BR112012011792A2 - "compostos e métodos para modulação de quinases, e indicações para os mesmos" - Google Patents

"compostos e métodos para modulação de quinases, e indicações para os mesmos"

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Publication number
BR112012011792A2
BR112012011792A2 BR112012011792A BR112012011792A BR112012011792A2 BR 112012011792 A2 BR112012011792 A2 BR 112012011792A2 BR 112012011792 A BR112012011792 A BR 112012011792A BR 112012011792 A BR112012011792 A BR 112012011792A BR 112012011792 A2 BR112012011792 A2 BR 112012011792A2
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Prior art keywords
cancer
methods
compounds
raf
protein kinase
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BR112012011792A
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English (en)
Inventor
Chao Zhang
Hanna Cho
Prabha N Ibrahim
Songyuan Shi
Wayne Spevak
Ying Zhang
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Plexxikon Inc
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Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of BR112012011792A2 publication Critical patent/BR112012011792A2/pt

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

compostos e métodos para modulação de quinases, e indicações para os mesmos. são descritos compostos e sais dos mesmos, formulações dos mesmos, conjugados dos mesmos, derivados dos mesmos, formas dos mesmos, e aplicações dos mesmos. em alguns aspectos e modalidades, os compostos descritos ou sais dos mesmos, formulações dos mesmos, conjugados dos mesmos, derivados dos mesmos, formas dos mesmos são ativos sobre no mínimo uma proteína quinase raf. em alguns aspectos e modalidades, os compostos descritos são ativos na inibição da proliferação de uma linhagem de células mutantes ras. também são descritos métodos de aplicação dos mesmos para tratar doenças e condições, incluindo doenças e condições associadas com atividade de proteína quinase mutante b-raf v600e, incluindo melanoma, glioma, gliobastoma multiforme, astrocitoma pilocítico, câncer colorretal, câncer da tiróide, câncer pulmonar, câncer de ovário, câncer de próstata, câncer de fígado, câncer da vesícula biliar, tumores estromais gastrointestinais, câncer do trato biliar, e colangiocarcinoma. também são descritos métodos de aplicação dos mesmos para tratar doenças e condições, incluindo doenças e condições associadas com atividade de proteína quinase c-raf-1, incluindo dor aguda, dor crônica ou doença do rim policístico.
BR112012011792A 2009-11-18 2010-11-18 "compostos e métodos para modulação de quinases, e indicações para os mesmos" BR112012011792A2 (pt)

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US26251009P 2009-11-18 2009-11-18
US38331010P 2010-09-15 2010-09-15
PCT/US2010/057293 WO2011063159A1 (en) 2009-11-18 2010-11-18 Compounds and methods for kinase modulation, and indications therefor

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WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
SG183036A1 (en) 2007-07-17 2012-08-30 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
WO2009143018A2 (en) 2008-05-19 2009-11-26 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
MX349923B (es) 2009-04-03 2017-08-21 Hoffmann La Roche Composiciones del ácido propano-1-sulfónico {3-[5-(4-cloro-fenil)- 1h-pirrolo [2,3-b]-piridina-3-carbonil]-2,4-difluoro-fenil]-amida y el uso de las mismas.
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