KR20140128314A - 다중특이적 결합제의 결합 파트너 검출 방법 - Google Patents

다중특이적 결합제의 결합 파트너 검출 방법 Download PDF

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Publication number
KR20140128314A
KR20140128314A KR1020147021674A KR20147021674A KR20140128314A KR 20140128314 A KR20140128314 A KR 20140128314A KR 1020147021674 A KR1020147021674 A KR 1020147021674A KR 20147021674 A KR20147021674 A KR 20147021674A KR 20140128314 A KR20140128314 A KR 20140128314A
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KR
South Korea
Prior art keywords
antibody
antigen
sample
binding
bispecific antibody
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Ceased
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KR1020147021674A
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English (en)
Korean (ko)
Inventor
카이-군나르 슈투벤라우히
우베 베쎌스
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에프. 호프만-라 로슈 아게
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Publication of KR20140128314A publication Critical patent/KR20140128314A/ko
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
KR1020147021674A 2012-02-01 2013-01-29 다중특이적 결합제의 결합 파트너 검출 방법 Ceased KR20140128314A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12153457.2 2012-02-01
EP12153457 2012-02-01
EP12182505.3 2012-08-31
EP12182505 2012-08-31
PCT/EP2013/051604 WO2013113663A1 (en) 2012-02-01 2013-01-29 Method for the detection of a binding partner of a multispecific binder

Publications (1)

Publication Number Publication Date
KR20140128314A true KR20140128314A (ko) 2014-11-05

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KR1020147021674A Ceased KR20140128314A (ko) 2012-02-01 2013-01-29 다중특이적 결합제의 결합 파트너 검출 방법

Country Status (10)

Country Link
US (3) US9945869B2 (enExample)
EP (1) EP2810074B1 (enExample)
JP (3) JP2015507193A (enExample)
KR (1) KR20140128314A (enExample)
CN (2) CN104105966B (enExample)
BR (1) BR112014017630A8 (enExample)
CA (1) CA2859268A1 (enExample)
MX (1) MX349661B (enExample)
RU (1) RU2620563C2 (enExample)
WO (1) WO2013113663A1 (enExample)

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KR20140128314A (ko) 2012-02-01 2014-11-05 에프. 호프만-라 로슈 아게 다중특이적 결합제의 결합 파트너 검출 방법
EP2872893B1 (en) 2012-07-13 2017-03-29 F. Hoffmann-La Roche AG Method for the detection of a multispecific antibody
JP6446044B2 (ja) * 2013-11-05 2018-12-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 結合分子の存在下で被検体の総量および／または総濃度を決定するための方法、ならびにそれに関係するキット、組成物および使用
CN104109197B (zh) * 2013-11-13 2017-05-10 叶森 一种双识别抗体片段的制备方法及其应用
CN108139394B (zh) * 2015-10-02 2020-10-30 豪夫迈·罗氏有限公司 用于确定同时结合的基于细胞的fret测定法
MA43028B1 (fr) 2015-10-02 2021-09-30 Hoffmann La Roche Anticorps bispécifiques pour pd1 et tim3
ES2927977T3 (es) * 2017-02-06 2022-11-14 Biotempt Bv Moduladores peptídicos de la interacción entre el péptido C humano y el receptor de elastina humana para uso terapéutico
KR102461885B1 (ko) 2017-04-03 2022-11-03 에프. 호프만-라 로슈 아게 항-pd-1 항체와 돌연변이 il-2 또는 il-15의 면역접합체
CA3052532A1 (en) 2017-04-05 2018-10-11 F. Hoffmann-La Roche Ag Bispecific antibodies specifically binding to pd1 and lag3
JP7370322B2 (ja) 2018-06-04 2023-10-27 中外製薬株式会社 複合体を検出する方法
EP3969907B1 (en) * 2019-05-13 2025-09-24 F. Hoffmann-La Roche AG Interference-suppressed pharmacokinetic immunoassay
WO2022065052A1 (ja) * 2020-09-24 2022-03-31 株式会社Ｊｖｃケンウッド 捕捉用抗体、固相担体、検出用抗体、固相担体粒子、並びに検出対象物質の測定キット及び測定方法
CN117805397A (zh) * 2024-02-29 2024-04-02 军科正源（北京）药物研究有限责任公司 检测游离vegf的方法

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CN104040350B (zh) 2011-12-19 2016-05-18 弗·哈夫曼-拉罗切有限公司 用于检测多特异性结合物的游离结合搭档的方法
KR20140128314A (ko) 2012-02-01 2014-11-05 에프. 호프만-라 로슈 아게 다중특이적 결합제의 결합 파트너 검출 방법
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Also Published As

Publication number Publication date
WO2013113663A1 (en) 2013-08-08
MX2014008762A (es) 2014-08-27
RU2014133701A (ru) 2016-03-27
CN106443016B (zh) 2019-08-13
JP2019113564A (ja) 2019-07-11
MX349661B (es) 2017-08-08
BR112014017630A2 (enExample) 2017-06-20
CA2859268A1 (en) 2013-08-08
JP6678792B2 (ja) 2020-04-08
US20210055304A1 (en) 2021-02-25
JP6502441B2 (ja) 2019-04-17
HK1202921A1 (en) 2015-10-09
JP2017223710A (ja) 2017-12-21
JP2015507193A (ja) 2015-03-05
EP2810074A1 (en) 2014-12-10
US20140342382A1 (en) 2014-11-20
CN104105966A (zh) 2014-10-15
RU2620563C2 (ru) 2017-05-26
CN104105966B (zh) 2016-10-26
US9945869B2 (en) 2018-04-17
BR112014017630A8 (pt) 2017-07-11
EP2810074B1 (en) 2017-08-23
CN106443016A (zh) 2017-02-22
US20180328942A1 (en) 2018-11-15
US10761097B2 (en) 2020-09-01

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