JP2015507193A - 多重特異性結合物の結合パートナーを検出するための方法 - Google Patents

多重特異性結合物の結合パートナーを検出するための方法 Download PDF

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JP2015507193A
JP2015507193A JP2014555164A JP2014555164A JP2015507193A JP 2015507193 A JP2015507193 A JP 2015507193A JP 2014555164 A JP2014555164 A JP 2014555164A JP 2014555164 A JP2014555164 A JP 2014555164A JP 2015507193 A JP2015507193 A JP 2015507193A
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antibody
antigen
sample
bispecific antibody
binding specificity
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Japanese (ja)
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カイ‐グナール シュトゥーベンラウフ
カイ‐グナール シュトゥーベンラウフ
ウーベ ヴェッセルス
ウーベ ヴェッセルス
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F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
JP2014555164A 2012-02-01 2013-01-29 多重特異性結合物の結合パートナーを検出するための方法 Pending JP2015507193A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12153457 2012-02-01
EP12153457.2 2012-02-01
EP12182505.3 2012-08-31
EP12182505 2012-08-31
PCT/EP2013/051604 WO2013113663A1 (en) 2012-02-01 2013-01-29 Method for the detection of a binding partner of a multispecific binder

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JP2017163827A Division JP6502441B2 (ja) 2012-02-01 2017-08-29 多重特異性結合物の結合パートナーを検出するための方法

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JP2014555164A Pending JP2015507193A (ja) 2012-02-01 2013-01-29 多重特異性結合物の結合パートナーを検出するための方法
JP2017163827A Active JP6502441B2 (ja) 2012-02-01 2017-08-29 多重特異性結合物の結合パートナーを検出するための方法
JP2019052527A Active JP6678792B2 (ja) 2012-02-01 2019-03-20 多重特異性結合物の結合パートナーを検出するための方法

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JP2019052527A Active JP6678792B2 (ja) 2012-02-01 2019-03-20 多重特異性結合物の結合パートナーを検出するための方法

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US (3) US9945869B2 (enExample)
EP (1) EP2810074B1 (enExample)
JP (3) JP2015507193A (enExample)
KR (1) KR20140128314A (enExample)
CN (2) CN104105966B (enExample)
BR (1) BR112014017630A8 (enExample)
CA (1) CA2859268A1 (enExample)
MX (1) MX349661B (enExample)
RU (1) RU2620563C2 (enExample)
WO (1) WO2013113663A1 (enExample)

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CN104105966B (zh) 2012-02-01 2016-10-26 弗·哈夫曼-拉罗切有限公司 用于检测多特异性结合物的结合搭档的方法
WO2014009474A1 (en) 2012-07-13 2014-01-16 F. Hoffmann-La Roche Ag Method for the detection of a multispecific binder
CA2926306C (en) * 2013-11-05 2022-12-06 F. Hoffmann-La Roche Ag A method for determining the total amount and/or concentration of an analyte in a sample
CN104109197B (zh) * 2013-11-13 2017-05-10 叶森 一种双识别抗体片段的制备方法及其应用
PE20180773A1 (es) 2015-10-02 2018-05-07 Hoffmann La Roche Anticuerpos biespecificos para pd1 y tim3
EP3356821B1 (en) * 2015-10-02 2019-10-23 H. Hoffnabb-La Roche Ag Cellular based fret assay for the determination of simultaneous binding
WO2018141969A1 (en) * 2017-02-06 2018-08-09 Biotempt B.V. Peptide modulators of the interaction between human c-peptide and human elastin receptor for therapeutic use
PT3606946T (pt) 2017-04-03 2022-10-17 Hoffmann La Roche Imunoconjugados de um anticorpo anti-pd-1 com uma il-2 mutante ou com il-15
CN116375876A (zh) 2017-04-05 2023-07-04 豪夫迈·罗氏有限公司 特异性结合pd1和lag3的双特异性抗体
US12493033B2 (en) * 2018-06-04 2025-12-09 Chugai Seiyaku Kabushiki Kaisha Method for detecting bi-specific antibody complex
EP3969907B1 (en) * 2019-05-13 2025-09-24 F. Hoffmann-La Roche AG Interference-suppressed pharmacokinetic immunoassay
WO2022065052A1 (ja) * 2020-09-24 2022-03-31 株式会社Ｊｖｃケンウッド 捕捉用抗体、固相担体、検出用抗体、固相担体粒子、並びに検出対象物質の測定キット及び測定方法
CN117805397A (zh) * 2024-02-29 2024-04-02 军科正源（北京）药物研究有限责任公司 检测游离vegf的方法

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CN104105966B (zh) 2016-10-26
BR112014017630A2 (enExample) 2017-06-20
US20140342382A1 (en) 2014-11-20
US20180328942A1 (en) 2018-11-15
US10761097B2 (en) 2020-09-01
BR112014017630A8 (pt) 2017-07-11
JP6678792B2 (ja) 2020-04-08
KR20140128314A (ko) 2014-11-05
JP6502441B2 (ja) 2019-04-17
MX2014008762A (es) 2014-08-27
HK1202921A1 (en) 2015-10-09
RU2014133701A (ru) 2016-03-27
WO2013113663A1 (en) 2013-08-08
CA2859268A1 (en) 2013-08-08
CN106443016B (zh) 2019-08-13
JP2019113564A (ja) 2019-07-11
MX349661B (es) 2017-08-08
JP2017223710A (ja) 2017-12-21
RU2620563C2 (ru) 2017-05-26
US9945869B2 (en) 2018-04-17
US20210055304A1 (en) 2021-02-25
CN104105966A (zh) 2014-10-15
CN106443016A (zh) 2017-02-22
EP2810074B1 (en) 2017-08-23
EP2810074A1 (en) 2014-12-10

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