BR112013021771B1 - Método ex vivo para produzir camundongo geneticamente modificado pela inserção de gene adam6 e método ex vivo para produzir anticorpo específico para antígeno de interesse - Google Patents

Método ex vivo para produzir camundongo geneticamente modificado pela inserção de gene adam6 e método ex vivo para produzir anticorpo específico para antígeno de interesse Download PDF

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BR112013021771B1
BR112013021771B1 BR112013021771-5A BR112013021771A BR112013021771B1 BR 112013021771 B1 BR112013021771 B1 BR 112013021771B1 BR 112013021771 A BR112013021771 A BR 112013021771A BR 112013021771 B1 BR112013021771 B1 BR 112013021771B1
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mouse
human
gene
adam6
immunoglobulin
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BR112013021771-5A
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Portuguese (pt)
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BR112013021771A2 (pt
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Lynn MacDonald
Sean Stevens
Andrew J. Murphy
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Regeneron Pharmaceuticals, Inc
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Application filed by Regeneron Pharmaceuticals, Inc filed Critical Regeneron Pharmaceuticals, Inc
Publication of BR112013021771A2 publication Critical patent/BR112013021771A2/pt
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BR112013021771-5A 2011-02-25 2012-02-24 Método ex vivo para produzir camundongo geneticamente modificado pela inserção de gene adam6 e método ex vivo para produzir anticorpo específico para antígeno de interesse BR112013021771B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161446895P 2011-02-25 2011-02-25
US61/446,895 2011-02-25
US201161497650P 2011-06-16 2011-06-16
US61/497,650 2011-06-16
US201261595200P 2012-02-06 2012-02-06
US61/595,200 2012-02-06
PCT/US2012/026416 WO2012141798A1 (en) 2011-02-25 2012-02-24 Adam6 mice

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Publication Number Publication Date
BR112013021771A2 BR112013021771A2 (pt) 2017-07-04
BR112013021771B1 true BR112013021771B1 (pt) 2022-11-16

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BR112013021771-5A BR112013021771B1 (pt) 2011-02-25 2012-02-24 Método ex vivo para produzir camundongo geneticamente modificado pela inserção de gene adam6 e método ex vivo para produzir anticorpo específico para antígeno de interesse

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US6596541B2 (en) * 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
SI1523496T1 (sl) 2002-07-18 2011-11-30 Merus B V Rekombinantno proizvajanje zmesi protiteles
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
EP2395017A3 (en) 2003-05-30 2012-12-19 Merus B.V. Design and use of paired variable regions of specific binding molecules
WO2006008548A2 (en) 2004-07-22 2006-01-26 Erasmus University Medical Centre Rotterdam Binding molecules
GB0905023D0 (en) 2009-03-24 2009-05-06 Univ Erasmus Medical Ct Binding molecules
EP3028565B1 (en) 2009-07-08 2017-09-27 Kymab Limited Animal models and therapeutic molecules
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
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