DE69609845D1 - Verfahren zur Herstellung von Epirubicin oder Zusatzsalzen davon, von Daunorubicin - Google Patents

Verfahren zur Herstellung von Epirubicin oder Zusatzsalzen davon, von Daunorubicin

Info

Publication number
DE69609845D1
DE69609845D1 DE69609845T DE69609845T DE69609845D1 DE 69609845 D1 DE69609845 D1 DE 69609845D1 DE 69609845 T DE69609845 T DE 69609845T DE 69609845 T DE69609845 T DE 69609845T DE 69609845 D1 DE69609845 D1 DE 69609845D1
Authority
DE
Germany
Prior art keywords
daunosamine
daunomycinone
epirubicin
daunorubicin
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69609845T
Other languages
English (en)
Other versions
DE69609845T2 (de
Inventor
Der Rijst Marcel Van
Johan Wilhelm Scheeren
Vos Dick De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmachemie BV
Original Assignee
Pharmachemie BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmachemie BV filed Critical Pharmachemie BV
Application granted granted Critical
Publication of DE69609845D1 publication Critical patent/DE69609845D1/de
Publication of DE69609845T2 publication Critical patent/DE69609845T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69609845T 1996-12-16 1996-12-16 Verfahren zur Herstellung von Epirubicin oder Zusatzsalzen davon, von Daunorubicin Expired - Fee Related DE69609845T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96203554A EP0848009B1 (de) 1996-12-16 1996-12-16 Verfahren zur Herstellung von Epirubicin oder Zusatzsalzen davon, von Daunorubicin

Publications (2)

Publication Number Publication Date
DE69609845D1 true DE69609845D1 (de) 2000-09-21
DE69609845T2 DE69609845T2 (de) 2000-12-21

Family

ID=8224702

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69609845T Expired - Fee Related DE69609845T2 (de) 1996-12-16 1996-12-16 Verfahren zur Herstellung von Epirubicin oder Zusatzsalzen davon, von Daunorubicin

Country Status (11)

Country Link
US (1) US5874550A (de)
EP (1) EP0848009B1 (de)
JP (1) JP4176845B2 (de)
AT (1) ATE195526T1 (de)
CA (1) CA2224764C (de)
DE (1) DE69609845T2 (de)
DK (1) DK0848009T3 (de)
ES (1) ES2151632T3 (de)
GR (1) GR3034608T3 (de)
PT (1) PT848009E (de)
SI (1) SI0848009T1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100785966B1 (ko) * 2000-08-10 2007-12-14 동아제약주식회사 안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
KR100850408B1 (ko) * 2000-08-10 2008-08-04 동아제약주식회사 안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
ATE520702T1 (de) * 2003-07-02 2011-09-15 Solux Corp Thermisch stabiles kristallines epirubicin- hydrochlorid und herstellungsverfahren dafür
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
WO2006111561A1 (en) * 2005-04-21 2006-10-26 Dsm Ip Assets B.V. Improved microbial production of anthracyclins
WO2007070820A2 (en) * 2005-12-13 2007-06-21 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
PL1990405T3 (pl) * 2007-05-08 2018-01-31 Provivo Oy Genetycznie zmodyfikowane szczepy wytwarzające metabolity będące antracyklinami użyteczne jako leki przeciwnowotworowe
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
AU2008361598B2 (en) * 2008-09-11 2015-02-12 Heraeus Precious Metals Gmbh & Co Kg Genetically modified strains for biotransformations in anthracycline production
PL2301943T3 (pl) 2009-09-08 2014-06-30 Heraeus Precious Metals Gmbh Krystalizacja epidaunorubicyny x HCI
KR101125460B1 (ko) * 2010-03-24 2012-03-28 동아제약주식회사 에피루비신 염산염의 신규한 결정형
DE102011103751A1 (de) * 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
CN105229019B (zh) 2013-07-02 2017-12-12 浙江海正药业股份有限公司 表阿霉素的制备方法及其中间体
TWI712611B (zh) 2015-03-30 2020-12-11 日商明治製菓藥業股份有限公司 泛艾黴素之製造方法及其新穎之製造中間體
CN104861014B (zh) * 2015-06-03 2017-09-29 道中道（菏泽）制药有限公司 一种盐酸表阿霉素结晶的制备方法
CN108473523B (zh) * 2016-01-11 2022-03-15 浙江海正药业股份有限公司 一种盐酸表柔比星的制备方法及其中间体
CN112574267A (zh) * 2019-09-28 2021-03-30 鲁南制药集团股份有限公司 一种盐酸表柔比星中间体化合物iii
CN114149473B (zh) * 2020-09-08 2024-03-15 鲁南制药集团股份有限公司 一种盐酸表柔比星的合成方法及其中间体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803124A (en) 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
GB1457632A (en) 1974-03-22 1976-12-08 Farmaceutici Italia Adriamycins
JPS61502956A (ja) 1984-06-14 1986-12-18 ビオガル　ジヨジセルジヤ−ル アドリアマイシン及びそのハロゲン化塩の調整法
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
IT1196503B (it) 1986-07-16 1988-11-16 Erba Farmitalia Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto
IT1230505B (it) * 1988-10-11 1991-10-25 Sicor Spa Procedimento per la conversione della daunorubicina in doxorubicina.
IT1275953B1 (it) * 1995-03-22 1997-10-24 Sicor Spa Procedimento per la preparazione di antibiotici della classe delle antracicline

