CN104105966B - 用于检测多特异性结合物的结合搭档的方法 - Google Patents

用于检测多特异性结合物的结合搭档的方法 Download PDF

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Publication number
CN104105966B
CN104105966B CN201380007278.5A CN201380007278A CN104105966B CN 104105966 B CN104105966 B CN 104105966B CN 201380007278 A CN201380007278 A CN 201380007278A CN 104105966 B CN104105966 B CN 104105966B
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antibody
antigen
sample
binding
idiotype
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Chinese (zh)
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CN104105966A (zh
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K-G·施图本拉赫
U·韦塞尔斯
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
CN201380007278.5A 2012-02-01 2013-01-29 用于检测多特异性结合物的结合搭档的方法 Active CN104105966B (zh)

Priority Applications (1)

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CN201610880999.2A CN106443016B (zh) 2012-02-01 2013-01-29 用于检测多特异性结合物的结合搭档的方法

Applications Claiming Priority (5)

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EP12153457 2012-02-01
EP12153457.2 2012-02-01
EP12182505 2012-08-31
EP12182505.3 2012-08-31
PCT/EP2013/051604 WO2013113663A1 (en) 2012-02-01 2013-01-29 Method for the detection of a binding partner of a multispecific binder

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CN104105966A CN104105966A (zh) 2014-10-15
CN104105966B true CN104105966B (zh) 2016-10-26

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US (3) US9945869B2 (enExample)
EP (1) EP2810074B1 (enExample)
JP (3) JP2015507193A (enExample)
KR (1) KR20140128314A (enExample)
CN (2) CN106443016B (enExample)
BR (1) BR112014017630A8 (enExample)
CA (1) CA2859268A1 (enExample)
MX (1) MX349661B (enExample)
RU (1) RU2620563C2 (enExample)
WO (1) WO2013113663A1 (enExample)

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WO2017055399A1 (en) * 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Cellular based fret assay for the determination of simultaneous binding
CN114773481B (zh) 2015-10-02 2025-04-29 豪夫迈·罗氏有限公司 对pd1和tim3特异性的双特异性抗体
JP7438757B2 (ja) * 2017-02-06 2024-02-27 バイオテンプト・ベー・フェー 治療用途のためのヒトｃペプチドとヒトエラスチン受容体との相互作用のペプチドモジュレーター
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WO2022065052A1 (ja) * 2020-09-24 2022-03-31 株式会社Ｊｖｃケンウッド 捕捉用抗体、固相担体、検出用抗体、固相担体粒子、並びに検出対象物質の測定キット及び測定方法
CN117805397A (zh) * 2024-02-29 2024-04-02 军科正源（北京）药物研究有限责任公司 检测游离vegf的方法

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Publication number Publication date
CA2859268A1 (en) 2013-08-08
JP2017223710A (ja) 2017-12-21
US20180328942A1 (en) 2018-11-15
EP2810074A1 (en) 2014-12-10
WO2013113663A1 (en) 2013-08-08
JP2015507193A (ja) 2015-03-05
CN106443016B (zh) 2019-08-13
CN104105966A (zh) 2014-10-15
EP2810074B1 (en) 2017-08-23
US10761097B2 (en) 2020-09-01
MX349661B (es) 2017-08-08
HK1202921A1 (en) 2015-10-09
KR20140128314A (ko) 2014-11-05
BR112014017630A8 (pt) 2017-07-11
US20140342382A1 (en) 2014-11-20
RU2620563C2 (ru) 2017-05-26
US20210055304A1 (en) 2021-02-25
CN106443016A (zh) 2017-02-22
MX2014008762A (es) 2014-08-27
US9945869B2 (en) 2018-04-17
RU2014133701A (ru) 2016-03-27
JP6502441B2 (ja) 2019-04-17
JP2019113564A (ja) 2019-07-11
BR112014017630A2 (enExample) 2017-06-20
JP6678792B2 (ja) 2020-04-08

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