BR112014017630A8 - Métodos para a determinação de presença e/ou da quantidade de um antígeno - Google Patents

Métodos para a determinação de presença e/ou da quantidade de um antígeno

Info

Publication number
BR112014017630A8
BR112014017630A8 BR112014017630A BR112014017630A BR112014017630A8 BR 112014017630 A8 BR112014017630 A8 BR 112014017630A8 BR 112014017630 A BR112014017630 A BR 112014017630A BR 112014017630 A BR112014017630 A BR 112014017630A BR 112014017630 A8 BR112014017630 A8 BR 112014017630A8
Authority
BR
Brazil
Prior art keywords
antigen
antibody
determining
methods
sample
Prior art date
Application number
BR112014017630A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112014017630A2 (enExample
Inventor
Stubenrauch Kay-Gunnar
Wessels Uwe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112014017630A2 publication Critical patent/BR112014017630A2/pt
Publication of BR112014017630A8 publication Critical patent/BR112014017630A8/pt

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306Solid-phase reaction mechanisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
BR112014017630A 2012-02-01 2013-01-29 Métodos para a determinação de presença e/ou da quantidade de um antígeno BR112014017630A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12153457 2012-02-01
EP12182505 2012-08-31
PCT/EP2013/051604 WO2013113663A1 (en) 2012-02-01 2013-01-29 Method for the detection of a binding partner of a multispecific binder

Publications (2)

Publication Number Publication Date
BR112014017630A2 BR112014017630A2 (enExample) 2017-06-20
BR112014017630A8 true BR112014017630A8 (pt) 2017-07-11

Family

ID=47624068

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014017630A BR112014017630A8 (pt) 2012-02-01 2013-01-29 Métodos para a determinação de presença e/ou da quantidade de um antígeno

Country Status (10)

Country Link
US (3) US9945869B2 (enExample)
EP (1) EP2810074B1 (enExample)
JP (3) JP2015507193A (enExample)
KR (1) KR20140128314A (enExample)
CN (2) CN104105966B (enExample)
BR (1) BR112014017630A8 (enExample)
CA (1) CA2859268A1 (enExample)
MX (1) MX349661B (enExample)
RU (1) RU2620563C2 (enExample)
WO (1) WO2013113663A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014017630A8 (pt) 2012-02-01 2017-07-11 Hoffmann La Roche Métodos para a determinação de presença e/ou da quantidade de um antígeno
JP6226976B2 (ja) 2012-07-13 2017-11-08 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 多重特異性結合物を検出するための方法
EP3066469B1 (en) * 2013-11-05 2017-10-11 Roche Diagnostics GmbH A method for determining the total amount and/or concentration of an analyte in the presence of a binding molecule as well as kits, compositions and uses relating thereto
CN104109197B (zh) * 2013-11-13 2017-05-10 叶森 一种双识别抗体片段的制备方法及其应用
RS62258B1 (sr) 2015-10-02 2021-09-30 Hoffmann La Roche Bispecifična antitela specifična za pd1 i tim3
WO2017055399A1 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Cellular based fret assay for the determination of simultaneous binding
US20200087374A1 (en) * 2017-02-06 2020-03-19 Resiliun B.V. Interaction between c-peptides and elastin receptor, a model for understanding vascular disease
JP7426825B2 (ja) 2017-04-03 2024-02-02 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト 抗pd-1抗体と突然変異il-2とまたはil-15とのイムノコンジュゲート
US11285207B2 (en) 2017-04-05 2022-03-29 Hoffmann-La Roche Inc. Bispecific antibodies specifically binding to PD1 and LAG3
EP3805757A4 (en) * 2018-06-04 2022-03-23 Chugai Seiyaku Kabushiki Kaisha Method for detecting complex
EP3969907B1 (en) * 2019-05-13 2025-09-24 F. Hoffmann-La Roche AG Interference-suppressed pharmacokinetic immunoassay
WO2022065052A1 (ja) * 2020-09-24 2022-03-31 株式会社Jvcケンウッド 捕捉用抗体、固相担体、検出用抗体、固相担体粒子、並びに検出対象物質の測定キット及び測定方法
CN117805397A (zh) * 2024-02-29 2024-04-02 军科正源(北京)药物研究有限责任公司 检测游离vegf的方法

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219730A (en) 1982-09-28 1993-06-15 New York University Idiotype-anti-idiotype immunoassay
US4828981A (en) 1983-08-24 1989-05-09 Synbiotics Corporation Immunoassays for determining Dirofilaria immitis infection using antiidiotype monoclonal antibody reagents
EP0170302A1 (fr) 1984-06-27 1986-02-05 l'Association internationale à but scientifique, dite: Institut international de pathologie cellulaire et moléculaire Procédé de dosage immunologique d'une substance dans un échantillon liquide au moyen d'anticorps anti-idiotypiques
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
EP0243471A4 (en) 1985-10-22 1989-07-11 Cooper Lipotech Inc SOLID PHASE LIPOSOME IMMUNOANALYSIS SYSTEM.
EP0446245B1 (en) 1988-11-03 1999-05-12 Igen International, Inc. Electrochemiluminescent assays
US5068088A (en) 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
IL100866A (en) 1991-02-06 1995-10-31 Igen Inc Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
NZ255041A (en) 1992-07-13 1996-11-26 Bionebraska Inc Preparation of a recombinant single copy polypeptide or portion thereof modified with a terminal alpha amino carbon reactive group and reactive side chain groups involving biologically added protective groups
JPH097096A (ja) 1995-06-20 1997-01-10 Alpine Electron Inc 緊急車両接近時の報知方法
JPH0975096A (ja) * 1995-09-14 1997-03-25 Snow Brand Milk Prod Co Ltd ラクトフェリンの測定法
WO1999027368A1 (en) 1997-11-21 1999-06-03 Unilever Plc Improvements in or relating to displacement assays
US6753189B1 (en) 1998-06-04 2004-06-22 Mizuho Medy Co., Ltd. Detection apparatus and method for the same
JPH11352129A (ja) * 1998-06-04 1999-12-24 Mizuho Medeii:Kk 検出装置及び検出方法
ATE315789T1 (de) * 1999-11-16 2006-02-15 Genentech Inc Elisa für vegf
GB0007088D0 (en) * 2000-03-23 2000-05-17 Torsana A S Detection of immunological memory determining the position of loci of pathologyand therapeutic t-cell conjugates
US6984494B2 (en) 2000-08-15 2006-01-10 Genentech, Inc. Analytical method
US7341837B2 (en) 2003-09-02 2008-03-11 Lawton Robert L Soluble analyte detection and amplification
WO2006096697A2 (en) * 2005-03-08 2006-09-14 Tanox, Inc. Methods for determining the bivalency of protein and antibody therapeutics
US7494776B2 (en) 2005-07-07 2009-02-24 Beckman Coulter, Inc. Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands
JP2009501913A (ja) 2005-07-21 2009-01-22 ゲンマブ エー/エス Fc受容体と結合する抗体原薬に関する効力アッセイ
CN101268372A (zh) * 2005-07-21 2008-09-17 根马布股份公司 与fc受体结合的抗体药物的药效测定
RU2517301C2 (ru) * 2006-10-04 2014-05-27 Дженентек, Инк. Твердофазный иммуноферментный анализ (elisa) для фактора роста эндотелия сосудов (vegf)
EP1917854A1 (en) 2006-11-06 2008-05-07 F. Hoffmann-La Roche Ag Method for producing anti idiotypic antibodies
US8227577B2 (en) 2007-12-21 2012-07-24 Hoffman-La Roche Inc. Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
BRPI0913406A2 (pt) * 2008-06-03 2018-01-09 Abbott Lab imunoglobulinas de domínio variável duplo e usos das mesmas
US20110195524A1 (en) * 2008-10-07 2011-08-11 Mats Inganas Semi-sequential assay for detection of an analyte in a sample
CN102369215B (zh) 2009-04-02 2015-01-21 罗切格利卡特公司 包含全长抗体和单链Fab片段的多特异性抗体
SI2417156T1 (sl) 2009-04-07 2015-06-30 Roche Glycart Ag Trivalentna, bispecifiäśna protitelesa
CN102448985B (zh) 2009-05-27 2015-08-05 霍夫曼-拉罗奇有限公司 三或四特异性抗体
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
US8703132B2 (en) 2009-06-18 2014-04-22 Hoffmann-La Roche, Inc. Bispecific, tetravalent antigen binding proteins
SG2014014823A (en) * 2009-10-19 2014-07-30 Hoffmann La Roche Non-cross-reactive anti igg antibodies
CN102207504A (zh) * 2011-03-23 2011-10-05 北京华创远航科技有限公司 一种酶联检测试剂盒及其制备方法
WO2013092611A2 (en) 2011-12-19 2013-06-27 F. Hoffmann - La Roche Ag Method for the detection of free binding partner of a multispecific binder
BR112014017630A8 (pt) 2012-02-01 2017-07-11 Hoffmann La Roche Métodos para a determinação de presença e/ou da quantidade de um antígeno
WO2013130412A1 (en) * 2012-02-27 2013-09-06 Bio-Rad Laboratories, Inc. Anti-immune complex antibodies
JP6226976B2 (ja) 2012-07-13 2017-11-08 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 多重特異性結合物を検出するための方法

