BR112012005126A2 - Cristalização de 4'-epidaunorubicina x hcl - Google Patents

Cristalização de 4'-epidaunorubicina x hcl

Info

Publication number
BR112012005126A2
BR112012005126A2 BR112012005126A BR112012005126A BR112012005126A2 BR 112012005126 A2 BR112012005126 A2 BR 112012005126A2 BR 112012005126 A BR112012005126 A BR 112012005126A BR 112012005126 A BR112012005126 A BR 112012005126A BR 112012005126 A2 BR112012005126 A2 BR 112012005126A2
Authority
BR
Brazil
Prior art keywords
epidaunorubicin
solvent
crystallization
mixtures
hcl
Prior art date
Application number
BR112012005126A
Other languages
English (en)
Other versions
BR112012005126A8 (pt
Inventor
Kunnari Tero
Bindernagel Holger
Weiser Sascha
Lupton Andrew
Wallert Stefan
Original Assignee
Heraeus Precious Metals Gmbh
Medac Ges Fuer Klinische Spezialpraeparate Mbh
Heraeus Deutschland Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41483008&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012005126(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Heraeus Precious Metals Gmbh, Medac Ges Fuer Klinische Spezialpraeparate Mbh, Heraeus Deutschland Gmbh & Co Kg filed Critical Heraeus Precious Metals Gmbh
Publication of BR112012005126A2 publication Critical patent/BR112012005126A2/pt
Publication of BR112012005126A8 publication Critical patent/BR112012005126A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

CRISTALIZAÇÃO DE 4'-EPIDAUNORUBICINA X HCL. A presente invenção refere-se a uma forma de hidrocloreto de 4'-epidaunorubicina cristalino a qual é estável e prontamente solúvel e a um processo para a produção do mesmo. Esse processo compreende cristalização de hidrocloreto de 4'-epidaunorubicina em um sistema de solvente incluindo (a) solventes halogenados e misturas dos mesmo, (b) solvente B, o qual é selecionado do grupo consistindo de C1 - C5 álcoois de cadeia reta e ramificada e misturas dos mesmos e (c) solvente CC, o qual é selecionado do grupo consistindo de C1 - C5 álcoois de cadeia reta e ramificada e misturas dos mesmos, em que o solvente C é selecionado pra proporcionar menor solubilidade ao hidrocloreto de 4'-epidaunorubicina do que o solvente.
BR112012005126A 2009-09-08 2010-09-08 Cristalização de 4'-epidaunorubicina x hcl BR112012005126A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09011459.6A EP2301943B1 (en) 2009-09-08 2009-09-08 Crystallization of epidaunorubicin x HCI
PCT/EP2010/005498 WO2011029576A1 (en) 2009-09-08 2010-09-08 Crystallization of 4'-epidaunorubicin x hci

Publications (2)

Publication Number Publication Date
BR112012005126A2 true BR112012005126A2 (pt) 2017-10-03
BR112012005126A8 BR112012005126A8 (pt) 2018-02-14

Family

ID=41483008

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012005126A BR112012005126A8 (pt) 2009-09-08 2010-09-08 Cristalização de 4'-epidaunorubicina x hcl

Country Status (16)

Country Link
US (3) US8686164B2 (pt)
EP (2) EP2636676A3 (pt)
JP (2) JP5858481B2 (pt)
KR (1) KR101480376B1 (pt)
CN (2) CN105713055A (pt)
AU (1) AU2010294532B2 (pt)
BR (1) BR112012005126A8 (pt)
CA (1) CA2772260C (pt)
HR (1) HRP20140263T1 (pt)
MX (1) MX2012002869A (pt)
PL (1) PL2301943T3 (pt)
RU (1) RU2564415C2 (pt)
SG (1) SG178461A1 (pt)
UA (1) UA111580C2 (pt)
WO (1) WO2011029576A1 (pt)
ZA (1) ZA201202405B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2636676A3 (en) 2009-09-08 2014-01-01 Heraeus Precious Metals GmbH & Co. KG Crystallization of epidaunorubicin x HCl
DE102011103751A1 (de) * 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
KR101428340B1 (ko) * 2012-12-31 2014-08-07 현대자동차주식회사 이온성 용매를 이용한 락타이드 제조법
WO2015149001A1 (en) 2014-03-27 2015-10-01 The Brigham And Women's Hospital, Inc. Metabolically-activated drug conjugates to overcome resistance in cancer therapy
DE102014208194A1 (de) 2014-04-30 2015-11-05 Heraeus Deutschland GmbH & Co. KG Aufreinigung von Epidaunorubicin
EP3279206B1 (en) 2015-03-30 2020-04-22 Meiji Seika Pharma Co., Ltd. Method for producing epirubicin and novel production intermediate therefor
CN109384822B (zh) * 2017-08-11 2021-08-03 鲁南制药集团股份有限公司 一种盐酸表柔比星晶型及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1506200A (en) 1975-04-30 1978-04-05 Farmaceutici Italia Glycosides
US4345068A (en) 1979-11-22 1982-08-17 Farmitalia Carlo Erba S.P.A. Process for the preparation of 4'-epidaunorubicin, 3',4'-diepidaunorubicin, their doxorubicin analogs, and intermediates used in said process
IT1155446B (it) 1982-12-23 1987-01-28 Erba Farmitalia Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine
JPS6442498A (en) * 1987-08-07 1989-02-14 Biogal Gyogyszergyar Improvement for collecting daunorubicin hydrochloride from fermentation liquid
IT1275953B1 (it) 1995-03-22 1997-10-24 Sicor Spa Procedimento per la preparazione di antibiotici della classe delle antracicline
ATE195526T1 (de) 1996-12-16 2000-09-15 Pharmachemie Bv Verfahren zur herstellung von epirubicin oder zusatzsalzen davon, von daunorubicin
EP1034181B1 (en) * 1997-11-28 2006-01-11 Dainippon Sumitomo Pharma Co., Ltd. Crystalline amrubicin hydrochloride
JP3900243B2 (ja) * 1997-12-05 2007-04-04 メルシャン株式会社 結晶質アントラサイクリン抗生物質およびその製造方法
ES2235518T3 (es) * 1998-10-16 2005-07-01 Mercian Corporation Cristalizacion de hidrocloruro de doxorubicina.
ATE520702T1 (de) * 2003-07-02 2011-09-15 Solux Corp Thermisch stabiles kristallines epirubicin- hydrochlorid und herstellungsverfahren dafür
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
JP2009521949A (ja) * 2006-01-04 2009-06-11 ドゥ−コープ テクノロジーズ リミテッド 凍結保護組成物およびその使用方法
ES2644422T3 (es) 2007-05-08 2017-11-28 Provivo Oy Cepas modificadas genéticamente que producen metabolitos de antraciclina útiles como fármacos para el cáncer
US20110081399A1 (en) * 2008-03-13 2011-04-07 Enbio Limited Surface modification of nitinol
EP2636676A3 (en) 2009-09-08 2014-01-01 Heraeus Precious Metals GmbH & Co. KG Crystallization of epidaunorubicin x HCl

Also Published As

Publication number Publication date
HRP20140263T1 (hr) 2014-04-25
CN103347891A (zh) 2013-10-09
US20120232291A1 (en) 2012-09-13
US9434756B2 (en) 2016-09-06
CN103347891B (zh) 2016-06-01
US20140357848A1 (en) 2014-12-04
WO2011029576A1 (en) 2011-03-17
JP2013503826A (ja) 2013-02-04
EP2301943B1 (en) 2014-01-08
UA111580C2 (uk) 2016-05-25
US20140148587A1 (en) 2014-05-29
KR20120068023A (ko) 2012-06-26
RU2564415C2 (ru) 2015-09-27
KR101480376B1 (ko) 2015-01-09
US8686164B2 (en) 2014-04-01
CA2772260A1 (en) 2011-03-17
EP2636676A2 (en) 2013-09-11
CA2772260C (en) 2015-02-24
RU2012113549A (ru) 2013-10-20
PL2301943T3 (pl) 2014-06-30
EP2301943A1 (en) 2011-03-30
ZA201202405B (en) 2012-12-27
SG178461A1 (en) 2012-03-29
MX2012002869A (es) 2012-09-07
JP2016094445A (ja) 2016-05-26
CN105713055A (zh) 2016-06-29
US8822658B2 (en) 2014-09-02
JP5858481B2 (ja) 2016-02-10
EP2636676A3 (en) 2014-01-01
AU2010294532A1 (en) 2012-03-08
BR112012005126A8 (pt) 2018-02-14
AU2010294532B2 (en) 2014-04-10

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: HERAEUS DEUTSCHLAND GMBH AND CO. KG (DE)

B25A Requested transfer of rights approved

Owner name: MEDAC GESELLSCHAFT FUER KLINISCHE SPEZIALPRAEPARAT

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07H 15/24

Ipc: C07H 15/24 (2006.01), A61P 35/00 (2006.01)

B350 Update of information on the portal [chapter 15.35 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements