-06 IL IL235543A patent/IL235543A0/en unknown
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2017
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2018
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JP2017088622A (ja) | 2017-05-25 |
US20190060437A1 (en) | 2019-02-28 |
WO2013174832A1 (en) | 2013-11-28 |
EP2852414A1 (en) | 2015-04-01 |
ES2820898T3 (es) | 2021-04-22 |
MX2014014067A (es) | 2015-02-04 |
CA2874210A1 (en) | 2013-11-28 |
RU2014151567A (ru) | 2016-07-10 |
AU2013265336A1 (en) | 2014-12-04 |
EP2852414B9 (en) | 2020-12-09 |
SG10201608675YA (en) | 2016-12-29 |
US20150104479A1 (en) | 2015-04-16 |
US10668143B2 (en) | 2020-06-02 |
EP2852414B1 (en) | 2020-07-08 |
SG11201407440WA (en) | 2014-12-30 |
CN104736180A (zh) | 2015-06-24 |
IL235543A0 (en) | 2015-01-29 |
US10124051B2 (en) | 2018-11-13 |
JP2015518845A (ja) | 2015-07-06 |
KR20150021933A (ko) | 2015-03-03 |
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