Also Published As

Publication number Publication date
KR20140128314A (ko) 2014-11-05
JP6502441B2 (ja) 2019-04-17
US20180328942A1 (en) 2018-11-15
MX349661B (es) 2017-08-08
CN104105966B (zh) 2016-10-26
CN104105966A (zh) 2014-10-15
CA2859268A1 (en) 2013-08-08
CN106443016B (zh) 2019-08-13
US9945869B2 (en) 2018-04-17
RU2014133701A (ru) 2016-03-27
US20210055304A1 (en) 2021-02-25
CN106443016A (zh) 2017-02-22
EP2810074B1 (en) 2017-08-23
HK1202921A1 (en) 2015-10-09
WO2013113663A1 (en) 2013-08-08
JP6678792B2 (ja) 2020-04-08
JP2015507193A (ja) 2015-03-05
JP2017223710A (ja) 2017-12-21
MX2014008762A (es) 2014-08-27
RU2620563C2 (ru) 2017-05-26
BR112014017630A2 (enExample) 2017-06-20
JP2019113564A (ja) 2019-07-11
US20140342382A1 (en) 2014-11-20
US10761097B2 (en) 2020-09-01
EP2810074A1 (en) 2014-12-10

Similar Documents

Publication Publication Date Title
BR112014017630A8 (pt) Métodos para a determinação de presença e/ou da quantidade de um antígeno
BR112014008382A2 (pt) anticorpo especificamente ligando a epítope no domínio sema do c-met
MX349003B (es) Metodo para la deteccion del asociado de union libre de un aglutinante multiespecifico.
DK2890717T3 (da) Diagnostiske assays og kits til detektering af folatreceptor 1
BR112016029634A2 (pt) kit, dispositivo e método para a detecção de câncer de fígado
BR112013021666A2 (pt) detecção de capacitância em ensaio eletroquímico com compensação de tempo de amostragem aprimorada
BR112014014077A2 (pt) método para realizar uma determinação quantitativa e/ou qualitativa de finos catalíticos em óleo combustível, e, sistema apropriado para determinar finos catalíticos em um óleo combustível
EA201590027A1 (ru) Способы детекции заболеваний или состояний
BR112014025384A8 (pt) método e sistema para executar ensaio automatizado e métodos para executar teste reflexivo em vários exemplares
EA201600085A1 (ru) Набор для обнаружения соевого события syht0h2
BR112014002616A2 (pt) método para detectar cãncer pancreático e reagente ou kit para detectar câncer pancreático
EP2698381A4 (en) ANTIBODIES, KIT AND METHOD FOR DETERMINING AMYLOID PEPTIDES
BR112014018831A2 (pt) método para otimizar sensibilidade e/ou seletividade de um sensor para um ou mais analitos, método para formar um sensor para um ou mais analitos, kit para a detecção de um ou mais analitos, método de identificação de um aptâmero, composição de matéria e aptâmeros.
BR112014012590A8 (pt) Anticorpos anti-cd98 e métodos de uso dos mesmos
MX2014015847A (es) Pruebas de cemento.
BR112012021590A2 (pt) detecção de capacitância em ensaio eletroquímico
BR112016002668A2 (pt) métodos e kits para prognosticar o risco de ter uma doença ou evento cardiovasculares
BR112018007842A2 (pt) imunoensaio para a detecção de cininogênio clivado de alto peso molecular, método, anticorpo isolado, kit para detectar um cininogênio de alto peso molecular clivado (hmwk)
BR112012023698A2 (pt) métodos, kits e composições para a detecção de mrsa
RU2015104737A (ru) Способ обнаружения мультиспецифического связывающего агента
MX353954B (es) Aptameros y metodos de diagnostico para detectar el receptor del factor de crecimiento epidermal (egf).
EP2599865A4 (en) MONOCLONAL ANTI-FDP ANTIBODY, FDP MEASURING REAGENT AND REAGENT KIT THEREFOR, AND FDP MEASUREMENT PROCEDURES
EP2762873A4 (en) METHOD FOR SPECIFIC DETECTION OF A TEST SUBSTANCE
BR112017021507A2 (pt) métodos para a seleção de inibidores seletivos e não seletivos de fosfatase
BR112014009223A2 (pt) método para o diagnóstico da doença de niemann-pick

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2551 DE 26-11-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.