Also Published As

Publication number Publication date
CA2224764A1 (en) 1998-06-16
US5874550A (en) 1999-02-23
DE69609845T2 (de) 2000-12-21
EP0848009A1 (de) 1998-06-17
PT848009E (pt) 2000-11-30
GR3034608T3 (en) 2001-01-31
SI0848009T1 (en) 2000-12-31
ES2151632T3 (es) 2001-01-01
CA2224764C (en) 2006-10-03
EP0848009B1 (de) 2000-08-16
JP4176845B2 (ja) 2008-11-05
ATE195526T1 (de) 2000-09-15
JPH10175991A (ja) 1998-06-30
DK0848009T3 (da) 2000-11-20

Similar Documents

Publication Publication Date Title
DE69609845D1 (de) Verfahren zur Herstellung von Epirubicin oder Zusatzsalzen davon, von Daunorubicin
EP0132732A3 (en) Homologues from aprotinine whose lys 15 amino acid is substituted by other amino acids, process for their preparation and their use as medicaments
ATE219047T1 (de) Verfahren zur herstellung von optisch reinen isomeren des formoterols
DK1082293T3 (da) Formoterol-polymorfer
DE69020794D1 (de) Enzymatische Entfernung einer aminoterminalen Proteinsequenz.
IE860305L (en) Method for purifying antihemophilic factor
ES2086346T3 (es) Derivados de acido quinoloncarboxilico, procedimiento para su fabricacion asi como su uso como agentes antiviricos.
FI892185A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten peptidiyhdisteiden valmistamiseksi
PT81528B (pt) Processo para a sintese de peptideos
ATE60308T1 (de) Verfahren zur herstellung fester aluminiumchlorid-zusammensetzungen.
ES2110481T3 (es) Procedimiento para la obtencion de acidos sialicos activados.
CU22900A3 (es) Preparacion de (poli)peptidos purificados.
CA2062788A1 (en) Improved process for preparing isepamicin
MA21305A1 (fr) Procede de preparation de l'acide (pyridyl-3)-3 ih,3h-pyrrono(i,2-c) thiazolecarboxylique-7 dextrocyre.
AR241137A2 (es) "procedimiento para preparar beta-metilen-2 o 3-tiofenetanamina".
DE59107545D1 (de) Salicylaldehyd- und Salicylsäurederivate sowie deren Schwefelanaloge, Verfahren und Zwischenprodukte zu ihrer Herstellung
DE3750117D1 (de) Verfahren zur Herstellung von Indolinon-2-Derivaten.
ATE99323T1 (de) Verfahren zur wiedergewinnung eines gereinigten epi-proteins aus einer loesung, insbesondere einer gaerungsloesung.
ATE93845T1 (de) Verfahren zur herstellung von 4,4'-bis-(4aminophenoxy)-diphenylsulfon.
AU6756987A (en) Process for producing l-amino acids or 5'-inosinic acid by fermentation
DE69021155D1 (de) Verfahren zur Herstellung von 2-Chlor-4-Fluorphenol.
RO95699A2 (ro) Derivati de 1,1' -oxibis-2n-benzamido-benzen si procedeu de prepararea acestora
BG51403A1 (en) Oligomer amonium salts of bromonitrosulphonic acids and method for their preparation
DE3777685D1 (de) Verfahren zur herstellung von 6,7-dihydro-5,8-dimethyl-9-fluor-1-oxo-1h,5h-benzo(i,j)chinolizin-2-carbonsaeure.
JPS57114565A (en) Preparation of peptide, and arginine derivative

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee