BR112013015430A2 - derivados de 5,6-diidro-imidazo[1,2-a]pirazin-8-ilamina úteis como inibidores de beta-secretase (bace) - Google Patents

derivados de 5,6-diidro-imidazo[1,2-a]pirazin-8-ilamina úteis como inibidores de beta-secretase (bace)

Info

Publication number
BR112013015430A2
BR112013015430A2 BR112013015430A BR112013015430A BR112013015430A2 BR 112013015430 A2 BR112013015430 A2 BR 112013015430A2 BR 112013015430 A BR112013015430 A BR 112013015430A BR 112013015430 A BR112013015430 A BR 112013015430A BR 112013015430 A2 BR112013015430 A2 BR 112013015430A2
Authority
BR
Brazil
Prior art keywords
dihydroimidazo
bace
pyrazin
inhibitors
derivatives useful
Prior art date
Application number
BR112013015430A
Other languages
English (en)
Portuguese (pt)
Inventor
Andrés Avelino Trabanco-Suarez
Daniel Oehlrich
Francisca Delgado-Jiménez
Gary John Tresadern
Henricus Jacobus Maria Gijsen
Juan Antonio Vega Ramiro
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112013015430A2 publication Critical patent/BR112013015430A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR112013015430A 2010-12-22 2011-12-21 derivados de 5,6-diidro-imidazo[1,2-a]pirazin-8-ilamina úteis como inibidores de beta-secretase (bace) BR112013015430A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10196568 2010-12-22
PCT/EP2011/073522 WO2012085038A1 (en) 2010-12-22 2011-12-21 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

Publications (1)

Publication Number Publication Date
BR112013015430A2 true BR112013015430A2 (pt) 2016-09-20

Family

ID=43923528

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013015430A BR112013015430A2 (pt) 2010-12-22 2011-12-21 derivados de 5,6-diidro-imidazo[1,2-a]pirazin-8-ilamina úteis como inibidores de beta-secretase (bace)

Country Status (20)

Country Link
US (1) US9840507B2 (zh)
EP (1) EP2655376B1 (zh)
JP (1) JP5834091B2 (zh)
KR (1) KR101866987B1 (zh)
CN (1) CN103403007B (zh)
AU (1) AU2011347377B2 (zh)
BR (1) BR112013015430A2 (zh)
CA (1) CA2819175C (zh)
CO (1) CO6721049A2 (zh)
EA (1) EA022409B1 (zh)
ES (1) ES2648143T3 (zh)
HK (1) HK1189221A1 (zh)
IL (1) IL227054A (zh)
MX (1) MX347912B (zh)
MY (1) MY170715A (zh)
NZ (1) NZ610948A (zh)
SG (1) SG191097A1 (zh)
UA (1) UA109459C2 (zh)
WO (1) WO2012085038A1 (zh)
ZA (1) ZA201304646B (zh)

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Also Published As

Publication number Publication date
EP2655376A1 (en) 2013-10-30
KR20130132556A (ko) 2013-12-04
ES2648143T3 (es) 2017-12-28
CA2819175A1 (en) 2012-06-28
IL227054A (en) 2016-09-29
ZA201304646B (en) 2014-12-23
SG191097A1 (en) 2013-08-30
EP2655376B1 (en) 2017-08-23
MX347912B (es) 2017-05-17
KR101866987B1 (ko) 2018-07-19
CO6721049A2 (es) 2013-07-31
NZ610948A (en) 2014-06-27
AU2011347377A1 (en) 2013-06-13
JP5834091B2 (ja) 2015-12-16
US9840507B2 (en) 2017-12-12
HK1189221A1 (zh) 2014-05-30
AU2011347377B2 (en) 2016-03-03
CN103403007A (zh) 2013-11-20
MY170715A (en) 2019-08-27
MX2013007294A (es) 2013-08-26
CN103403007B (zh) 2015-12-09
CA2819175C (en) 2019-01-08
EA022409B1 (ru) 2015-12-30
EA201390932A1 (ru) 2013-11-29
US20130274266A1 (en) 2013-10-17
JP2014500293A (ja) 2014-01-09
UA109459C2 (xx) 2015-08-25
WO2012085038A1 (en) 2012-06-28

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