BR112012011792A2 - "compostos e métodos para modulação de quinases, e indicações para os mesmos" - Google Patents
"compostos e métodos para modulação de quinases, e indicações para os mesmos"Info
- Publication number
- BR112012011792A2 BR112012011792A2 BR112012011792A BR112012011792A BR112012011792A2 BR 112012011792 A2 BR112012011792 A2 BR 112012011792A2 BR 112012011792 A BR112012011792 A BR 112012011792A BR 112012011792 A BR112012011792 A BR 112012011792A BR 112012011792 A2 BR112012011792 A2 BR 112012011792A2
- Authority
- BR
- Brazil
- Prior art keywords
- cancer
- methods
- compounds
- raf
- protein kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C07—ORGANIC CHEMISTRY
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
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- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
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- Endocrinology (AREA)
- Cardiology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26251009P | 2009-11-18 | 2009-11-18 | |
US38331010P | 2010-09-15 | 2010-09-15 | |
PCT/US2010/057293 WO2011063159A1 (fr) | 2009-11-18 | 2010-11-18 | Composés et méthodes utilisés pour la modulation des kinases et indications à cet effet |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012011792A2 true BR112012011792A2 (pt) | 2015-10-13 |
Family
ID=44060002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012011792A BR112012011792A2 (pt) | 2009-11-18 | 2010-11-18 | "compostos e métodos para modulação de quinases, e indicações para os mesmos" |
Country Status (20)
Country | Link |
---|---|
US (2) | US8673928B2 (fr) |
EP (1) | EP2501236B1 (fr) |
JP (2) | JP2013511541A (fr) |
KR (1) | KR20120097512A (fr) |
CN (2) | CN105906631A (fr) |
AU (2) | AU2010321883A1 (fr) |
BR (1) | BR112012011792A2 (fr) |
CA (1) | CA2781287C (fr) |
CL (1) | CL2012001303A1 (fr) |
CO (1) | CO6551689A2 (fr) |
ES (1) | ES2627911T3 (fr) |
IL (1) | IL219567A0 (fr) |
MA (1) | MA33811B1 (fr) |
MX (1) | MX2012005827A (fr) |
MY (1) | MY156210A (fr) |
NZ (1) | NZ599872A (fr) |
PE (1) | PE20121335A1 (fr) |
RU (1) | RU2012125070A (fr) |
SG (1) | SG10201407718WA (fr) |
WO (1) | WO2011063159A1 (fr) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008063888A2 (fr) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Composés modulant l'activité de c-fms et/ou de c-kit et utilisations associées |
BRPI0814423B1 (pt) | 2007-07-17 | 2022-04-19 | Plexxikon, Inc | Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos |
US8158636B2 (en) | 2008-05-19 | 2012-04-17 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
AR078033A1 (es) | 2009-04-03 | 2011-10-12 | Plexxikon Inc | Una dispersion solida, que contiene al compuesto {3-[5-(4-(cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico, composiciones y formulaciones que comprenden a dicha dispersion solida; metodos para fabricar dicha dispersion solida, formas 1 y 2 de |
ES2633317T3 (es) | 2009-11-06 | 2017-09-20 | Plexxikon, Inc. | Compuestos y métodos para la modulación de quinasas, e indicaciones para ello |
SG10201407718WA (en) | 2009-11-18 | 2015-01-29 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
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US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
SG11201509338QA (en) | 2013-05-30 | 2015-12-30 | Plexxikon Inc | Compounds for kinase modulation, and indications therefor |
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2010
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- 2010-11-18 JP JP2012540066A patent/JP2013511541A/ja active Pending
- 2010-11-18 NZ NZ599872A patent/NZ599872A/en not_active IP Right Cessation
- 2010-11-18 RU RU2012125070/04A patent/RU2012125070A/ru not_active Application Discontinuation
- 2010-11-18 US US12/949,741 patent/US8673928B2/en active Active
- 2010-11-18 WO PCT/US2010/057293 patent/WO2011063159A1/fr active Application Filing
- 2010-11-18 PE PE2012000671A patent/PE20121335A1/es not_active Application Discontinuation
- 2010-11-18 AU AU2010321883A patent/AU2010321883A1/en not_active Abandoned
- 2010-11-18 KR KR1020127015004A patent/KR20120097512A/ko not_active Application Discontinuation
- 2010-11-18 CN CN201610244552.6A patent/CN105906631A/zh active Pending
- 2010-11-18 CN CN2010800616210A patent/CN102740698A/zh active Pending
- 2010-11-18 ES ES10832209.0T patent/ES2627911T3/es active Active
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- 2010-11-18 MX MX2012005827A patent/MX2012005827A/es active IP Right Grant
- 2010-11-18 CA CA2781287A patent/CA2781287C/fr active Active
- 2010-11-18 BR BR112012011792A patent/BR112012011792A2/pt not_active IP Right Cessation
- 2010-11-18 EP EP10832209.0A patent/EP2501236B1/fr active Active
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2012
- 2012-05-03 IL IL219567A patent/IL219567A0/en unknown
- 2012-05-17 CO CO12081901A patent/CO6551689A2/es unknown
- 2012-05-18 CL CL2012001303A patent/CL2012001303A1/es unknown
- 2012-06-11 MA MA34954A patent/MA33811B1/fr unknown
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2014
- 2014-03-17 US US14/216,980 patent/US9617267B2/en active Active
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2016
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Also Published As
Publication number | Publication date |
---|---|
IL219567A0 (en) | 2012-06-28 |
JP2016185958A (ja) | 2016-10-27 |
KR20120097512A (ko) | 2012-09-04 |
PE20121335A1 (es) | 2012-10-12 |
US20110152258A1 (en) | 2011-06-23 |
NZ599872A (en) | 2014-08-29 |
EP2501236B1 (fr) | 2017-03-29 |
US9617267B2 (en) | 2017-04-11 |
AU2016200485A1 (en) | 2016-02-18 |
AU2016200485B2 (en) | 2017-09-28 |
CN102740698A (zh) | 2012-10-17 |
WO2011063159A1 (fr) | 2011-05-26 |
MY156210A (en) | 2016-01-29 |
CN105906631A (zh) | 2016-08-31 |
US20140288070A1 (en) | 2014-09-25 |
US8673928B2 (en) | 2014-03-18 |
JP6194389B2 (ja) | 2017-09-06 |
CO6551689A2 (es) | 2012-10-31 |
MA33811B1 (fr) | 2012-12-03 |
CA2781287C (fr) | 2018-07-31 |
MX2012005827A (es) | 2012-06-19 |
SG10201407718WA (en) | 2015-01-29 |
AU2010321883A1 (en) | 2012-05-31 |
RU2012125070A (ru) | 2013-12-27 |
EP2501236A4 (fr) | 2013-05-15 |
EP2501236A1 (fr) | 2012-09-26 |
JP2013511541A (ja) | 2013-04-04 |
ES2627911T3 (es) | 2017-08-01 |
CA2781287A1 (fr) | 2011-05-26 |
CL2012001303A1 (es) | 2012-10-05 |
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