ATE195526T1 - Verfahren zur herstellung von epirubicin oder zusatzsalzen davon, von daunorubicin - Google Patents

Verfahren zur herstellung von epirubicin oder zusatzsalzen davon, von daunorubicin

Info

Publication number
ATE195526T1
ATE195526T1 AT96203554T AT96203554T ATE195526T1 AT E195526 T1 ATE195526 T1 AT E195526T1 AT 96203554 T AT96203554 T AT 96203554T AT 96203554 T AT96203554 T AT 96203554T AT E195526 T1 ATE195526 T1 AT E195526T1
Authority
AT
Austria
Prior art keywords
daunosamine
daunomycinone
daunorubicin
group
converted
Prior art date
Application number
AT96203554T
Other languages
English (en)
Inventor
Der Rijst Marcel Van
Johan Wilhelm Scheeren
Vos Dick De
Original Assignee
Pharmachemie Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmachemie Bv filed Critical Pharmachemie Bv
Application granted granted Critical
Publication of ATE195526T1 publication Critical patent/ATE195526T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT96203554T 1996-12-16 1996-12-16 Verfahren zur herstellung von epirubicin oder zusatzsalzen davon, von daunorubicin ATE195526T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96203554A EP0848009B1 (de) 1996-12-16 1996-12-16 Verfahren zur Herstellung von Epirubicin oder Zusatzsalzen davon, von Daunorubicin

Publications (1)

Publication Number Publication Date
ATE195526T1 true ATE195526T1 (de) 2000-09-15

Family

ID=8224702

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96203554T ATE195526T1 (de) 1996-12-16 1996-12-16 Verfahren zur herstellung von epirubicin oder zusatzsalzen davon, von daunorubicin

Country Status (11)

Country Link
US (1) US5874550A (de)
EP (1) EP0848009B1 (de)
JP (1) JP4176845B2 (de)
AT (1) ATE195526T1 (de)
CA (1) CA2224764C (de)
DE (1) DE69609845T2 (de)
DK (1) DK0848009T3 (de)
ES (1) ES2151632T3 (de)
GR (1) GR3034608T3 (de)
PT (1) PT848009E (de)
SI (1) SI0848009T1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100785966B1 (ko) * 2000-08-10 2007-12-14 동아제약주식회사 안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
KR100850408B1 (ko) * 2000-08-10 2008-08-04 동아제약주식회사 안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
CN100412084C (zh) * 2003-07-02 2008-08-20 獀洛克斯股份有限公司 热稳定的结晶盐酸表柔比星及其制造方法
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
WO2006111561A1 (en) * 2005-04-21 2006-10-26 Dsm Ip Assets B.V. Improved microbial production of anthracyclins
EP1976858B1 (de) 2005-12-13 2016-01-06 Solux Corporation Verfahren zur herstellung von 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
ES2644422T3 (es) * 2007-05-08 2017-11-28 Provivo Oy Cepas modificadas genéticamente que producen metabolitos de antraciclina útiles como fármacos para el cáncer
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
AU2008361598B2 (en) * 2008-09-11 2015-02-12 Heraeus Precious Metals Gmbh & Co Kg Genetically modified strains for biotransformations in anthracycline production
EP2636676A3 (de) 2009-09-08 2014-01-01 Heraeus Precious Metals GmbH & Co. KG Kristallisierung von Epidaunorubicin x HCI
KR101125460B1 (ko) 2010-03-24 2012-03-28 동아제약주식회사 에피루비신 염산염의 신규한 결정형
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
WO2015000132A1 (zh) 2013-07-02 2015-01-08 浙江海正药业股份有限公司 表阿霉素的制备方法及其中间体
EP3279206B1 (de) 2015-03-30 2020-04-22 Meiji Seika Pharma Co., Ltd. Verfahren zur herstellung von epirubicin und neues herstellungszwischenprodukt dafür
CN104861014B (zh) * 2015-06-03 2017-09-29 道中道（菏泽）制药有限公司 一种盐酸表阿霉素结晶的制备方法
WO2017120729A1 (zh) * 2016-01-11 2017-07-20 浙江海正药业股份有限公司 一种盐酸表柔比星的制备方法及其中间体
CN112574267A (zh) * 2019-09-28 2021-03-30 鲁南制药集团股份有限公司 一种盐酸表柔比星中间体化合物iii
CN114149473B (zh) * 2020-09-08 2024-03-15 鲁南制药集团股份有限公司 一种盐酸表柔比星的合成方法及其中间体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803124A (en) 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
GB1457632A (en) 1974-03-22 1976-12-08 Farmaceutici Italia Adriamycins
WO1986000073A1 (en) 1984-06-14 1986-01-03 BIOGAL Gyógyszergyár Process for preparing adriamycine and halide salts thereof
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
IT1196503B (it) 1986-07-16 1988-11-16 Erba Farmitalia Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto
IT1230505B (it) * 1988-10-11 1991-10-25 Sicor Spa Procedimento per la conversione della daunorubicina in doxorubicina.
IT1275953B1 (it) * 1995-03-22 1997-10-24 Sicor Spa Procedimento per la preparazione di antibiotici della classe delle antracicline

Also Published As

Publication number Publication date
CA2224764C (en) 2006-10-03
SI0848009T1 (en) 2000-12-31
JP4176845B2 (ja) 2008-11-05
EP0848009B1 (de) 2000-08-16
DE69609845D1 (de) 2000-09-21
EP0848009A1 (de) 1998-06-17
CA2224764A1 (en) 1998-06-16
GR3034608T3 (en) 2001-01-31
JPH10175991A (ja) 1998-06-30
ES2151632T3 (es) 2001-01-01
DK0848009T3 (da) 2000-11-20
PT848009E (pt) 2000-11-30
US5874550A (en) 1999-02-23
DE69609845T2 (de) 2000-12-21

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee