CY1122565T1 - Συνθεσεις και μεθοδοι μη χειρουργικης θεραπειας βλεφαροπτωσης - Google Patents
Συνθεσεις και μεθοδοι μη χειρουργικης θεραπειας βλεφαροπτωσηςInfo
- Publication number
- CY1122565T1 CY1122565T1 CY20191101170T CY191101170T CY1122565T1 CY 1122565 T1 CY1122565 T1 CY 1122565T1 CY 20191101170 T CY20191101170 T CY 20191101170T CY 191101170 T CY191101170 T CY 191101170T CY 1122565 T1 CY1122565 T1 CY 1122565T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compositions
- methods
- oxymetazoline
- surgical treatment
- eyelash
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
- B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Mechanical Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Παρέχονται φαρμακευτικές συνθέσεις και μέθοδοι χρήσης των συνθέσεων για τη μη χειρουργική θεραπεία της βλεφαρόπτωσης (πτώση βλεφάρων). Σε μία εφαρμογή, η σύνθεση περιλαμβάνει 0,1% οξυμεταζολίνη, μορφοποιημένη φαρμακοτεχνικά για τοπική χρήση στο μάτι. Σε μία εφαρμογή, η σύνθεση περιλαμβάνει συνεργικό συνδυασμό οξυμεταζολίνης και φαινυλεφρίνης, μορφοποιημένη φαρμακοτεχνικά για τοπική χρήση στο μάτι. Η οξυμεταζολίνη μόνη της δεν προκαλεί διαστολή της κόρης (μυδρίαση) και ο συνεργικός συνδυασμός οξυμεταζολίνης και φαινυλεφρίνης δεν επάγει κλινικά σημαντική μυδρίαση. Εκτός της επίτευξης επιθυμητού αισθητικού αποτελέσματος, οι συνθέσεις και οι μέθοδοι της εφεύρεσης μπορούν να βελτιώσουν τα οπτικά πεδία, τα οποία τίθενται σε κίνδυνο λόγω της βλεφαρόπτωσης.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161448949P | 2011-03-03 | 2011-03-03 | |
US13/218,584 US20120225918A1 (en) | 2011-03-03 | 2011-08-26 | Compositions and Methods for Non-Surgical Treatment of Ptosis |
US13/270,577 US8357714B2 (en) | 2011-03-03 | 2011-10-11 | Compositions and methods for non-surgical treatment of ptosis |
PCT/US2012/026496 WO2012118704A1 (en) | 2011-03-03 | 2012-02-24 | Compositions and methods for non-surgical treatment of ptosis |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122565T1 true CY1122565T1 (el) | 2021-01-27 |
Family
ID=46753678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191101170T CY1122565T1 (el) | 2011-03-03 | 2019-11-07 | Συνθεσεις και μεθοδοι μη χειρουργικης θεραπειας βλεφαροπτωσης |
Country Status (23)
Country | Link |
---|---|
US (8) | US20120225918A1 (el) |
EP (2) | EP2680829B1 (el) |
JP (1) | JP6106100B2 (el) |
KR (1) | KR101889392B1 (el) |
CN (1) | CN103501771B (el) |
AU (1) | AU2012223615B2 (el) |
BR (1) | BR112013022094A2 (el) |
CA (1) | CA2827285C (el) |
CY (1) | CY1122565T1 (el) |
DK (1) | DK2680829T3 (el) |
ES (1) | ES2750123T3 (el) |
HR (1) | HRP20192266T1 (el) |
HU (1) | HUE046740T2 (el) |
LT (1) | LT2680829T (el) |
MX (1) | MX345042B (el) |
PL (1) | PL2680829T3 (el) |
PT (1) | PT2680829T (el) |
RS (1) | RS59636B1 (el) |
RU (1) | RU2582392C2 (el) |
SG (1) | SG192801A1 (el) |
SI (1) | SI2680829T1 (el) |
WO (1) | WO2012118704A1 (el) |
ZA (1) | ZA201307262B (el) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120225918A1 (en) | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
AU2012311239B2 (en) | 2011-09-20 | 2017-10-19 | Allergan, Inc. | Compositions and methods for treating presbyopia, mild hyperopia, and irregular astigmatism |
US20140329874A1 (en) * | 2013-05-06 | 2014-11-06 | Allergan, Inc. | Alpha adrenergic agonists for the treatment of tissue trauma |
CA2869060A1 (en) * | 2014-07-28 | 2016-01-28 | Queen's University At Kingston | Dosage forms and methods for diagnosing sympathetic nervous system dysfunction |
