GR3034608T3 - A process for preparing epirubicin or acid addition salts thereof from daunorubicin - Google Patents

A process for preparing epirubicin or acid addition salts thereof from daunorubicin

Info

Publication number
GR3034608T3
GR3034608T3 GR20000402292T GR20000402292T GR3034608T3 GR 3034608 T3 GR3034608 T3 GR 3034608T3 GR 20000402292 T GR20000402292 T GR 20000402292T GR 20000402292 T GR20000402292 T GR 20000402292T GR 3034608 T3 GR3034608 T3 GR 3034608T3
Authority
GR
Greece
Prior art keywords
daunosamine
daunomycinone
daunorubicin
group
converted
Prior art date
Application number
GR20000402292T
Other languages
English (en)
Inventor
Der Rijst Marcel Van
Johan Wilhelm Scheeren
Vos Dick De
Original Assignee
Pharmachemie Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmachemie Bv filed Critical Pharmachemie Bv
Publication of GR3034608T3 publication Critical patent/GR3034608T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GR20000402292T 1996-12-16 2000-10-12 A process for preparing epirubicin or acid addition salts thereof from daunorubicin GR3034608T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96203554A EP0848009B1 (en) 1996-12-16 1996-12-16 A process for preparing epirubicin or acid addition salts thereof from daunorubicin

Publications (1)

Publication Number Publication Date
GR3034608T3 true GR3034608T3 (en) 2001-01-31

Family

ID=8224702

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000402292T GR3034608T3 (en) 1996-12-16 2000-10-12 A process for preparing epirubicin or acid addition salts thereof from daunorubicin

Country Status (11)

Country Link
US (1) US5874550A (el)
EP (1) EP0848009B1 (el)
JP (1) JP4176845B2 (el)
AT (1) ATE195526T1 (el)
CA (1) CA2224764C (el)
DE (1) DE69609845T2 (el)
DK (1) DK0848009T3 (el)
ES (1) ES2151632T3 (el)
GR (1) GR3034608T3 (el)
PT (1) PT848009E (el)
SI (1) SI0848009T1 (el)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100850408B1 (ko) * 2000-08-10 2008-08-04 동아제약주식회사 안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
KR100785966B1 (ko) * 2000-08-10 2007-12-14 동아제약주식회사 안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
EP1638509B1 (en) * 2003-07-02 2015-12-30 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
WO2006111561A1 (en) * 2005-04-21 2006-10-26 Dsm Ip Assets B.V. Improved microbial production of anthracyclins
US9035032B2 (en) * 2005-12-13 2015-05-19 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
ES2644422T3 (es) 2007-05-08 2017-11-28 Provivo Oy Cepas modificadas genéticamente que producen metabolitos de antraciclina útiles como fármacos para el cáncer
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
JP2012501663A (ja) * 2008-09-11 2012-01-26 ヴェー・ツェー・ヘレウス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・ウント・コンパニー・コマンディット・ゲゼルシャフト アントラサイクリン産生における生体内変換のための遺伝子組み換え菌株
EP2301943B1 (en) 2009-09-08 2014-01-08 Heraeus Precious Metals GmbH & Co. KG Crystallization of epidaunorubicin x HCI
KR101125460B1 (ko) * 2010-03-24 2012-03-28 동아제약주식회사 에피루비신 염산염의 신규한 결정형
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
CN105229019B (zh) 2013-07-02 2017-12-12 浙江海正药业股份有限公司 表阿霉素的制备方法及其中间体
WO2016159092A1 (ja) 2015-03-30 2016-10-06 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 エピルビシンの製造方法およびその新規な製造中間体
CN104861014B (zh) * 2015-06-03 2017-09-29 道中道（菏泽）制药有限公司 一种盐酸表阿霉素结晶的制备方法
WO2017120729A1 (zh) * 2016-01-11 2017-07-20 浙江海正药业股份有限公司 一种盐酸表柔比星的制备方法及其中间体
CN112574267A (zh) * 2019-09-28 2021-03-30 鲁南制药集团股份有限公司 一种盐酸表柔比星中间体化合物iii
CN114149473B (zh) * 2020-09-08 2024-03-15 鲁南制药集团股份有限公司 一种盐酸表柔比星的合成方法及其中间体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803124A (en) 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
GB1457632A (en) 1974-03-22 1976-12-08 Farmaceutici Italia Adriamycins
JPS61502956A (ja) 1984-06-14 1986-12-18 ビオガル　ジヨジセルジヤ−ル アドリアマイシン及びそのハロゲン化塩の調整法
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
IT1196503B (it) 1986-07-16 1988-11-16 Erba Farmitalia Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto
IT1230505B (it) * 1988-10-11 1991-10-25 Sicor Spa Procedimento per la conversione della daunorubicina in doxorubicina.
IT1275953B1 (it) * 1995-03-22 1997-10-24 Sicor Spa Procedimento per la preparazione di antibiotici della classe delle antracicline

Also Published As

Publication number Publication date
DE69609845D1 (de) 2000-09-21
DK0848009T3 (da) 2000-11-20
JPH10175991A (ja) 1998-06-30
US5874550A (en) 1999-02-23
JP4176845B2 (ja) 2008-11-05
EP0848009A1 (en) 1998-06-17
CA2224764C (en) 2006-10-03
ES2151632T3 (es) 2001-01-01
DE69609845T2 (de) 2000-12-21
ATE195526T1 (de) 2000-09-15
CA2224764A1 (en) 1998-06-16
PT848009E (pt) 2000-11-30
SI0848009T1 (en) 2000-12-31
EP0848009B1 (en) 2000-08-16

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