BR112013018516B1 - Construto de expressão de ácido nucleico, método de produção de uma proteína alfa-galactosidase humana recombinante, proteína alfagalactosidase humana, composição farmacêutica, e, uso de uma proteína alfagalactosidase humana ou de uma composição - Google Patents

Construto de expressão de ácido nucleico, método de produção de uma proteína alfa-galactosidase humana recombinante, proteína alfagalactosidase humana, composição farmacêutica, e, uso de uma proteína alfagalactosidase humana ou de uma composição Download PDF

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BR112013018516B1
BR112013018516B1 BR112013018516-3A BR112013018516A BR112013018516B1 BR 112013018516 B1 BR112013018516 B1 BR 112013018516B1 BR 112013018516 A BR112013018516 A BR 112013018516A BR 112013018516 B1 BR112013018516 B1 BR 112013018516B1
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Prior art keywords
human
galactosidase
protein
plant
seq
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BR112013018516-3A
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English (en)
Portuguese (pt)
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BR112013018516A2 (pt
Inventor
Avidor Shulman
Uri Hanania
Tali Kizhner
Yoseph Shaaltiel
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Protalix Ltd
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Priority claimed from PCT/IL2011/000209 external-priority patent/WO2011107990A1/en
Application filed by Protalix Ltd filed Critical Protalix Ltd
Publication of BR112013018516A2 publication Critical patent/BR112013018516A2/pt
Publication of BR112013018516B1 publication Critical patent/BR112013018516B1/pt

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    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon

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  • Plant Pathology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
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BR112013018516-3A 2011-01-20 2011-09-07 Construto de expressão de ácido nucleico, método de produção de uma proteína alfa-galactosidase humana recombinante, proteína alfagalactosidase humana, composição farmacêutica, e, uso de uma proteína alfagalactosidase humana ou de uma composição BR112013018516B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161434499P 2011-01-20 2011-01-20
US201161434503P 2011-01-20 2011-01-20
US61/434,503 2011-01-20
US61/434,499 2011-01-20
ILPCT/IL2011/000209 2011-03-02
PCT/IL2011/000209 WO2011107990A1 (en) 2010-03-02 2011-03-02 Stabilized alpha-galactosidase and uses thereof
PCT/IL2011/000719 WO2012098537A1 (en) 2011-01-20 2011-09-07 Nucleic acid construct for expression of alpha-galactosidase in plants and plant cells

Publications (2)

Publication Number Publication Date
BR112013018516A2 BR112013018516A2 (pt) 2019-05-21
BR112013018516B1 true BR112013018516B1 (pt) 2023-11-07

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BR112013018516-3A BR112013018516B1 (pt) 2011-01-20 2011-09-07 Construto de expressão de ácido nucleico, método de produção de uma proteína alfa-galactosidase humana recombinante, proteína alfagalactosidase humana, composição farmacêutica, e, uso de uma proteína alfagalactosidase humana ou de uma composição

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US (1) US9732333B2 (enExample)
EP (2) EP2665814B1 (enExample)
JP (1) JP5913372B2 (enExample)
KR (1) KR101883803B1 (enExample)
CN (1) CN103443270B (enExample)
AU (1) AU2011356137A1 (enExample)
BR (1) BR112013018516B1 (enExample)
CA (1) CA2824791A1 (enExample)
CY (1) CY1122794T1 (enExample)
DK (2) DK2665814T3 (enExample)
ES (1) ES2774190T3 (enExample)
IL (1) IL227552B (enExample)
LT (2) LT3272861T (enExample)
PL (1) PL3272861T3 (enExample)
PT (1) PT3272861T (enExample)
RS (1) RS60129B1 (enExample)
SI (1) SI3272861T1 (enExample)
SM (1) SMT202000201T1 (enExample)
WO (1) WO2012098537A1 (enExample)

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BRPI0815324A2 (pt) 2007-08-20 2015-07-14 Protalix Ltd "conjugado protêico que contém sacarídeos, processo de separação do conjugado protêico que contém sacarídeos, composição farmacêutica do conjugado protêico que contém sacarídeos, uso do conjugado protêico que contém sacarídeos e composto do conjugado protêico que contém sacarídeos"
US9194011B2 (en) 2009-11-17 2015-11-24 Protalix Ltd. Stabilized alpha-galactosidase and uses thereof
DK2665814T3 (en) 2011-01-20 2017-09-11 Protalix Ltd NUCLEIC ACID CONSTRUCTION FOR EXPRESSION OF ALPHA-GALACTOSIDASE IN PLANTS AND PLANT CELLS
WO2014136113A1 (en) 2013-03-06 2014-09-12 Protalix Ltd. Chimeric polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same
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TW202332774A (zh) * 2013-10-23 2023-08-16 美商健臻公司 重組醣蛋白及其用途
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CN110381987A (zh) * 2017-01-05 2019-10-25 波塔力克斯有限公司 使用稳定化α-半乳糖苷酶治疗法布里病的治疗方法
IL257269A (en) * 2018-01-31 2018-04-09 Olender Tsviya Signaling is directed to the endoplasmic reticulum
KR102209198B1 (ko) * 2019-04-02 2021-02-02 주식회사 바이오앱 식물에서의 발현이 최적화된 재조합 이리신 유전자 및 이를 이용한 재조합 이리신 단백질의 생산 방법
KR102213745B1 (ko) 2019-04-16 2021-02-09 주식회사 바이오앱 돼지 유행성 설사병 바이러스 백신 조성물 및 이의 제조 방법
WO2020256372A1 (ko) 2019-06-17 2020-12-24 주식회사 바이오앱 아프리카 돼지열병의 진단을 위한 항원 생산용 재조합 벡터 및 이의 용도
WO2023027402A1 (ko) 2021-08-27 2023-03-02 주식회사 바이오앱 아프리카 돼지열병 바이러스 유래 항원 단백질을 포함하는 아프리카 돼지열병의 예방용 백신
KR102726138B1 (ko) 2023-10-17 2024-11-14 대한민국 백시니아 바이러스 재조합 a33r 단백질 및 이를 포함하는 오르소폭스바이러스 항체 진단 키트

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