US20190000808A1 (en) * | 2015-07-13 | 2019-01-03 | Allergan, Inc. | Composition and methods for the treatment of blephopharoptosis |
AU2017211793B2 (en) * | 2016-01-26 | 2022-11-24 | Levation Pharma Ltd. | Compositions and uses of alpha-adrenergic agents |
CN106726115B (zh) * | 2016-12-22 | 2023-01-20 | 上海交通大学医学院附属第九人民医院 | 一种眼睑功能矫正器 |
CN106938039A (zh) * | 2017-03-29 | 2017-07-11 | 卢仁华 | 眼睑下垂的治疗药物 |
WO2019204401A1 (en) * | 2018-04-19 | 2019-10-24 | Presbyopia Therapies Llc | Compositions and methods for the treatment of presbyopia |
CN108635434A (zh) * | 2018-06-24 | 2018-10-12 | 吴安相 | 一种治疗眼睑下垂的侗族中药配方 |
WO2020109957A1 (en) * | 2018-11-26 | 2020-06-04 | Cellix Bio Private Limited | Ophthalmic compositions and methods for the treatment of skin diseases and eye diseases |
US10799481B1 (en) | 2019-05-06 | 2020-10-13 | Rvl Pharmaceuticals, Inc. | Compositions and methods for treating ocular disorders |
EP4138882A4 (en) * | 2020-04-23 | 2024-04-10 | Okogen Inc | TREATMENT OF VIRAL CONJUNCTIVITIS |
US20240156786A1 (en) | 2021-03-03 | 2024-05-16 | Voom, Llc | Compositions and methods for treatment of blepharitis |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1117588B (de) | 1960-09-30 | 1961-11-23 | Merck Ag E | Verfahren zur Herstellung eines neuen Imidazolinderivates |
US3670087A (en) * | 1970-10-16 | 1972-06-13 | Miles Lab | Method of lowering intraocular pressure |
IE51421B1 (en) * | 1980-08-01 | 1986-12-24 | Smith & Nephew Ass | Ophthalmic compositions containing triamterene |
US4407791A (en) | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
DE3227741A1 (de) | 1982-07-24 | 1984-01-26 | Hoechst Ag, 6230 Frankfurt | 1-phenyl-isochinolinderivate und verfahren zu ihrer herstellung |
FR2549015B1 (fr) * | 1983-07-13 | 1986-06-13 | Oreal | Ensemble compte-gouttes |
US5459133A (en) * | 1992-06-05 | 1995-10-17 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
AU4582797A (en) * | 1996-09-13 | 1998-04-02 | Regents Of The University Of California, The | Methods for treatment of retinal diseases |
AU7081598A (en) * | 1997-04-24 | 1998-11-13 | Taisho Pharmaceutical Co., Ltd. | Eye drops |
EP0903151A1 (en) * | 1997-09-22 | 1999-03-24 | ASTA Medica Aktiengesellschaft | Use of combinations comprising non-sedating antihistamines and alpha-adrenergic drugs for the topical treatment of rhinitis/conjunctivitis and cold, cold-like and/or flu symptoms |
US5885550A (en) * | 1998-07-02 | 1999-03-23 | Vallier; Deandra K. | Ophthalmic whitening solution |
TWI283669B (en) * | 1999-06-10 | 2007-07-11 | Allergan Inc | Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors |
US6730691B1 (en) | 2000-02-10 | 2004-05-04 | Miles A. Galin | Uses of alpha adrenergic blocking agents |
US6572849B2 (en) * | 2000-09-20 | 2003-06-03 | Lee Shahinian, Jr. | Self-preserved antibacterial nasal, inhalable, and topical ophthalmic preparations and medications |
JP2004509920A (ja) * | 2000-09-29 | 2004-04-02 | ボード オブ トラスティーズ オペレーティング ミシガン ステート ユニヴァーシティ | カテコールアミン医薬組成物および方法 |
US7780976B2 (en) * | 2002-05-30 | 2010-08-24 | Eye Care And Cure, Asia | Apparatus and method for delivering controlled quantities of one or more agents to the eye |
AR039703A1 (es) * | 2002-06-20 | 2005-03-09 | Novartis Consumer Health Sa | Composiciones nasales |
US6806364B2 (en) | 2002-07-29 | 2004-10-19 | Ast Products, Inc. | Ophthalmic compositions |
US20060177430A1 (en) * | 2002-12-20 | 2006-08-10 | Chakshu Research Inc | Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer |
US7812049B2 (en) | 2004-01-22 | 2010-10-12 | Vicept Therapeutics, Inc. | Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists |
US7022740B2 (en) | 2004-04-29 | 2006-04-04 | Leonard Mackles | Lubricious ophthalmic solutions |
US7618615B2 (en) * | 2004-08-13 | 2009-11-17 | Healthpartners Research Foundation | Methods for providing neuroprotection for the animal central nervous system against neurodegeneration caused by ischemia |
JP4942328B2 (ja) * | 2004-11-01 | 2012-05-30 | ロート製薬株式会社 | ビタミンb6類含有水性組成物 |
US8758816B2 (en) | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
JP4956981B2 (ja) * | 2005-01-05 | 2012-06-20 | 大正製薬株式会社 | オキシメタゾリン含有水性組成物 |
JP5275214B2 (ja) | 2006-03-17 | 2013-08-28 | ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッド | 酸化に不安定な成分を含む眼科用安定組成物 |
JP2009535342A (ja) * | 2006-04-26 | 2009-10-01 | アーシエックス, インコーポレイテッド | 眼瞼腫脹の予防および処置のための組成物 |
US8466203B2 (en) | 2006-12-06 | 2013-06-18 | David Choohyun Paik | Method of stabilizing human eye tissue by reaction with nitrite and related agents such as nitro compounds |
CN101977595A (zh) * | 2007-11-08 | 2011-02-16 | 阿西克斯医疗公司 | 用于治疗以及预防眼睑肿胀的组合物 |
ES2910374T3 (es) * | 2009-03-17 | 2022-05-12 | Nicox Ophthalmics Inc | Formulaciones oftálmicas de cetirizina y procedimientos de uso |
EP2437602A4 (en) | 2009-06-05 | 2014-02-19 | Aciex Therapeutics Inc | OPHTHALMIC FORMULATIONS, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THEIR USE |
KR20130128375A (ko) | 2010-08-06 | 2013-11-26 | 갈데르마 리서치 & 디벨로프먼트 | 피부 질환을 치료 또는 예방하기 위한 화합물들의 배합물 |
ES2618907T3 (es) | 2010-12-03 | 2017-06-22 | Allergan, Inc. | Composiciones farmacéuticas en crema que comprenden oximetazolina |
RU2648439C2 (ru) * | 2011-02-15 | 2018-03-26 | Аллерган, Инк. | Фармацевтическая композиция в виде крема, содержащая оксиметазолин, для лечения симптомов розацеа |
US20120225918A1 (en) | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
WO2013177594A2 (en) | 2012-05-25 | 2013-11-28 | Xlear, Inc. | Xylitol-based anti-mucosal compositions and related methods and compositions |
UA119324C2 (uk) | 2013-04-02 | 2019-06-10 | Теміс Медікер Лімітед | Композиції фармацевтично активних речовин, що містять моноетиловий ефір діетиленгліколю або інші алкільні похідні |
ES2796871T3 (es) | 2014-06-11 | 2020-11-30 | Epi Health Llc | Formulaciones de oximetazolina estabilizadas y sus usos |
EP3302426A4 (en) | 2015-05-29 | 2018-12-05 | Sydnexis, Inc. | D2o stabilized pharmaceutical formulations |
US20190000808A1 (en) * | 2015-07-13 | 2019-01-03 | Allergan, Inc. | Composition and methods for the treatment of blephopharoptosis |
AU2017211793B2 (en) | 2016-01-26 | 2022-11-24 | Levation Pharma Ltd. | Compositions and uses of alpha-adrenergic agents |
US10799481B1 (en) * | 2019-05-06 | 2020-10-13 | Rvl Pharmaceuticals, Inc. | Compositions and methods for treating ocular disorders |
-
2011
- 2011-08-26 US US13/218,584 patent/US20120225918A1/en not_active Abandoned
- 2011-10-11 US US13/270,577 patent/US8357714B2/en active Active
-
2012
- 2012-02-24 ES ES12709421T patent/ES2750123T3/es active Active
- 2012-02-24 CN CN201280011433.6A patent/CN103501771B/zh active Active
- 2012-02-24 KR KR1020137026050A patent/KR101889392B1/ko active IP Right Grant
- 2012-02-24 LT LTEP12709421.7T patent/LT2680829T/lt unknown
- 2012-02-24 MX MX2013009597A patent/MX345042B/es active IP Right Grant
- 2012-02-24 RS RS20191580A patent/RS59636B1/sr unknown
- 2012-02-24 SG SG2013062245A patent/SG192801A1/en unknown
- 2012-02-24 EP EP12709421.7A patent/EP2680829B1/en active Active
- 2012-02-24 DK DK12709421T patent/DK2680829T3/da active
