BR112013022094A2 - composições e métodos para o tratamento não cirúrgico da ptose - Google Patents
composições e métodos para o tratamento não cirúrgico da ptoseInfo
- Publication number
- BR112013022094A2 BR112013022094A2 BR112013022094A BR112013022094A BR112013022094A2 BR 112013022094 A2 BR112013022094 A2 BR 112013022094A2 BR 112013022094 A BR112013022094 A BR 112013022094A BR 112013022094 A BR112013022094 A BR 112013022094A BR 112013022094 A2 BR112013022094 A2 BR 112013022094A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- ptosis
- methods
- oxymetazoline
- surgical treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
- B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Mechanical Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
resumo patente de invenção: "composições e métodos para o tratamento não cirúrgico da ptose". a presente invenção refere-se a composições farmacêuticas, e métodos de uso das composições, para o tratamento não cirúrgico da ptose (queda da pálpebra). em uma modalidade, a composição inclui oximetazolina a 0,1% formulado para a administração tópica a um olho. em uma modalidade, a composição inclui uma combinação sinergística de oximetazolina e fenilefrina, formulada para a administração tópica a um olho. a oximetazolina sozinha não causa nenhuma dilatação na pupila (midríase), e uma combinação sinergística de oximetazolina e fenilefrina não induz nenhuma midríase clinicamente significativa. além de propiciar efeitos cosméticos desejáveis, as composições e os métodos da invenção podem melhorar os campos visuais de algum outro modo comprometidos pela ptose.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161448949P | 2011-03-03 | 2011-03-03 | |
| US13/218,584 US20120225918A1 (en) | 2011-03-03 | 2011-08-26 | Compositions and Methods for Non-Surgical Treatment of Ptosis |
| US13/270,577 US8357714B2 (en) | 2011-03-03 | 2011-10-11 | Compositions and methods for non-surgical treatment of ptosis |
| PCT/US2012/026496 WO2012118704A1 (en) | 2011-03-03 | 2012-02-24 | Compositions and methods for non-surgical treatment of ptosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013022094A2 true BR112013022094A2 (pt) | 2017-06-27 |
Family
ID=46753678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013022094A BR112013022094A2 (pt) | 2011-03-03 | 2012-02-24 | composições e métodos para o tratamento não cirúrgico da ptose |
Country Status (23)
| Country | Link |
|---|---|
| US (8) | US20120225918A1 (pt) |
| EP (2) | EP3653205A3 (pt) |
| JP (1) | JP6106100B2 (pt) |
| KR (1) | KR101889392B1 (pt) |
| CN (1) | CN103501771B (pt) |
| AU (1) | AU2012223615B2 (pt) |
| BR (1) | BR112013022094A2 (pt) |
| CA (1) | CA2827285C (pt) |
| CY (1) | CY1122565T1 (pt) |
| DK (1) | DK2680829T3 (pt) |
| ES (1) | ES2750123T3 (pt) |
| HR (1) | HRP20192266T1 (pt) |
| HU (1) | HUE046740T2 (pt) |
| LT (1) | LT2680829T (pt) |
| MX (1) | MX345042B (pt) |
| PL (1) | PL2680829T3 (pt) |
| PT (1) | PT2680829T (pt) |
| RS (1) | RS59636B1 (pt) |
| RU (1) | RU2582392C2 (pt) |
| SG (1) | SG192801A1 (pt) |
| SI (1) | SI2680829T1 (pt) |
| WO (1) | WO2012118704A1 (pt) |
| ZA (1) | ZA201307262B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120225918A1 (en) * | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
| TR201903465T4 (tr) | 2011-09-20 | 2019-04-22 | Allergan Inc | Presbiyopi, hafif hiperopi ve düzensiz astigmatizmin tedavi edilmesine yönelik bileşimler ve yöntemler. |
| KR20160005351A (ko) * | 2013-05-06 | 2016-01-14 | 알러간, 인코포레이티드 | 조직 외상의 치료를 위한 알파 아드레날린 작용제 |
| CA2869060A1 (en) * | 2014-07-28 | 2016-01-28 | Queen's University At Kingston | Dosage forms and methods for diagnosing sympathetic nervous system dysfunction |
| US20190000808A1 (en) * | 2015-07-13 | 2019-01-03 | Allergan, Inc. | Composition and methods for the treatment of blephopharoptosis |
| CA3012660A1 (en) | 2016-01-26 | 2017-08-03 | Levation Pharma Ltd. | Composition of alpha-adrenergic agents for the treatment of ptosis |
| CN106726115B (zh) * | 2016-12-22 | 2023-01-20 | 上海交通大学医学院附属第九人民医院 | 一种眼睑功能矫正器 |
| CN106938039A (zh) * | 2017-03-29 | 2017-07-11 | 卢仁华 | 眼睑下垂的治疗药物 |
| WO2019204401A1 (en) * | 2018-04-19 | 2019-10-24 | Presbyopia Therapies Llc | Compositions and methods for the treatment of presbyopia |
| CN108635434A (zh) * | 2018-06-24 | 2018-10-12 | 吴安相 | 一种治疗眼睑下垂的侗族中药配方 |
| BR112021009700A2 (pt) * | 2018-11-26 | 2021-08-17 | Cellix Bio Private Limited | composto de fórmula i, ii e iii e hidratos, solvatos, pró-fármacos, enantiômeros e estereoisômeros farmaceuticamente aceitáveis destes, composição farmacêutica e composto da estrutura |
| US10814001B1 (en) | 2019-05-06 | 2020-10-27 | Rvl Pharmaceuticals, Inc. | Oxymetazoline compositions |
| CA3180714A1 (en) * | 2020-04-23 | 2021-10-28 | Okogen, Inc. | Treatment of viral conjunctivitis |
| WO2022187306A1 (en) | 2021-03-03 | 2022-09-09 | Voom, Llc | Compositions and methods for treatment of blepharitis |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1117588B (de) | 1960-09-30 | 1961-11-23 | Merck Ag E | Verfahren zur Herstellung eines neuen Imidazolinderivates |
| US3670087A (en) * | 1970-10-16 | 1972-06-13 | Miles Lab | Method of lowering intraocular pressure |
| IE51421B1 (en) * | 1980-08-01 | 1986-12-24 | Smith & Nephew Ass | Ophthalmic compositions containing triamterene |
| US4407791A (en) | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| DE3227741A1 (de) | 1982-07-24 | 1984-01-26 | Hoechst Ag, 6230 Frankfurt | 1-phenyl-isochinolinderivate und verfahren zu ihrer herstellung |
| FR2549015B1 (fr) * | 1983-07-13 | 1986-06-13 | Oreal | Ensemble compte-gouttes |
| US5459133A (en) * | 1992-06-05 | 1995-10-17 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
| AU4582797A (en) * | 1996-09-13 | 1998-04-02 | Regents Of The University Of California, The | Methods for treatment of retinal diseases |
| AU7081598A (en) * | 1997-04-24 | 1998-11-13 | Taisho Pharmaceutical Co., Ltd. | Eye drops |
| EP0903151A1 (en) * | 1997-09-22 | 1999-03-24 | ASTA Medica Aktiengesellschaft | Use of combinations comprising non-sedating antihistamines and alpha-adrenergic drugs for the topical treatment of rhinitis/conjunctivitis and cold, cold-like and/or flu symptoms |
| US5885550A (en) * | 1998-07-02 | 1999-03-23 | Vallier; Deandra K. | Ophthalmic whitening solution |
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| EP3943069A1 (en) * | 2009-03-17 | 2022-01-26 | Nicox Ophthalmics, Inc. | Ophthalmic formulations of cetirizine and methods of use |
| CA2764477A1 (en) | 2009-06-05 | 2010-12-09 | Aciex Therapeutics, Inc. | Ophthalmic formulations, methods of manufacture, and methods of using same |
| US20130190317A1 (en) | 2010-08-06 | 2013-07-25 | Galderma Research & Development Snc | Combination of compounds for treating or preventing skin diseases |
| JP6030067B2 (ja) | 2010-12-03 | 2016-11-24 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 薬学的クリーム組成物および使用法 |
| EP3578178A1 (en) * | 2011-02-15 | 2019-12-11 | Aclaris Therapeutics, Inc. | Pharmaceutical composition comprising oxymetazoline |
| US20120225918A1 (en) | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
| AU2013266067B2 (en) | 2012-05-25 | 2016-10-06 | Xlear, Inc. | Xylitol-based anti-mucosal compositions and related methods and compositions |
| UA119324C2 (uk) | 2013-04-02 | 2019-06-10 | Теміс Медікер Лімітед | Композиції фармацевтично активних речовин, що містять моноетиловий ефір діетиленгліколю або інші алкільні похідні |
| AU2015274532B2 (en) | 2014-06-11 | 2020-06-11 | Epi Health, Llc | Stabilized oxymetazoline formulations and their uses |
| CN107847432A (zh) | 2015-05-29 | 2018-03-27 | 西德奈克西斯公司 | D2o稳定化的药物制剂 |
| US20190000808A1 (en) * | 2015-07-13 | 2019-01-03 | Allergan, Inc. | Composition and methods for the treatment of blephopharoptosis |
| CA3012660A1 (en) | 2016-01-26 | 2017-08-03 | Levation Pharma Ltd. | Composition of alpha-adrenergic agents for the treatment of ptosis |
| US10814001B1 (en) * | 2019-05-06 | 2020-10-27 | Rvl Pharmaceuticals, Inc. | Oxymetazoline compositions |
-
2011
- 2011-08-26 US US13/218,584 patent/US20120225918A1/en not_active Abandoned
- 2011-10-11 US US13/270,577 patent/US8357714B2/en active Active
-
2012
- 2012-02-24 MX MX2013009597A patent/MX345042B/es active IP Right Grant
- 2012-02-24 BR BR112013022094A patent/BR112013022094A2/pt not_active Application Discontinuation
- 2012-02-24 CA CA2827285A patent/CA2827285C/en active Active
- 2012-02-24 LT LTEP12709421.7T patent/LT2680829T/lt unknown
- 2012-02-24 PL PL12709421T patent/PL2680829T3/pl unknown
- 2012-02-24 JP JP2013556744A patent/JP6106100B2/ja active Active
- 2012-02-24 HU HUE12709421A patent/HUE046740T2/hu unknown
- 2012-02-24 SG SG2013062245A patent/SG192801A1/en unknown
- 2012-02-24 EP EP19199263.5A patent/EP3653205A3/en active Pending
- 2012-02-24 PT PT127094217T patent/PT2680829T/pt unknown
- 2012-02-24 SI SI201231705T patent/SI2680829T1/sl unknown
- 2012-02-24 RS RS20191580A patent/RS59636B1/sr unknown
- 2012-02-24 ES ES12709421T patent/ES2750123T3/es active Active
- 2012-02-24 KR KR1020137026050A patent/KR101889392B1/ko active IP Right Grant
- 2012-02-24 WO PCT/US2012/026496 patent/WO2012118704A1/en active Application Filing
- 2012-02-24 RU RU2013142602/15A patent/RU2582392C2/ru active
- 2012-02-24 EP EP12709421.7A patent/EP2680829B1/en active Active
- 2012-02-24 AU AU2012223615A patent/AU2012223615B2/en active Active
- 2012-02-24 DK DK12709421T patent/DK2680829T3/da active
- 2012-02-24 CN CN201280011433.6A patent/CN103501771B/zh active Active
- 2012-02-29 US US13/408,364 patent/US9018240B2/en active Active
-
2013
- 2013-09-27 ZA ZA2013/07262A patent/ZA201307262B/en unknown
-
2015
- 2015-02-18 US US14/625,099 patent/US9867808B2/en active Active
-
2017
- 2017-12-11 US US15/837,325 patent/US20180338953A1/en not_active Abandoned
-
2019
- 2019-09-20 US US16/577,262 patent/US10912765B2/en active Active
- 2019-11-07 CY CY20191101170T patent/CY1122565T1/el unknown
- 2019-12-17 HR HRP20192266TT patent/HRP20192266T1/hr unknown
-
2020
- 2020-06-04 US US16/892,645 patent/US20200360345A1/en not_active Abandoned
-
2022
- 2022-02-24 US US17/679,278 patent/US20220218669A1/en active Pending
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