- 2012-02-24 BR BR112013022094A patent/BR112013022094A2/pt not_active Application Discontinuation
- 2012-02-24 WO PCT/US2012/026496 patent/WO2012118704A1/en active Application Filing
- 2012-02-24 EP EP19199263.5A patent/EP3653205A3/en active Pending
- 2012-02-24 PT PT127094217T patent/PT2680829T/pt unknown
- 2012-02-24 RU RU2013142602/15A patent/RU2582392C2/ru active
- 2012-02-24 SI SI201231705T patent/SI2680829T1/sl unknown
- 2012-02-24 JP JP2013556744A patent/JP6106100B2/ja active Active
- 2012-02-24 PL PL12709421T patent/PL2680829T3/pl unknown
- 2012-02-24 HU HUE12709421A patent/HUE046740T2/hu unknown
- 2012-02-24 CA CA2827285A patent/CA2827285C/en active Active
- 2012-02-24 AU AU2012223615A patent/AU2012223615B2/en active Active
- 2012-02-29 US US13/408,364 patent/US9018240B2/en active Active
-
2013
- 2013-09-27 ZA ZA2013/07262A patent/ZA201307262B/en unknown
-
2015
- 2015-02-18 US US14/625,099 patent/US9867808B2/en active Active
-
2017
- 2017-12-11 US US15/837,325 patent/US20180338953A1/en not_active Abandoned
-
2019
- 2019-09-20 US US16/577,262 patent/US10912765B2/en active Active
- 2019-11-07 CY CY20191101170T patent/CY1122565T1/el unknown
- 2019-12-17 HR HRP20192266TT patent/HRP20192266T1/hr unknown
-
2020
- 2020-06-04 US US16/892,645 patent/US20200360345A1/en not_active Abandoned
-
2022
- 2022-02-24 US US17/679,278 patent/US20220218669A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1122565T1 (el) | Συνθεσεις και μεθοδοι μη χειρουργικης θεραπειας βλεφαροπτωσης | |
CY1124311T1 (el) | Παρεμποδιστες dna-pk | |
CO2019007810A2 (es) | Compuestos de amino-triazolopiridina y su uso en el tratamiento del cáncer | |
BR112015020389A8 (pt) | compostos carbazol úteis como inibidores de bromodomínio, seu uso, bem como composição e produto farmacêuticos compreendendo os mesmos | |
CY1118379T1 (el) | Αναστολεις ιου ηπατιτιδας c | |
CY1119163T1 (el) | Αμιδια πυριδονης ως ρυθμιστες διαυλων νατριου | |
CY1126109T1 (el) | Αναστολεις toy trpc6 | |
IN2014DN09434A (el) | ||
BR112015017997A2 (pt) | amidas de quinolina e quinazolina como moduladores de canais de sódio | |
EA201592250A1 (ru) | Пиразолопирролидиновые производные и их применение в лечение заболеваний | |
EA201500298A1 (ru) | Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы | |
MX2020010999A (es) | Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos. | |
CY1117326T1 (el) | Παραγωγο κατεχολαμινης χρησιμο για τη θεραπεια ασθενειας parkinson | |
AU2012253759A8 (en) | Tricyclic sulfonamide compounds and methods of making and using same | |
EA201391486A1 (ru) | Способы и композиции для лечения болезни паркинсона | |
BR112014026176A2 (pt) | dipiridilaminas substituídas e usos das mesmas | |
EA201201658A1 (ru) | Производные пиперидина и их применение для лечения метаболических нарушений | |
CO6491060A2 (es) | Compuestos y composiciones para el tratamiento de enfermedades parasitarias | |
UY30377A1 (es) | Inhibidores triciclicos fusionados de sulfonamida de gama-secretasa | |
EA201590183A1 (ru) | Производные азаиндола, выступающие в качестве ингибиторов pi3k | |
UY35551A (es) | Derivados heteroarilos como inhibidores de aldosterona sintasa | |
CY1116234T1 (el) | Υποκατεστημενα 2-οξυ-κινολινο-3-καρβοξαμιδια σαν διαμορφωτες kcnq2/3 | |
EA201400064A1 (ru) | Офтальмологическая фармацевтическая композиция для местного применения, которая содержит регорафениб | |
ECSP10010597A (es) | Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativas | |
MX2015008187A (es) | Inhibidores de alk deuterados. |